Cholecystokinin: From Gallbladder to Cognition and Beyond covers the biology, physiology, and pathophysiological roles of cholecystokinin (CCK) peptides. The book begins with a historical overview before providing in-depth chapters on the biology of CCK, from biogenesis to cell expression, including intestinal and extraintestinal endocrine cells, the central and peripheral nervous system, and receptor function. CCK phylogenesis is explored across various species, including fish, birds, insects and amphibians. The physiology of CCK covers intestinal CCK secretion, the gallbladder and pancreas, and the role of CCK in the gut-brain axis, gastrointestinal motor function, appetite regulation, and cardiovascular function.
Methods used for CCK research are also discussed. A number of chapters then covers the roles of CCK in various diseases, including metabolic diseases, tumors, psychiatric illness, the immune system and nociception, as well as potential therapeutic approaches targeting CCK receptors.
1. Cholecystokinin - p. i 2. Cover image - p. i 3. Title page - p. i 4. Table of Contents - p. i 5. Front Matter - p. i 6. Copyright - p. iv 7. Contributors - p. xix 8. Preface - p. xxii 9. Series preface - p. xxv 10. Part I: History - p. xxv 11. Chapter 1 Milestones in the history of cholecystokinin - p. 3 12. Part II: Biology of cholecystokinin - p. 18 13. Chapter 2 Evolutionarily conserved roles of cholecystokinin signaling - p. 21 14. Chapter 3 The biogenesis and cell-specific expression of cholecystokinin peptides - p. 71 15. Chapter 4 Cholecystokinin in intestinal and extraintestinal endocrine cells - p. 87 16. Chapter 5 Cholecystokinin in the central and peripheral nervous system - p. 101 17. Chapter 6 Cholecystokinin 1 and 2 receptors - p. 161 18. Chapter 7 The relationship between cholecystokinin and gastrin - p. 179 19. Part III: Physiology of cholecystokinin - p. 191 20. Chapter 8 Intestinal cholecystokinin secretion - p. 195 21. Chapter 9 Cholecystokinin and the gut-brain axis - p. 219 22. Chapter 10 CCK and the gallbladder - p. 253 23. Chapter 11 Cholecystokinin and the exocrine pancreas - p. 281 24. Chapter 12 Islet effects of cholecystokinin and exploitation in diabetes - p. 305 25. Chapter 13 Cholecystokinin and gastrointestinal motor function - p. 327 26. Chapter 14 Effect of cholecystokinin on food intake and appetite - p. 359 27. Chapter 15 Cholecystokinin, nutrient preference, and taste aversion - p. 383 28. Chapter 16 Cholecystokinin in peripheral and central cardiovascular control - p. 407 29. Chapter 17 Cholecystokinin in cardiac myocytes - p. 423 30. Part IV: Methods used for cholecystokinin research - p. 438 31. Chapter 18 Measurement of cholecystokinin in biological fluids - p. 441 32. Chapter 19 Cholecystokinin knockout mice: peripheral and central phenotypes - p. 461 33. Part V: Cholecystokinin in disease - p. 474 34. Chapter 20 Cholecystokinin in obesity and other disorders of eating - p. 477 35. Chapter 21 Cholecystokinin in tumors - p. 493 36. Chapter 22 Cholecystokinin and panic disorder - p. 505 37. Chapter 23 Cholecystokinin and the immune system - p. 523 38. Chapter 24 Cholecystokinin in nociception and pain - p. 557 39. Part VI: Cholecystokinin-based novel therapeutic approaches - p. 581 40. Chapter 25 Potential therapeutics targeting cholecystokinin 1 receptors - p. 585 41. Chapter 26 Reflections on cholecystokinin research: Past, present, and future - p. 597 42. Index - p. 601
Cholecystokinin: From Gallbladder to Cognition and Beyond covers the biology, physiology, and pathophysiological roles of cholecystokinin (CCK) peptides. The book begins with a historical overview before providing in-depth chapters on the biology of CCK, from biogenesis to cell expression, including intestinal and extraintestinal endocrine cells, the central and peripheral nervous system, and receptor function. CCK phylogenesis is explored across various species, including fish, birds, insects and amphibians. The physiology of CCK covers intestinal CCK secretion, the gallbladder and pancreas, and the role of CCK in the gut-brain axis, gastrointestinal motor function, appetite regulation, and cardiovascular function.
Methods used for CCK research are also discussed. A number of chapters then covers the roles of CCK in various diseases, including metabolic diseases, tumors, psychiatric illness, the immune system and nociception, as well as potential therapeutic approaches targeting CCK receptors.
1. Cholecystokinin - p. i 2. Cover image - p. i 3. Title page - p. i 4. Table of Contents - p. i 5. Front Matter - p. i 6. Copyright - p. iv 7. Contributors - p. xix 8. Preface - p. xxii 9. Series preface - p. xxv 10. Part I: History - p. xxv 11. Chapter 1 Milestones in the history of cholecystokinin - p. 3 12. Part II: Biology of cholecystokinin - p. 18 13. Chapter 2 Evolutionarily conserved roles of cholecystokinin signaling - p. 21 14. Chapter 3 The biogenesis and cell-specific expression of cholecystokinin peptides - p. 71 15. Chapter 4 Cholecystokinin in intestinal and extraintestinal endocrine cells - p. 87 16. Chapter 5 Cholecystokinin in the central and peripheral nervous system - p. 101 17. Chapter 6 Cholecystokinin 1 and 2 receptors - p. 161 18. Chapter 7 The relationship between cholecystokinin and gastrin - p. 179 19. Part III: Physiology of cholecystokinin - p. 191 20. Chapter 8 Intestinal cholecystokinin secretion - p. 195 21. Chapter 9 Cholecystokinin and the gut-brain axis - p. 219 22. Chapter 10 CCK and the gallbladder - p. 253 23. Chapter 11 Cholecystokinin and the exocrine pancreas - p. 281 24. Chapter 12 Islet effects of cholecystokinin and exploitation in diabetes - p. 305 25. Chapter 13 Cholecystokinin and gastrointestinal motor function - p. 327 26. Chapter 14 Effect of cholecystokinin on food intake and appetite - p. 359 27. Chapter 15 Cholecystokinin, nutrient preference, and taste aversion - p. 383 28. Chapter 16 Cholecystokinin in peripheral and central cardiovascular control - p. 407 29. Chapter 17 Cholecystokinin in cardiac myocytes - p. 423 30. Part IV: Methods used for cholecystokinin research - p. 438 31. Chapter 18 Measurement of cholecystokinin in biological fluids - p. 441 32. Chapter 19 Cholecystokinin knockout mice: peripheral and central phenotypes - p. 461 33. Part V: Cholecystokinin in disease - p. 474 34. Chapter 20 Cholecystokinin in obesity and other disorders of eating - p. 477 35. Chapter 21 Cholecystokinin in tumors - p. 493 36. Chapter 22 Cholecystokinin and panic disorder - p. 505 37. Chapter 23 Cholecystokinin and the immune system - p. 523 38. Chapter 24 Cholecystokinin in nociception and pain - p. 557 39. Part VI: Cholecystokinin-based novel therapeutic approaches - p. 581 40. Chapter 25 Potential therapeutics targeting cholecystokinin 1 receptors - p. 585 41. Chapter 26 Reflections on cholecystokinin research: Past, present, and future - p. 597 42. Index - p. 601
