Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases.
Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation.
1. Chapter 1: A Brief Introduction to Chromatin Regulation and Dynamics - p. xxii 2. Chapter 2: Histone Modifications and Histone Variants in Pluripotency and Differentiation - p. 34 3. Chapter 3: Dynamics and Function of DNA Methylation During Development - p. 64 4. Chapter 4: ATP-Dependent Chromatin Remodeling: From Development to Disease - p. 94 5. Chapter 5: Chromatin Dynamics During the Cell Cycle - p. 116 6. Chapter 6: Epigenetic Regulation of Replication and Replication Timing - p. 139 7. Chapter 7: Regulation of Cellular Identity by Polycomb and Trithorax Proteins - p. 163 8. Chapter 8: Interplay Between Chromatin and Splicing - p. 189 9. Chapter 9: Crosstalk Between Non-Coding RNAs and the Epigenome in Development - p. 209 10. Chapter 10: Epigenetic Regulation of Nucleolar Functions - p. 234 11. Chapter 11: Chromatin Dynamics and DNA Repair - p. 274 12. Chapter 12: Regulation of Centromeric Chromatin - p. 302 13. Chapter 13: Telomere Maintenance in the Dynamic Nuclear Architecture - p. 324 14. Chapter 14: Epigenetic Regulation of X-Chromosome Inactivation - p. 352 15. Chapter 15: Interaction Between Cellular Metabolic States and Chromatin Dynamics - p. 371 16. Chapter 16: Circadian Plasticity of Chromatin States - p. 398 17. Chapter 17: 3D Nuclear Architecture and Epigenetic Memories: Regulators of Phenotypic Plasticity in Development, Aging and Cancer - p. 416 18. Index - p. 460
Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases.
Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation.
1. Chapter 1: A Brief Introduction to Chromatin Regulation and Dynamics - p. xxii 2. Chapter 2: Histone Modifications and Histone Variants in Pluripotency and Differentiation - p. 34 3. Chapter 3: Dynamics and Function of DNA Methylation During Development - p. 64 4. Chapter 4: ATP-Dependent Chromatin Remodeling: From Development to Disease - p. 94 5. Chapter 5: Chromatin Dynamics During the Cell Cycle - p. 116 6. Chapter 6: Epigenetic Regulation of Replication and Replication Timing - p. 139 7. Chapter 7: Regulation of Cellular Identity by Polycomb and Trithorax Proteins - p. 163 8. Chapter 8: Interplay Between Chromatin and Splicing - p. 189 9. Chapter 9: Crosstalk Between Non-Coding RNAs and the Epigenome in Development - p. 209 10. Chapter 10: Epigenetic Regulation of Nucleolar Functions - p. 234 11. Chapter 11: Chromatin Dynamics and DNA Repair - p. 274 12. Chapter 12: Regulation of Centromeric Chromatin - p. 302 13. Chapter 13: Telomere Maintenance in the Dynamic Nuclear Architecture - p. 324 14. Chapter 14: Epigenetic Regulation of X-Chromosome Inactivation - p. 352 15. Chapter 15: Interaction Between Cellular Metabolic States and Chromatin Dynamics - p. 371 16. Chapter 16: Circadian Plasticity of Chromatin States - p. 398 17. Chapter 17: 3D Nuclear Architecture and Epigenetic Memories: Regulators of Phenotypic Plasticity in Development, Aging and Cancer - p. 416 18. Index - p. 460
