Heart Failure in the Child and Young Adult: From Bench to Bedside combines multiple etiologies for pediatric heart failure, including congenital heart disease, cardiomyopathies, infectious diseases and metabolic abnormalities. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure, then progresses through diagnosis, management, treatment and surgery, finally concluding with advanced special topics, including genetics, self-management and nanomedicine.
1. Introduction - p. 181 2. Epidemiology - p. 181 3. Pathophysiology - p. 181 4. Clinical Presentations - p. 184 5. Diagnosis and Workup - p. 185 6. Treatment - p. 191 7. Recovery, Cardiomyopathy, and Heart Transplantation - p. 194 8. Activity Restrictions - p. 195 9. Chapter 17. Dilated Cardiomyopathy - p. 203 10. Chapter 18. Clinical Features of Restrictive Cardiomyopathy and Constrictive Pericarditis - p. 215 11. Chapter 19. Hypertrophic Cardiomyopathy - p. 239 12. Introduction - p. 239 13. Definition - p. 239 14. Diagnostic Criteria - p. 239 15. Etiology and Classification - p. 240 16. Pathophysiology and Natural History - p. 241 17. Genetics of Sarcomeric Hypertrophic Cardiomyopathy - p. 242 18. Hypertrophic Cardiomyopathy Diagnostic Testing - p. 243 19. Morphologic Variations in Hypertrophic Cardiomyopathy - p. 247 20. Clinical Manifestations, Course, and Outcomes - p. 248 21. Hypertrophic Cardiomyopathy Subtypes - p. 252 22. Hypertrophic Cardiomyopathy Versus Athletic Heart Syndrome - p. 255 23. Screening for Hypertrophic Cardiomyopathy - p. 256 24. Hypertrophic Cardiomyopathy Symptoms and Management - p. 256 25. Pharmacological Therapy - p. 257 26. Interventional Therapy - p. 258 27. Prevention of Sudden Death - p. 258 28. Management of Special Circumstances - p. 261 29. Conclusion - p. 261 30. Abbreviations - p. 261 31. Chapter 20. Left Ventricular Noncompaction Cardiomyopathy - p. 269 32. Chapter 21. Arrhythmogenic Right Ventricular Cardiomyopathy - p. 291 33. Chapter 22. Valvular Insufficiency and Heart Failure - p. 297 34. Chapter 23. Valvular Stenosis and Heart Failure - p. 307 35. Chapter 24. Ischemic Coronary Artery Disease - p. 317 36. Chapter 25. Chronic Heart Failure in Congenital Heart Disease Including Single Ventricle Circulation - p. 323 37. Chapter 26. Heart Failure in Adults With Congenital Heart Disease - p. 331 38. Introduction - p. 331 39. Epidemiology - p. 331 40. General Concepts, Definition, and Classification - p. 332 41. High-Risk Groups and Lesion-Specific Factors - p. 333 42. Tetralogy of Fallot - p. 333 43. Systemic Right Ventricle - p. 334 44. Single Ventricle Circulation - p. 334 45. Eisenmenger Syndrome - p. 335 46. Diagnosis of Heart Failure in Adult Congenital Heart Disease - p. 335 47. Comorbidities and Complications Associated With Heart Failure in Adult Congenital Heart Disease - p. 337 48. Management of Heart Failure in Adult Congenital Heart Disease - p. 338 49. Invasive Hemodynamic Evaluation and Transcatheter Interventions in Adult Congenital Heart Disease–Related Heart Failure - p. 343 50. Arrhythmia Interventions in Adult Congenital Heart Disease–Related Heart Failure - p. 344 51. Surgical Interventions in Adult Congenital Heart Disease–Related Heart Failure - p. 344 52. Conclusion - p. 345 53. Chapter 27. Dysrhythmias and Ventricular Dysfunction and Heart Failure - p. 353 54. Chapter 28. Fetal Heart Failure - p. 369 55. Chapter 29. Heart Failure in the Neonate - p. 383 56. Chapter 30. Right Heart Failure in Pediatric Pulmonary Hypertension - p. 399 57. Chapter 31. Childhood Cardiorenal Syndrome - p. 413 58. Chapter 32. Heart Failure in Pediatric Oncologic Disease - p. 425 59. Chapter 33. The Failing Myocardium in Sepsis - p. 445 60. Chapter 34. Outpatient Management of Pediatric HF - p. 457 61. Chapter 35. Quality of Life and Psychosocial Care in Pediatric Heart Failure - p. 467 62. Chapter 36. Quality Metrics and Quality Improvement in Pediatric Heart Failure - p. 473 63. Chapter 37. Nursing Aspects of Heart Failure - p. 481 64. Section III. Medical Treatment for Pediatric Heart Failure - p. 492 65. Chapter 38. Diuretics and Invasive Fluid Management Strategies - p. 495 66. Chapter 39. The Use of Inotropic Agents in Acute Decompensated Heart Failure - p. 511 67. Chapter 40. Phosphodiesterase Inhibitors - p. 517 68. Chapter 41. Use of Vasodilators in Heart Failure - p. 523 69. Chapter 42. Beta-Adrenergic Receptor Blockade - p. 539 70. Chapter 43. Recognition and Treatment of Low Cardiac Output States in Pediatric Cardiac Intensive Care - p. 543 71. History and Significance - p. 543 72. Clinical Signs of Low Cardiac Output Syndrome - p. 543 73. Causes of Low Cardiac Output After Congenital Heart Surgery - p. 545 74. Diagnosis of Low Cardiac Output Syndrome - p. 547 75. Treatment of Low Cardiac Output Syndrome - p. 548 76. Management of Pulmonary Hypertension - p. 554 77. Management of Right Ventricular Failure - p. 555 78. Ventilation Strategies After Cardiac Surgery - p. 555 79. Conclusion - p. 556 80. Chapter 44. New Therapeutic Strategies in Heart Failure - p. 565 81. Chapter 45. Electrophysiologic Devices in Heart Failure - p. 575 82. Chapter 46. Catheter Device Therapies for Heart Failure - p. 583 83. Obstruction Lesions - p. 583 84. Shunt Lesions - p. 600 85. Miscellaneous - p. 609 86. Section IV. Cardiac Surgery and Pediatric Heart Failure - p. 622 87. Chapter 47. Posttransplant Heart Failure - p. 625 88. Chapter 48. Surgical Management of the Failing Systemic Ventricle - p. 639 89. Chapter 49. Valve Interventions in the Young Adult With Heart Failure - p. 655 90. Chapter 50. Principles of Mechanical Cardiopulmonary Support - p. 675 91. Chapter 51. Short-Term Mechanical Cardiopulmonary Support Devices - p. 683 92. Chapter 52. Decision-Making in Ventricular Assist Device Support in Pediatric Advanced Heart Failure Patients - p. 699 93. Chapter 53. Long-Term Ventricular Assist Devices in Children - p. 707 94. Chapter 54. Adult Experience With Long Term Devices - p. 719 95. Chapter 55. Future of Mechanical Circulatory Support Devices in Children and Young Adults - p. 733 96. Section V. Special Topics - p. 740 97. Chapter 56. Genetic Testing - p. 743 98. Chapter 57. Data Management and Analytics - p. 749 99. Chapter 58. Outpatient Monitoring and Self-Care - p. 755 100. Chapter 59. Regenerative Medicine/Injured Human Hearts - p. 773 101. Chapter 60. Nanomedicine and Nanotechnology for Heart Failure Research, Diagnosis, and Treatment - p. 779 102. Chapter 61. Nutritional Assessment and Management in Pediatric Heart Failure - p. 785 103. Index - p. 791
Heart Failure in the Child and Young Adult: From Bench to Bedside combines multiple etiologies for pediatric heart failure, including congenital heart disease, cardiomyopathies, infectious diseases and metabolic abnormalities. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure, then progresses through diagnosis, management, treatment and surgery, finally concluding with advanced special topics, including genetics, self-management and nanomedicine.
1. Introduction - p. 181 2. Epidemiology - p. 181 3. Pathophysiology - p. 181 4. Clinical Presentations - p. 184 5. Diagnosis and Workup - p. 185 6. Treatment - p. 191 7. Recovery, Cardiomyopathy, and Heart Transplantation - p. 194 8. Activity Restrictions - p. 195 9. Chapter 17. Dilated Cardiomyopathy - p. 203 10. Chapter 18. Clinical Features of Restrictive Cardiomyopathy and Constrictive Pericarditis - p. 215 11. Chapter 19. Hypertrophic Cardiomyopathy - p. 239 12. Introduction - p. 239 13. Definition - p. 239 14. Diagnostic Criteria - p. 239 15. Etiology and Classification - p. 240 16. Pathophysiology and Natural History - p. 241 17. Genetics of Sarcomeric Hypertrophic Cardiomyopathy - p. 242 18. Hypertrophic Cardiomyopathy Diagnostic Testing - p. 243 19. Morphologic Variations in Hypertrophic Cardiomyopathy - p. 247 20. Clinical Manifestations, Course, and Outcomes - p. 248 21. Hypertrophic Cardiomyopathy Subtypes - p. 252 22. Hypertrophic Cardiomyopathy Versus Athletic Heart Syndrome - p. 255 23. Screening for Hypertrophic Cardiomyopathy - p. 256 24. Hypertrophic Cardiomyopathy Symptoms and Management - p. 256 25. Pharmacological Therapy - p. 257 26. Interventional Therapy - p. 258 27. Prevention of Sudden Death - p. 258 28. Management of Special Circumstances - p. 261 29. Conclusion - p. 261 30. Abbreviations - p. 261 31. Chapter 20. Left Ventricular Noncompaction Cardiomyopathy - p. 269 32. Chapter 21. Arrhythmogenic Right Ventricular Cardiomyopathy - p. 291 33. Chapter 22. Valvular Insufficiency and Heart Failure - p. 297 34. Chapter 23. Valvular Stenosis and Heart Failure - p. 307 35. Chapter 24. Ischemic Coronary Artery Disease - p. 317 36. Chapter 25. Chronic Heart Failure in Congenital Heart Disease Including Single Ventricle Circulation - p. 323 37. Chapter 26. Heart Failure in Adults With Congenital Heart Disease - p. 331 38. Introduction - p. 331 39. Epidemiology - p. 331 40. General Concepts, Definition, and Classification - p. 332 41. High-Risk Groups and Lesion-Specific Factors - p. 333 42. Tetralogy of Fallot - p. 333 43. Systemic Right Ventricle - p. 334 44. Single Ventricle Circulation - p. 334 45. Eisenmenger Syndrome - p. 335 46. Diagnosis of Heart Failure in Adult Congenital Heart Disease - p. 335 47. Comorbidities and Complications Associated With Heart Failure in Adult Congenital Heart Disease - p. 337 48. Management of Heart Failure in Adult Congenital Heart Disease - p. 338 49. Invasive Hemodynamic Evaluation and Transcatheter Interventions in Adult Congenital Heart Disease–Related Heart Failure - p. 343 50. Arrhythmia Interventions in Adult Congenital Heart Disease–Related Heart Failure - p. 344 51. Surgical Interventions in Adult Congenital Heart Disease–Related Heart Failure - p. 344 52. Conclusion - p. 345 53. Chapter 27. Dysrhythmias and Ventricular Dysfunction and Heart Failure - p. 353 54. Chapter 28. Fetal Heart Failure - p. 369 55. Chapter 29. Heart Failure in the Neonate - p. 383 56. Chapter 30. Right Heart Failure in Pediatric Pulmonary Hypertension - p. 399 57. Chapter 31. Childhood Cardiorenal Syndrome - p. 413 58. Chapter 32. Heart Failure in Pediatric Oncologic Disease - p. 425 59. Chapter 33. The Failing Myocardium in Sepsis - p. 445 60. Chapter 34. Outpatient Management of Pediatric HF - p. 457 61. Chapter 35. Quality of Life and Psychosocial Care in Pediatric Heart Failure - p. 467 62. Chapter 36. Quality Metrics and Quality Improvement in Pediatric Heart Failure - p. 473 63. Chapter 37. Nursing Aspects of Heart Failure - p. 481 64. Section III. Medical Treatment for Pediatric Heart Failure - p. 492 65. Chapter 38. Diuretics and Invasive Fluid Management Strategies - p. 495 66. Chapter 39. The Use of Inotropic Agents in Acute Decompensated Heart Failure - p. 511 67. Chapter 40. Phosphodiesterase Inhibitors - p. 517 68. Chapter 41. Use of Vasodilators in Heart Failure - p. 523 69. Chapter 42. Beta-Adrenergic Receptor Blockade - p. 539 70. Chapter 43. Recognition and Treatment of Low Cardiac Output States in Pediatric Cardiac Intensive Care - p. 543 71. History and Significance - p. 543 72. Clinical Signs of Low Cardiac Output Syndrome - p. 543 73. Causes of Low Cardiac Output After Congenital Heart Surgery - p. 545 74. Diagnosis of Low Cardiac Output Syndrome - p. 547 75. Treatment of Low Cardiac Output Syndrome - p. 548 76. Management of Pulmonary Hypertension - p. 554 77. Management of Right Ventricular Failure - p. 555 78. Ventilation Strategies After Cardiac Surgery - p. 555 79. Conclusion - p. 556 80. Chapter 44. New Therapeutic Strategies in Heart Failure - p. 565 81. Chapter 45. Electrophysiologic Devices in Heart Failure - p. 575 82. Chapter 46. Catheter Device Therapies for Heart Failure - p. 583 83. Obstruction Lesions - p. 583 84. Shunt Lesions - p. 600 85. Miscellaneous - p. 609 86. Section IV. Cardiac Surgery and Pediatric Heart Failure - p. 622 87. Chapter 47. Posttransplant Heart Failure - p. 625 88. Chapter 48. Surgical Management of the Failing Systemic Ventricle - p. 639 89. Chapter 49. Valve Interventions in the Young Adult With Heart Failure - p. 655 90. Chapter 50. Principles of Mechanical Cardiopulmonary Support - p. 675 91. Chapter 51. Short-Term Mechanical Cardiopulmonary Support Devices - p. 683 92. Chapter 52. Decision-Making in Ventricular Assist Device Support in Pediatric Advanced Heart Failure Patients - p. 699 93. Chapter 53. Long-Term Ventricular Assist Devices in Children - p. 707 94. Chapter 54. Adult Experience With Long Term Devices - p. 719 95. Chapter 55. Future of Mechanical Circulatory Support Devices in Children and Young Adults - p. 733 96. Section V. Special Topics - p. 740 97. Chapter 56. Genetic Testing - p. 743 98. Chapter 57. Data Management and Analytics - p. 749 99. Chapter 58. Outpatient Monitoring and Self-Care - p. 755 100. Chapter 59. Regenerative Medicine/Injured Human Hearts - p. 773 101. Chapter 60. Nanomedicine and Nanotechnology for Heart Failure Research, Diagnosis, and Treatment - p. 779 102. Chapter 61. Nutritional Assessment and Management in Pediatric Heart Failure - p. 785 103. Index - p. 791
