Immunity to Immunotherapy in Cancer: Mechanisms and Limitations explores the intricate interplay between cancer therapy and the immune system, addressing why some patients do not respond to immunotherapy and scientific solutions in development. The book examines molecular strategies of immune evasion within the tumor microenvironment, providing insights into factors like tumor heterogeneity and immune checkpoint mechanisms that contribute to resistance. Highlighting promising approaches such as combination therapies, personalized medicine, and novel immunotherapeutic agents, the book aims to enhance patient outcomes and advance cancer immunotherapy.
Designed as a comprehensive guide for professionals and researchers, this textbook offers an overview of the latest scientific discoveries and practical applications in cancer therapy. It serves as an invaluable resource for scientists, doctors, academicians, and students, presenting a path toward more effective, non-toxic, and customized cancer treatments. This book is essential for anyone interested in the future of cancer therapy.
1. Chapter 1. Introduction to immunity in cancer - p. 3 2. Chapter 2. Role of innate immunity in cancer immunology - p. 29 3. Chapter 3. Role of dendritic cells in cancer immunology - p. 59 4. Chapter 4. Role of natural killer cells in cancer immunology - p. 83 5. Chapter 5. Role of B-cells in tumor immunity - p. 103 6. Chapter 6. Role of CD4+ T-cells in cancer immunology - p. 129 7. Chapter 7. Role of regulatory T-cells and Th17 cells in tumor microenvironment - p. 155 8. Chapter 8. Role of monocytes, macrophages, and polymorphonuclear cells in cancer immunology - p. 181 9. Chapter 9. Role of cytokines in cancer immunology - p. 219 10. Chapter 10. Role of chemokines and chemokine receptors in cancer immunology - p. 265 11. Chapter 11. Role of the inflammasome in cancer immunology - p. 299 12. Chapter 12. Current advanced immunological tools and databases in tumor immunity - p. 331 13. Chapter 13. Tumor heterogeneity and therapeutic resistance - p. 355 14. Part II. Cancer immunotherapy - p. P2 15. Chapter 14. Cancer immunotherapy: Pros, cons, and beyond - p. 381 16. Chapter 15. Role of monoclonal antibody, immune checkpoint inhibitors, and programmed death ligand 1 in cancer immunotherapy - p. 411 17. Chapter 16. Role of chimeric antigen receptor-T cell in cancer immunotherapy - p. 429 18. Chapter 17. Role of small molecule-based drugs in cancer immunotherapy - p. 453 19. Chapter 18. Role of adoptive cell therapy in cancer immunotherapy - p. 473 20. Chapter 19. Role of cancer vaccines in cancer immunotherapy - p. 501 21. Chapter 20. Role of radiotherapy/chemotherapy in cancer immunotherapy - p. 529 22. Index - p. 550
Immunity to Immunotherapy in Cancer: Mechanisms and Limitations explores the intricate interplay between cancer therapy and the immune system, addressing why some patients do not respond to immunotherapy and scientific solutions in development. The book examines molecular strategies of immune evasion within the tumor microenvironment, providing insights into factors like tumor heterogeneity and immune checkpoint mechanisms that contribute to resistance. Highlighting promising approaches such as combination therapies, personalized medicine, and novel immunotherapeutic agents, the book aims to enhance patient outcomes and advance cancer immunotherapy.
Designed as a comprehensive guide for professionals and researchers, this textbook offers an overview of the latest scientific discoveries and practical applications in cancer therapy. It serves as an invaluable resource for scientists, doctors, academicians, and students, presenting a path toward more effective, non-toxic, and customized cancer treatments. This book is essential for anyone interested in the future of cancer therapy.
1. Chapter 1. Introduction to immunity in cancer - p. 3 2. Chapter 2. Role of innate immunity in cancer immunology - p. 29 3. Chapter 3. Role of dendritic cells in cancer immunology - p. 59 4. Chapter 4. Role of natural killer cells in cancer immunology - p. 83 5. Chapter 5. Role of B-cells in tumor immunity - p. 103 6. Chapter 6. Role of CD4+ T-cells in cancer immunology - p. 129 7. Chapter 7. Role of regulatory T-cells and Th17 cells in tumor microenvironment - p. 155 8. Chapter 8. Role of monocytes, macrophages, and polymorphonuclear cells in cancer immunology - p. 181 9. Chapter 9. Role of cytokines in cancer immunology - p. 219 10. Chapter 10. Role of chemokines and chemokine receptors in cancer immunology - p. 265 11. Chapter 11. Role of the inflammasome in cancer immunology - p. 299 12. Chapter 12. Current advanced immunological tools and databases in tumor immunity - p. 331 13. Chapter 13. Tumor heterogeneity and therapeutic resistance - p. 355 14. Part II. Cancer immunotherapy - p. P2 15. Chapter 14. Cancer immunotherapy: Pros, cons, and beyond - p. 381 16. Chapter 15. Role of monoclonal antibody, immune checkpoint inhibitors, and programmed death ligand 1 in cancer immunotherapy - p. 411 17. Chapter 16. Role of chimeric antigen receptor-T cell in cancer immunotherapy - p. 429 18. Chapter 17. Role of small molecule-based drugs in cancer immunotherapy - p. 453 19. Chapter 18. Role of adoptive cell therapy in cancer immunotherapy - p. 473 20. Chapter 19. Role of cancer vaccines in cancer immunotherapy - p. 501 21. Chapter 20. Role of radiotherapy/chemotherapy in cancer immunotherapy - p. 529 22. Index - p. 550
