Control of Cell Cycle and Cell Proliferation, Volume 135 in the Advances in Protein Chemistry and Structural Biology series, presents chapters on a variety topics, including Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest, Viral infection on through Cell Cycle Regulation, Analyzing drug resistant mutation in CDK4 gene and identification of potential inhibitors through structure based virtual screening approach, Controlling cell proliferation by targeting CDK6 using drug repurposing approach, The role of the nucleolus in regulating cell cycle, Chromatin regulators in DNA replication and genome stability maintenance during S-phase, Role of macrophage in cancer cell progression and targeted immunotherapies, and much more.
1. Cover image - p. i 2. Table of Contents - p. iii 3. Copyright - p. iii 4. Contributors - p. iii 5. Chapter One: Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest in cancer - p. 7 6. Chapter Two: Cyclin-dependent kinases in cancer: Role, regulation, and therapeutic targeting - p. 21 7. Chapter Three: Computational screening and structural analysis of Gly201Arg and Gly201Asp missense mutations in human cyclin-dependent kinase 4 protein - p. 63 8. Chapter Four: Controlling cell proliferation by targeting cyclin-dependent kinase 6 using drug repurposing approach - p. 97 9. Chapter Five: CDK regulators—Cell cycle progression or apoptosis—Scenarios in normal cells and cancerous cells - p. 144 10. Chapter Six: Insights into the aberrant CDK4/6 signaling pathway as a therapeutic target in tumorigenesis - p. 179 11. Chapter Seven: The role of the nucleolus in regulating the cell cycle and the DNA damage response - p. 203 12. Chapter Eight: Chromatin regulators in DNA replication and genome stability maintenance during S-phase - p. 254 13. Chapter Nine: Role of macrophages in cancer progression and targeted immunotherapies - p. 294 14. Chapter Ten: Therapeutic targets in cancer treatment: Cell cycle proteins - p. 313 15. Chapter Eleven: Anti-cancer drug molecules targeting cancer cell cycle and proliferation - p. 359 16. Chapter Twelve: Cellular signals integrate cell cycle and metabolic control in cancer - p. 397 17. Chapter Thirteen: Therapeutic targeting and HSC proliferation by small molecules and biologicals - p. 450 18. Chapter Fourteen: Mechanism of cell cycle regulation and cell proliferation during human viral infection - p. 497
Control of Cell Cycle and Cell Proliferation, Volume 135 in the Advances in Protein Chemistry and Structural Biology series, presents chapters on a variety topics, including Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest, Viral infection on through Cell Cycle Regulation, Analyzing drug resistant mutation in CDK4 gene and identification of potential inhibitors through structure based virtual screening approach, Controlling cell proliferation by targeting CDK6 using drug repurposing approach, The role of the nucleolus in regulating cell cycle, Chromatin regulators in DNA replication and genome stability maintenance during S-phase, Role of macrophage in cancer cell progression and targeted immunotherapies, and much more.
1. Cover image - p. i 2. Table of Contents - p. iii 3. Copyright - p. iii 4. Contributors - p. iii 5. Chapter One: Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest in cancer - p. 7 6. Chapter Two: Cyclin-dependent kinases in cancer: Role, regulation, and therapeutic targeting - p. 21 7. Chapter Three: Computational screening and structural analysis of Gly201Arg and Gly201Asp missense mutations in human cyclin-dependent kinase 4 protein - p. 63 8. Chapter Four: Controlling cell proliferation by targeting cyclin-dependent kinase 6 using drug repurposing approach - p. 97 9. Chapter Five: CDK regulators—Cell cycle progression or apoptosis—Scenarios in normal cells and cancerous cells - p. 144 10. Chapter Six: Insights into the aberrant CDK4/6 signaling pathway as a therapeutic target in tumorigenesis - p. 179 11. Chapter Seven: The role of the nucleolus in regulating the cell cycle and the DNA damage response - p. 203 12. Chapter Eight: Chromatin regulators in DNA replication and genome stability maintenance during S-phase - p. 254 13. Chapter Nine: Role of macrophages in cancer progression and targeted immunotherapies - p. 294 14. Chapter Ten: Therapeutic targets in cancer treatment: Cell cycle proteins - p. 313 15. Chapter Eleven: Anti-cancer drug molecules targeting cancer cell cycle and proliferation - p. 359 16. Chapter Twelve: Cellular signals integrate cell cycle and metabolic control in cancer - p. 397 17. Chapter Thirteen: Therapeutic targeting and HSC proliferation by small molecules and biologicals - p. 450 18. Chapter Fourteen: Mechanism of cell cycle regulation and cell proliferation during human viral infection - p. 497
