Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. ix 6. Preface - p. xi 7. Chapter 1. An Historical Perspective: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology - p. 1 8. Chapter 2. The Endoplasmic Reticulum Chaperone GRP78 Also Functions as a Cell Surface Signaling Receptor - p. 9 9. Chapter 3. Cell Surface GRP78: Anchoring and Translocation Mechanisms and Therapeutic Potential in Cancer - p. 41 10. Chapter 4. Cell Surface GRP78: A Novel Regulator of Tissue Factor Procoagulant Activity - p. 63 11. Chapter 5. Novel Cell Surface Targets for the Plasminogen Activating System in the Brain: Implications for Human Disease - p. 87 12. Chapter 6. Cell Surface GRP78: A Targetable Marker of Cancer Stem-Like Cells - p. 99 13. Chapter 7. Escherichia coli Subtilase Cleaves Cell Surface GRP78 Preventing COOH-Terminal Domain Signaling - p. 111 14. Index - p. 127
Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. ix 6. Preface - p. xi 7. Chapter 1. An Historical Perspective: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology - p. 1 8. Chapter 2. The Endoplasmic Reticulum Chaperone GRP78 Also Functions as a Cell Surface Signaling Receptor - p. 9 9. Chapter 3. Cell Surface GRP78: Anchoring and Translocation Mechanisms and Therapeutic Potential in Cancer - p. 41 10. Chapter 4. Cell Surface GRP78: A Novel Regulator of Tissue Factor Procoagulant Activity - p. 63 11. Chapter 5. Novel Cell Surface Targets for the Plasminogen Activating System in the Brain: Implications for Human Disease - p. 87 12. Chapter 6. Cell Surface GRP78: A Targetable Marker of Cancer Stem-Like Cells - p. 99 13. Chapter 7. Escherichia coli Subtilase Cleaves Cell Surface GRP78 Preventing COOH-Terminal Domain Signaling - p. 111 14. Index - p. 127
