Written with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper diagnostic techniques when reporting on breast specimens. Dr. David J. Dabbs and a team of internationally acclaimed pathologists incorporate genomic and molecular information, gross and microscopic findings, radiologic and laboratory diagnosis, theranostics, and immunohistochemistry to cover every aspect of benign and malignant lesions of the breast, helping you minimize diagnostic variation and error in the sign-out room.
Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer.
Incorporates the latest classifications of breast pathology and molecular diagnosis.
Organizes each topical chapter around relevant genomic and molecular information, clinical presentation, gross and microscopic pathologic findings and diagnostic and molecular immunohistochemistry.
Maps immunohistochemistry for each entity according to diagnostic, theranostic, and genomic applications, with specific regard to disease entities in each chapter.
Discusses breast specimen handling in detail to assure proper sampling and processing for optimal molecular and immunohistochemistry resulting.
Supplies a convenient quick reference at the beginning of each chapter that includes all relevant diagnostic, theranostic, and genomic data for fast retrieval.
Features approximately 2,000 full-color pathological images that clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease.
Includes biomarker guideline updates throughout.
Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays.
1. Introduction - p. 177 2. Hormone Receptors in Breast Carcinoma - p. 177 3. HER2 (ERBB2) Oncogene in Breast Cancer - p. 183 4. Other relevant prognostic/predictive markers - p. 194 5. Summary - p. 200 6. Acknowledgments - p. 200 7. References - p. 200 8. 10. Molecular-Based Testing in Breast Disease for Therapeutic Decisions - p. 213 9. 11. Diagnostic Immunohistology of the Breast - p. 250 10. Introduction - p. 250 11. Assessment of Stromal Invasion - p. 250 12. Immunohistochemistry of papillary lesions - p. 254 13. Proliferative Ductal Epithelial Lesions and in Situ Carcinomas - p. 261 14. Tumor Type Identification by Immunohistochemistry - p. 265 15. Lobular Carcinoma Variants and Former Lobular Variants - p. 270 16. Immunohistochemistry for Identifying Special Types of Breast Carcinomas - p. 270 17. Paget’s Disease of the Breast - p. 278 18. Detection of Lymphatic Space Invasion - p. 279 19. Sentinel Lymph Node Examination - p. 279 20. Systemic Metastasis of Breast Carcinoma - p. 284 21. Fibroepithelial Tumors - p. 287 22. References - p. 292 23. 12. Fibroepithelial Lesions - p. 305 24. 13. Papilloma and Papillary Lesions - p. 332 25. 14. Adenosis and Microglandular Adenosis - p. 352 26. 15. Nipple Adenoma (Florid Papillomatosis of the Nipple) - p. 377 27. 16. Radial Scar - p. 389 28. 17. Myoepithelial Lesions of the Breast - p. 404 29. 18. Fibrocystic Change and Usual Epithelial Hyperplasia of Ductal Type Fibrocystic Change - p. 426 30. 19. Columnar Cell Change, Flat Epithelial Atypia, and Atypical Ductal Epithelial Hyperplasia - p. 456 31. 20. Molecular Classification of Breast Carcinoma - p. 477 32. 21. Lobular Neoplasia and Invasive Lobular Carcinoma - p. 504 33. 22. Ductal Carcinoma In Situ - p. 543 34. 23. Invasive Ductal Carcinoma of No Special Type and Histological Grade - p. 571 35. 24. Triple-Negative and Basal-like Carcinoma - p. 589 36. 25. Metaplastic Breast Carcinoma - p. 618 37. 26. Apocrine Carcinoma of the Breast - p. 643 38. 27. Paget’s Disease of the Breast - p. 657 39. 28. Pathology of Neoadjuvant Therapeutic Response of Breast Carcinoma - p. 665 40. 29. Special Types of Invasive Breast Carcinoma: Tubular Carcinoma, Cribriform Carcinoma, Mucinous Carcinoma, Micropapillary Carcinoma - p. 688 41. 30. Rare Breast Carcinomas: Adenoid Cystic Carcinoma, Neuroendocrine Carcinoma, Secretory Carcinoma, Carcinoma With Osteoclast-like Giant Cells, Lipid-Rich Carcinoma, and Glycogen-Rich Clear Cell Carcinoma - p. 724 42. 31. Mesenchymal Tumors of the Breast - p. 752 43. Hamartoma - p. 752 44. Benign Vascular Lesions - p. 753 45. Malignant Vascular Tumors - p. 762 46. Myofibroblastic and Fibroblastic Tumors and Tumor-like Proliferations - p. 776 47. Smooth Muscle Tumors - p. 792 48. Adipocytic Tumors - p. 795 49. Other Sarcomas - p. 798 50. Peripheral Nerve Sheath Tumors - p. 800 51. References - p. 807 52. 32. Neoplasia of the Male Breast - p. 828 53. Introduction - p. 828 54. Embryogenesis and Puberty - p. 828 55. Benign Proliferative Lesions - p. 829 56. Benign Papillary Lesions - p. 830 57. Fibroepithelial Lesions - p. 832 58. Gynecomastia - p. 832 59. Other Benign Disorders of the Male Breast - p. 837 60. Carcinoma of the Male Breast - p. 837 61. Screening and Diagnosis - p. 840 62. Precursor Lesions - p. 841 63. Invasive Carcinoma - p. 844 64. Summary - p. 860 65. References - p. 860 66. 33. Breast Tumors in Children and Adolescents - p. 873 67. 34. Hematolymphoid Tumors of the Breast - p. 898 68. 35. Metastatic Tumors in the Breast - p. 932 69. 36. Next-Generation Sequencing and the Management of Patients With Clinically Advanced Breast Cancer - p. 954 70. Index - p. 977
Written with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper diagnostic techniques when reporting on breast specimens. Dr. David J. Dabbs and a team of internationally acclaimed pathologists incorporate genomic and molecular information, gross and microscopic findings, radiologic and laboratory diagnosis, theranostics, and immunohistochemistry to cover every aspect of benign and malignant lesions of the breast, helping you minimize diagnostic variation and error in the sign-out room.
Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer.
Incorporates the latest classifications of breast pathology and molecular diagnosis.
Organizes each topical chapter around relevant genomic and molecular information, clinical presentation, gross and microscopic pathologic findings and diagnostic and molecular immunohistochemistry.
Maps immunohistochemistry for each entity according to diagnostic, theranostic, and genomic applications, with specific regard to disease entities in each chapter.
Discusses breast specimen handling in detail to assure proper sampling and processing for optimal molecular and immunohistochemistry resulting.
Supplies a convenient quick reference at the beginning of each chapter that includes all relevant diagnostic, theranostic, and genomic data for fast retrieval.
Features approximately 2,000 full-color pathological images that clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease.
Includes biomarker guideline updates throughout.
Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays.
1. Introduction - p. 177 2. Hormone Receptors in Breast Carcinoma - p. 177 3. HER2 (ERBB2) Oncogene in Breast Cancer - p. 183 4. Other relevant prognostic/predictive markers - p. 194 5. Summary - p. 200 6. Acknowledgments - p. 200 7. References - p. 200 8. 10. Molecular-Based Testing in Breast Disease for Therapeutic Decisions - p. 213 9. 11. Diagnostic Immunohistology of the Breast - p. 250 10. Introduction - p. 250 11. Assessment of Stromal Invasion - p. 250 12. Immunohistochemistry of papillary lesions - p. 254 13. Proliferative Ductal Epithelial Lesions and in Situ Carcinomas - p. 261 14. Tumor Type Identification by Immunohistochemistry - p. 265 15. Lobular Carcinoma Variants and Former Lobular Variants - p. 270 16. Immunohistochemistry for Identifying Special Types of Breast Carcinomas - p. 270 17. Paget’s Disease of the Breast - p. 278 18. Detection of Lymphatic Space Invasion - p. 279 19. Sentinel Lymph Node Examination - p. 279 20. Systemic Metastasis of Breast Carcinoma - p. 284 21. Fibroepithelial Tumors - p. 287 22. References - p. 292 23. 12. Fibroepithelial Lesions - p. 305 24. 13. Papilloma and Papillary Lesions - p. 332 25. 14. Adenosis and Microglandular Adenosis - p. 352 26. 15. Nipple Adenoma (Florid Papillomatosis of the Nipple) - p. 377 27. 16. Radial Scar - p. 389 28. 17. Myoepithelial Lesions of the Breast - p. 404 29. 18. Fibrocystic Change and Usual Epithelial Hyperplasia of Ductal Type Fibrocystic Change - p. 426 30. 19. Columnar Cell Change, Flat Epithelial Atypia, and Atypical Ductal Epithelial Hyperplasia - p. 456 31. 20. Molecular Classification of Breast Carcinoma - p. 477 32. 21. Lobular Neoplasia and Invasive Lobular Carcinoma - p. 504 33. 22. Ductal Carcinoma In Situ - p. 543 34. 23. Invasive Ductal Carcinoma of No Special Type and Histological Grade - p. 571 35. 24. Triple-Negative and Basal-like Carcinoma - p. 589 36. 25. Metaplastic Breast Carcinoma - p. 618 37. 26. Apocrine Carcinoma of the Breast - p. 643 38. 27. Paget’s Disease of the Breast - p. 657 39. 28. Pathology of Neoadjuvant Therapeutic Response of Breast Carcinoma - p. 665 40. 29. Special Types of Invasive Breast Carcinoma: Tubular Carcinoma, Cribriform Carcinoma, Mucinous Carcinoma, Micropapillary Carcinoma - p. 688 41. 30. Rare Breast Carcinomas: Adenoid Cystic Carcinoma, Neuroendocrine Carcinoma, Secretory Carcinoma, Carcinoma With Osteoclast-like Giant Cells, Lipid-Rich Carcinoma, and Glycogen-Rich Clear Cell Carcinoma - p. 724 42. 31. Mesenchymal Tumors of the Breast - p. 752 43. Hamartoma - p. 752 44. Benign Vascular Lesions - p. 753 45. Malignant Vascular Tumors - p. 762 46. Myofibroblastic and Fibroblastic Tumors and Tumor-like Proliferations - p. 776 47. Smooth Muscle Tumors - p. 792 48. Adipocytic Tumors - p. 795 49. Other Sarcomas - p. 798 50. Peripheral Nerve Sheath Tumors - p. 800 51. References - p. 807 52. 32. Neoplasia of the Male Breast - p. 828 53. Introduction - p. 828 54. Embryogenesis and Puberty - p. 828 55. Benign Proliferative Lesions - p. 829 56. Benign Papillary Lesions - p. 830 57. Fibroepithelial Lesions - p. 832 58. Gynecomastia - p. 832 59. Other Benign Disorders of the Male Breast - p. 837 60. Carcinoma of the Male Breast - p. 837 61. Screening and Diagnosis - p. 840 62. Precursor Lesions - p. 841 63. Invasive Carcinoma - p. 844 64. Summary - p. 860 65. References - p. 860 66. 33. Breast Tumors in Children and Adolescents - p. 873 67. 34. Hematolymphoid Tumors of the Breast - p. 898 68. 35. Metastatic Tumors in the Breast - p. 932 69. 36. Next-Generation Sequencing and the Management of Patients With Clinically Advanced Breast Cancer - p. 954 70. Index - p. 977
