Caspases as Molecular Targets for Cancer Therapy discusses the recent developments on targeted therapies for cancer using caspases. It describes the selection of specific caspases for cancer therapy with the current standard of care and highlights numerous assay techniques for caspase activities. This book discusses topics such as mutations within apoptosis gene, inflammatory caspases, tumor suppression, and the different caspase types and their role in anticancer activity. In addition, it discusses caspase activity assay procedure and future perspectives. It is a valuable resource for researchers, students, and members of biomedical and medical fields who want to learn more about novel anticancer targeted therapies.
1. Chapter 1 : Introduction to caspases, its function, mechanism, and classification - p. Page x 2. Chapter 2 : Mutations within apoptosis gene and caspases - p. Page 12 3. Chapter 3 : Inflammatory caspase-1, -4, and -5 and their role in anticancer activity - p. Page 31 4. Chapter 4 : Caspase-2 and tumor suppression - p. Page 52 5. Chapter 5 : Caspase-3: A promising target for anticancer agents - p. Page 67 6. Chapter 6 : Caspase 7 mutations and their activators - p. Page 102 7. Chapter 7 : Reinstating the expression and activation of caspase-8 and caspase-10 in cancer therapy - p. Page 123 8. Chapter 8 : Caspase-9 gene mutation and its activators - p. Page 176 9. Chapter 9 : Caspases activity assay procedures - p. Page 196 10. Chapter 10 : Current and future prospective of caspases targeting in cancer therapy - p. Page 225 11. Index - p. Page 239
Caspases as Molecular Targets for Cancer Therapy discusses the recent developments on targeted therapies for cancer using caspases. It describes the selection of specific caspases for cancer therapy with the current standard of care and highlights numerous assay techniques for caspase activities. This book discusses topics such as mutations within apoptosis gene, inflammatory caspases, tumor suppression, and the different caspase types and their role in anticancer activity. In addition, it discusses caspase activity assay procedure and future perspectives. It is a valuable resource for researchers, students, and members of biomedical and medical fields who want to learn more about novel anticancer targeted therapies.
1. Chapter 1 : Introduction to caspases, its function, mechanism, and classification - p. Page x 2. Chapter 2 : Mutations within apoptosis gene and caspases - p. Page 12 3. Chapter 3 : Inflammatory caspase-1, -4, and -5 and their role in anticancer activity - p. Page 31 4. Chapter 4 : Caspase-2 and tumor suppression - p. Page 52 5. Chapter 5 : Caspase-3: A promising target for anticancer agents - p. Page 67 6. Chapter 6 : Caspase 7 mutations and their activators - p. Page 102 7. Chapter 7 : Reinstating the expression and activation of caspase-8 and caspase-10 in cancer therapy - p. Page 123 8. Chapter 8 : Caspase-9 gene mutation and its activators - p. Page 176 9. Chapter 9 : Caspases activity assay procedures - p. Page 196 10. Chapter 10 : Current and future prospective of caspases targeting in cancer therapy - p. Page 225 11. Index - p. Page 239
