Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xi 6. Preface - p. xv 7. Section I: Computational Approaches - p. xvi 8. Chapter One: Physical Accuracy Leads to Biological Relevance: Best Practices For Simulating Ligand-Gated Ion Channels Interacting With General Anesthetics - p. xvi 9. Chapter Two: Computational Approaches to Studying Voltage-Gated Ion Channel Modulation by General Anesthetics - p. 24 10. Chapter Three: Molecular Mechanics Parameterization of Anesthetic Molecules - p. 59 11. Chapter Four: Insights Into Receptor-Based Anesthetic Pharmacophores and Anesthetic–Protein Interactions - p. 76 12. Chapter Five: Understanding Anesthetic Mechanisms: Analysis of the Complex Kinetics of Ligand-Gated Ion Channels - p. 95 13. Section II: Genetics and Model Organisms - p. 110 14. Chapter Six: General Genetic Strategies - p. 110 15. Chapter Seven: Approaches to Anesthetic Mechanisms: The C. elegans Model - p. 132 16. Chapter Eight: Using Drosophila to Understand General Anesthesia: From Synapses to Behavior - p. 151 17. Chapter Nine: High-Throughput Screening to Identify Anesthetic Ligands Using Xenopus laevis Tadpoles - p. 176 18. Chapter Ten: Zebrafish: A Pharmacogenetic Model for Anesthesia - p. 187 19. Chapter Eleven: The Mouse as a Model Organism for Assessing Anesthetic Sensitivity - p. 209 20. Section III: Photolabeling - p. 228 21. Chapter Twelve: Identification of General Anesthetic Target Protein-Binding Sites by Photoaffinity Labeling and Mass Spectrometry - p. 228 22. Section IV: Xenon - p. 246 23. Chapter Thirteen: Xenon–Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR - p. 246 24. Chapter Fourteen: Methods for Defining the Neuroprotective Properties of Xenon - p. 272 25. Chapter Fifteen: Xenon Anesthesia and CT: Noninvasive Measures of Brain Anesthetic Concentration - p. 288 26. Section V: Electrophysiology - p. 298 27. Chapter Sixteen: Native System and Cultured Cell Electrophysiology for Investigating Anesthetic Mechanisms - p. 298 28. Chapter Seventeen: Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics - p. 338 29. Chapter Eighteen: Combining Mutations and Electrophysiology to Map Anesthetic Sites on Ligand-Gated Ion Channels - p. 368 30. Chapter Nineteen: HCN and K2P Channels in Anesthetic Mechanisms Research - p. 389
Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xi 6. Preface - p. xv 7. Section I: Computational Approaches - p. xvi 8. Chapter One: Physical Accuracy Leads to Biological Relevance: Best Practices For Simulating Ligand-Gated Ion Channels Interacting With General Anesthetics - p. xvi 9. Chapter Two: Computational Approaches to Studying Voltage-Gated Ion Channel Modulation by General Anesthetics - p. 24 10. Chapter Three: Molecular Mechanics Parameterization of Anesthetic Molecules - p. 59 11. Chapter Four: Insights Into Receptor-Based Anesthetic Pharmacophores and Anesthetic–Protein Interactions - p. 76 12. Chapter Five: Understanding Anesthetic Mechanisms: Analysis of the Complex Kinetics of Ligand-Gated Ion Channels - p. 95 13. Section II: Genetics and Model Organisms - p. 110 14. Chapter Six: General Genetic Strategies - p. 110 15. Chapter Seven: Approaches to Anesthetic Mechanisms: The C. elegans Model - p. 132 16. Chapter Eight: Using Drosophila to Understand General Anesthesia: From Synapses to Behavior - p. 151 17. Chapter Nine: High-Throughput Screening to Identify Anesthetic Ligands Using Xenopus laevis Tadpoles - p. 176 18. Chapter Ten: Zebrafish: A Pharmacogenetic Model for Anesthesia - p. 187 19. Chapter Eleven: The Mouse as a Model Organism for Assessing Anesthetic Sensitivity - p. 209 20. Section III: Photolabeling - p. 228 21. Chapter Twelve: Identification of General Anesthetic Target Protein-Binding Sites by Photoaffinity Labeling and Mass Spectrometry - p. 228 22. Section IV: Xenon - p. 246 23. Chapter Thirteen: Xenon–Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR - p. 246 24. Chapter Fourteen: Methods for Defining the Neuroprotective Properties of Xenon - p. 272 25. Chapter Fifteen: Xenon Anesthesia and CT: Noninvasive Measures of Brain Anesthetic Concentration - p. 288 26. Section V: Electrophysiology - p. 298 27. Chapter Sixteen: Native System and Cultured Cell Electrophysiology for Investigating Anesthetic Mechanisms - p. 298 28. Chapter Seventeen: Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics - p. 338 29. Chapter Eighteen: Combining Mutations and Electrophysiology to Map Anesthetic Sites on Ligand-Gated Ion Channels - p. 368 30. Chapter Nineteen: HCN and K2P Channels in Anesthetic Mechanisms Research - p. 389
