Capsaicin, the Pungent Principle in Hot Pepper: From Basic Pharmacology to Therapeutic Applications explores capsaicin's biological and pharmacological characteristics, from its discovery and isolation to its receptor identification and antagonists. The book's structure is divided into three sections, starting with the historical development of research on capsaicin. This foundational section provides a thorough understanding of the compound's journey from a simple pungent ingredient to a significant element in pharmacological studies. The second part of the book delves into capsaicin’s biological effects and pharmacology, covering areas such as nociception, pain, salivary secretion, body temperature regulation, and blood pressure regulation.
Finally, the book examines the clinical applications of capsaicin, discussing potential future developments in desensitization, pain relief, injections, effects on the tumor microenvironment, appetite control, and longevity. This book is invaluable for pharmacology researchers and clinicians in pain management and cancer, offering insights into the unique characteristics and therapeutic potential of capsaicin.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Acknowledgments - p. ix 7. Section 1. Single section - p. S1 8. Chapter 1. Capsaicin and its receptor, TRPV1: History, chemistry, and biological background - p. 3 9. Chapter 2. The capsaicin receptor, TRPV1 - p. 65 10. Chapter 3. The biological effects and pharmacology of capsaicin - p. 125 11. 3.1 Life without TRPV1 - p. 125 12. 3.2 Life with too much TRPV1 - p. 132 13. 3.3 The pharmacology of capsaicin I – nociception and pain - p. 133 14. 3.4 The pharmacology of capsaicin II – neurogenic inflammation - p. 148 15. 3.5 The pharmacology of capsaicin III – body temperature regulation - p. 152 16. 3.6 The pharmacology of capsaicin IV – blood pressure regulation - p. 161 17. 3.7 Capsaicin analogs - p. 173 18. 3.8 Endogenous capsaicin analogs (“endovanilloids”): do they exist? - p. 179 19. Chapter 4. Current uses of capsaicin in the clinic - p. 201 20. 4.1 Capsaicin desensitization: clinical potential - p. 201 21. 4.2 Topical capsaicin cream for pain relief - p. 211 22. 4.3 Topical capsaicin for itch relief - p. 223 23. 4.4 High-dose capsaicin patch (8% w/w, 179mg capsaicin) for pain and itch relief - p. 229 24. 4.5 Site-specific capsaicin injections for pain relief - p. 243 25. 4.6 Site-directed resiniferatoxin injections: “molecular scalpel” to silence pain pathways - p. 250 26. 4.7 QX-314 for pain relief - p. 257 27. 4.8 Intravesical capsaicin and resiniferatoxin for overactive bladder and lower urinary tract pain - p. 257 28. 4.9 Intranasal capsaicin for rhinitis and headache - p. 269 29. 4.10 TRPV1 antagonists in clinical studies - p. 272 30. Chapter 5. Novel, innovative uses of capsaicin in medical practice - p. 301 31. 5.1 Capsaicin for nausea and vomiting - p. 301 32. 5.2 Capsaicin for improved swallowing and aspiration prevention in patients with dysphagia - p. 306 33. 5.3 Thinking outside of box I—capsaicin in oral health - p. 310 34. 5.4 Thinking outside of box II—Capsaicin-containing shampoo or scalp-tonic to reverse hair loss - p. 312 35. 5.5 Thinking outside of box III - topical capsaicin for acne vulgaris - p. 314 36. 5.6 Altered TRPV1 expression and/or function in human disease: implications for diagnosis and therapy - p. 315 37. 5.7 Capsaicin and cancer: Friend, foe, or innocent bystander? - p. 328 38. 5.8 Capsaicin: a potent new weapon to kill cancer cells? - p. 336 39. 5.9 The capsaicin receptor TRPV1 in cancer cells: therapeutic target, diagnostic marker, or prognostic significance? - p. 337 40. 5.10 Neuroimmune regulation of cancer: Capsaicin-sensitive afferents in the tumor microenvironment - p. 343 41. 5.11 Neuroimmune regulation of autoimmune and infectious diseases including sepsis: Role of capsaicin-positive afferents - p. 351 42. Chapter 6. Dietary capsaicin as nutraceutical - p. 377 43. Chapter 7. Current state of the field (take-home message) - p. 413 44. Concluding remarks - p. 421 45. Index - p. 423
Capsaicin, the Pungent Principle in Hot Pepper: From Basic Pharmacology to Therapeutic Applications explores capsaicin's biological and pharmacological characteristics, from its discovery and isolation to its receptor identification and antagonists. The book's structure is divided into three sections, starting with the historical development of research on capsaicin. This foundational section provides a thorough understanding of the compound's journey from a simple pungent ingredient to a significant element in pharmacological studies. The second part of the book delves into capsaicin’s biological effects and pharmacology, covering areas such as nociception, pain, salivary secretion, body temperature regulation, and blood pressure regulation.
Finally, the book examines the clinical applications of capsaicin, discussing potential future developments in desensitization, pain relief, injections, effects on the tumor microenvironment, appetite control, and longevity. This book is invaluable for pharmacology researchers and clinicians in pain management and cancer, offering insights into the unique characteristics and therapeutic potential of capsaicin.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Acknowledgments - p. ix 7. Section 1. Single section - p. S1 8. Chapter 1. Capsaicin and its receptor, TRPV1: History, chemistry, and biological background - p. 3 9. Chapter 2. The capsaicin receptor, TRPV1 - p. 65 10. Chapter 3. The biological effects and pharmacology of capsaicin - p. 125 11. 3.1 Life without TRPV1 - p. 125 12. 3.2 Life with too much TRPV1 - p. 132 13. 3.3 The pharmacology of capsaicin I – nociception and pain - p. 133 14. 3.4 The pharmacology of capsaicin II – neurogenic inflammation - p. 148 15. 3.5 The pharmacology of capsaicin III – body temperature regulation - p. 152 16. 3.6 The pharmacology of capsaicin IV – blood pressure regulation - p. 161 17. 3.7 Capsaicin analogs - p. 173 18. 3.8 Endogenous capsaicin analogs (“endovanilloids”): do they exist? - p. 179 19. Chapter 4. Current uses of capsaicin in the clinic - p. 201 20. 4.1 Capsaicin desensitization: clinical potential - p. 201 21. 4.2 Topical capsaicin cream for pain relief - p. 211 22. 4.3 Topical capsaicin for itch relief - p. 223 23. 4.4 High-dose capsaicin patch (8% w/w, 179mg capsaicin) for pain and itch relief - p. 229 24. 4.5 Site-specific capsaicin injections for pain relief - p. 243 25. 4.6 Site-directed resiniferatoxin injections: “molecular scalpel” to silence pain pathways - p. 250 26. 4.7 QX-314 for pain relief - p. 257 27. 4.8 Intravesical capsaicin and resiniferatoxin for overactive bladder and lower urinary tract pain - p. 257 28. 4.9 Intranasal capsaicin for rhinitis and headache - p. 269 29. 4.10 TRPV1 antagonists in clinical studies - p. 272 30. Chapter 5. Novel, innovative uses of capsaicin in medical practice - p. 301 31. 5.1 Capsaicin for nausea and vomiting - p. 301 32. 5.2 Capsaicin for improved swallowing and aspiration prevention in patients with dysphagia - p. 306 33. 5.3 Thinking outside of box I—capsaicin in oral health - p. 310 34. 5.4 Thinking outside of box II—Capsaicin-containing shampoo or scalp-tonic to reverse hair loss - p. 312 35. 5.5 Thinking outside of box III - topical capsaicin for acne vulgaris - p. 314 36. 5.6 Altered TRPV1 expression and/or function in human disease: implications for diagnosis and therapy - p. 315 37. 5.7 Capsaicin and cancer: Friend, foe, or innocent bystander? - p. 328 38. 5.8 Capsaicin: a potent new weapon to kill cancer cells? - p. 336 39. 5.9 The capsaicin receptor TRPV1 in cancer cells: therapeutic target, diagnostic marker, or prognostic significance? - p. 337 40. 5.10 Neuroimmune regulation of cancer: Capsaicin-sensitive afferents in the tumor microenvironment - p. 343 41. 5.11 Neuroimmune regulation of autoimmune and infectious diseases including sepsis: Role of capsaicin-positive afferents - p. 351 42. Chapter 6. Dietary capsaicin as nutraceutical - p. 377 43. Chapter 7. Current state of the field (take-home message) - p. 413 44. Concluding remarks - p. 421 45. Index - p. 423
