Chemoresistance in Glioblastoma: Understanding and Management gives clear insights into the detailed characteristic aspects of glioblastoma disease and the different therapeutic targets that are employed in reducing resistance to chemotherapeutic agents. The book delves deep into the root causes of multidrug resistance and the quest for novel molecular targets among growth factors, receptors, signal transduction proteins, microRNAs, transcription factors, proto-oncogenes, and tumor suppressor genes. In addition, it gives insights on the pathological and molecular features of glioblastoma and the role of cancer stem cells in the resistance to chemo and immunotherapy.
While designed as a comprehensive guide, the book also serves as a valuable reference for professionals seeking to deepen their understanding, refine their skills, and explore new avenues within chemoresistance.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xvii 8. About the editors - p. xix 9. Foreword - p. xxi 10. Chapter 1. Molecular mechanisms underlying treatment resistance in glioblastoma and current therapies - p. 1 11. Chapter 2. A comprehensive outline of glioblastoma and molecular chemotherapy - p. 27 12. Chapter 3. Brain tumors: diagnosis and treatment - p. 77 13. Chapter 4. Unveiling the therapeutic tapestry: mRNA and RNA vaccines in the nexus of glioblastoma's pathological and molecular landscape - p. 115 14. Chapter 5. Cell cycle arrest and apoptosis in glioblastoma - p. 139 15. Chapter 6. Cancer stem cells in resisting chemotherapy and the recurrence of glioblastoma multiforme - p. 171 16. Chapter 7. Variability in natural invasion of tumor cells patterns in human glioblastoma - p. 201 17. Chapter 8. Epigenome in gliomas: novel targets for therapy - p. 241 18. Chapter 9. Adaptation of mitochondria in drug resistance of cancer: frequency, mechanisms, and control - p. 261 19. Chapter 10. Hindrance in immunotherapy resistant glioblastoma - p. 279 20. Chapter 11. Dynamics of glioblastoma chemotherapy in blood–brain barrier - p. 329 21. Chapter 12. Epigenetic modifications and therapies of gliomas: a precision medicine perspective - p. 359 22. Index - p. 387
Chemoresistance in Glioblastoma: Understanding and Management gives clear insights into the detailed characteristic aspects of glioblastoma disease and the different therapeutic targets that are employed in reducing resistance to chemotherapeutic agents. The book delves deep into the root causes of multidrug resistance and the quest for novel molecular targets among growth factors, receptors, signal transduction proteins, microRNAs, transcription factors, proto-oncogenes, and tumor suppressor genes. In addition, it gives insights on the pathological and molecular features of glioblastoma and the role of cancer stem cells in the resistance to chemo and immunotherapy.
While designed as a comprehensive guide, the book also serves as a valuable reference for professionals seeking to deepen their understanding, refine their skills, and explore new avenues within chemoresistance.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xvii 8. About the editors - p. xix 9. Foreword - p. xxi 10. Chapter 1. Molecular mechanisms underlying treatment resistance in glioblastoma and current therapies - p. 1 11. Chapter 2. A comprehensive outline of glioblastoma and molecular chemotherapy - p. 27 12. Chapter 3. Brain tumors: diagnosis and treatment - p. 77 13. Chapter 4. Unveiling the therapeutic tapestry: mRNA and RNA vaccines in the nexus of glioblastoma's pathological and molecular landscape - p. 115 14. Chapter 5. Cell cycle arrest and apoptosis in glioblastoma - p. 139 15. Chapter 6. Cancer stem cells in resisting chemotherapy and the recurrence of glioblastoma multiforme - p. 171 16. Chapter 7. Variability in natural invasion of tumor cells patterns in human glioblastoma - p. 201 17. Chapter 8. Epigenome in gliomas: novel targets for therapy - p. 241 18. Chapter 9. Adaptation of mitochondria in drug resistance of cancer: frequency, mechanisms, and control - p. 261 19. Chapter 10. Hindrance in immunotherapy resistant glioblastoma - p. 279 20. Chapter 11. Dynamics of glioblastoma chemotherapy in blood–brain barrier - p. 329 21. Chapter 12. Epigenetic modifications and therapies of gliomas: a precision medicine perspective - p. 359 22. Index - p. 387
