Written for fellows, practicing nephrologists, and internists who treat patients with disorders affecting the renal system, Comprehensive Clinical Nephrology, 7th Edition, offers a practical approach to this complex field, supported by underlying scientific facts and pathophysiology. World leaders in nephrology provide current information on clinical procedures and conditions, covering everything from fluid and electrolyte disorders to hypertension, diabetes, dialysis, transplantation, and more—all in a single, convenient volume.
Provides a "just right" amount of basic science and practical clinical guidance to help you make efficient and informed decisions.
Contains new chapters on Blood Pressure Management in the Dialysis Patient, Kidney Diseases Associated with Corona Viruses, Ultrasound Imaging in Nephrology, and Radiologic and Nuclear Imaging in Nephrology.
Includes more than 1,500 full-color illustrations that highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management.
Covers key topics such as COVID-19, chronic kidney disease, end stage kidney disease, kidney transplantation, glomerular disease, onco-nephrology, dialysis, and much more.
Features popular, color-coded algorithms that provide easy access to important content: yellow boxes for general information, green boxes for therapeutic intervention, and blue boxes for necessary investigations.
Includes quick-reference boxes with links to clinical guidelines in all relevant chapters, plus self-assessment questions online.
1. 16. Introduction to Glomerular Disease: Clinical Presentations - p. 193 2. 17. Introduction to Glomerular Disease: Histologic Classification and Pathogenesis - p. 207 3. 18. Minimal Change Disease - p. 217 4. 19. Primary and Secondary (Nongenetic) Causes of Focal and Segmental Glomerulosclerosis - p. 226 5. 20. Inherited Causes of Nephrotic Syndrome - p. 237 6. 21. Membranous Nephropathy - p. 245 7. 22. Immunoglobulin-Mediated Glomerulonephritis With a Membranoproliferative Pattern of Injury and Cryoglobulinemic Glomerulonephritis - p. 259 8. 23. Glomerulonephritis Associated With Complement Disorders - p. 268 9. 24. Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis (Henoch-Schönlein Purpura) - p. 274 10. 25. Anti–Glomerular Basement Membrane Disease and Goodpasture Disease - p. 285 11. 26. Renal and Systemic Vasculitis - p. 294 12. 27. Lupus Nephritis - p. 309 13. 28. Monoclonal Immunoglobulin–Related Glomerular Diseases and Renal Amyloidosis - p. 323 14. 29. Rare Glomerular Disorders - p. 337 15. 30. Thrombotic Microangiopathies, Including Hemolytic Uremic Syndrome - p. 350 16. Section V. Diabetic Kidney Disease - p. 363 17. 31. Pathogenesis, Clinical Manifestations, and Natural History of Diabetic Kidney Disease - p. 363 18. 32. Prevention and Treatment of Diabetic Kidney Disease - p. 380 19. 33. Management of Patients With Diabetes and Chronic Kidney Disease - p. 389 20. Section VI. Hypertension - p. 403 21. 34. Normal Blood Pressure Control and the Evaluation of Hypertension - p. 403 22. 35. Primary Hypertension - p. 419 23. 36. Nonpharmacologic Prevention and Treatment of Hypertension - p. 428 24. 37. Pharmacologic Treatment of Hypertension - p. 436 25. 38. Evaluation and Treatment of Hypertensive Urgencies and Emergencies - p. 451 26. 39. Endocrine Causes of Hypertension: Aldosterone - p. 460 27. 40. Other Endocrine Causes of Hypertension - p. 471 28. 41. Neurogenic Hypertension, Including Hypertension Associated With Stroke or Spinal Cord Injury - p. 483 29. 42. Blood Pressure Management in the Dialysis Patient - p. 492 30. Section VII. Renovascular Disease - p. 500 31. 43. Renovascular Hypertension, Atherosclerotic Renal Vascular Disease, and Thromboembolic Kidney Disease - p. 500 32. Section VIII. Pregnancy and Renal Disease - p. 519 33. 44. Kidney Physiology and Complications in Normal Pregnancy - p. 519 34. 45. Pregnancy With Preexisting Kidney Disease - p. 538 35. Section IX. Hereditary and Congenital Diseases of the Kidney - p. 548 36. 46. Autosomal Dominant Polycystic Kidney Disease - p. 548 37. 47. Other Cystic Kidney Diseases - p. 561 38. 48. Alport Syndrome and Other Familial Glomerular Syndromes - p. 576 39. 49. Inherited Disorders of Sodium and Water Handling - p. 589 40. 50. Fanconi Syndrome and Other Proximal Tubule Disorders - p. 600 41. 51. Sickle Cell Diseases and the Kidney - p. 611 42. 52. Congenital Anomalies of the Kidney and Urinary Tract - p. 621 43. Section X. Infectious Diseases and the Kidney - p. 640 44. 53. Urinary Tract Infections in Adults - p. 640 45. 54. Tuberculosis of the Urinary Tract - p. 653 46. 55. Fungal Infections of the Urinary Tract - p. 665 47. 56. The Kidney in Schistosomiasis - p. 670 48. 57. Glomerular Diseases Associated With Infection - p. 679 49. 58. Human Immunodeficiency Virus Infection and the Kidney - p. 694 50. 59. Kidney Diseases Associated With Coronaviruses - p. 703 51. Section XI. Urologic Disorders - p. 708 52. 60. Nephrolithiasis and Nephrocalcinosis - p. 708 53. 61. Urinary Tract Obstruction - p. 722 54. 62. Primary Vesicoureteral Reflux and Reflux Nephropathy - p. 735 55. 63. Urologic Issues for the Nephrologist - p. 743 56. Section XII. Tubulointerstitial and Vascular Diseases - p. 754 57. 64. Acute Interstitial Nephritis - p. 754 58. 65. Chronic Interstitial Nephritis - p. 763 59. 66. Endemic Nephropathies - p. 775 60. Section XIII. Renal Disease and Cancer - p. 781 61. 67. Oncology: Kidney Disease in Cancer Patients - p. 781 62. 68. Myeloma and the Kidney - p. 791 63. 69. Kidney Disease in Liver, Cardiac, Lung, and Hematopoietic Stem Cell Transplantation - p. 799 64. Section XIV. Acute Kidney Injury - p. 809 65. 70. Pathophysiology and Etiology of Acute Kidney Injury - p. 809 66. 71. Acute Kidney Injury in the Tropics - p. 826 67. 72. Diagnosis and Clinical Evaluation of Acute Kidney Injury - p. 835 68. 73. Epidemiology and Prognostic Impact of Acute Kidney Injury and Acute Kidney Disease - p. 845 69. 74. Prevention and Nondialytic Management of Acute Kidney Injury - p. 850 70. 75. Extracorporeal Therapies for Acute Kidney Injury and Heart Failure - p. 863 71. 76. Hepatorenal Syndrome - p. 881 72. Section XV. Drug Therapy in Kidney Disease - p. 892 73. 77. Principles of Drug Therapy, Dosing, and Prescribing in Chronic Kidney Disease and Kidney Replacement Therapy - p. 892 74. 78. Common Issues in Prescribing in Kidney Disease and Kidney Replacement Therapy - p. 903 75. 79. Herbal and Over-the-Counter Medicines and the Kidney - p. 918 76. Section XVI. Chronic Kidney Disease and Uremic Syndrome - p. 927 77. 80. Epidemiology of Chronic Kidney Disease and Dialysis - p. 927 78. 81. Pathophysiology of Disease Progression in Proteinuric and Nonproteinuric Kidney Disease - p. 937 79. 82. Slowing the Progression of Kidney Disease - p. 947 80. 83. Clinical Evaluation and Management of Chronic Kidney Disease - p. 959 81. 84. Pathogenesis and Risk of Cardiovascular Disease in Chronic Kidney Disease - p. 967 82. 85. Practical Management of Cardiovascular Disease in Chronic Kidney Disease - p. 973 83. 86. Anemia in Chronic Kidney Disease - p. 983 84. 87. Other Blood and Immune Disorders in Chronic Kidney Disease - p. 991 85. 88. Bone and Mineral Disorders in Chronic Kidney Disease - p. 1002 86. 89. Neurologic Complications of Chronic Kidney Disease - p. 1018 87. 90. Nutrition in Chronic Kidney Disease - p. 1024 88. 91. Dermatologic Manifestations of Chronic Kidney Disease - p. 1031 89. 92. Acquired Cystic Kidney Disease and Malignant Neoplasms - p. 1040 90. Section XVII. Geriatric and Palliative Nephrology - p. 1046 91. 93. Geriatric Nephrology - p. 1046 92. 94. Palliative Nephrology - p. 1054 93. Section XVIII. Dialytic Therapies - p. 1060 94. 95. Approach to Kidney Replacement Therapy - p. 1060 95. 96. Vascular Access for Hemodialysis - p. 1072 96. 97. Diagnostic and Interventional Nephrology - p. 1083 97. 98. Hemodialysis: Principles and Techniques - p. 1091 98. 99. Hemodialysis: Dialysis Prescription and Adequacy - p. 1100 99. 100. Acute Complications During Hemodialysis - p. 1108 100. 101. Peritoneal Dialysis: Principles, Techniques, and Adequacy - p. 1120 101. 102. Complications of Peritoneal Dialysis - p. 1130 102. 103. Extracorporeal Therapies for Drug Overdose and Poisoning - p. 1140 103. 104. Plasma Exchange - p. 1149 104. Section XIX. Transplantation - p. 1158 105. 105. Immunologic Principles in Kidney Transplantation - p. 1158 106. 106. Immunosuppressive Medications in Kidney Transplantation - p. 1169 107. 107. Evaluation and Preoperative Management of Kidney Transplant Recipient and Donor - p. 1178 108. 108. Kidney Transplantation Surgery - p. 1191 109. 109. Prophylaxis and Treatment of Kidney Transplant Rejection - p. 1202 110. 110. Infections and Malignancies in the Kidney Transplant Recipient - p. 1213 111. 111. Cardiovascular Disease and Metabolic Abnormalities in the Kidney Transplant Recipient - p. 1232 112. 112. Chronic Allograft Injury - p. 1244 113. 113. Recurrent Disease in Kidney Transplantation - p. 1254 114. 114. Outcomes of Kidney Transplantation: Identification, Measures, and Evaluation - p. 1264 115. Index - p. 1273 116. Self-Assessment Answers - p. 1.e1
Written for fellows, practicing nephrologists, and internists who treat patients with disorders affecting the renal system, Comprehensive Clinical Nephrology, 7th Edition, offers a practical approach to this complex field, supported by underlying scientific facts and pathophysiology. World leaders in nephrology provide current information on clinical procedures and conditions, covering everything from fluid and electrolyte disorders to hypertension, diabetes, dialysis, transplantation, and more—all in a single, convenient volume.
Provides a "just right" amount of basic science and practical clinical guidance to help you make efficient and informed decisions.
Contains new chapters on Blood Pressure Management in the Dialysis Patient, Kidney Diseases Associated with Corona Viruses, Ultrasound Imaging in Nephrology, and Radiologic and Nuclear Imaging in Nephrology.
Includes more than 1,500 full-color illustrations that highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management.
Covers key topics such as COVID-19, chronic kidney disease, end stage kidney disease, kidney transplantation, glomerular disease, onco-nephrology, dialysis, and much more.
Features popular, color-coded algorithms that provide easy access to important content: yellow boxes for general information, green boxes for therapeutic intervention, and blue boxes for necessary investigations.
Includes quick-reference boxes with links to clinical guidelines in all relevant chapters, plus self-assessment questions online.
1. 16. Introduction to Glomerular Disease: Clinical Presentations - p. 193 2. 17. Introduction to Glomerular Disease: Histologic Classification and Pathogenesis - p. 207 3. 18. Minimal Change Disease - p. 217 4. 19. Primary and Secondary (Nongenetic) Causes of Focal and Segmental Glomerulosclerosis - p. 226 5. 20. Inherited Causes of Nephrotic Syndrome - p. 237 6. 21. Membranous Nephropathy - p. 245 7. 22. Immunoglobulin-Mediated Glomerulonephritis With a Membranoproliferative Pattern of Injury and Cryoglobulinemic Glomerulonephritis - p. 259 8. 23. Glomerulonephritis Associated With Complement Disorders - p. 268 9. 24. Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis (Henoch-Schönlein Purpura) - p. 274 10. 25. Anti–Glomerular Basement Membrane Disease and Goodpasture Disease - p. 285 11. 26. Renal and Systemic Vasculitis - p. 294 12. 27. Lupus Nephritis - p. 309 13. 28. Monoclonal Immunoglobulin–Related Glomerular Diseases and Renal Amyloidosis - p. 323 14. 29. Rare Glomerular Disorders - p. 337 15. 30. Thrombotic Microangiopathies, Including Hemolytic Uremic Syndrome - p. 350 16. Section V. Diabetic Kidney Disease - p. 363 17. 31. Pathogenesis, Clinical Manifestations, and Natural History of Diabetic Kidney Disease - p. 363 18. 32. Prevention and Treatment of Diabetic Kidney Disease - p. 380 19. 33. Management of Patients With Diabetes and Chronic Kidney Disease - p. 389 20. Section VI. Hypertension - p. 403 21. 34. Normal Blood Pressure Control and the Evaluation of Hypertension - p. 403 22. 35. Primary Hypertension - p. 419 23. 36. Nonpharmacologic Prevention and Treatment of Hypertension - p. 428 24. 37. Pharmacologic Treatment of Hypertension - p. 436 25. 38. Evaluation and Treatment of Hypertensive Urgencies and Emergencies - p. 451 26. 39. Endocrine Causes of Hypertension: Aldosterone - p. 460 27. 40. Other Endocrine Causes of Hypertension - p. 471 28. 41. Neurogenic Hypertension, Including Hypertension Associated With Stroke or Spinal Cord Injury - p. 483 29. 42. Blood Pressure Management in the Dialysis Patient - p. 492 30. Section VII. Renovascular Disease - p. 500 31. 43. Renovascular Hypertension, Atherosclerotic Renal Vascular Disease, and Thromboembolic Kidney Disease - p. 500 32. Section VIII. Pregnancy and Renal Disease - p. 519 33. 44. Kidney Physiology and Complications in Normal Pregnancy - p. 519 34. 45. Pregnancy With Preexisting Kidney Disease - p. 538 35. Section IX. Hereditary and Congenital Diseases of the Kidney - p. 548 36. 46. Autosomal Dominant Polycystic Kidney Disease - p. 548 37. 47. Other Cystic Kidney Diseases - p. 561 38. 48. Alport Syndrome and Other Familial Glomerular Syndromes - p. 576 39. 49. Inherited Disorders of Sodium and Water Handling - p. 589 40. 50. Fanconi Syndrome and Other Proximal Tubule Disorders - p. 600 41. 51. Sickle Cell Diseases and the Kidney - p. 611 42. 52. Congenital Anomalies of the Kidney and Urinary Tract - p. 621 43. Section X. Infectious Diseases and the Kidney - p. 640 44. 53. Urinary Tract Infections in Adults - p. 640 45. 54. Tuberculosis of the Urinary Tract - p. 653 46. 55. Fungal Infections of the Urinary Tract - p. 665 47. 56. The Kidney in Schistosomiasis - p. 670 48. 57. Glomerular Diseases Associated With Infection - p. 679 49. 58. Human Immunodeficiency Virus Infection and the Kidney - p. 694 50. 59. Kidney Diseases Associated With Coronaviruses - p. 703 51. Section XI. Urologic Disorders - p. 708 52. 60. Nephrolithiasis and Nephrocalcinosis - p. 708 53. 61. Urinary Tract Obstruction - p. 722 54. 62. Primary Vesicoureteral Reflux and Reflux Nephropathy - p. 735 55. 63. Urologic Issues for the Nephrologist - p. 743 56. Section XII. Tubulointerstitial and Vascular Diseases - p. 754 57. 64. Acute Interstitial Nephritis - p. 754 58. 65. Chronic Interstitial Nephritis - p. 763 59. 66. Endemic Nephropathies - p. 775 60. Section XIII. Renal Disease and Cancer - p. 781 61. 67. Oncology: Kidney Disease in Cancer Patients - p. 781 62. 68. Myeloma and the Kidney - p. 791 63. 69. Kidney Disease in Liver, Cardiac, Lung, and Hematopoietic Stem Cell Transplantation - p. 799 64. Section XIV. Acute Kidney Injury - p. 809 65. 70. Pathophysiology and Etiology of Acute Kidney Injury - p. 809 66. 71. Acute Kidney Injury in the Tropics - p. 826 67. 72. Diagnosis and Clinical Evaluation of Acute Kidney Injury - p. 835 68. 73. Epidemiology and Prognostic Impact of Acute Kidney Injury and Acute Kidney Disease - p. 845 69. 74. Prevention and Nondialytic Management of Acute Kidney Injury - p. 850 70. 75. Extracorporeal Therapies for Acute Kidney Injury and Heart Failure - p. 863 71. 76. Hepatorenal Syndrome - p. 881 72. Section XV. Drug Therapy in Kidney Disease - p. 892 73. 77. Principles of Drug Therapy, Dosing, and Prescribing in Chronic Kidney Disease and Kidney Replacement Therapy - p. 892 74. 78. Common Issues in Prescribing in Kidney Disease and Kidney Replacement Therapy - p. 903 75. 79. Herbal and Over-the-Counter Medicines and the Kidney - p. 918 76. Section XVI. Chronic Kidney Disease and Uremic Syndrome - p. 927 77. 80. Epidemiology of Chronic Kidney Disease and Dialysis - p. 927 78. 81. Pathophysiology of Disease Progression in Proteinuric and Nonproteinuric Kidney Disease - p. 937 79. 82. Slowing the Progression of Kidney Disease - p. 947 80. 83. Clinical Evaluation and Management of Chronic Kidney Disease - p. 959 81. 84. Pathogenesis and Risk of Cardiovascular Disease in Chronic Kidney Disease - p. 967 82. 85. Practical Management of Cardiovascular Disease in Chronic Kidney Disease - p. 973 83. 86. Anemia in Chronic Kidney Disease - p. 983 84. 87. Other Blood and Immune Disorders in Chronic Kidney Disease - p. 991 85. 88. Bone and Mineral Disorders in Chronic Kidney Disease - p. 1002 86. 89. Neurologic Complications of Chronic Kidney Disease - p. 1018 87. 90. Nutrition in Chronic Kidney Disease - p. 1024 88. 91. Dermatologic Manifestations of Chronic Kidney Disease - p. 1031 89. 92. Acquired Cystic Kidney Disease and Malignant Neoplasms - p. 1040 90. Section XVII. Geriatric and Palliative Nephrology - p. 1046 91. 93. Geriatric Nephrology - p. 1046 92. 94. Palliative Nephrology - p. 1054 93. Section XVIII. Dialytic Therapies - p. 1060 94. 95. Approach to Kidney Replacement Therapy - p. 1060 95. 96. Vascular Access for Hemodialysis - p. 1072 96. 97. Diagnostic and Interventional Nephrology - p. 1083 97. 98. Hemodialysis: Principles and Techniques - p. 1091 98. 99. Hemodialysis: Dialysis Prescription and Adequacy - p. 1100 99. 100. Acute Complications During Hemodialysis - p. 1108 100. 101. Peritoneal Dialysis: Principles, Techniques, and Adequacy - p. 1120 101. 102. Complications of Peritoneal Dialysis - p. 1130 102. 103. Extracorporeal Therapies for Drug Overdose and Poisoning - p. 1140 103. 104. Plasma Exchange - p. 1149 104. Section XIX. Transplantation - p. 1158 105. 105. Immunologic Principles in Kidney Transplantation - p. 1158 106. 106. Immunosuppressive Medications in Kidney Transplantation - p. 1169 107. 107. Evaluation and Preoperative Management of Kidney Transplant Recipient and Donor - p. 1178 108. 108. Kidney Transplantation Surgery - p. 1191 109. 109. Prophylaxis and Treatment of Kidney Transplant Rejection - p. 1202 110. 110. Infections and Malignancies in the Kidney Transplant Recipient - p. 1213 111. 111. Cardiovascular Disease and Metabolic Abnormalities in the Kidney Transplant Recipient - p. 1232 112. 112. Chronic Allograft Injury - p. 1244 113. 113. Recurrent Disease in Kidney Transplantation - p. 1254 114. 114. Outcomes of Kidney Transplantation: Identification, Measures, and Evaluation - p. 1264 115. Index - p. 1273 116. Self-Assessment Answers - p. 1.e1
