Delivery of Therapeutics for Biogerontological Interventions: From Concepts to Experimental Design provides tactics on how to facilitate planning and research in interventive biogerontology. The book helps create clearer directions for the translation of existing advances in delivery technologies, from lab to practice. It is ideal as a starting point for scientists, clinicians and those interested in the field of biogerontology, biomedicine or nanotechnology, comprehensively discussing how to translate bench works to practicable tactics that retard the aging process. Using support from recent advances reported in literature, this title takes advantage of delivery technologies to develop biogerontological interventions, from concept to experimental design.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Foreword - p. ix 6. Preface - p. xi 7. Abbreviations - p. xiii 8. Part I: From Concepts to Plans - p. xvi 9. Chapter 1. Theoretical frameworks for intervention development - p. 3 10. Chapter 2. Available delivery technologies for intervention execution - p. 13 11. Part II: From Plans to Technologies - p. 19 12. Chapter 3. Design of viral vectors for genetic manipulation - p. 25 13. Chapter 4. Design of polymeric vectors for genetic manipulation - p. 37 14. Chapter 5. Design of cyclodextrin-based systems for intervention execution - p. 49 15. Chapter 6. Design of upconversion nanoparticles for intervention execution - p. 61 16. Chapter 7. Design of hydrogel-based nanoparticles for intervention execution - p. 73 17. Part III: From Technologies to Interventions - p. 81 18. Chapter 8. Use of delivery technologies to mediate RNA degradation - p. 87 19. Chapter 9. Use of delivery technologies to manipulate miRNA expression - p. 99 20. Chapter 10. Use of delivery technologies to modulate protein kinase activity - p. 109 21. Chapter 11. Use of delivery technologies to manipulate mitochondrial metabolism - p. 119 22. Chapter 12. Use of delivery technologies to mediate tissue regeneration and repair - p. 131 23. Chapter 13. Use of delivery technologies to mediate herbal interventions - p. 141 24. Part IV: From Interventions to Practice - p. 148 25. Chapter 14. Biological barriers to cellular interventions - p. 153 26. Chapter 15. Technical barriers to systemic interventions - p. 161 27. Chapter 16. Ethical barriers to intervention development - p. 169 28. Chapter 17. Social barriers to intervention success - p. 175 29. Index - p. 181
Delivery of Therapeutics for Biogerontological Interventions: From Concepts to Experimental Design provides tactics on how to facilitate planning and research in interventive biogerontology. The book helps create clearer directions for the translation of existing advances in delivery technologies, from lab to practice. It is ideal as a starting point for scientists, clinicians and those interested in the field of biogerontology, biomedicine or nanotechnology, comprehensively discussing how to translate bench works to practicable tactics that retard the aging process. Using support from recent advances reported in literature, this title takes advantage of delivery technologies to develop biogerontological interventions, from concept to experimental design.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Foreword - p. ix 6. Preface - p. xi 7. Abbreviations - p. xiii 8. Part I: From Concepts to Plans - p. xvi 9. Chapter 1. Theoretical frameworks for intervention development - p. 3 10. Chapter 2. Available delivery technologies for intervention execution - p. 13 11. Part II: From Plans to Technologies - p. 19 12. Chapter 3. Design of viral vectors for genetic manipulation - p. 25 13. Chapter 4. Design of polymeric vectors for genetic manipulation - p. 37 14. Chapter 5. Design of cyclodextrin-based systems for intervention execution - p. 49 15. Chapter 6. Design of upconversion nanoparticles for intervention execution - p. 61 16. Chapter 7. Design of hydrogel-based nanoparticles for intervention execution - p. 73 17. Part III: From Technologies to Interventions - p. 81 18. Chapter 8. Use of delivery technologies to mediate RNA degradation - p. 87 19. Chapter 9. Use of delivery technologies to manipulate miRNA expression - p. 99 20. Chapter 10. Use of delivery technologies to modulate protein kinase activity - p. 109 21. Chapter 11. Use of delivery technologies to manipulate mitochondrial metabolism - p. 119 22. Chapter 12. Use of delivery technologies to mediate tissue regeneration and repair - p. 131 23. Chapter 13. Use of delivery technologies to mediate herbal interventions - p. 141 24. Part IV: From Interventions to Practice - p. 148 25. Chapter 14. Biological barriers to cellular interventions - p. 153 26. Chapter 15. Technical barriers to systemic interventions - p. 161 27. Chapter 16. Ethical barriers to intervention development - p. 169 28. Chapter 17. Social barriers to intervention success - p. 175 29. Index - p. 181
