Brody’s Human Pharmacology is a well-established and much-loved textbook that guides students of medicine, pharmacology and other health professions through pharmacology from both basic and clinical perspectives.
What can be a very difficult and complex topic is divided into easily digestible chapters, each of which is clearly structured from a therapeutic overview to mechanisms of action, relationships to clinical responses, pharmacokinetics, pharmacovigilance, new developments, and clinical relevance for all health professionals.
1. 1. Introduction - p. 2 2. 2. Cellular Receptors and Drug Concentration–Response Relationships - p. 4 3. 3. Pharmacokinetics - p. 21 4. 4. Pharmacogenetics - p. 41 5. 5. Drug Discovery, Development, and Regulation - p. 49 6. Section 2: Chemical Mediators and Drugs Affecting Autonomic and Neuromuscular Synapses - p. 57 7. 6. Introduction to the Autonomic Nervous System - p. 58 8. Cholinergic Drugs - p. 67 9. 7. Muscarinic Agonists, Cholinesterase Inhibitors, and Their Clinical Uses - p. 68 10. 8. Muscarinic Antagonists and Their Clinical Uses - p. 79 11. 9. Nicotinic Agonists and Their Clinical Uses - p. 84 12. 10. Neuromuscular Blocking Drugs and Nicotinic Antagonists - p. 89 13. Adrenergic Drugs - p. 94 14. 11. Adrenergic Agonists and Their Clinical Uses - p. 95 15. 12. Adrenergic Antagonists and Their Clinical Uses - p. 107 16. Section 3: Drug Treatment for Disorders Affecting the Central Nervous System - p. 116 17. 13. The Central Nervous System - p. 117 18. 14. Drug Therapy for Alzheimer Disease and Other Cognitive Disorders/Dementias - p. 129 19. 15. Pharmacotherapy of Basal Ganglia Disorders: Parkinson Disease and Huntington Disease - p. 136 20. 16. Drug Therapy for Psychoses and Bipolar Disorder - p. 145 21. 17. Drug Therapy for Depression and Anxiety - p. 154 22. 18. Drug Therapy for the Management of Attention Deficit-Hyperactivity Disorder - p. 169 23. 19. Drug Therapy for Insomnia and the Hypersomnias - p. 178 24. 20. Drug Therapy for Managing Obesity and Eating Disorders - p. 186 25. 21. Treatment of Seizure Disorders - p. 192 26. 22. Drug Therapy for Spasticity Disorders - p. 207 27. 23. Ethanol, Other Alcohols, and Medications for Alcohol Use Disorder - p. 213 28. 24. Psychoactive Compounds and Substance Use Disorder - p. 223 29. Section 4: Drug Therapy for Pain Management - p. 236 30. 25. Introduction - p. 237 31. 26. General Anesthetics - p. 241 32. 27. Local Anesthetics - p. 252 33. 28. Opioid Analgesics - p. 260 34. 29. Nonsteroidal Antiinflammatory Drugs and Acetaminophen - p. 269 35. 30. Cannabinoids - p. 277 36. 31. Drug Therapy for Migraine Headache - p. 284 37. Section 5: Treatment of Inflammatory, Allergic and Immunologic Disorders - p. 292 38. 32. Drug Therapy for Gout and Hyperuricemia - p. 293 39. 33. Pharmacological Interventions for Allergic Reactions - p. 298 40. 34. Immunosuppressants for Autoimmune Disorders and Organ Transplantation - p. 306 41. 35. Drug Therapy for Rheumatoid Arthritis - p. 314 42. Section 6: Drug Treatment for Cardiovascular Diseases - p. 321 43. 36. Introduction to the Regulation of Cardiovascular Function - p. 322 44. 37. Overview of Hypertension Management and Drugs That Decrease Sympathetic Tone - p. 328 45. 38. Diuretics and Drugs That Affect Volume and Electrolyte Content - p. 333 46. 39. Drugs Affecting the Renin-Angiotensin-Aldosterone System - p. 348 47. 40. Calcium-Channel Blockers - p. 354 48. 41. Vasodilators for Hypertensive Crises, Pulmonary Hypertension, and Erectile Dysfunction - p. 359 49. 42. Treatment of Hyperlipidemias and Atherosclerotic Cardiovascular Disease - p. 367 50. 43. Treatment of Myocardial Ischemia and Angina Pectoris - p. 378 51. 44. Treatment of Heart Failure - p. 384 52. 45. Antiarrhythmic Drugs - p. 392 53. 46. Anticoagulant, Antiplatelet, and Fibrinolytic Medications - p. 406 54. 47. Drug Therapy for Hemophilia and the Deficiency Anemias - p. 416 55. Section 7: Treatment of Endocrine Disorders - p. 423 56. 48. Introduction to Endocrine Pharmacology - p. 424 57. 49. Treatment of Hypothalamic and Pituitary Disorders - p. 428 58. 50. Diagnosis and Treatment of Adrenocorticosteroid Disorders - p. 437 59. 51. Female Hormone Regulation - p. 446 60. 52. Androgens, Antiandrogens, and Their Clinical Uses - p. 462 61. 53. Drug Therapy for the Management of Diabetes - p. 469 62. 54. Drug Therapy for the Management of Thyroid Disorders - p. 485 63. 55. Calcium Regulating Hormones and Other Agents Affecting Bone - p. 494 64. Section 8: Chemotherapy - p. 505 65. Infectious Diseases - p. 505 66. 56. Principles of Antimicrobial Use - p. 506 67. 57. Drugs Targeting Bacterial Cell Walls and Membranes - p. 521 68. 58. Drugs Targeting Bacterial Protein Synthesis - p. 537 69. 59. Drugs Targeting Bacterial DNA - p. 551 70. 60. Antimycobacterial Agents - p. 560 71. 61. Drugs Targeting Resistant Organisms - p. 569 72. Parasitic Diseases - p. 574 73. 62. Antifungal Agents - p. 575 74. 63. Antimalarial and Other Antiprotozoal Agents - p. 585 75. 64. Anthelmintics and Ectoparasiticides - p. 596 76. Viruses - p. 601 77. 65. Antiviral Agents - p. 602 78. 66. Antiretroviral Drugs for HIV - p. 613 79. Cancer - p. 622 80. 67. Principles of Cancer and Antineoplastic Drug Use - p. 623 81. 68. Cytotoxic Agents - p. 632 82. 69. Targeted Anticancer Agents - p. 651 83. 70. Immunological and Cell-Based Therapies - p. 663 84. Section 9: Special Considerations - p. 671 85. 71. Therapeutic Use of Hematopoietic Growth Factors - p. 672 86. 72. Gastrointestinal Disorders and Their Treatment - p. 677 87. 73. Pharmacological Interventions for Asthma and Chronic Obstructive Pulmonary Disorders - p. 688 88. 74. Dietary Supplements, Nutraceuticals, and Natural Products - p. 699 89. 75. Essentials of Toxicology - p. 706 90. 76. Therapeutic Considerations for Pregnant, Pediatric, Geriatric, and Obese Individuals - p. 711 91. Appendix - p. 716 92. Index - p. 729
Brody’s Human Pharmacology is a well-established and much-loved textbook that guides students of medicine, pharmacology and other health professions through pharmacology from both basic and clinical perspectives.
What can be a very difficult and complex topic is divided into easily digestible chapters, each of which is clearly structured from a therapeutic overview to mechanisms of action, relationships to clinical responses, pharmacokinetics, pharmacovigilance, new developments, and clinical relevance for all health professionals.
1. 1. Introduction - p. 2 2. 2. Cellular Receptors and Drug Concentration–Response Relationships - p. 4 3. 3. Pharmacokinetics - p. 21 4. 4. Pharmacogenetics - p. 41 5. 5. Drug Discovery, Development, and Regulation - p. 49 6. Section 2: Chemical Mediators and Drugs Affecting Autonomic and Neuromuscular Synapses - p. 57 7. 6. Introduction to the Autonomic Nervous System - p. 58 8. Cholinergic Drugs - p. 67 9. 7. Muscarinic Agonists, Cholinesterase Inhibitors, and Their Clinical Uses - p. 68 10. 8. Muscarinic Antagonists and Their Clinical Uses - p. 79 11. 9. Nicotinic Agonists and Their Clinical Uses - p. 84 12. 10. Neuromuscular Blocking Drugs and Nicotinic Antagonists - p. 89 13. Adrenergic Drugs - p. 94 14. 11. Adrenergic Agonists and Their Clinical Uses - p. 95 15. 12. Adrenergic Antagonists and Their Clinical Uses - p. 107 16. Section 3: Drug Treatment for Disorders Affecting the Central Nervous System - p. 116 17. 13. The Central Nervous System - p. 117 18. 14. Drug Therapy for Alzheimer Disease and Other Cognitive Disorders/Dementias - p. 129 19. 15. Pharmacotherapy of Basal Ganglia Disorders: Parkinson Disease and Huntington Disease - p. 136 20. 16. Drug Therapy for Psychoses and Bipolar Disorder - p. 145 21. 17. Drug Therapy for Depression and Anxiety - p. 154 22. 18. Drug Therapy for the Management of Attention Deficit-Hyperactivity Disorder - p. 169 23. 19. Drug Therapy for Insomnia and the Hypersomnias - p. 178 24. 20. Drug Therapy for Managing Obesity and Eating Disorders - p. 186 25. 21. Treatment of Seizure Disorders - p. 192 26. 22. Drug Therapy for Spasticity Disorders - p. 207 27. 23. Ethanol, Other Alcohols, and Medications for Alcohol Use Disorder - p. 213 28. 24. Psychoactive Compounds and Substance Use Disorder - p. 223 29. Section 4: Drug Therapy for Pain Management - p. 236 30. 25. Introduction - p. 237 31. 26. General Anesthetics - p. 241 32. 27. Local Anesthetics - p. 252 33. 28. Opioid Analgesics - p. 260 34. 29. Nonsteroidal Antiinflammatory Drugs and Acetaminophen - p. 269 35. 30. Cannabinoids - p. 277 36. 31. Drug Therapy for Migraine Headache - p. 284 37. Section 5: Treatment of Inflammatory, Allergic and Immunologic Disorders - p. 292 38. 32. Drug Therapy for Gout and Hyperuricemia - p. 293 39. 33. Pharmacological Interventions for Allergic Reactions - p. 298 40. 34. Immunosuppressants for Autoimmune Disorders and Organ Transplantation - p. 306 41. 35. Drug Therapy for Rheumatoid Arthritis - p. 314 42. Section 6: Drug Treatment for Cardiovascular Diseases - p. 321 43. 36. Introduction to the Regulation of Cardiovascular Function - p. 322 44. 37. Overview of Hypertension Management and Drugs That Decrease Sympathetic Tone - p. 328 45. 38. Diuretics and Drugs That Affect Volume and Electrolyte Content - p. 333 46. 39. Drugs Affecting the Renin-Angiotensin-Aldosterone System - p. 348 47. 40. Calcium-Channel Blockers - p. 354 48. 41. Vasodilators for Hypertensive Crises, Pulmonary Hypertension, and Erectile Dysfunction - p. 359 49. 42. Treatment of Hyperlipidemias and Atherosclerotic Cardiovascular Disease - p. 367 50. 43. Treatment of Myocardial Ischemia and Angina Pectoris - p. 378 51. 44. Treatment of Heart Failure - p. 384 52. 45. Antiarrhythmic Drugs - p. 392 53. 46. Anticoagulant, Antiplatelet, and Fibrinolytic Medications - p. 406 54. 47. Drug Therapy for Hemophilia and the Deficiency Anemias - p. 416 55. Section 7: Treatment of Endocrine Disorders - p. 423 56. 48. Introduction to Endocrine Pharmacology - p. 424 57. 49. Treatment of Hypothalamic and Pituitary Disorders - p. 428 58. 50. Diagnosis and Treatment of Adrenocorticosteroid Disorders - p. 437 59. 51. Female Hormone Regulation - p. 446 60. 52. Androgens, Antiandrogens, and Their Clinical Uses - p. 462 61. 53. Drug Therapy for the Management of Diabetes - p. 469 62. 54. Drug Therapy for the Management of Thyroid Disorders - p. 485 63. 55. Calcium Regulating Hormones and Other Agents Affecting Bone - p. 494 64. Section 8: Chemotherapy - p. 505 65. Infectious Diseases - p. 505 66. 56. Principles of Antimicrobial Use - p. 506 67. 57. Drugs Targeting Bacterial Cell Walls and Membranes - p. 521 68. 58. Drugs Targeting Bacterial Protein Synthesis - p. 537 69. 59. Drugs Targeting Bacterial DNA - p. 551 70. 60. Antimycobacterial Agents - p. 560 71. 61. Drugs Targeting Resistant Organisms - p. 569 72. Parasitic Diseases - p. 574 73. 62. Antifungal Agents - p. 575 74. 63. Antimalarial and Other Antiprotozoal Agents - p. 585 75. 64. Anthelmintics and Ectoparasiticides - p. 596 76. Viruses - p. 601 77. 65. Antiviral Agents - p. 602 78. 66. Antiretroviral Drugs for HIV - p. 613 79. Cancer - p. 622 80. 67. Principles of Cancer and Antineoplastic Drug Use - p. 623 81. 68. Cytotoxic Agents - p. 632 82. 69. Targeted Anticancer Agents - p. 651 83. 70. Immunological and Cell-Based Therapies - p. 663 84. Section 9: Special Considerations - p. 671 85. 71. Therapeutic Use of Hematopoietic Growth Factors - p. 672 86. 72. Gastrointestinal Disorders and Their Treatment - p. 677 87. 73. Pharmacological Interventions for Asthma and Chronic Obstructive Pulmonary Disorders - p. 688 88. 74. Dietary Supplements, Nutraceuticals, and Natural Products - p. 699 89. 75. Essentials of Toxicology - p. 706 90. 76. Therapeutic Considerations for Pregnant, Pediatric, Geriatric, and Obese Individuals - p. 711 91. Appendix - p. 716 92. Index - p. 729
