Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes.
This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis.
In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. ix 6. Preface - p. xiii 7. Chapter 1. Cytology of the Central Nervous System - p. 1 8. Chapter 2. Ion Channels - p. 11 9. Chapter 2.1. Translational Correlation: Temporal Lobe Epilepsy and Hippocampal Sclerosis - p. 45 10. Chapter 3. Neurotransmitters and Neurotransmission in the Developing and Adult Nervous System - p. 49 11. Chapter 3.1. Translational Correlation: Myasthenia Gravis and Other Neuromuscular Junction Disorders - p. 85 12. Chapter 4. Synaptic Development - p. 89 13. Chapter 5. The Peripheral and Central Nervous System - p. 113 14. Chapter 5.1. Translational Correlation: Peripheral Neuropathy - p. 131 15. Chapter 5.2. Translational Correlation: Guillain–Barré Syndrome - p. 137 16. Chapter 6. The Blood–Brain Barrier: A Restricted Gateway to the Brain - p. 141 17. Chapter 7. Autoregulation of Cerebral Blood Flow - p. 147 18. Chapter 7.1. Translational Correlation: Stroke - p. 151 19. Chapter 7.2. Translational Correlation: Migraine - p. 159 20. Chapter 8. The Vestibular System - p. 167 21. Chapter 8.1. Translational Correlation: Vertigo - p. 185 22. Chapter 9. The Cerebellum - p. 191 23. Chapter 9.1. Translational Correlation: Disorders of the Cerebellum - p. 213 24. Chapter 10. The Basal Ganglia - p. 219 25. Chapter 10.1. Translational Correlation: Disorders of the Basal Ganglia - p. 227 26. Chapter 11. Choroid Plexus–Cerebrospinal Fluid Transport Dynamics: Support of Brain Health and a Role in Neurotherapeutics - p. 233 27. Chapter 12. The Cerebral Cortex - p. 263 28. Chapter 13. The Thalamus - p. 289 29. Chapter 14. Cranial Nerves and Brainstem - p. 299 30. Chapter 14.1. Translational Correlation: Bell’s Palsy - p. 311 31. Chapter 15. Hypothalamic–Pituitary Regulation - p. 317 32. Chapter 16. Neuroendocrinimmunology: A Primer - p. 333 33. Chapter 16.1. Translational Correlation: Clinical Neuroimmunology - p. 341 34. Chapter 16.2. Translational Correlation: Multiple Sclerosis - p. 359 35. Chapter 17. The Olfactory System - p. 363 36. Chapter 18. Intranasal Trigeminal Chemoreception - p. 379 37. Chapter 19. Vision - p. 399 38. Chapter 20. Oculomotor Systems and Control - p. 439 39. Chapter 21. A Modern Clinicopathological Approach to Traumatic Brain Injury - p. 467 40. Chapter 21.1. Translational Correlation: Disorders of the Spinal Cord - p. 489 41. Chapter 21.2. Translational Correlation: Abnormalities of the CSF System - p. 495 42. Chapter 22. Posttraumatic Stress Disorder - p. 499 43. Chapter 23. Somatosensation and Pain - p. 517 44. Chapter 23.1. Translational Correlation: Trigeminal Neuralgia - p. 541 45. Chapter 24. Neurogenesis as a Factor in the Functional Plasticity of the Nervous System - p. 545 46. Chapter 25. Axonal Degeneration and Regeneration in the Peripheral and Central Nervous Systems - p. 553 47. Chapter 25.1. Translational Correlation: Sarcopenia - p. 577 48. Chapter 26. Audition - p. 579 49. Chapter 27. Body Clocks in Health and Disease - p. 599 50. Chapter 27.1. Translational Correlation: Sleep Disorders - p. 617 51. Chapter 28. The Experience of Consciousness - p. 623 52. Chapter 29. The Emotional Brain - p. 635 53. Chapter 29.1. Translational Correlation: Limbic Encephalitis - p. 657 54. Chapter 30. Stress, Mood, and Pathways to Depression - p. 663 55. Chapter 31. Language Processing, Development and Evolution - p. 679 56. Chapter 32. Memory - p. 693 57. Chapter 32.1. Translational Correlation: Alzheimer’s Disease - p. 709 58. Chapter 33. Neurobiology of Drugs of Abuse - p. 715 59. Index - p. 723
Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes.
This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis.
In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. ix 6. Preface - p. xiii 7. Chapter 1. Cytology of the Central Nervous System - p. 1 8. Chapter 2. Ion Channels - p. 11 9. Chapter 2.1. Translational Correlation: Temporal Lobe Epilepsy and Hippocampal Sclerosis - p. 45 10. Chapter 3. Neurotransmitters and Neurotransmission in the Developing and Adult Nervous System - p. 49 11. Chapter 3.1. Translational Correlation: Myasthenia Gravis and Other Neuromuscular Junction Disorders - p. 85 12. Chapter 4. Synaptic Development - p. 89 13. Chapter 5. The Peripheral and Central Nervous System - p. 113 14. Chapter 5.1. Translational Correlation: Peripheral Neuropathy - p. 131 15. Chapter 5.2. Translational Correlation: Guillain–Barré Syndrome - p. 137 16. Chapter 6. The Blood–Brain Barrier: A Restricted Gateway to the Brain - p. 141 17. Chapter 7. Autoregulation of Cerebral Blood Flow - p. 147 18. Chapter 7.1. Translational Correlation: Stroke - p. 151 19. Chapter 7.2. Translational Correlation: Migraine - p. 159 20. Chapter 8. The Vestibular System - p. 167 21. Chapter 8.1. Translational Correlation: Vertigo - p. 185 22. Chapter 9. The Cerebellum - p. 191 23. Chapter 9.1. Translational Correlation: Disorders of the Cerebellum - p. 213 24. Chapter 10. The Basal Ganglia - p. 219 25. Chapter 10.1. Translational Correlation: Disorders of the Basal Ganglia - p. 227 26. Chapter 11. Choroid Plexus–Cerebrospinal Fluid Transport Dynamics: Support of Brain Health and a Role in Neurotherapeutics - p. 233 27. Chapter 12. The Cerebral Cortex - p. 263 28. Chapter 13. The Thalamus - p. 289 29. Chapter 14. Cranial Nerves and Brainstem - p. 299 30. Chapter 14.1. Translational Correlation: Bell’s Palsy - p. 311 31. Chapter 15. Hypothalamic–Pituitary Regulation - p. 317 32. Chapter 16. Neuroendocrinimmunology: A Primer - p. 333 33. Chapter 16.1. Translational Correlation: Clinical Neuroimmunology - p. 341 34. Chapter 16.2. Translational Correlation: Multiple Sclerosis - p. 359 35. Chapter 17. The Olfactory System - p. 363 36. Chapter 18. Intranasal Trigeminal Chemoreception - p. 379 37. Chapter 19. Vision - p. 399 38. Chapter 20. Oculomotor Systems and Control - p. 439 39. Chapter 21. A Modern Clinicopathological Approach to Traumatic Brain Injury - p. 467 40. Chapter 21.1. Translational Correlation: Disorders of the Spinal Cord - p. 489 41. Chapter 21.2. Translational Correlation: Abnormalities of the CSF System - p. 495 42. Chapter 22. Posttraumatic Stress Disorder - p. 499 43. Chapter 23. Somatosensation and Pain - p. 517 44. Chapter 23.1. Translational Correlation: Trigeminal Neuralgia - p. 541 45. Chapter 24. Neurogenesis as a Factor in the Functional Plasticity of the Nervous System - p. 545 46. Chapter 25. Axonal Degeneration and Regeneration in the Peripheral and Central Nervous Systems - p. 553 47. Chapter 25.1. Translational Correlation: Sarcopenia - p. 577 48. Chapter 26. Audition - p. 579 49. Chapter 27. Body Clocks in Health and Disease - p. 599 50. Chapter 27.1. Translational Correlation: Sleep Disorders - p. 617 51. Chapter 28. The Experience of Consciousness - p. 623 52. Chapter 29. The Emotional Brain - p. 635 53. Chapter 29.1. Translational Correlation: Limbic Encephalitis - p. 657 54. Chapter 30. Stress, Mood, and Pathways to Depression - p. 663 55. Chapter 31. Language Processing, Development and Evolution - p. 679 56. Chapter 32. Memory - p. 693 57. Chapter 32.1. Translational Correlation: Alzheimer’s Disease - p. 709 58. Chapter 33. Neurobiology of Drugs of Abuse - p. 715 59. Index - p. 723
