Cryptic Enzymes and Moonlighting Proteins, a new volume in the Foundations and Frontiers in Enzymology series, offers a thorough overview of cryptic enzymes and moonlighting proteins in signaling cascades. In early chapters, leading international contributors discuss evolutionary considerations for moonlighting proteins, moonlighting interactions in the extracellular matrix, eukaryotic moonlighting proteins, modulating, moonlighting kinases, moonlighting proteins in neurobiology signaling, metabolic enzymes moonlighting as RNA binding and regulatory proteins. Later, methods-driven chapters discuss practical aspects of identifying hidden moonlighting domains in proteins, computational approaches and bioinformatic tools for the identification of cryptic enzymes, establishing cryptic enzyme interactomes, and assessing contributions of moonlighting proteins to signal cascades.
The book also explores recent advances in research and brings together an array of information across different fields to enable better targeting of these exciting proteins and their interactomes. With a clear focus on the role of moonlighting and cryptic enzymes in signal transduction, users will find examples of cryptic enzymes across species, as well as those in human healthy biology and pathogenesis.
1. Chapter 1. Introduction and overview of moonlighting enzymes in signal cascades - p. 1 2. Chapter 2. Extracellular vesicles enabling moonlighting proteins - p. 11 3. Chapter 3. Moonlighting proteins in neurobiology signaling mediated by G protein-coupled receptors - p. 31 4. Chapter 4. Metabolic enzymes co-opted in oncogenic signalling - p. 75 5. Chapter 5. Metabolic enzymes moonlighting as RNA binding and regulatory proteins - p. 103 6. Chapter 6. Cryptic enzymes as fine tuners of signaling cascades - p. 119 7. Chapter 7. Dual function plant cryptic nucleotide cyclases - p. 135 8. Chapter 8. Crypto adenylate cyclases coming of age - p. 173 9. Chapter 9. Crypto adenylate cyclases moonlighting with phosphodiesterases in complex proteins - p. 183 10. Chapter 10. Gas-sensing H-NOX hemoproteins in plants and beyond - p. 195 11. Chapter 11. Modulating the immune response via cryptic enzymes - p. 217 12. Chapter 12. Cryptic moonlighting enzymes enable crosstalk with other signaling molecules - p. 239 13. Chapter 13. Identifying hidden moonlighting proteins and protein regions - p. 257 14. Chapter 14. Establishing cryptic enzyme interactomes - p. 277 15. Chapter 15. Nucleotidyl cyclase activities of TIR1/AFB auxin receptors: new insights into the mechanism of auxin signaling - p. 299 16. Chapter 16. Uncovering moonlighting proteins in cell organelles - p. 323 17. Index - p. 357
Cryptic Enzymes and Moonlighting Proteins, a new volume in the Foundations and Frontiers in Enzymology series, offers a thorough overview of cryptic enzymes and moonlighting proteins in signaling cascades. In early chapters, leading international contributors discuss evolutionary considerations for moonlighting proteins, moonlighting interactions in the extracellular matrix, eukaryotic moonlighting proteins, modulating, moonlighting kinases, moonlighting proteins in neurobiology signaling, metabolic enzymes moonlighting as RNA binding and regulatory proteins. Later, methods-driven chapters discuss practical aspects of identifying hidden moonlighting domains in proteins, computational approaches and bioinformatic tools for the identification of cryptic enzymes, establishing cryptic enzyme interactomes, and assessing contributions of moonlighting proteins to signal cascades.
The book also explores recent advances in research and brings together an array of information across different fields to enable better targeting of these exciting proteins and their interactomes. With a clear focus on the role of moonlighting and cryptic enzymes in signal transduction, users will find examples of cryptic enzymes across species, as well as those in human healthy biology and pathogenesis.
1. Chapter 1. Introduction and overview of moonlighting enzymes in signal cascades - p. 1 2. Chapter 2. Extracellular vesicles enabling moonlighting proteins - p. 11 3. Chapter 3. Moonlighting proteins in neurobiology signaling mediated by G protein-coupled receptors - p. 31 4. Chapter 4. Metabolic enzymes co-opted in oncogenic signalling - p. 75 5. Chapter 5. Metabolic enzymes moonlighting as RNA binding and regulatory proteins - p. 103 6. Chapter 6. Cryptic enzymes as fine tuners of signaling cascades - p. 119 7. Chapter 7. Dual function plant cryptic nucleotide cyclases - p. 135 8. Chapter 8. Crypto adenylate cyclases coming of age - p. 173 9. Chapter 9. Crypto adenylate cyclases moonlighting with phosphodiesterases in complex proteins - p. 183 10. Chapter 10. Gas-sensing H-NOX hemoproteins in plants and beyond - p. 195 11. Chapter 11. Modulating the immune response via cryptic enzymes - p. 217 12. Chapter 12. Cryptic moonlighting enzymes enable crosstalk with other signaling molecules - p. 239 13. Chapter 13. Identifying hidden moonlighting proteins and protein regions - p. 257 14. Chapter 14. Establishing cryptic enzyme interactomes - p. 277 15. Chapter 15. Nucleotidyl cyclase activities of TIR1/AFB auxin receptors: new insights into the mechanism of auxin signaling - p. 299 16. Chapter 16. Uncovering moonlighting proteins in cell organelles - p. 323 17. Index - p. 357
