Marijuana is the most commonly used psychotropic drug in the United States, after alcohol. With the legalization and decriminalization of cannabis, momentum continues to build and propelled by the reduction of stigma associated to its consumption, there is growing concern regarding the long-term impact on brain function and behavior.
Cannabis and the Developing Brain aims to provide comprehensive research on the effects of cannabis during neurodevelopment stages (i.e., perinatal and adolescent ages). This book introduces readers to vivo neural circuits, molecular and cellular mechanisms affected by cannabis exposure during three different temporal windows of brain vulnerability. Second, it offers a unique insight to shared neurobiological features of cannabinoid exposure during different developmental periods. Lastly, Cannabis and the Developing Brain determines the adverse impact of developmental cannabinoid exposure on specific cognition, emotion and behaviors.
1. Cannabis and the Developing Brain - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. In Memoriam - p. v 7. Contributors - p. xv 8. Preface - p. xix 9. Chapter 1 Pre-clinical models of neurodevelopmental cannabinoid exposure - p. 1 10. Chapter 2 Epigenetic imprint: An underlying link to developmental effects of prenatal cannabis exposure - p. 13 11. Chapter 3 Impact of adolescent THC exposure on later adulthood: Focus on mesocorticolimbic function and behaviors - p. 23 12. Chapter 4 Endocannabinoids and sex differences in the developing social behavior network - p. 59 13. Chapter 5 Behavioral consequences of pre/peri-natal Cannabis exposure - p. 79 14. Chapter 6 Correlates and consequences of cannabinoid exposure on adolescent brain remodeling: Focus on glial cells and epigenetics - p. 95 15. Chapter 7 Effects of prenatal THC exposure on the mesolimbic dopamine system: Unveiling an endophenotype of sensory information processing deficits - p. 107 16. Chapter 8 Perinatal cannabis exposure and long-term consequences on synaptic programming - p. 129 17. Chapter 9 Molecular and cellular principles of endocannabinoid signaling and their sensitivity to cannabis in the developing brain - p. 149 18. Chapter 10 How adolescent cannabinoid exposure sets the stage for long-term emotional and cognitive dysregulation: Impacts on molecular and neuronal risk pathways - p. 171 19. Chapter 11 Molecular mechanisms underlying cannabis-induced risk of psychosis - p. 197 20. Chapter 12 Synthetic cannabinoids: State-of-the-art with a focus on fertility and development - p. 243 21. Chapter 13 Prenatal THC exposure interferes with the neurodevelopmental role of endocannabinoid signaling - p. 259 22. Chapter 14 Cannabis effects on the adolescent brain - p. 283 23. Index - p. 331
Marijuana is the most commonly used psychotropic drug in the United States, after alcohol. With the legalization and decriminalization of cannabis, momentum continues to build and propelled by the reduction of stigma associated to its consumption, there is growing concern regarding the long-term impact on brain function and behavior.
Cannabis and the Developing Brain aims to provide comprehensive research on the effects of cannabis during neurodevelopment stages (i.e., perinatal and adolescent ages). This book introduces readers to vivo neural circuits, molecular and cellular mechanisms affected by cannabis exposure during three different temporal windows of brain vulnerability. Second, it offers a unique insight to shared neurobiological features of cannabinoid exposure during different developmental periods. Lastly, Cannabis and the Developing Brain determines the adverse impact of developmental cannabinoid exposure on specific cognition, emotion and behaviors.
1. Cannabis and the Developing Brain - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. In Memoriam - p. v 7. Contributors - p. xv 8. Preface - p. xix 9. Chapter 1 Pre-clinical models of neurodevelopmental cannabinoid exposure - p. 1 10. Chapter 2 Epigenetic imprint: An underlying link to developmental effects of prenatal cannabis exposure - p. 13 11. Chapter 3 Impact of adolescent THC exposure on later adulthood: Focus on mesocorticolimbic function and behaviors - p. 23 12. Chapter 4 Endocannabinoids and sex differences in the developing social behavior network - p. 59 13. Chapter 5 Behavioral consequences of pre/peri-natal Cannabis exposure - p. 79 14. Chapter 6 Correlates and consequences of cannabinoid exposure on adolescent brain remodeling: Focus on glial cells and epigenetics - p. 95 15. Chapter 7 Effects of prenatal THC exposure on the mesolimbic dopamine system: Unveiling an endophenotype of sensory information processing deficits - p. 107 16. Chapter 8 Perinatal cannabis exposure and long-term consequences on synaptic programming - p. 129 17. Chapter 9 Molecular and cellular principles of endocannabinoid signaling and their sensitivity to cannabis in the developing brain - p. 149 18. Chapter 10 How adolescent cannabinoid exposure sets the stage for long-term emotional and cognitive dysregulation: Impacts on molecular and neuronal risk pathways - p. 171 19. Chapter 11 Molecular mechanisms underlying cannabis-induced risk of psychosis - p. 197 20. Chapter 12 Synthetic cannabinoids: State-of-the-art with a focus on fertility and development - p. 243 21. Chapter 13 Prenatal THC exposure interferes with the neurodevelopmental role of endocannabinoid signaling - p. 259 22. Chapter 14 Cannabis effects on the adolescent brain - p. 283 23. Index - p. 331
