More than 60 years since its first publication, Clinical Pharmacology remains an invaluable textbook that no clinician or prescriber, medical or pharmacy student should be without.
This highly trusted guide to drug therapy covers the key elements of therapeutic pharmacology, including health technology assessment, drug regulation, dependence and toxicology, as well as polypharmacy. The essentials of clinical pharmacology are discussed by body system, balancing science with practice to support good prescribing.
The thirteenth edition of Clinical Pharmacology has been fully updated to suit today’s context and therapeutic settings.
1. Cover image - p. c 2. Quotes - p. ii 3. Title page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. v 6. Preface - p. vii 7. Contributors - p. ix 8. Acknowledgements - p. xiii 9. Section 1 General - p. 1 10. Chapter 1 Clinical pharmacology - p. 2 11. Chapter 2 Topics in drug therapy - p. 5 12. Chapter 3 Discovery and development of drugs - p. 27 13. Chapter 4 Evaluation of drugs in humans - p. 36 14. Chapter 5 Health technology assessment for pharmaceutical products - p. 47 15. Chapter 6 Regulation of medicines - p. 54 16. Chapter 7 Classification and naming of drugs - p. 64 17. Chapter 8 Polypharmacy and medicines optimisation - p. 68 18. Section 2 From pharmacology to toxicology - p. 90 19. Chapter 9 General pharmacology - p. 91 20. Chapter 10 Unwanted effects and adverse drug reactions - p. 126 21. Chapter 11 Poisoning, overdose, antidotes - p. 139 22. Chapter 12 Drug dependence - p. 155 23. Section 3 Infection and inflammation - p. 180 24. Chapter 13 Chemotherapy of infections - p. 181 25. Chapter 14 Antibacterial drugs - p. 193 26. Chapter 15 Chemotherapy of bacterial infections - p. 213 27. Chapter 16 Viral, fungal, protozoal and helminthic infections - p. 236 28. Chapter 17 Therapeutics for COVID-19 - p. 266 29. Chapter 18 Drugs for inflammation and joint disease - p. 273 30. Chapter 19 Drugs and the skin - p. 296 31. Section 4 Nervous system - p. 313 32. Chapter 20 Pain and analgesics - p. 314 33. Chapter 21 Anaesthesia and neuromuscular block - p. 337 34. Chapter 22 Psychotropic drugs - p. 353 35. Chapter 23 Neurological disorders – epilepsy, Parkinson’s disease and multiple sclerosis - p. 396 36. Section 5 Cardiorespiratory and renal systems - p. 424 37. Chapter 24 Cholinergic and antimuscarinic (anticholinergic) mechanisms and drugs - p. 425 38. Chapter 25 Adrenergic mechanisms and drugs - p. 436 39. Chapter 26 Cardiovascular disease and heart failure - p. 448 40. Chapter 27 Cardiac arrhythmias - p. 482 41. Chapter 28 Hyperlipidaemias - p. 496 42. Chapter 29 Kidney and genitourinary tract - p. 508 43. Chapter 30 Respiratory system - p. 526 44. Section 6 Blood and neoplastic disease - p. 542 45. Chapter 31 Drugs and haemostasis - p. 543 46. Chapter 32 Red blood cell disorders - p. 560 47. Chapter 33 Neoplastic disease and immunosuppression - p. 576 48. Section 7 Gastrointestinal system - p. 593 49. Chapter 34 Oesophagus, stomach and duodenum - p. 594 50. Chapter 35 Intestines - p. 603 51. Chapter 36 Liver and biliary tract - p. 614 52. Section 8 Endocrine system, metabolic conditions - p. 625 53. Chapter 37 Adrenal corticosteroids, antagonists, corticotropin - p. 626 54. Chapter 38 Diabetes mellitus and obesity - p. 640 55. Chapter 39 Thyroid hormones, antithyroid drugs - p. 659 56. Chapter 40 Hypothalamic, pituitary and sex hormones - p. 669 57. Chapter 41 Vitamins, calcium and bone - p. 688 58. Index - p. 704
More than 60 years since its first publication, Clinical Pharmacology remains an invaluable textbook that no clinician or prescriber, medical or pharmacy student should be without.
This highly trusted guide to drug therapy covers the key elements of therapeutic pharmacology, including health technology assessment, drug regulation, dependence and toxicology, as well as polypharmacy. The essentials of clinical pharmacology are discussed by body system, balancing science with practice to support good prescribing.
The thirteenth edition of Clinical Pharmacology has been fully updated to suit today’s context and therapeutic settings.
1. Cover image - p. c 2. Quotes - p. ii 3. Title page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. v 6. Preface - p. vii 7. Contributors - p. ix 8. Acknowledgements - p. xiii 9. Section 1 General - p. 1 10. Chapter 1 Clinical pharmacology - p. 2 11. Chapter 2 Topics in drug therapy - p. 5 12. Chapter 3 Discovery and development of drugs - p. 27 13. Chapter 4 Evaluation of drugs in humans - p. 36 14. Chapter 5 Health technology assessment for pharmaceutical products - p. 47 15. Chapter 6 Regulation of medicines - p. 54 16. Chapter 7 Classification and naming of drugs - p. 64 17. Chapter 8 Polypharmacy and medicines optimisation - p. 68 18. Section 2 From pharmacology to toxicology - p. 90 19. Chapter 9 General pharmacology - p. 91 20. Chapter 10 Unwanted effects and adverse drug reactions - p. 126 21. Chapter 11 Poisoning, overdose, antidotes - p. 139 22. Chapter 12 Drug dependence - p. 155 23. Section 3 Infection and inflammation - p. 180 24. Chapter 13 Chemotherapy of infections - p. 181 25. Chapter 14 Antibacterial drugs - p. 193 26. Chapter 15 Chemotherapy of bacterial infections - p. 213 27. Chapter 16 Viral, fungal, protozoal and helminthic infections - p. 236 28. Chapter 17 Therapeutics for COVID-19 - p. 266 29. Chapter 18 Drugs for inflammation and joint disease - p. 273 30. Chapter 19 Drugs and the skin - p. 296 31. Section 4 Nervous system - p. 313 32. Chapter 20 Pain and analgesics - p. 314 33. Chapter 21 Anaesthesia and neuromuscular block - p. 337 34. Chapter 22 Psychotropic drugs - p. 353 35. Chapter 23 Neurological disorders – epilepsy, Parkinson’s disease and multiple sclerosis - p. 396 36. Section 5 Cardiorespiratory and renal systems - p. 424 37. Chapter 24 Cholinergic and antimuscarinic (anticholinergic) mechanisms and drugs - p. 425 38. Chapter 25 Adrenergic mechanisms and drugs - p. 436 39. Chapter 26 Cardiovascular disease and heart failure - p. 448 40. Chapter 27 Cardiac arrhythmias - p. 482 41. Chapter 28 Hyperlipidaemias - p. 496 42. Chapter 29 Kidney and genitourinary tract - p. 508 43. Chapter 30 Respiratory system - p. 526 44. Section 6 Blood and neoplastic disease - p. 542 45. Chapter 31 Drugs and haemostasis - p. 543 46. Chapter 32 Red blood cell disorders - p. 560 47. Chapter 33 Neoplastic disease and immunosuppression - p. 576 48. Section 7 Gastrointestinal system - p. 593 49. Chapter 34 Oesophagus, stomach and duodenum - p. 594 50. Chapter 35 Intestines - p. 603 51. Chapter 36 Liver and biliary tract - p. 614 52. Section 8 Endocrine system, metabolic conditions - p. 625 53. Chapter 37 Adrenal corticosteroids, antagonists, corticotropin - p. 626 54. Chapter 38 Diabetes mellitus and obesity - p. 640 55. Chapter 39 Thyroid hormones, antithyroid drugs - p. 659 56. Chapter 40 Hypothalamic, pituitary and sex hormones - p. 669 57. Chapter 41 Vitamins, calcium and bone - p. 688 58. Index - p. 704
