Cellular Senescence and Cardiac Aging: Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases offers a comprehensive and up-to-date exploration of the molecular and cellular processes driving cardiac aging, with a special focus on cellular senescence. This authoritative volume bridges cutting-edge, basic science with clinical applications, detailing how senescent cells contribute to age-related cardiovascular diseases and highlighting innovative therapeutic approaches such as senolytics and regenerative medicine. Ideal for graduate students, researchers, and clinicians in biomedical sciences, cardiology, pharmacology, and regenerative medicine, this book provides essential insights into biomarkers, epigenetics, autophagy, and emerging treatments.
With contributions from global experts, it also addresses gender and ethnic disparities, ensuring a broad and inclusive perspective. This indispensable resource equips readers with the knowledge needed to advance research and improve patient care in the rapidly evolving field of cardiac aging.
1. Chapter 1. Introduction to cardiac aging and cellular senescence - p. 1 2. Chapter 2. Cardiac aging beyond senescence: structural, functional, and physiological changes - p. 25 3. Chapter 3. Molecular mechanisms of senescence in cardiomyocytes - p. 41 4. Chapter 4. Cellular senescence in atherosclerosis and heart failure: pathophysiology and clinical implications - p. 63 5. Chapter 5. Senescence-associated secretory phenotype in cardiac tissue - p. 79 6. Chapter 6. Mitochondrial dysfunction, oxidative stress, and cardiac aging - p. 97 7. Chapter 7. Telomere attrition and cardiovascular senescence - p. 111 8. Chapter 8. Epigenetic modifications in cardiac aging and senescence - p. 131 9. Chapter 9. Senescence-induced cardiac fibrosis and remodeling - p. 149 10. Chapter 10. Metabolic disorders, obesity, and accelerated cardiac senescence - p. 167 11. Chapter 11. Autophagy, mitophagy, and senescence in the heart - p. 179 12. Chapter 12. Senolytics and senomorphics: emerging therapeutic strategies - p. 197 13. Chapter 13. Biomarkers of senescence in cardiovascular diseases - p. 213 14. Chapter 14. Noninvasive techniques for tracking cardiac aging - p. 231 15. Chapter 15. Clinical trials and translational advances targeting cardiac aging - p. 249 16. Chapter 16. Gender differences and ethnic disparities in cardiac aging - p. 265 17. Chapter 17. Regenerative medicine and stem cell approaches in cardiac aging - p. 281 18. Chapter 18. Future perspectives: personalized medicine and senescence modulation in cardiovascular health - p. 299 19. Index - p. 321
Cellular Senescence and Cardiac Aging: Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases offers a comprehensive and up-to-date exploration of the molecular and cellular processes driving cardiac aging, with a special focus on cellular senescence. This authoritative volume bridges cutting-edge, basic science with clinical applications, detailing how senescent cells contribute to age-related cardiovascular diseases and highlighting innovative therapeutic approaches such as senolytics and regenerative medicine. Ideal for graduate students, researchers, and clinicians in biomedical sciences, cardiology, pharmacology, and regenerative medicine, this book provides essential insights into biomarkers, epigenetics, autophagy, and emerging treatments.
With contributions from global experts, it also addresses gender and ethnic disparities, ensuring a broad and inclusive perspective. This indispensable resource equips readers with the knowledge needed to advance research and improve patient care in the rapidly evolving field of cardiac aging.
1. Chapter 1. Introduction to cardiac aging and cellular senescence - p. 1 2. Chapter 2. Cardiac aging beyond senescence: structural, functional, and physiological changes - p. 25 3. Chapter 3. Molecular mechanisms of senescence in cardiomyocytes - p. 41 4. Chapter 4. Cellular senescence in atherosclerosis and heart failure: pathophysiology and clinical implications - p. 63 5. Chapter 5. Senescence-associated secretory phenotype in cardiac tissue - p. 79 6. Chapter 6. Mitochondrial dysfunction, oxidative stress, and cardiac aging - p. 97 7. Chapter 7. Telomere attrition and cardiovascular senescence - p. 111 8. Chapter 8. Epigenetic modifications in cardiac aging and senescence - p. 131 9. Chapter 9. Senescence-induced cardiac fibrosis and remodeling - p. 149 10. Chapter 10. Metabolic disorders, obesity, and accelerated cardiac senescence - p. 167 11. Chapter 11. Autophagy, mitophagy, and senescence in the heart - p. 179 12. Chapter 12. Senolytics and senomorphics: emerging therapeutic strategies - p. 197 13. Chapter 13. Biomarkers of senescence in cardiovascular diseases - p. 213 14. Chapter 14. Noninvasive techniques for tracking cardiac aging - p. 231 15. Chapter 15. Clinical trials and translational advances targeting cardiac aging - p. 249 16. Chapter 16. Gender differences and ethnic disparities in cardiac aging - p. 265 17. Chapter 17. Regenerative medicine and stem cell approaches in cardiac aging - p. 281 18. Chapter 18. Future perspectives: personalized medicine and senescence modulation in cardiovascular health - p. 299 19. Index - p. 321
