Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression.
1. Cancer Stem Cells and Signaling Pathways - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Dedication - p. Page v 7. Contents - p. Page vii 8. List of contributors - p. Page viii 9. Preface - p. Page viii 10. List of Illustrations - p. Page x 11. List of Tables - p. Page xi 12. Chapter 1 : Origin of cancer stem cells and the signaling pathways associated with stem cells and cancer stem cells - p. Page xi 13. Chapter 2 : The importance of niche in therapeutic strategies targeting normal and cancer stem cells - p. Page 12 14. Chapter 3 : Cancer stem cell research: a phosphoproteomic approach - p. Page 31 15. Chapter 4 : Role of mechanotransduction in stem cells and cancer progression - p. Page 46 16. Chapter 5 : Cancer stem cell signaling in neuroblastoma progression—in touch with reality - p. Page 68 17. Chapter 6 : Role of cancer stem cells in developing chemoresistance of solid tumor - p. Page 113 18. Chapter 7 : Cell surface markers and signaling pathways of cancer stem cells: target for potent therapeutics - p. Page 129 19. Chapter 8 : Lung cancer stem cells markers and their potential therapeutic molecular targets - p. Page 148 20. Chapter 9 : Role of cancer stem cells in maintenance of tumor heterogeneity in brain tumors - p. Page 160 21. Chapter 10 : Colorectal cancer stem cells: overview and potential targeted therapy - p. Page 182 22. Chapter 11 : Pancreatic cancer stem cells and inflammation: milestones achieved and challenges ahead - p. Page 201 23. Chapter 12 : Epigenetic modification: key regulator of reprogramming in cancer stem cells - p. Page 222 24. Chapter 13 : Regulation of cancer stemness, cell signaling, reactive oxygen species, and microRNAs in cancer stem cells - p. Page 239 25. Chapter 14 : The stem cell niche: key role on cell therapy in regenerative medicine - p. Page 259 26. Chapter 15 : Controlled and targeted proliferation of stem cells for therapeutic application - p. Page 273 27. Chapter 16 : MicroRNAs as a theranostics: combating breast cancer stem cells - p. Page 291 28. Chapter 17 : Chemical approaches to stem cell and signaling pathways for therapeutics - p. Page 305 29. Chapter 18 : Responsive biomimetic nanocarriers and its role in stem cell–based targeting therapeutics - p. Page 320 30. Chapter 19 : Stem cell signaling in nephroblastoma with reference to Wilms tumor - p. Page 333 31. Chapter 20 : Brain cancer stem cells: overview and potential targeted therapy - p. Page 347 32. Chapter 21 : Pancreatic cancer and stem cell - p. Page 359 33. Chapter 22 : Epigenetic modulation of cancer stem cells in vitro 3D models - p. Page 376 34. Chapter 23 : Epigentic signaling: regulation of cancer stem cells in colorectal cancer - p. Page 390 35. Chapter 24 : Cancer stem cells, signalling pathways and chemopreventive effects of phytochemicals in androgen-regulated cancers - p. Page 404 36. Chapter 25 : Biomarkers and signaling pathways of esophageal cancer stem cells: promising targets to limit the metastatic potential and stemness - p. Page 431 37. Chapter 26 : miRNA signaling networks of therapeutic interest involved in angiogenesis regulation by cancer stem cells - p. Page 452 38. Chapter 27 : An altered metabolic landscape drives quiescence to the reawakening of cancer stem cells - p. Page 468 39. Chapter 28 : Canonical WNT signaling pathway in cancer stem cells and potential inhibitors of therapeutic importance - p. Page 482 40. Chapter 29 : A mechanistic view of the role of thyroid cancer stem cells in microenvironment - p. Page 497 41. Chapter 30 : Cancer stem cells and maintenance of tumor heterogeneity/microenvironment - p. Page 513 42. Chapter 31 : An overview of the potent role of proto-oncogenes in tissue-specific stem cells - p. Page 526 43. Chapter 32 : Components of cancer stem cells microenvironment: influence on the tumorigenic property and stemness in cancer stem cells - p. Page 544 44. Chapter 33 : An overview of hepatocellular carcinoma stem cells and potential targeted therapies - p. Page 572 45. Chapter 34 : Cancer stem cell–derived exosomes: what is known to date - p. Page 588 46. Chapter 35 : Signaling mechanisms of chemoresistance in breast cancer stem cells for therapeutics - p. Page 602 47. Index - p. Page 624
Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression.
1. Cancer Stem Cells and Signaling Pathways - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Dedication - p. Page v 7. Contents - p. Page vii 8. List of contributors - p. Page viii 9. Preface - p. Page viii 10. List of Illustrations - p. Page x 11. List of Tables - p. Page xi 12. Chapter 1 : Origin of cancer stem cells and the signaling pathways associated with stem cells and cancer stem cells - p. Page xi 13. Chapter 2 : The importance of niche in therapeutic strategies targeting normal and cancer stem cells - p. Page 12 14. Chapter 3 : Cancer stem cell research: a phosphoproteomic approach - p. Page 31 15. Chapter 4 : Role of mechanotransduction in stem cells and cancer progression - p. Page 46 16. Chapter 5 : Cancer stem cell signaling in neuroblastoma progression—in touch with reality - p. Page 68 17. Chapter 6 : Role of cancer stem cells in developing chemoresistance of solid tumor - p. Page 113 18. Chapter 7 : Cell surface markers and signaling pathways of cancer stem cells: target for potent therapeutics - p. Page 129 19. Chapter 8 : Lung cancer stem cells markers and their potential therapeutic molecular targets - p. Page 148 20. Chapter 9 : Role of cancer stem cells in maintenance of tumor heterogeneity in brain tumors - p. Page 160 21. Chapter 10 : Colorectal cancer stem cells: overview and potential targeted therapy - p. Page 182 22. Chapter 11 : Pancreatic cancer stem cells and inflammation: milestones achieved and challenges ahead - p. Page 201 23. Chapter 12 : Epigenetic modification: key regulator of reprogramming in cancer stem cells - p. Page 222 24. Chapter 13 : Regulation of cancer stemness, cell signaling, reactive oxygen species, and microRNAs in cancer stem cells - p. Page 239 25. Chapter 14 : The stem cell niche: key role on cell therapy in regenerative medicine - p. Page 259 26. Chapter 15 : Controlled and targeted proliferation of stem cells for therapeutic application - p. Page 273 27. Chapter 16 : MicroRNAs as a theranostics: combating breast cancer stem cells - p. Page 291 28. Chapter 17 : Chemical approaches to stem cell and signaling pathways for therapeutics - p. Page 305 29. Chapter 18 : Responsive biomimetic nanocarriers and its role in stem cell–based targeting therapeutics - p. Page 320 30. Chapter 19 : Stem cell signaling in nephroblastoma with reference to Wilms tumor - p. Page 333 31. Chapter 20 : Brain cancer stem cells: overview and potential targeted therapy - p. Page 347 32. Chapter 21 : Pancreatic cancer and stem cell - p. Page 359 33. Chapter 22 : Epigenetic modulation of cancer stem cells in vitro 3D models - p. Page 376 34. Chapter 23 : Epigentic signaling: regulation of cancer stem cells in colorectal cancer - p. Page 390 35. Chapter 24 : Cancer stem cells, signalling pathways and chemopreventive effects of phytochemicals in androgen-regulated cancers - p. Page 404 36. Chapter 25 : Biomarkers and signaling pathways of esophageal cancer stem cells: promising targets to limit the metastatic potential and stemness - p. Page 431 37. Chapter 26 : miRNA signaling networks of therapeutic interest involved in angiogenesis regulation by cancer stem cells - p. Page 452 38. Chapter 27 : An altered metabolic landscape drives quiescence to the reawakening of cancer stem cells - p. Page 468 39. Chapter 28 : Canonical WNT signaling pathway in cancer stem cells and potential inhibitors of therapeutic importance - p. Page 482 40. Chapter 29 : A mechanistic view of the role of thyroid cancer stem cells in microenvironment - p. Page 497 41. Chapter 30 : Cancer stem cells and maintenance of tumor heterogeneity/microenvironment - p. Page 513 42. Chapter 31 : An overview of the potent role of proto-oncogenes in tissue-specific stem cells - p. Page 526 43. Chapter 32 : Components of cancer stem cells microenvironment: influence on the tumorigenic property and stemness in cancer stem cells - p. Page 544 44. Chapter 33 : An overview of hepatocellular carcinoma stem cells and potential targeted therapies - p. Page 572 45. Chapter 34 : Cancer stem cell–derived exosomes: what is known to date - p. Page 588 46. Chapter 35 : Signaling mechanisms of chemoresistance in breast cancer stem cells for therapeutics - p. Page 602 47. Index - p. Page 624
