Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods—from single cell RNA sequencing to second generation super resolution fluorescence microscopy—on advancing our understanding.
Clear, readable explanations provide a concise story about how cells function at the molecular level.
An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.
Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.
Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.
Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.
1. Section I Introduction to Cell Biology - p. 1 2. Chapter 1 Cells as the Basis of Life on Earth - p. 3 3. Chapter 2 Evolution of Life on Earth - p. 15 4. Section II Chemical and Physical Background - p. 29 5. Chapter 3 Molecules: Structures and Dynamics - p. 33 6. Chapter 4 Biophysical Principles - p. 55 7. Chapter 5 Macromolecular Assembly - p. 65 8. Chapter 6 Research Strategies - p. 79 9. Section III Chromatin, Chromosomes, and the Cell Nucleus - p. 107 10. Chapter 7 Chromosome Organization - p. 111 11. Chapter 8 DNA Packaging in Chromatin and Chromosomes - p. 131 12. Chapter 9 Nuclear Structure and Dynamics - p. 151 13. Section IV Central Dogma: From Gene to Protein - p. 169 14. Chapter 10 Gene Expression* - p. 173 15. Chapter 11 Eukaryotic RNA Processing - p. 199 16. Chapter 12 Protein Synthesis and Folding - p. 219 17. Section V Membrane Structure and Function - p. 233 18. Chapter 13 Membrane Structure and Dynamics - p. 237 19. Chapter 14 Membrane Pumps - p. 251 20. Chapter 15 Membrane Carriers - p. 263 21. Chapter 16 Membrane Channels - p. 271 22. Chapter 17 Membrane Physiology - p. 295 23. Section VI Cellular Organelles and Membrane Trafficking - p. 309 24. Chapter 18 Posttranslational Targeting of Proteins - p. 313 25. Chapter 19 Mitochondria, Chloroplasts, Peroxisomes - p. 327 26. Chapter 20 Endoplasmic Reticulum - p. 341 27. Chapter 21 Mechanisms of Vesicular Transport - p. 365 28. Chapter 22 Secretory Membrane System and Golgi Apparatus - p. 377 29. Chapter 23 Endocytosis and the Endosomal Membrane System - p. 393 30. Chapter 24 Processing and Degradation of Cellular Components - p. 411 31. Section VII Signaling Mechanisms - p. 425 32. Chapter 25 Plasma Membrane Receptors - p. 429 33. Chapter 26 Protein Hardware for Signaling - p. 445 34. Chapter 27 Second Messengers - p. 463 35. Chapter 28 Integration of Signals - p. 483 36. Section VIII Cellular Adhesion and the Extracellular Matrix - p. 507 37. Chapter 29 Cells of the Extracellular Matrix and Immune Systems of Animals - p. 511 38. Chapter 30 Extracellular Matrix Molecules - p. 527 39. Chapter 31 Cellular Adhesion - p. 547 40. Chapter 32 Intercellular Junctions - p. 565 41. Chapter 33 Connective Tissues - p. 577 42. Section IX Cytoskeleton and Cellular Motility - p. 593 43. Chapter 34 Actin and Actin-Binding Proteins - p. 597 44. Chapter 35 Microtubules and Centrosomes - p. 615 45. Chapter 36 Intermediate Filaments - p. 635 46. Chapter 37 Motor Proteins - p. 645 47. Chapter 38 Intracellular Motility - p. 661 48. Chapter 39 Cellular Motility - p. 673 49. Chapter 40 Muscles - p. 693 50. Section X Cell Cycle - p. 715 51. Chapter 41 Introduction to the Cell Cycle - p. 719 52. Chapter 42 G1 Phase and Regulation of Cell Proliferation - p. 735 53. Chapter 43 S Phase and DNA Replication - p. 751 54. Chapter 44 G2 Phase: Responses toDNA Damage and Control ofEntry Into Mitosis - p. 769 55. Chapter 45 Mitosis - p. 781 56. Chapter 46 Cytokinesis - p. 801 57. Chapter 47 Meiosis - p. 813 58. Chapter 48 Cell Death - p. 833 59. Cell SnapShots - p. 855 60. Glossary - p. 877 61. Index - p. 907
Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods—from single cell RNA sequencing to second generation super resolution fluorescence microscopy—on advancing our understanding.
Clear, readable explanations provide a concise story about how cells function at the molecular level.
An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.
Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.
Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.
Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.
1. Section I Introduction to Cell Biology - p. 1 2. Chapter 1 Cells as the Basis of Life on Earth - p. 3 3. Chapter 2 Evolution of Life on Earth - p. 15 4. Section II Chemical and Physical Background - p. 29 5. Chapter 3 Molecules: Structures and Dynamics - p. 33 6. Chapter 4 Biophysical Principles - p. 55 7. Chapter 5 Macromolecular Assembly - p. 65 8. Chapter 6 Research Strategies - p. 79 9. Section III Chromatin, Chromosomes, and the Cell Nucleus - p. 107 10. Chapter 7 Chromosome Organization - p. 111 11. Chapter 8 DNA Packaging in Chromatin and Chromosomes - p. 131 12. Chapter 9 Nuclear Structure and Dynamics - p. 151 13. Section IV Central Dogma: From Gene to Protein - p. 169 14. Chapter 10 Gene Expression* - p. 173 15. Chapter 11 Eukaryotic RNA Processing - p. 199 16. Chapter 12 Protein Synthesis and Folding - p. 219 17. Section V Membrane Structure and Function - p. 233 18. Chapter 13 Membrane Structure and Dynamics - p. 237 19. Chapter 14 Membrane Pumps - p. 251 20. Chapter 15 Membrane Carriers - p. 263 21. Chapter 16 Membrane Channels - p. 271 22. Chapter 17 Membrane Physiology - p. 295 23. Section VI Cellular Organelles and Membrane Trafficking - p. 309 24. Chapter 18 Posttranslational Targeting of Proteins - p. 313 25. Chapter 19 Mitochondria, Chloroplasts, Peroxisomes - p. 327 26. Chapter 20 Endoplasmic Reticulum - p. 341 27. Chapter 21 Mechanisms of Vesicular Transport - p. 365 28. Chapter 22 Secretory Membrane System and Golgi Apparatus - p. 377 29. Chapter 23 Endocytosis and the Endosomal Membrane System - p. 393 30. Chapter 24 Processing and Degradation of Cellular Components - p. 411 31. Section VII Signaling Mechanisms - p. 425 32. Chapter 25 Plasma Membrane Receptors - p. 429 33. Chapter 26 Protein Hardware for Signaling - p. 445 34. Chapter 27 Second Messengers - p. 463 35. Chapter 28 Integration of Signals - p. 483 36. Section VIII Cellular Adhesion and the Extracellular Matrix - p. 507 37. Chapter 29 Cells of the Extracellular Matrix and Immune Systems of Animals - p. 511 38. Chapter 30 Extracellular Matrix Molecules - p. 527 39. Chapter 31 Cellular Adhesion - p. 547 40. Chapter 32 Intercellular Junctions - p. 565 41. Chapter 33 Connective Tissues - p. 577 42. Section IX Cytoskeleton and Cellular Motility - p. 593 43. Chapter 34 Actin and Actin-Binding Proteins - p. 597 44. Chapter 35 Microtubules and Centrosomes - p. 615 45. Chapter 36 Intermediate Filaments - p. 635 46. Chapter 37 Motor Proteins - p. 645 47. Chapter 38 Intracellular Motility - p. 661 48. Chapter 39 Cellular Motility - p. 673 49. Chapter 40 Muscles - p. 693 50. Section X Cell Cycle - p. 715 51. Chapter 41 Introduction to the Cell Cycle - p. 719 52. Chapter 42 G1 Phase and Regulation of Cell Proliferation - p. 735 53. Chapter 43 S Phase and DNA Replication - p. 751 54. Chapter 44 G2 Phase: Responses toDNA Damage and Control ofEntry Into Mitosis - p. 769 55. Chapter 45 Mitosis - p. 781 56. Chapter 46 Cytokinesis - p. 801 57. Chapter 47 Meiosis - p. 813 58. Chapter 48 Cell Death - p. 833 59. Cell SnapShots - p. 855 60. Glossary - p. 877 61. Index - p. 907
