Biotechnology Engineering: A Practical Approach on Bioprocess Development from Lab to Industrial Scale offers a comprehensive guide on biotechnology engineering, focusing on transforming research and development into commercially viable industrial processes. The book addresses the needs of the market by providing structured chapters, practical methods, and real-world case studies. Readers will gain valuable insights into bioprocessing basics, scalable solutions, optimization techniques, and collaboration opportunities. The text also covers essential regulatory compliance information, bridging the gap between theoretical knowledge and practical applications.
The book is a vital resource for academics, scientists, engineers, and professionals in bioprocess development. It includes detailed discussions, calculations, and case studies, modern bioreactors, and software tools used in the industry. Serving as a desktop reference, it effectively combines theory with real-world applications to support the development of bioprocesses on all scales.
1. Introduction - p. xxi 2. PART A Cell culture & Kinetic study - p. 1 3. Chapter 1 Culturing of microbial, animal, and plant cells in lab scale - p. 3 4. Chapter 2 Microbial growth and cell kinetics - p. 23 5. Chapter 3 Design, optimization, and inoculum development for culturing the cells - p. 41 6. Chapter 4 Lab scale studies on submerged liquid fermentation (SLF) and solid-state fermentation (SSF) - p. 51 7. PART B Bioreactor handling and operation - p. 69 8. Chapter 5 Fundamentals on bioreactors, operation modes and control system mechanisms - p. 71 9. Chapter 6 Design aspects and aseptic maintenance of bioreactors - p. 107 10. Chapter 7 Cleaning techniques for bioreactors and regulatory standards - p. 125 11. Chapter 8 Bioreactor sterilization and sterility maintenance in biotechnological cultivation processes - p. 151 12. Chapter 9 Standard operating procedures (SOPs) and auditing in bioprocess industries - p. 181 13. Chapter 10 Operation and control of submerged liquid fermenters - p. 205 14. Chapter 11 Operation and control of submerged solid fermenters - p. 229 15. Chapter 12 Equipment for product recovery and purification - p. 247 16. Chapter 13 Modern reactors and software tools in bioprocess development - p. 293 17. PART C Bioreactor Scale up aspects and case studies - p. 307 18. Chapter 14 Scale-up rules and reactor accessories - p. 309 19. Chapter 15 Scale-up strategies for submerged liquid fermentation - p. 335 20. Chapter 16 Scale-up strategies for solid-state fermentation - p. 345 21. Chapter 17 Scale-up constraint from lab scale to industrial scale - p. 375 22. PART D Bioproducts - p. 389 23. Chapter 18 Commercial bioproducts from bioreactor - p. 391 24. Chapter 19 Bioproducts from fermentation and their economic impact - p. 411 25. Chapter 20 Manufacturing techniques for bioproducts - p. 429 26. Index - p. 445
Biotechnology Engineering: A Practical Approach on Bioprocess Development from Lab to Industrial Scale offers a comprehensive guide on biotechnology engineering, focusing on transforming research and development into commercially viable industrial processes. The book addresses the needs of the market by providing structured chapters, practical methods, and real-world case studies. Readers will gain valuable insights into bioprocessing basics, scalable solutions, optimization techniques, and collaboration opportunities. The text also covers essential regulatory compliance information, bridging the gap between theoretical knowledge and practical applications.
The book is a vital resource for academics, scientists, engineers, and professionals in bioprocess development. It includes detailed discussions, calculations, and case studies, modern bioreactors, and software tools used in the industry. Serving as a desktop reference, it effectively combines theory with real-world applications to support the development of bioprocesses on all scales.
1. Introduction - p. xxi 2. PART A Cell culture & Kinetic study - p. 1 3. Chapter 1 Culturing of microbial, animal, and plant cells in lab scale - p. 3 4. Chapter 2 Microbial growth and cell kinetics - p. 23 5. Chapter 3 Design, optimization, and inoculum development for culturing the cells - p. 41 6. Chapter 4 Lab scale studies on submerged liquid fermentation (SLF) and solid-state fermentation (SSF) - p. 51 7. PART B Bioreactor handling and operation - p. 69 8. Chapter 5 Fundamentals on bioreactors, operation modes and control system mechanisms - p. 71 9. Chapter 6 Design aspects and aseptic maintenance of bioreactors - p. 107 10. Chapter 7 Cleaning techniques for bioreactors and regulatory standards - p. 125 11. Chapter 8 Bioreactor sterilization and sterility maintenance in biotechnological cultivation processes - p. 151 12. Chapter 9 Standard operating procedures (SOPs) and auditing in bioprocess industries - p. 181 13. Chapter 10 Operation and control of submerged liquid fermenters - p. 205 14. Chapter 11 Operation and control of submerged solid fermenters - p. 229 15. Chapter 12 Equipment for product recovery and purification - p. 247 16. Chapter 13 Modern reactors and software tools in bioprocess development - p. 293 17. PART C Bioreactor Scale up aspects and case studies - p. 307 18. Chapter 14 Scale-up rules and reactor accessories - p. 309 19. Chapter 15 Scale-up strategies for submerged liquid fermentation - p. 335 20. Chapter 16 Scale-up strategies for solid-state fermentation - p. 345 21. Chapter 17 Scale-up constraint from lab scale to industrial scale - p. 375 22. PART D Bioproducts - p. 389 23. Chapter 18 Commercial bioproducts from bioreactor - p. 391 24. Chapter 19 Bioproducts from fermentation and their economic impact - p. 411 25. Chapter 20 Manufacturing techniques for bioproducts - p. 429 26. Index - p. 445
