With Cholesterol, Drs. Anna Bukiya and Alex Dopico have compiled a comprehensive resource on biological and clinical aspects of cholesterol, spanning biophysics and biochemistry, as well as the latest pharmacological discoveries employed to tackle disorders associated with abnormal cholesterol levels. Early chapters on basic biology offer guidance in cholesterol lab chemistry, cholesterol metabolism and synthesis, molecular evolution of cholesterol and sterols, cholesterol peptides, and cholesterol modulation. Chapters on cellular and organismal development discuss cholesterol transport in blood, lipoproteins, and cholesterol metabolism; cholesterol detection in the blood; cellular cholesterol levels; hypercholesterolemia; and the role of cholesterol in early human development. Pathophysical specialists consider familial hypobetalipoproteinemia, critical illness and cholesterol levels, coronary artery disease, CESD, cholesterol and viral pathology, cholesterol and neurodegenerative disorders, and cholesterol and substance use disorders. A final section examines pharmacology of drug delivery systems targeting cholesterol related disorders, cholesterol receptors, cholesterol reduction, statins, citrate lyase, cyclodextrins, and clinical management.
Cholesterol: From Biophysics and Biochemistry to Pathology and Pharmacology empowers researchers, students, and clinicians across various disciplines to advance new cholesterol-based studies, improve clinical management, and drive drug discovery.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xiii 7. Preface - p. xvii 8. Afterword - p. xix 9. Section 1: Cholesterol chemistry and cell function - p. xx 10. Chapter 1. Cholesterol chemistry and laboratory synthesis - p. 3 11. Chapter 2. Molecular evolution of cholesterol and other higher sterols in relation to membrane structure - p. 25 12. Chapter 3. Role of cholesterol in maintaining the physical properties of the plasma membrane - p. 41 13. Chapter 4. The fundamental interaction of cholesterol with lipid membranes: The umbrella model - p. 73 14. Chapter 5. Model peptides and cholesterol - p. 99 15. Chapter 6. Cholesterol and ceramide: An unlikely pair - p. 111 16. Chapter 7. Cholesterol-recognizing amino acid consensus motifs in transmembrane proteins: Comparative analysis of in silico studies and structural data - p. 127 17. Chapter 8. Effects of cholesterol on the GPCR AT1 receptor and its interplay with AT1 antagonists - p. 147 18. Chapter 9. Principles of cholesterol regulation of ion channels - p. 197 19. Chapter 10. Fluorescent probes for microscopy visualization of cholesterol topography and dynamics in membranes - p. 205 20. Chapter 11. Cholesterol transport in blood, lipoproteins, and cholesterol metabolism - p. 231 21. Chapter 12. Common laboratory research methods for detection and quantification of cholesterol - p. 259 22. Chapter 13. Approaches for modifying cellular cholesterol levels and their application to mechanistic studies: Examples from the ion channel field - p. 294 23. Section 2: Cholesterol homeostasis and its disruption - p. 340 24. Chapter 14. Diet-induced hypercholesterolemia in small laboratory animal models - p. 346 25. Chapter 15. Nutrition and cholesterol metabolism - p. 375 26. Chapter 16. Cholesterol and early development - p. 403 27. Clinical and biochemical diagnostic methods: What do blood lipid levels tell us? - p. 451 28. Chapter 18. Familial hypobetalipoproteinemia and abetalipoproteinemia - p. 475 29. Chapter 19. Critical illness and cholesterol levels - p. 481 30. Chapter 20. Familial hypercholesterolemia - p. 501 31. Chapter 21. Niemann-Pick type C disease (NPC) - p. 530 32. Chapter 22. Rare monogenic disorders of cholesterol metabolism - p. 553 33. Chapter 23. Secondary (acquired) hypercholesterolemia - p. 609 34. Chapter 24. Blood lipids and molecular pathways of atherogenesis - p. 623 35. Chapter 25. Lysosomal acid lipase: Roles in rare deficiency diseases, myeloid cell biology, innate immunity, and common neutral lipid diseases - p. 639 36. Chapter 26. Cholesterol and pathogens - p. 675 37. Chapter 27. Involvement of cholesterol and β-amyloid in the initiation and progression of Alzheimer’s disease - p. 715 38. Chapter 28. Cholesterol and alcohol - p. 747 39. Section 3: Pharmacological considerations and perspectives - p. 767 40. Chapter 29. Cholesterol stiffening of lipid membranes and drug interactions: Insights from neutron spin echo and deuterium NMR spectroscopy - p. 771 41. Chapter 30. Cholesterol in drug delivery systems - p. 797 42. Chapter 31. Modification of vascular receptor pharmacology by cholesterol: From molecular determinants to impact on arterial function - p. 825 43. Chapter 32. Clinical strategies for reducing cholesterol levels - p. 853 44. Chapter 33. Medicinal chemistry and pharmacology of statins - p. 903 45. Chapter 34. Cyclodextrins as promising therapeutics against cholesterol overload - p. 927 46. Chapter 35. Hyperlipidemia and rheumatoid arthritis - p. 969 47. Chapter 36. Management of hypercholesterolemia in individuals living with HIV/AIDS - p. 1010 48. Index - p. 1021
With Cholesterol, Drs. Anna Bukiya and Alex Dopico have compiled a comprehensive resource on biological and clinical aspects of cholesterol, spanning biophysics and biochemistry, as well as the latest pharmacological discoveries employed to tackle disorders associated with abnormal cholesterol levels. Early chapters on basic biology offer guidance in cholesterol lab chemistry, cholesterol metabolism and synthesis, molecular evolution of cholesterol and sterols, cholesterol peptides, and cholesterol modulation. Chapters on cellular and organismal development discuss cholesterol transport in blood, lipoproteins, and cholesterol metabolism; cholesterol detection in the blood; cellular cholesterol levels; hypercholesterolemia; and the role of cholesterol in early human development. Pathophysical specialists consider familial hypobetalipoproteinemia, critical illness and cholesterol levels, coronary artery disease, CESD, cholesterol and viral pathology, cholesterol and neurodegenerative disorders, and cholesterol and substance use disorders. A final section examines pharmacology of drug delivery systems targeting cholesterol related disorders, cholesterol receptors, cholesterol reduction, statins, citrate lyase, cyclodextrins, and clinical management.
Cholesterol: From Biophysics and Biochemistry to Pathology and Pharmacology empowers researchers, students, and clinicians across various disciplines to advance new cholesterol-based studies, improve clinical management, and drive drug discovery.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xiii 7. Preface - p. xvii 8. Afterword - p. xix 9. Section 1: Cholesterol chemistry and cell function - p. xx 10. Chapter 1. Cholesterol chemistry and laboratory synthesis - p. 3 11. Chapter 2. Molecular evolution of cholesterol and other higher sterols in relation to membrane structure - p. 25 12. Chapter 3. Role of cholesterol in maintaining the physical properties of the plasma membrane - p. 41 13. Chapter 4. The fundamental interaction of cholesterol with lipid membranes: The umbrella model - p. 73 14. Chapter 5. Model peptides and cholesterol - p. 99 15. Chapter 6. Cholesterol and ceramide: An unlikely pair - p. 111 16. Chapter 7. Cholesterol-recognizing amino acid consensus motifs in transmembrane proteins: Comparative analysis of in silico studies and structural data - p. 127 17. Chapter 8. Effects of cholesterol on the GPCR AT1 receptor and its interplay with AT1 antagonists - p. 147 18. Chapter 9. Principles of cholesterol regulation of ion channels - p. 197 19. Chapter 10. Fluorescent probes for microscopy visualization of cholesterol topography and dynamics in membranes - p. 205 20. Chapter 11. Cholesterol transport in blood, lipoproteins, and cholesterol metabolism - p. 231 21. Chapter 12. Common laboratory research methods for detection and quantification of cholesterol - p. 259 22. Chapter 13. Approaches for modifying cellular cholesterol levels and their application to mechanistic studies: Examples from the ion channel field - p. 294 23. Section 2: Cholesterol homeostasis and its disruption - p. 340 24. Chapter 14. Diet-induced hypercholesterolemia in small laboratory animal models - p. 346 25. Chapter 15. Nutrition and cholesterol metabolism - p. 375 26. Chapter 16. Cholesterol and early development - p. 403 27. Clinical and biochemical diagnostic methods: What do blood lipid levels tell us? - p. 451 28. Chapter 18. Familial hypobetalipoproteinemia and abetalipoproteinemia - p. 475 29. Chapter 19. Critical illness and cholesterol levels - p. 481 30. Chapter 20. Familial hypercholesterolemia - p. 501 31. Chapter 21. Niemann-Pick type C disease (NPC) - p. 530 32. Chapter 22. Rare monogenic disorders of cholesterol metabolism - p. 553 33. Chapter 23. Secondary (acquired) hypercholesterolemia - p. 609 34. Chapter 24. Blood lipids and molecular pathways of atherogenesis - p. 623 35. Chapter 25. Lysosomal acid lipase: Roles in rare deficiency diseases, myeloid cell biology, innate immunity, and common neutral lipid diseases - p. 639 36. Chapter 26. Cholesterol and pathogens - p. 675 37. Chapter 27. Involvement of cholesterol and β-amyloid in the initiation and progression of Alzheimer’s disease - p. 715 38. Chapter 28. Cholesterol and alcohol - p. 747 39. Section 3: Pharmacological considerations and perspectives - p. 767 40. Chapter 29. Cholesterol stiffening of lipid membranes and drug interactions: Insights from neutron spin echo and deuterium NMR spectroscopy - p. 771 41. Chapter 30. Cholesterol in drug delivery systems - p. 797 42. Chapter 31. Modification of vascular receptor pharmacology by cholesterol: From molecular determinants to impact on arterial function - p. 825 43. Chapter 32. Clinical strategies for reducing cholesterol levels - p. 853 44. Chapter 33. Medicinal chemistry and pharmacology of statins - p. 903 45. Chapter 34. Cyclodextrins as promising therapeutics against cholesterol overload - p. 927 46. Chapter 35. Hyperlipidemia and rheumatoid arthritis - p. 969 47. Chapter 36. Management of hypercholesterolemia in individuals living with HIV/AIDS - p. 1010 48. Index - p. 1021
