Brain Banking, Volume 150, serves as the only book on the market offering comprehensive coverage of the functional realities of brain banking. It focuses on brain donor recruitment strategies, brain bank networks, ethical issues, brain dissection/tissue processing/tissue dissemination, neuropathological diagnosis, brain donor data, and techniques in brain tissue analysis. In accordance with massive initiatives, such as BRAIN and the EU Human Brain Project, abnormalities and potential therapeutic targets of neurological and psychiatric disorders need to be validated in human brain tissue, thus requiring substantial numbers of well characterized human brains of high tissue quality with neurological and psychiatric diseases.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Handbook of Clinical Neurology 3rd Series - p. v 6. Foreword - p. vii 7. Preface - p. ix 8. Contributors - p. xi 9. Section I: Brain donor recruitment strategies - p. xi 10. Chapter 1: The Netherlands Brain Bank for Psychiatry - p. xi 11. Chapter 2: Brain donation procedures in the Sudden Death Brain Bank in Edinburgh - p. 16 12. Section II: Brain bank networks - p. 27 13. Chapter 3: Autism BrainNet: A network of postmortem brain banks established to facilitate autism research - p. 27 14. Chapter 4: The NIH NeuroBioBank: creating opportunities for human brain research - p. 39 15. Section III: Ethical aspects of brain banking and management of brain banks - p. 48 16. Chapter 5: Design of a European code of conduct for brain banking - p. 48 17. Chapter 6: A review of brain biorepository management and operations - p. 81 18. Chapter 7: A new viewpoint: running a nonprofit brain bank as a business - p. 92 19. Section IV: Brain dissection, tissue processing, and tissue dissemination - p. 101 20. Chapter 8: The New York Brain Bank of Columbia University: practical highlights of 35 years of experience - p. 101 21. Chapter 9: Neurochemical markers as potential indicators of postmortem tissue quality - p. 118 22. Section V: Neuropathologic diagnosis - p. 127 23. Chapter 10: Minimal neuropathologic diagnosis for brain banking in the normal middle-aged and aged brain and in neurodegenerative disorders - p. 127 24. Chapter 11: Brain donation at autopsy: clinical characterization and toxicologic analyses - p. 141 25. Section VI: Brain donor data: clinical, genetic, radiologic, and research data storage and mining - p. 154 26. Chapter 12: Information technology for brain banking - p. 154 27. Chapter 13: Collecting, storing, and mining research data in a brain bank - p. 165 28. Chapter 14: What can we learn about brain donors? Use of clinical information in human postmortem brain research - p. 179 29. Chapter 15: The art of matching brain tissue from patients and controls for postmortem research - p. 196 30. Section VII: Human brain tissue analyses: old and new techniques - p. 217 31. Chapter 16: Considerations for optimal use of postmortem human brains for molecular psychiatry: lessons from schizophrenia - p. 217 32. Chapter 17: Epigenetic analysis of human postmortem brain tissue - p. 235 33. Chapter 18: Laser microdissection and gene expression profiling in the human postmortem brain - p. 261 34. Chapter 19: Purification of cells from fresh human brain tissue: primary human glial cells - p. 272 35. Chapter 20: Proteomics and lipidomics in the human brain - p. 283 36. Chapter 21: 3D imaging in the postmortem human brain with CLARITY and CUBIC - p. 302 37. Chapter 22: Neuronal life after death: electrophysiologic recordings from neurons in adult human brain tissue obtained through surgical resection or postmortem - p. 317 38. Chapter 23: Postmortem magnetic resonance imaging - p. 333 39. Chapter 24: Cyto- and receptor architectonic mapping of the human brain - p. 354 40. Chapter 25: Mapping pathologic circuitry in schizophrenia - p. 387 41. Index - p. 419
Brain Banking, Volume 150, serves as the only book on the market offering comprehensive coverage of the functional realities of brain banking. It focuses on brain donor recruitment strategies, brain bank networks, ethical issues, brain dissection/tissue processing/tissue dissemination, neuropathological diagnosis, brain donor data, and techniques in brain tissue analysis. In accordance with massive initiatives, such as BRAIN and the EU Human Brain Project, abnormalities and potential therapeutic targets of neurological and psychiatric disorders need to be validated in human brain tissue, thus requiring substantial numbers of well characterized human brains of high tissue quality with neurological and psychiatric diseases.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Handbook of Clinical Neurology 3rd Series - p. v 6. Foreword - p. vii 7. Preface - p. ix 8. Contributors - p. xi 9. Section I: Brain donor recruitment strategies - p. xi 10. Chapter 1: The Netherlands Brain Bank for Psychiatry - p. xi 11. Chapter 2: Brain donation procedures in the Sudden Death Brain Bank in Edinburgh - p. 16 12. Section II: Brain bank networks - p. 27 13. Chapter 3: Autism BrainNet: A network of postmortem brain banks established to facilitate autism research - p. 27 14. Chapter 4: The NIH NeuroBioBank: creating opportunities for human brain research - p. 39 15. Section III: Ethical aspects of brain banking and management of brain banks - p. 48 16. Chapter 5: Design of a European code of conduct for brain banking - p. 48 17. Chapter 6: A review of brain biorepository management and operations - p. 81 18. Chapter 7: A new viewpoint: running a nonprofit brain bank as a business - p. 92 19. Section IV: Brain dissection, tissue processing, and tissue dissemination - p. 101 20. Chapter 8: The New York Brain Bank of Columbia University: practical highlights of 35 years of experience - p. 101 21. Chapter 9: Neurochemical markers as potential indicators of postmortem tissue quality - p. 118 22. Section V: Neuropathologic diagnosis - p. 127 23. Chapter 10: Minimal neuropathologic diagnosis for brain banking in the normal middle-aged and aged brain and in neurodegenerative disorders - p. 127 24. Chapter 11: Brain donation at autopsy: clinical characterization and toxicologic analyses - p. 141 25. Section VI: Brain donor data: clinical, genetic, radiologic, and research data storage and mining - p. 154 26. Chapter 12: Information technology for brain banking - p. 154 27. Chapter 13: Collecting, storing, and mining research data in a brain bank - p. 165 28. Chapter 14: What can we learn about brain donors? Use of clinical information in human postmortem brain research - p. 179 29. Chapter 15: The art of matching brain tissue from patients and controls for postmortem research - p. 196 30. Section VII: Human brain tissue analyses: old and new techniques - p. 217 31. Chapter 16: Considerations for optimal use of postmortem human brains for molecular psychiatry: lessons from schizophrenia - p. 217 32. Chapter 17: Epigenetic analysis of human postmortem brain tissue - p. 235 33. Chapter 18: Laser microdissection and gene expression profiling in the human postmortem brain - p. 261 34. Chapter 19: Purification of cells from fresh human brain tissue: primary human glial cells - p. 272 35. Chapter 20: Proteomics and lipidomics in the human brain - p. 283 36. Chapter 21: 3D imaging in the postmortem human brain with CLARITY and CUBIC - p. 302 37. Chapter 22: Neuronal life after death: electrophysiologic recordings from neurons in adult human brain tissue obtained through surgical resection or postmortem - p. 317 38. Chapter 23: Postmortem magnetic resonance imaging - p. 333 39. Chapter 24: Cyto- and receptor architectonic mapping of the human brain - p. 354 40. Chapter 25: Mapping pathologic circuitry in schizophrenia - p. 387 41. Index - p. 419
