Known for its concise, easy-to-read writing style and comprehensive coverage, Cecil Essentials of Medicine has been a favorite of students, residents, and instructors through nine outstanding editions. This revised 10th Edition continues the tradition of excellence with a focus on high-yield core knowledge of key importance to anyone entering or established in the field of internal medicine. Fully revised and updated by editors Edward J. Wing and Fred J. Schiffman, along with other leading teachers and experts in the field, Cecil Essentials remains clinically focused and solidly grounded in basic science.
1. SECTION I. Introduction to Medicine - p. xix 2. 1. Introduction to Medicine - p. 2 3. SECTION II. Cardiovascular Disease - p. 2 4. 2. Structure and Function of the Normal Heart and Blood Vessels - p. 4 5. 3. Evaluation of the Patient With Cardiovascular Disease - p. 10 6. 4. Diagnostic Tests and Procedures in the Patient With Cardiovascular Disease - p. 24 7. 5. Heart Failure and Cardiomyopathy - p. 43 8. 6. Congenital Heart Disease - p. 55 9. 7. Valvular Heart Disease - p. 64 10. 8. Coronary Heart Disease - p. 77 11. 9. Cardiac Arrhythmias - p. 99 12. 10. Pericardial and Myocardial Disease - p. 123 13. 11. Other Cardiac Topics - p. 131 14. 12. Vascular Diseases and Hypertension - p. 139 15. SECTION III. Pulmonary and Critical Care Medicine - p. 160 16. 13. Lung in Health and Disease - p. 162 17. 14. General Approach to Patients With Respiratory Disorders - p. 165 18. 15. Evaluating Lung Structure and Function - p. 169 19. 16. Obstructive Lung Diseases - p. 185 20. 17. Interstitial Lung Diseases - p. 199 21. 18. Pulmonary Vascular Diseases - p. 216 22. 19. Disorders of the Pleura, Mediastinum, and Chest Wall - p. 221 23. 20. Respiratory Failure - p. 227 24. 21. Transitions in Care From Pediatric to Adult Providers for Individuals With Pulmonary Disease - p. 234 25. SECTION IV. Preoperative and Postoperative Care - p. 238 26. 22. Preoperative and Postoperative Care - p. 240 27. SECTION V. Renal Disease - p. 249 28. 23. Renal Structure and Function - p. 251 29. 24. Approach to the Patient With Renal Disease - p. 258 30. 25. Fluid and Electrolyte Disorders - p. 268 31. 26. Glomerular Diseases - p. 282 32. 27. Major Nonglomerular Disorders of the Kidney - p. 298 33. 28. Vascular Disorders of the Kidney - p. 312 34. 29. Acute Kidney Injury - p. 324 35. 30. Chronic Kidney Disease - p. 334 36. SECTION VI. Gastrointestinal Disease - p. 341.e1 37. 31. Common Clinical Manifestations of Gastrointestinal Disease: Abdominal Pain - p. 343 38. 32. Common Clinical Manifestations of Gastrointestinal Disease: Gastrointestinal Hemorrhage - p. 347 39. 33. Common Clinical Manifestations of Gastrointestinal Disease: Malabsorption - p. 351 40. 34. Common Clinical Manifestations of Gastrointestinal Disease: Diarrhea - p. 358 41. 35. Endoscopic and Imaging Procedures - p. 363 42. 36. Esophageal Disorders - p. 370 43. 37. Diseases of the Stomach and Duodenum - p. 379 44. 38. Inflammatory Bowel Disease - p. 392 45. 39. Diseases of the Pancreas - p. 402 46. SECTION VII. Diseases of the Liver and Biliary System - p. 415 47. 40. Laboratory Tests in Liver Diseases - p. 417 48. 41. Jaundice - p. 420 49. 42. Acute and Chronic Hepatitis - p. 426 50. 43. Acute Liver Failure - p. 434 51. 44. Cirrhosis of the Liver and Its Complications - p. 437 52. 45. Disorders of the Gallbladder and Biliary Tract - p. 448 53. SECTION VIII. Hematologic Disease - p. 455 54. 46. Hematopoiesis and Hematopoietic Failure - p. 457 55. 47. Clonal Disorders of the Hematopoietic Stem Cell - p. 470 56. 48. Disorders of Red Blood Cells - p. 489 57. 49. Clinical Disorders of Granulocytes and Monocytes - p. 501 58. 50. Disorders of Lymphocytes - p. 506 59. 51. Normal Hemostasis - p. 522 60. 52. Disorders of Hemostasis: Bleeding - p. 530 61. 53. Disorders of Hemostasis: Thrombosis - p. 550 62. SECTION IX. Oncologic Disease - p. 561 63. 54. Cancer Biology - p. 563 64. 55. Cancer Epidemiology - p. 571 65. 56. Principles of Cancer Therapy - p. 577 66. 57. Lung Cancer - p. 583 67. 58. Gastrointestinal Cancers - p. 589 68. 59. Genitourinary Cancers - p. 595 69. 60. Breast Cancer - p. 601 70. 61. Gynecological Cancer - p. 607 71. 62. Other Solid Tumors (Head and Neck, Sarcomas, Melanoma, Unknown Primary) - p. 615 72. 63. Complications of Cancer and Cancer Treatment - p. 620 73. SECTION X. Endocrine Disease and Metabolic Disease - p. 624 74. 64. Hypothalamic-Pituitary Axis - p. 626 75. 65. Thyroid Gland - p. 635 76. 66. Adrenal Gland - p. 645 77. 67. Male Reproductive Endocrinology - p. 657 78. 68. Diabetes Mellitus, Hypoglycemia - p. 662 79. 69. Obesity - p. 678 80. 70. Malnutrition, Nutritional Assessment, and Nutritional Support in Adult Patients - p. 686 81. 71. Disorders of Lipid Metabolism - p. 692 82. SECTION XI. Women’s Health - p. 699 83. 72. Women’s Health Topics - p. 701 84. SECTION XII. Men’s Health - p. 712 85. 73. Men’s Health Topics - p. 714 86. SECTION XIII. Diseases of Bone and Bone Mineral Metabolism - p. 727 87. 74. Normal Physiology of Bone and Mineral Homeostasis - p. 729 88. 75. Disorders of Serum Minerals - p. 739 89. 76. Metabolic Bone Diseases - p. 748 90. 77. Osteoporosis - p. 757 91. SECTION XIV. Musculoskeletal and Connective Tissue Disease - p. 765 92. 78. Approach to the Patient With Rheumatic Disease - p. 767 93. 79. Rheumatoid Arthritis - p. 771 94. 80. Spondyloarthritis - p. 778 95. 81. Systemic Lupus Erythematosus - p. 783 96. 82. Systemic Sclerosis - p. 794 97. 83. Systemic Vasculitis - p. 801 98. 84. Crystal Arthropathies - p. 807 99. 85. Osteoarthritis - p. 813 100. 86. Nonarticular Soft Tissue Disorders - p. 818 101. 87. Rheumatic Manifestations of Systemic Disorders and Sjögren’s Syndrome - p. 822 102. SECTION XV. Infectious Disease - p. 828 103. 88. Host Defenses Against Infection - p. 830 104. 89. Laboratory Diagnosis of Infectious Diseases - p. 842 105. 90. Fever and Febrile Syndromes - p. 848 106. 91. Bacteremia and Sepsis - p. 858 107. 92. Infections of the Central Nervous System - p. 865 108. 93. Infections of the Head and Neck - p. 882 109. 94. Infections of the Lower Respiratory Tract - p. 887 110. 95. Infections of the Heart and Blood Vessels - p. 895 111. 96. Acute Bacterial Skin and Skin Structure Infections - p. 903 112. 97. Intraabdominal Infections - p. 910 113. 98. Infectious Diarrhea - p. 916 114. 99. Infections Involving Bone and Joints - p. 922 115. 100. Urinary Tract Infections - p. 925 116. 101. Health Care–Associated Infections - p. 929 117. 102. Sexually Transmitted Infections - p. 935 118. 103. Human Immunodeficiency Virus Infection - p. 944 119. 104. Infections in the Immunocompromised Host - p. 963 120. 105. Infectious Diseases of Travelers: Protozoal and Helminthic Infections - p. 973 121. SECTION XVI. Neurologic Disease - p. 979 122. 106. Neurologic Evaluation of the Patient - p. 981 123. 107. Disorders of Consciousness - p. 986 124. 108. Disorders of Sleep - p. 992 125. 109. Cortical Syndromes - p. 997 126. 110. Dementia and Memory Disturbances - p. 1001 127. 111. Major Disorders of Mood, Thoughts, and Behavior - p. 1007 128. 112. Autonomic Nervous System Disorders - p. 1013 129. 113. Headache, Neck and Back Pain, and Cranial Neuralgias - p. 1017 130. 114. Disorders of Vision and Hearing - p. 1025 131. 115. Dizziness and Vertigo - p. 1033 132. 116. Disorders of the Motor System - p. 1037 133. 117. Congenital, Developmental, and Neurocutaneous Disorders - p. 1048 134. 118. Cerebrovascular Disease - p. 1056 135. 119. Traumatic Brain Injury and Spinal Cord Injury - p. 1069 136. 120. Epilepsy - p. 1073 137. 121. Central Nervous System Tumors - p. 1087 138. 122. Demyelinating and Inflammatory Disorders - p. 1092 139. 123. Neuromuscular Diseases: Disorders of the Motor Neuron and Plexus and Peripheral Nerve Disease - p. 1101 140. 124. Muscle Diseases - p. 1111 141. 125. Neuromuscular Junction Disease - p. 1122 142. SECTION XVII. Geriatrics - p. 1124 143. 126. The Aging Patient - p. 1126 144. SECTION XVIII. Palliative Care - p. 1139 145. 127. Palliative Care - p. 1141 146. SECTION XIX. Alcohol and Substance Use - p. 1149 147. 128. Alcohol and Substance Use - p. 1151 148. APPENDIX - p. 1165 149. Appendix. Coronavirus Disease 2019 (COVID-19) - p. 1166 150. Index - p. 1174
Known for its concise, easy-to-read writing style and comprehensive coverage, Cecil Essentials of Medicine has been a favorite of students, residents, and instructors through nine outstanding editions. This revised 10th Edition continues the tradition of excellence with a focus on high-yield core knowledge of key importance to anyone entering or established in the field of internal medicine. Fully revised and updated by editors Edward J. Wing and Fred J. Schiffman, along with other leading teachers and experts in the field, Cecil Essentials remains clinically focused and solidly grounded in basic science.
1. SECTION I. Introduction to Medicine - p. xix 2. 1. Introduction to Medicine - p. 2 3. SECTION II. Cardiovascular Disease - p. 2 4. 2. Structure and Function of the Normal Heart and Blood Vessels - p. 4 5. 3. Evaluation of the Patient With Cardiovascular Disease - p. 10 6. 4. Diagnostic Tests and Procedures in the Patient With Cardiovascular Disease - p. 24 7. 5. Heart Failure and Cardiomyopathy - p. 43 8. 6. Congenital Heart Disease - p. 55 9. 7. Valvular Heart Disease - p. 64 10. 8. Coronary Heart Disease - p. 77 11. 9. Cardiac Arrhythmias - p. 99 12. 10. Pericardial and Myocardial Disease - p. 123 13. 11. Other Cardiac Topics - p. 131 14. 12. Vascular Diseases and Hypertension - p. 139 15. SECTION III. Pulmonary and Critical Care Medicine - p. 160 16. 13. Lung in Health and Disease - p. 162 17. 14. General Approach to Patients With Respiratory Disorders - p. 165 18. 15. Evaluating Lung Structure and Function - p. 169 19. 16. Obstructive Lung Diseases - p. 185 20. 17. Interstitial Lung Diseases - p. 199 21. 18. Pulmonary Vascular Diseases - p. 216 22. 19. Disorders of the Pleura, Mediastinum, and Chest Wall - p. 221 23. 20. Respiratory Failure - p. 227 24. 21. Transitions in Care From Pediatric to Adult Providers for Individuals With Pulmonary Disease - p. 234 25. SECTION IV. Preoperative and Postoperative Care - p. 238 26. 22. Preoperative and Postoperative Care - p. 240 27. SECTION V. Renal Disease - p. 249 28. 23. Renal Structure and Function - p. 251 29. 24. Approach to the Patient With Renal Disease - p. 258 30. 25. Fluid and Electrolyte Disorders - p. 268 31. 26. Glomerular Diseases - p. 282 32. 27. Major Nonglomerular Disorders of the Kidney - p. 298 33. 28. Vascular Disorders of the Kidney - p. 312 34. 29. Acute Kidney Injury - p. 324 35. 30. Chronic Kidney Disease - p. 334 36. SECTION VI. Gastrointestinal Disease - p. 341.e1 37. 31. Common Clinical Manifestations of Gastrointestinal Disease: Abdominal Pain - p. 343 38. 32. Common Clinical Manifestations of Gastrointestinal Disease: Gastrointestinal Hemorrhage - p. 347 39. 33. Common Clinical Manifestations of Gastrointestinal Disease: Malabsorption - p. 351 40. 34. Common Clinical Manifestations of Gastrointestinal Disease: Diarrhea - p. 358 41. 35. Endoscopic and Imaging Procedures - p. 363 42. 36. Esophageal Disorders - p. 370 43. 37. Diseases of the Stomach and Duodenum - p. 379 44. 38. Inflammatory Bowel Disease - p. 392 45. 39. Diseases of the Pancreas - p. 402 46. SECTION VII. Diseases of the Liver and Biliary System - p. 415 47. 40. Laboratory Tests in Liver Diseases - p. 417 48. 41. Jaundice - p. 420 49. 42. Acute and Chronic Hepatitis - p. 426 50. 43. Acute Liver Failure - p. 434 51. 44. Cirrhosis of the Liver and Its Complications - p. 437 52. 45. Disorders of the Gallbladder and Biliary Tract - p. 448 53. SECTION VIII. Hematologic Disease - p. 455 54. 46. Hematopoiesis and Hematopoietic Failure - p. 457 55. 47. Clonal Disorders of the Hematopoietic Stem Cell - p. 470 56. 48. Disorders of Red Blood Cells - p. 489 57. 49. Clinical Disorders of Granulocytes and Monocytes - p. 501 58. 50. Disorders of Lymphocytes - p. 506 59. 51. Normal Hemostasis - p. 522 60. 52. Disorders of Hemostasis: Bleeding - p. 530 61. 53. Disorders of Hemostasis: Thrombosis - p. 550 62. SECTION IX. Oncologic Disease - p. 561 63. 54. Cancer Biology - p. 563 64. 55. Cancer Epidemiology - p. 571 65. 56. Principles of Cancer Therapy - p. 577 66. 57. Lung Cancer - p. 583 67. 58. Gastrointestinal Cancers - p. 589 68. 59. Genitourinary Cancers - p. 595 69. 60. Breast Cancer - p. 601 70. 61. Gynecological Cancer - p. 607 71. 62. Other Solid Tumors (Head and Neck, Sarcomas, Melanoma, Unknown Primary) - p. 615 72. 63. Complications of Cancer and Cancer Treatment - p. 620 73. SECTION X. Endocrine Disease and Metabolic Disease - p. 624 74. 64. Hypothalamic-Pituitary Axis - p. 626 75. 65. Thyroid Gland - p. 635 76. 66. Adrenal Gland - p. 645 77. 67. Male Reproductive Endocrinology - p. 657 78. 68. Diabetes Mellitus, Hypoglycemia - p. 662 79. 69. Obesity - p. 678 80. 70. Malnutrition, Nutritional Assessment, and Nutritional Support in Adult Patients - p. 686 81. 71. Disorders of Lipid Metabolism - p. 692 82. SECTION XI. Women’s Health - p. 699 83. 72. Women’s Health Topics - p. 701 84. SECTION XII. Men’s Health - p. 712 85. 73. Men’s Health Topics - p. 714 86. SECTION XIII. Diseases of Bone and Bone Mineral Metabolism - p. 727 87. 74. Normal Physiology of Bone and Mineral Homeostasis - p. 729 88. 75. Disorders of Serum Minerals - p. 739 89. 76. Metabolic Bone Diseases - p. 748 90. 77. Osteoporosis - p. 757 91. SECTION XIV. Musculoskeletal and Connective Tissue Disease - p. 765 92. 78. Approach to the Patient With Rheumatic Disease - p. 767 93. 79. Rheumatoid Arthritis - p. 771 94. 80. Spondyloarthritis - p. 778 95. 81. Systemic Lupus Erythematosus - p. 783 96. 82. Systemic Sclerosis - p. 794 97. 83. Systemic Vasculitis - p. 801 98. 84. Crystal Arthropathies - p. 807 99. 85. Osteoarthritis - p. 813 100. 86. Nonarticular Soft Tissue Disorders - p. 818 101. 87. Rheumatic Manifestations of Systemic Disorders and Sjögren’s Syndrome - p. 822 102. SECTION XV. Infectious Disease - p. 828 103. 88. Host Defenses Against Infection - p. 830 104. 89. Laboratory Diagnosis of Infectious Diseases - p. 842 105. 90. Fever and Febrile Syndromes - p. 848 106. 91. Bacteremia and Sepsis - p. 858 107. 92. Infections of the Central Nervous System - p. 865 108. 93. Infections of the Head and Neck - p. 882 109. 94. Infections of the Lower Respiratory Tract - p. 887 110. 95. Infections of the Heart and Blood Vessels - p. 895 111. 96. Acute Bacterial Skin and Skin Structure Infections - p. 903 112. 97. Intraabdominal Infections - p. 910 113. 98. Infectious Diarrhea - p. 916 114. 99. Infections Involving Bone and Joints - p. 922 115. 100. Urinary Tract Infections - p. 925 116. 101. Health Care–Associated Infections - p. 929 117. 102. Sexually Transmitted Infections - p. 935 118. 103. Human Immunodeficiency Virus Infection - p. 944 119. 104. Infections in the Immunocompromised Host - p. 963 120. 105. Infectious Diseases of Travelers: Protozoal and Helminthic Infections - p. 973 121. SECTION XVI. Neurologic Disease - p. 979 122. 106. Neurologic Evaluation of the Patient - p. 981 123. 107. Disorders of Consciousness - p. 986 124. 108. Disorders of Sleep - p. 992 125. 109. Cortical Syndromes - p. 997 126. 110. Dementia and Memory Disturbances - p. 1001 127. 111. Major Disorders of Mood, Thoughts, and Behavior - p. 1007 128. 112. Autonomic Nervous System Disorders - p. 1013 129. 113. Headache, Neck and Back Pain, and Cranial Neuralgias - p. 1017 130. 114. Disorders of Vision and Hearing - p. 1025 131. 115. Dizziness and Vertigo - p. 1033 132. 116. Disorders of the Motor System - p. 1037 133. 117. Congenital, Developmental, and Neurocutaneous Disorders - p. 1048 134. 118. Cerebrovascular Disease - p. 1056 135. 119. Traumatic Brain Injury and Spinal Cord Injury - p. 1069 136. 120. Epilepsy - p. 1073 137. 121. Central Nervous System Tumors - p. 1087 138. 122. Demyelinating and Inflammatory Disorders - p. 1092 139. 123. Neuromuscular Diseases: Disorders of the Motor Neuron and Plexus and Peripheral Nerve Disease - p. 1101 140. 124. Muscle Diseases - p. 1111 141. 125. Neuromuscular Junction Disease - p. 1122 142. SECTION XVII. Geriatrics - p. 1124 143. 126. The Aging Patient - p. 1126 144. SECTION XVIII. Palliative Care - p. 1139 145. 127. Palliative Care - p. 1141 146. SECTION XIX. Alcohol and Substance Use - p. 1149 147. 128. Alcohol and Substance Use - p. 1151 148. APPENDIX - p. 1165 149. Appendix. Coronavirus Disease 2019 (COVID-19) - p. 1166 150. Index - p. 1174
