Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers.In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders.
1. Chromatin Readers in Health and Disease - p. i 2. Cover Image - p. i 3. Translational Epigenetics Series - p. ii 4. Title Page - p. iii 5. Table of Contents - p. iii 6. Copyright - p. iv 7. Contributors - p. xiii 8. Preface - p. xvii 9. Chapter 1 ADD domains—A regulatory hub in chromatin biology and disease - p. 3 10. Chapter 2 The BAH domain: A versatile histone modification reader - p. 13 11. Chapter 3 BRCT domains as chromatin readers: Structure, function, and clinical implications - p. 31 12. Chapter 4 The bromodomain acyl-lysine readers in human health and disease - p. 57 13. Chapter 5 CHROMO domain readers: A rainbow of opportunities - p. 99 14. Chapter 6 The MBT proteins: Methyl-lysine readers for stem cells, development, and tumors - p. 195 15. Chapter 7 Epigenetically decipherING the genome: A role for PHDs - p. 217 16. Chapter 8 Recognition of histone methylation and DNA by the PWWP domain: Mechanism and function - p. 239 17. Chapter 9 Spin repeats and human pathologies - p. 257 18. Chapter 10 Chromatin readers of the WD-repeat containing protein family - p. 279 19. Chapter 11 The multifunctional YEATS domain in chromatin biology - p. 311 20. Chapter 12 DNA methylation and reader or writer proteins: Differentiation and disease - p. 343 21. Chapter 13 CUT&RUN and CUT&Tag: Low-input methods for genome-wide mapping of chromatin proteins - p. 371 22. Index - p. 387
Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers.In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders.
1. Chromatin Readers in Health and Disease - p. i 2. Cover Image - p. i 3. Translational Epigenetics Series - p. ii 4. Title Page - p. iii 5. Table of Contents - p. iii 6. Copyright - p. iv 7. Contributors - p. xiii 8. Preface - p. xvii 9. Chapter 1 ADD domains—A regulatory hub in chromatin biology and disease - p. 3 10. Chapter 2 The BAH domain: A versatile histone modification reader - p. 13 11. Chapter 3 BRCT domains as chromatin readers: Structure, function, and clinical implications - p. 31 12. Chapter 4 The bromodomain acyl-lysine readers in human health and disease - p. 57 13. Chapter 5 CHROMO domain readers: A rainbow of opportunities - p. 99 14. Chapter 6 The MBT proteins: Methyl-lysine readers for stem cells, development, and tumors - p. 195 15. Chapter 7 Epigenetically decipherING the genome: A role for PHDs - p. 217 16. Chapter 8 Recognition of histone methylation and DNA by the PWWP domain: Mechanism and function - p. 239 17. Chapter 9 Spin repeats and human pathologies - p. 257 18. Chapter 10 Chromatin readers of the WD-repeat containing protein family - p. 279 19. Chapter 11 The multifunctional YEATS domain in chromatin biology - p. 311 20. Chapter 12 DNA methylation and reader or writer proteins: Differentiation and disease - p. 343 21. Chapter 13 CUT&RUN and CUT&Tag: Low-input methods for genome-wide mapping of chromatin proteins - p. 371 22. Index - p. 387
