Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery.
Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. xi 7. About the Editor - p. xiii 8. About the Series Editor - p. xv 9. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy” - p. xvii 10. Preface - p. xix 11. Chapter 1: Overview of Pancreatic Cancer Biology - p. xix 12. Chapter 2: Chemoresistance in Pancreatic Cancer: Emphasis on Age and Gender - p. 11 13. Chapter 3: EMT Contributes to Chemoresistance in Pancreatic Cancer - p. 23 14. Chapter 4: Pancreatic Cancer Resistance to Gemcitabine - p. 43 15. Chapter 5: Pancreatic Cancer and Possible Therapeutic Options - p. 56 16. Chapter 6: Curcumin and Genistein Enhance the Sensitivity of Pancreatic Cancer to Chemotherapy - p. 85 17. Chapter 7: Terpenoids as Potential Targeted Therapeutics of Pancreatic Cancer: Current Advances and Future Directions - p. 109 18. Chapter 8: Small Molecules and Pancreatic Cancer Trials and Troubles - p. 116 19. Chapter 9: Targeting the Epigenome as a Therapeutic Strategy for Pancreatic Tumors: DNA and Histone Modifying Enzymes - p. 131 20. Chapter 10: Are Nanocarriers Effective for the Diagnosis and Treatment of Pancreatic Cancer? - p. 157 21. Chapter 11: Molecular Markers for Treatment Response and Toxicity of Gemcitabine - p. 174 22. Index - p. 197
Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery.
Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. xi 7. About the Editor - p. xiii 8. About the Series Editor - p. xv 9. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy” - p. xvii 10. Preface - p. xix 11. Chapter 1: Overview of Pancreatic Cancer Biology - p. xix 12. Chapter 2: Chemoresistance in Pancreatic Cancer: Emphasis on Age and Gender - p. 11 13. Chapter 3: EMT Contributes to Chemoresistance in Pancreatic Cancer - p. 23 14. Chapter 4: Pancreatic Cancer Resistance to Gemcitabine - p. 43 15. Chapter 5: Pancreatic Cancer and Possible Therapeutic Options - p. 56 16. Chapter 6: Curcumin and Genistein Enhance the Sensitivity of Pancreatic Cancer to Chemotherapy - p. 85 17. Chapter 7: Terpenoids as Potential Targeted Therapeutics of Pancreatic Cancer: Current Advances and Future Directions - p. 109 18. Chapter 8: Small Molecules and Pancreatic Cancer Trials and Troubles - p. 116 19. Chapter 9: Targeting the Epigenome as a Therapeutic Strategy for Pancreatic Tumors: DNA and Histone Modifying Enzymes - p. 131 20. Chapter 10: Are Nanocarriers Effective for the Diagnosis and Treatment of Pancreatic Cancer? - p. 157 21. Chapter 11: Molecular Markers for Treatment Response and Toxicity of Gemcitabine - p. 174 22. Index - p. 197
