Brain Edema: From Molecular Mechanisms to Clinical Practice brings together the most widely recognized experts in experimental and clinical brain edema research to review the current knowledge gathered on the molecular and cellular pathophysiology and clinical management of brain edema. This timely book also discusses future directions of research and treatment.
Brain edema is an integral and acutely life-threatening part of the pathophysiology of multiple cerebral and non-cerebral disorders, including traumatic brain injury, cerebral ischemia, brain tumors, cardiac arrest, altitude sickness and liver failure. Affecting millions worldwide, research over the past few years has shown that a plethora of complex molecular and cellular mechanisms contribute to this pathological accumulation of water in the brain parenchyma.
In parallel, the development of new neuroimaging tools has provided a new way to examine how edema develops longitudinally and in real time, both in pre-clinical models and in patients. Despite intense research over the past few decades, therapeutic options are still limited and sometimes not effective.
1. Introduction: Brain Edema Formation—Significance for Patient Outcome - p. xvii 2. Section I: General Introduction - p. xxiv 3. Chapter 1. Physiology of Cerebral Blood Vessels - p. 3 4. Chapter 2. Blood–Brain Interfaces Organization in Relation to Inorganic Ion Transport, CSF Secretion, and Circulation - p. 29 5. Section II: Techniques to Investigate Cerebral Blood - p. 45 6. Chapter 3. Noninvasive Imaging Techniques for Brain Edema: From Basic Science to the Clinic - p. 51 7. Chapter 4. Experimental Techniques to Investigate the Formation of Brain Edema In Vivo - p. 71 8. Chapter 5. In Vitro Models of the Blood–Brain Barrier to Better Understand the Pathophysiology of Brain Edema - p. 85 9. Section III: Molecular Basis and Concepts in Brain Edema Formation for New Treatment Development - p. 98 10. Chapter 6. The Extracellular and Perivascular Spaces of the Brain - p. 105 11. Chapter 7. Blood-Brain Barrier Mechanisms of Edema Formation: The Role of Ion Transporters and Channels - p. 129 12. Chapter 8. Mechanisms of Cell-Volume Regulation in the Central Nervous System - p. 151 13. Chapter 9. Role of Aquaporins in the Formation and Resolution of Brain Edema - p. 163 14. Chapter 10. Sur1–Trpm4-Promising Target for Brain Edema Treatment in Brain Edema: From Molecular Mechanisms to Clinical Practice - p. 183 15. Chapter 11. Role of Matrix Metalloproteinases in Brain Edema - p. 199 16. Section IV: Brain Edema Process in Preclinical Models - p. 209 17. Chapter 12. Edema and BBB Breakdown in Stroke - p. 219 18. Chapter 13. Brain Edema Formation in Traumatic Brain Injury - p. 235 19. Chapter 14. Spinal Cord Edema After Spinal Cord Injury: From Pathogenesis to Management - p. 261 20. Chapter 15. Brain Edema in Acute Liver Failure - p. 277 21. Chapter 16. Blood–Brain Barrier and Edema in Brain Tumors - p. 293 22. Chapter 17. Water Homeostasis Dysfunction in Epilepsy - p. 315 23. Chapter 18. Water Homeostasis Dysfunctions and Edema in Neuroinflammatory Disease - p. 337 24. Chapter 19. Experimental Therapies for Brain Edema and Intracranial Hypertension - p. 353 25. Section V: Clinical Features and Management of Brain Edema - p. 366 26. Chapter 20. Clinical Monitoring of Brain Edema - p. 377 27. Chapter 21. Brain Edema in Developing Brain Diseases - p. 393 28. Chapter 22. Cerebral Edema in Cerebrovascular Diseases - p. 431 29. Chapter 23. Traumatic Brain Injury and Edema Treatment - p. 457 30. Chapter 24. Treatment of Edema Formation in Oncology - p. 477 31. Chapter 25. Perspectives on Future Translational Research on Brain Edema - p. 497 32. Index - p. 507
Brain Edema: From Molecular Mechanisms to Clinical Practice brings together the most widely recognized experts in experimental and clinical brain edema research to review the current knowledge gathered on the molecular and cellular pathophysiology and clinical management of brain edema. This timely book also discusses future directions of research and treatment.
Brain edema is an integral and acutely life-threatening part of the pathophysiology of multiple cerebral and non-cerebral disorders, including traumatic brain injury, cerebral ischemia, brain tumors, cardiac arrest, altitude sickness and liver failure. Affecting millions worldwide, research over the past few years has shown that a plethora of complex molecular and cellular mechanisms contribute to this pathological accumulation of water in the brain parenchyma.
In parallel, the development of new neuroimaging tools has provided a new way to examine how edema develops longitudinally and in real time, both in pre-clinical models and in patients. Despite intense research over the past few decades, therapeutic options are still limited and sometimes not effective.
1. Introduction: Brain Edema Formation—Significance for Patient Outcome - p. xvii 2. Section I: General Introduction - p. xxiv 3. Chapter 1. Physiology of Cerebral Blood Vessels - p. 3 4. Chapter 2. Blood–Brain Interfaces Organization in Relation to Inorganic Ion Transport, CSF Secretion, and Circulation - p. 29 5. Section II: Techniques to Investigate Cerebral Blood - p. 45 6. Chapter 3. Noninvasive Imaging Techniques for Brain Edema: From Basic Science to the Clinic - p. 51 7. Chapter 4. Experimental Techniques to Investigate the Formation of Brain Edema In Vivo - p. 71 8. Chapter 5. In Vitro Models of the Blood–Brain Barrier to Better Understand the Pathophysiology of Brain Edema - p. 85 9. Section III: Molecular Basis and Concepts in Brain Edema Formation for New Treatment Development - p. 98 10. Chapter 6. The Extracellular and Perivascular Spaces of the Brain - p. 105 11. Chapter 7. Blood-Brain Barrier Mechanisms of Edema Formation: The Role of Ion Transporters and Channels - p. 129 12. Chapter 8. Mechanisms of Cell-Volume Regulation in the Central Nervous System - p. 151 13. Chapter 9. Role of Aquaporins in the Formation and Resolution of Brain Edema - p. 163 14. Chapter 10. Sur1–Trpm4-Promising Target for Brain Edema Treatment in Brain Edema: From Molecular Mechanisms to Clinical Practice - p. 183 15. Chapter 11. Role of Matrix Metalloproteinases in Brain Edema - p. 199 16. Section IV: Brain Edema Process in Preclinical Models - p. 209 17. Chapter 12. Edema and BBB Breakdown in Stroke - p. 219 18. Chapter 13. Brain Edema Formation in Traumatic Brain Injury - p. 235 19. Chapter 14. Spinal Cord Edema After Spinal Cord Injury: From Pathogenesis to Management - p. 261 20. Chapter 15. Brain Edema in Acute Liver Failure - p. 277 21. Chapter 16. Blood–Brain Barrier and Edema in Brain Tumors - p. 293 22. Chapter 17. Water Homeostasis Dysfunction in Epilepsy - p. 315 23. Chapter 18. Water Homeostasis Dysfunctions and Edema in Neuroinflammatory Disease - p. 337 24. Chapter 19. Experimental Therapies for Brain Edema and Intracranial Hypertension - p. 353 25. Section V: Clinical Features and Management of Brain Edema - p. 366 26. Chapter 20. Clinical Monitoring of Brain Edema - p. 377 27. Chapter 21. Brain Edema in Developing Brain Diseases - p. 393 28. Chapter 22. Cerebral Edema in Cerebrovascular Diseases - p. 431 29. Chapter 23. Traumatic Brain Injury and Edema Treatment - p. 457 30. Chapter 24. Treatment of Edema Formation in Oncology - p. 477 31. Chapter 25. Perspectives on Future Translational Research on Brain Edema - p. 497 32. Index - p. 507
