For dermatology residents and trainees, as well as those in clinical practice, Dermatology is the leading reference for understanding, diagnosing, and treating the full spectrum of skin disease—and is the key resource that residents rely on throughout their training and certification. Widely recognized for its easy-in, easy-out approach, this revised 5th Edition turns complex information into user-friendly visual content through the use of clear, templated chapters, digestible artwork, and easy-to-follow algorithms and tables. This two-volume masterwork provides complete, authoritative coverage of basic science, clinical practice of both adult and pediatric dermatology, dermatopathology, and dermatologic surgery—more than any other source, making it the gold standard reference in the field today.
1. INTRODUCTION TO CLINICAL DERMATOLOGY - p. 1 2. THE ROLE OF DERMATOPATHOLOGY IN CLINICOPATHOLOGIC CORRELATION - p. 12 3. INTRODUCTION TO THE USE OF DERMOSCOPY (DERMATOSCOPY) - p. 32 4. INTRODUCTION TO CONFOCAL MICROSCOPY - p. 39 5. INTRODUCTION TO ARTIFICIAL INTELLIGENCE - p. 42 6. CONCLUSION - p. 45 7. REFERENCES - p. 46.e7 8. 1. Anatomy and Pathophysiology - p. 47 9. 2. Skin Development and Maintenance - p. 58 10. 3. Molecular Biology - p. 68 11. 4. Immunology - p. 81 12. Section 2: Pruritus - p. 99.e1 13. 5. Cutaneous Neurophysiology - p. 100 14. 6. Pruritus and Dysesthesia - p. 110 15. 7. Psychocutaneous Diseases - p. 128 16. Section 3: Papulosquamous and Eczematous Dermatoses - p. 138.e4 17. 8. Psoriasis - p. 139 18. 9. Other Papulosquamous Disorders - p. 164 19. 10. Erythroderma - p. 177 20. 11. Lichen Planus and Lichenoid Dermatoses - p. 189 21. 12. Atopic Dermatitis - p. 210 22. 13. Other Eczematous Eruptions - p. 231.e5 23. 14. Allergic Contact Dermatitis - p. 246 24. 15. Irritant Contact Dermatitis - p. 267 25. 16. Occupational Dermatoses - p. 279 26. 17. Dermatoses Due to Plants - p. 291 27. Section 4: Urticarias, Erythemas, and Purpuras - p. 308.e2 28. 18. Urticaria and Angioedema - p. 309 29. 19. Figurate Erythemas - p. 327 30. 20. Erythema Multiforme, Stevens–Johnson Syndrome, and Toxic Epidermal Necrolysis - p. 339 31. 21. Drug Reactions - p. 355 32. 22. Purpura: Mechanisms and Differential Diagnosis - p. 385 33. 23. Cutaneous Manifestations of Microvascular Occlusion Syndromes - p. 397 34. 24. Cutaneous Vasculitis - p. 418 35. Abstract - p. 418 36. Chapter Contents - p. 418 37. INTRODUCTION - p. 418 38. CLASSIFICATION - p. 418 39. EPIDEMIOLOGY - p. 418 40. PATHOGENESIS - p. 418 41. GENERAL CLINICAL FEATURES - p. 418 42. PATHOLOGY - p. 419 43. DIFFERENTIAL DIAGNOSIS - p. 421 44. SMALL VESSEL VASCULITIS - p. 421 45. PREDOMINANTLY SMALL AND MEDIUM-SIZED VESSEL VASCULITIDES - p. 434 46. PREDOMINANTLY MEDIUM-SIZED VESSEL VASCULITIS - p. 444 47. TEMPORAL ARTERITIS (GIANT CELL ARTERITIS) - p. 446 48. DIAGNOSTIC APPROACH TO A PATIENT WITH SUSPECTED VASCULITIS - p. 446 49. EREFERENCES - p. 449.e5 50. REFERENCES - p. 449.e5 51. 25. Neutrophilic Dermatoses - p. 450 52. 26. Eosinophil-Associated Dermatoses - p. 470 53. 27. Pregnancy Dermatoses - p. 480 54. Section 5: Vesiculobullous Diseases - p. 490.e12 55. 28. The Biology of the Basement Membrane - p. 491 56. 29. Pemphigus - p. 501 57. 30. Pemphigoid Group - p. 517 58. 31. Dermatitis Herpetiformis and Linear IgA Bullous Dermatosis - p. 534 59. 32. Epidermolysis Bullosa - p. 545 60. 33. Other Vesiculobullous Diseases - p. 560 61. 34. Vesiculopustular and Erosive Disorders in Newborns and Infants - p. 568 62. Section 6: Adnexal Diseases - p. 585.e3 63. 35. Structure and Function of Eccrine, Apocrine, and Sebaceous Glands - p. 586 64. 36. Acne Vulgaris - p. 592 65. 37. Rosacea and Related Disorders - p. 610 66. 38. Folliculitis, Follicular Occlusion Tetrad, and Other Follicular Disorders - p. 622 67. 39. Diseases of the Eccrine and Apocrine Sweat Glands - p. 641 68. Section 7: Rheumatologic Dermatology - p. 656.e1 69. 40. Autoantibodies Encountered in Patients with Autoimmune Connective Tissue Diseases - p. 657 70. 41. Lupus Erythematosus - p. 670 71. 42. Dermatomyositis - p. 689 72. 43. Systemic Sclerosis (Scleroderma) and Related Disorders - p. 702 73. 44. Morphea and Lichen Sclerosus - p. 717 74. 45. Other Rheumatologic Disorders and Autoinflammatory Diseases - p. 732 75. Section 8: Metabolic and Systemic Diseases - p. 752.e1 76. 46. Mucinoses - p. 753 77. 47. Amyloidosis - p. 765 78. 48. Deposition Diseases - p. 774.e2 79. 49. Porphyria - p. 784 80. 50. Calcifying and Ossifying Disorders of the Skin - p. 796 81. 51. Nutritional Diseases - p. 807 82. 52. Graft-versus-Host Disease - p. 824.e3 83. 53. Dermatologic Manifestations in Patients with Systemic Disease - p. 833 84. Section 9: Genodermatoses - p. 857.e2 85. 54. Basic Principles of Genetics - p. 858 86. 55. Genetic Basis of Cutaneous Diseases - p. 869 87. 56. Biology of Keratinocytes - p. 883 88. 57. Ichthyoses, Erythrokeratodermas, and Related Disorders - p. 894 89. Abstract - p. 894 90. Chapter Contents - p. 894 91. INTRODUCTION - p. 894 92. COMMON ICHTHYOSES - p. 900 93. KERATINOPATHIC ICHTHYOSES - p. 903 94. AUTOSOMAL RECESSIVE CONGENITAL ICHTHYOSES - p. 907 95. SYNDROMIC ICHTHYOSES - p. 913 96. ERYTHROKERATODERMAS - p. 918 97. X-LINKED DOMINANT ICHTHYOSIFORM DISORDERS - p. 922 98. OTHER ICHTHYOSES, PEELING SKIN SYNDROMES, AND RELATED DISORDERS - p. 925 99. REFERENCES - p. 930.e5 100. 58. Palmoplantar Keratodermas - p. 931 101. 59. Darier Disease and Hailey–Hailey Disease - p. 951 102. 60. Primary Immunodeficiencies - p. 962 103. Abstract - p. 962 104. Chapter Contents - p. 962 105. INTRODUCTION - p. 962 106. ATAXIA–TELANGIECTASIA - p. 962 107. CHRONIC MUCOCUTANEOUS CANDIDIASIS - p. 965 108. CARTILAGE–HAIR HYPOPLASIA SYNDROME - p. 969 109. CHÉDIAK–HIGASHI SYNDROME - p. 969 110. COMPLEMENT DISORDERS - p. 971 111. CHRONIC GRANULOMATOUS DISEASE - p. 973 112. HYPERIMMUNOGLOBULIN E SYNDROMES - p. 978 113. IMMUNOGLOBULIN DEFICIENCIES - p. 981 114. IPEX SYNDROME - p. 981 115. LEUKOCYTE ADHESION DEFICIENCY - p. 981 116. SEVERE COMBINED IMMUNODEFICIENCY AND OMENN SYNDROME - p. 986 117. WISKOTT–ALDRICH SYNDROME - p. 988 118. REFERENCES - p. 991.e3 119. 61. Neurofibromatosis and Tuberous Sclerosis Complex - p. 992 120. 62. Mosaicism and Linear Lesions - p. 1012 121. 63. Other Genodermatoses - p. 1035 122. Abstract - p. 1035 123. Chapter Contents - p. 1035 124. DISORDERS FEATURING TUMORIGENESIS - p. 1035 125. MULTIPLE ENDOCRINE NEOPLASIA - p. 1035 126. PTEN HAMARTOMA TUMOR SYNDROME, INCLUDING COWDEN SYNDROME - p. 1035 127. GARDNER SYNDROME (VARIANT OF FAMILIAL ADENOMATOUS POLYPOSIS) - p. 1040 128. MUIR–TORRE SYNDROME (VARIANT OF LYNCH SYNDROME) - p. 1041 129. ENZYME DEFICIENCY DISEASES - p. 1043 130. ALKAPTONURIA - p. 1043 131. BIOTINIDASE AND HOLOCARBOXYLASE SYNTHETASE DEFICIENCIES - p. 1044 132. FABRY DISEASE - p. 1044 133. FUCOSIDOSIS - p. 1045 134. GAUCHER DISEASE - p. 1046 135. HARTNUP DISEASE - p. 1047 136. MITOCHONDRIAL DISORDERS - p. 1048 137. ACID SPHINGOMYELINASE DEFICIENCY (NIEMANN–PICK DISEASE) - p. 1048 138. PHENYLKETONURIA - p. 1048 139. Acknowledgment - p. 1049 140. PREMATURE AGING SYNDROMES AND POIKILODERMAS - p. 1049 141. HUTCHINSON–GILFORD PROGERIA SYNDROME - p. 1049 142. WERNER SYNDROME - p. 1054 143. ECTODERMAL DYSPLASIAS - p. 1055 144. HYPOHIDROTIC ECTODERMAL DYSPLASIA - p. 1057 145. HYPOHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNE DEFICIENCY - p. 1059 146. HIDROTIC ECTODERMAL DYSPLASIA - p. 1060 147. WITKOP TOOTH AND NAIL SYNDROME - p. 1061 148. ANKYLOBLEPHARON–ECTODERMAL DEFECTS–CLEFT LIP/PALATE SYNDROME - p. 1061 149. ECTODERMAL DYSPLASIA–ECTRODACTYLY–CLEFTING SYNDROME - p. 1062 150. Acknowledgments and disclosures - p. 1063 151. REFERENCES - p. 1066.e2 152. 64. Developmental Anomalies - p. 1067 153. Section 10: Pigmentary Disorders - p. 1085.e3 154. 65. Melanocyte Biology - p. 1086 155. 66. Vitiligo and Other Disorders of Hypopigmentation - p. 1098 156. 67. Disorders of Hyperpigmentation - p. 1125 157. Section 11: Hair, Nails, and Mucous Membranes - p. 1154.e4 158. 68. Biology of Hair and Nails - p. 1155 159. 69. Alopecias - p. 1173 160. 70. Hypertrichosis and Hirsutism - p. 1198 161. 71. Nail Disorders - p. 1214 162. 72. Oral Diseases - p. 1232 163. 73. Anogenital (Non-venereal) Diseases - p. 1255 164. Section 12: Infections, Infestations, and Bites - p. 1272.e3 165. 74. Bacterial Diseases - p. 1273 166. Abstract - p. 1273 167. Chapter Contents - p. 1273 168. THE CUTANEOUS MICROBIOTA - p. 1273 169. GRAM-POSITIVE BACTERIA - p. 1273 170. GRAM-NEGATIVE BACTERIA - p. 1293 171. SPIROCHETES - p. 1303 172. BACTERIA PREVIOUSLY CLASSIFIED AS FUNGI - p. 1306 173. REFERENCES - p. 1309.e8 174. 75. Mycobacterial Infections - p. 1310 175. 76. Rickettsial Diseases - p. 1333 176. 77. Fungal Diseases - p. 1343 177. 78. Cutaneous Manifestations of HIV Infection - p. 1376 178. 79. Human Papillomaviruses - p. 1394 179. 80. Human Herpesviruses - p. 1412 180. 81. Other Viral Diseases - p. 1437 181. 82. Sexually Transmitted Infections - p. 1461 182. 83. Protozoa and Worms - p. 1485 183. 84. Infestations - p. 1519 184. 85. Bites and Stings - p. 1533 185. Section 13: Disorders Due to Physical Agents - p. 1552.e3 186. 86. Ultraviolet Radiation - p. 1553 187. 87. Photodermatologic Disorders - p. 1564 188. 88. Environmental and Sports-Related Skin Diseases - p. 1585 189. 89. Signs of Substance Use Disorder - p. 1611 190. 90. Skin Signs of Abuse - p. 1622 191. Section 14: Disorders of Langerhans Cells and Macrophages - p. 1628.e1 192. 91. Histiocytoses - p. 1629 193. 92. Xanthomas - p. 1649 194. 93. Non-infectious Granulomas - p. 1660 195. 94. Foreign Body Reactions - p. 1681 196. Section 15: Atrophies and Disorders of Dermal Connective Tissues - p. 1692.e2 197. 95. Biology of the Extracellular Matrix - p. 1693 198. 96. Perforating Diseases - p. 1707 199. 97. Heritable Disorders of Connective Tissue - p. 1714 200. 98. Dermal Hypertrophies - p. 1730 201. 99. Atrophies of Connective Tissue - p. 1741 202. Section 16: Disorders of Subcutaneous Fat - p. 1750.e2 203. 100. Panniculitis - p. 1751 204. 101. Lipodystrophies - p. 1775 205. Section 17: Vascular Disorders - p. 1789.e2 206. 102. Vascular Biology - p. 1790 207. 103. Infantile Hemangiomas - p. 1801 208. 104. Vascular Malformations - p. 1819 209. 105. Ulcers Ariela Hafner and Eli Sprecher - p. 1844 210. 106. Other Vascular Disorders - p. 1864 211. Section 18: Neoplasms of the Skin - p. 1874.e3 212. 107. Principles of Cutaneous Tumor Biology - p. 1875 213. 108. Actinic Keratosis, Basal Cell Carcinoma, and Squamous Cell Carcinoma - p. 1888 214. 109. Benign Epidermal Tumors and Proliferations - p. 1911 215. 110. Cysts - p. 1935 216. 111. Adnexal Neoplasms - p. 1948 217. 112. Benign Melanocytic Neoplasms and Melanotic Lesions - p. 1973 218. 113. Melanoma - p. 2009 219. Abstract - p. 2009 220. Chapter Contents - p. 2009 221. INTRODUCTION - p. 2009 222. MOLECULAR PATHOGENESIS - p. 2009 223. HOST IMMUNE RESPONSE TO MELANOMA - p. 2010 224. EPIDEMIOLOGY - p. 2010 225. RISK FACTORS FOR CUTANEOUS MELANOMA - p. 2012 226. TYPES OF PRIMARY MELANOMAS - p. 2016 227. OTHER MELANOMA VARIANTS - p. 2019 228. MELANOMA AND PREGNANCY - p. 2022 229. MELANOMA IN THE PEDIATRIC AND ADOLESCENT POPULATION - p. 2022 230. DIAGNOSIS - p. 2022 231. PATHOLOGY - p. 2025 232. STAGING - p. 2030 233. PROGNOSIS - p. 2031 234. EVALUATION OF A PATIENT WITH SUSPECTED MELANOMA - p. 2031 235. MANAGEMENT - p. 2034 236. MELANOMA SURVEILLANCE - p. 2040 237. REFERENCES - p. 2044.e9 238. 114. Vascular Neoplasms and Neoplastic-Like Proliferations - p. 2045 239. Abstract - p. 2045 240. Chapter Contents - p. 2045 241. INTRODUCTION - p. 2045 242. BENIGN VASCULAR NEOPLASMS AND REACTIVE HYPERPLASIAS - p. 2045 243. BORDERLINE AND LOW-GRADE MALIGNANT VASCULAR NEOPLASMS - p. 2060 244. MALIGNANT VASCULAR NEOPLASMS - p. 2067 245. PERIVASCULAR NEOPLASMS AND NEOPLASTIC-LIKE PROLIFERATIONS - p. 2070 246. REFERENCES - p. 2076.e5 247. 115. Neural and Neuroendocrine Neoplasms (Other than Neurofibromatosis) - p. 2077 248. 116. Fibroblastic, Myofibroblastic, and “Fibrohistiocytic” Proliferations and Neoplasms of the Skin - p. 2096 249. 117. Smooth Muscle, Adipose, and Cartilage Neoplasms - p. 2116 250. 118. Mastocytosis - p. 2131 251. 119. B Cell Lymphomas of the Skin - p. 2142 252. 120. Cutaneous T Cell Lymphoma - p. 2156 253. 121. Other Lymphoproliferative and Myeloproliferative Diseases - p. 2177 254. 122. Cutaneous Metastases - p. 2189 255. Section 19: Medical Therapy - p. 2196.e2 256. 123. Public Health and Dermatology - p. 2197 257. 124-1. Skin Barrier - p. 2206 258. 125. Glucocorticoids - p. 2217 259. 126. Retinoids - p. 2231 260. 127. Antimicrobial Drugs - p. 2246 261. 128. Systemic Immunomodulators - p. 2272 262. 129. Other Topical Medications - p. 2295 263. 130. Other Systemic Drugs - p. 2311 264. 131. Drug Interactions - p. 2330 265. 132. Sunscreens and Photoprotection - p. 2344 266. 133. Complementary and Alternative Medicine - p. 2354 267. Section 20: Physical Treatment Modalities - p. 2361.e1 268. 134. Ultraviolet Therapy - p. 2362 269. 135. Photodynamic Therapy - p. 2379 270. 136. Lasers and Other Energy-Based Technologies – Principles and Skin Interactions - p. 2390 271. 137. Lasers and Other Energy-Based Therapies - p. 2400 272. 138. Cryosurgery - p. 2422 273. 139. Radiotherapy - p. 2430 274. 140. Electrosurgery - p. 2442 275. Section 21: Surgery - p. 2450 276. 141. Biology of Wound Healing - p. 2451 277. 142. Surgical Anatomy of the Head and Neck - p. 2464 278. 143. Anesthesia - p. 2479 279. 144. Wound Closure Materials and Instruments - p. 2489 280. 145. Dressings - p. 2501 281. 146. Biopsy Techniques and Basic Excisions - p. 2517 282. 147. Flaps - p. 2534 283. 148. Grafts - p. 2556 284. 149. Nail Surgery - p. 2570 285. 150. Mohs Micrographic Surgery - p. 2582 286. 151. Surgical Complications and Optimizing Outcomes - p. 2596 287. Section 22: Cosmetic Surgery - p. 2610.e2 288. 152. Evaluation of Beauty and the Aging Face - p. 2611 289. 153. Cosmetics and Cosmeceuticals - p. 2619 290. 154. Chemical and Mechanical Skin Resurfacing - p. 2633 291. 155. Phlebology and Treatment of Leg Veins - p. 2650 292. 156. Body Contouring: Liposuction and Non-invasive Modalities - p. 2666.e1 293. 157. Hair Restoration - p. 2678 294. 158. Injectable Soft Tissue Augmentation - p. 2691 295. 159. Botulinum Toxin - p. 2705 296. Index - p. I-1
For dermatology residents and trainees, as well as those in clinical practice, Dermatology is the leading reference for understanding, diagnosing, and treating the full spectrum of skin disease—and is the key resource that residents rely on throughout their training and certification. Widely recognized for its easy-in, easy-out approach, this revised 5th Edition turns complex information into user-friendly visual content through the use of clear, templated chapters, digestible artwork, and easy-to-follow algorithms and tables. This two-volume masterwork provides complete, authoritative coverage of basic science, clinical practice of both adult and pediatric dermatology, dermatopathology, and dermatologic surgery—more than any other source, making it the gold standard reference in the field today.
1. INTRODUCTION TO CLINICAL DERMATOLOGY - p. 1 2. THE ROLE OF DERMATOPATHOLOGY IN CLINICOPATHOLOGIC CORRELATION - p. 12 3. INTRODUCTION TO THE USE OF DERMOSCOPY (DERMATOSCOPY) - p. 32 4. INTRODUCTION TO CONFOCAL MICROSCOPY - p. 39 5. INTRODUCTION TO ARTIFICIAL INTELLIGENCE - p. 42 6. CONCLUSION - p. 45 7. REFERENCES - p. 46.e7 8. 1. Anatomy and Pathophysiology - p. 47 9. 2. Skin Development and Maintenance - p. 58 10. 3. Molecular Biology - p. 68 11. 4. Immunology - p. 81 12. Section 2: Pruritus - p. 99.e1 13. 5. Cutaneous Neurophysiology - p. 100 14. 6. Pruritus and Dysesthesia - p. 110 15. 7. Psychocutaneous Diseases - p. 128 16. Section 3: Papulosquamous and Eczematous Dermatoses - p. 138.e4 17. 8. Psoriasis - p. 139 18. 9. Other Papulosquamous Disorders - p. 164 19. 10. Erythroderma - p. 177 20. 11. Lichen Planus and Lichenoid Dermatoses - p. 189 21. 12. Atopic Dermatitis - p. 210 22. 13. Other Eczematous Eruptions - p. 231.e5 23. 14. Allergic Contact Dermatitis - p. 246 24. 15. Irritant Contact Dermatitis - p. 267 25. 16. Occupational Dermatoses - p. 279 26. 17. Dermatoses Due to Plants - p. 291 27. Section 4: Urticarias, Erythemas, and Purpuras - p. 308.e2 28. 18. Urticaria and Angioedema - p. 309 29. 19. Figurate Erythemas - p. 327 30. 20. Erythema Multiforme, Stevens–Johnson Syndrome, and Toxic Epidermal Necrolysis - p. 339 31. 21. Drug Reactions - p. 355 32. 22. Purpura: Mechanisms and Differential Diagnosis - p. 385 33. 23. Cutaneous Manifestations of Microvascular Occlusion Syndromes - p. 397 34. 24. Cutaneous Vasculitis - p. 418 35. Abstract - p. 418 36. Chapter Contents - p. 418 37. INTRODUCTION - p. 418 38. CLASSIFICATION - p. 418 39. EPIDEMIOLOGY - p. 418 40. PATHOGENESIS - p. 418 41. GENERAL CLINICAL FEATURES - p. 418 42. PATHOLOGY - p. 419 43. DIFFERENTIAL DIAGNOSIS - p. 421 44. SMALL VESSEL VASCULITIS - p. 421 45. PREDOMINANTLY SMALL AND MEDIUM-SIZED VESSEL VASCULITIDES - p. 434 46. PREDOMINANTLY MEDIUM-SIZED VESSEL VASCULITIS - p. 444 47. TEMPORAL ARTERITIS (GIANT CELL ARTERITIS) - p. 446 48. DIAGNOSTIC APPROACH TO A PATIENT WITH SUSPECTED VASCULITIS - p. 446 49. EREFERENCES - p. 449.e5 50. REFERENCES - p. 449.e5 51. 25. Neutrophilic Dermatoses - p. 450 52. 26. Eosinophil-Associated Dermatoses - p. 470 53. 27. Pregnancy Dermatoses - p. 480 54. Section 5: Vesiculobullous Diseases - p. 490.e12 55. 28. The Biology of the Basement Membrane - p. 491 56. 29. Pemphigus - p. 501 57. 30. Pemphigoid Group - p. 517 58. 31. Dermatitis Herpetiformis and Linear IgA Bullous Dermatosis - p. 534 59. 32. Epidermolysis Bullosa - p. 545 60. 33. Other Vesiculobullous Diseases - p. 560 61. 34. Vesiculopustular and Erosive Disorders in Newborns and Infants - p. 568 62. Section 6: Adnexal Diseases - p. 585.e3 63. 35. Structure and Function of Eccrine, Apocrine, and Sebaceous Glands - p. 586 64. 36. Acne Vulgaris - p. 592 65. 37. Rosacea and Related Disorders - p. 610 66. 38. Folliculitis, Follicular Occlusion Tetrad, and Other Follicular Disorders - p. 622 67. 39. Diseases of the Eccrine and Apocrine Sweat Glands - p. 641 68. Section 7: Rheumatologic Dermatology - p. 656.e1 69. 40. Autoantibodies Encountered in Patients with Autoimmune Connective Tissue Diseases - p. 657 70. 41. Lupus Erythematosus - p. 670 71. 42. Dermatomyositis - p. 689 72. 43. Systemic Sclerosis (Scleroderma) and Related Disorders - p. 702 73. 44. Morphea and Lichen Sclerosus - p. 717 74. 45. Other Rheumatologic Disorders and Autoinflammatory Diseases - p. 732 75. Section 8: Metabolic and Systemic Diseases - p. 752.e1 76. 46. Mucinoses - p. 753 77. 47. Amyloidosis - p. 765 78. 48. Deposition Diseases - p. 774.e2 79. 49. Porphyria - p. 784 80. 50. Calcifying and Ossifying Disorders of the Skin - p. 796 81. 51. Nutritional Diseases - p. 807 82. 52. Graft-versus-Host Disease - p. 824.e3 83. 53. Dermatologic Manifestations in Patients with Systemic Disease - p. 833 84. Section 9: Genodermatoses - p. 857.e2 85. 54. Basic Principles of Genetics - p. 858 86. 55. Genetic Basis of Cutaneous Diseases - p. 869 87. 56. Biology of Keratinocytes - p. 883 88. 57. Ichthyoses, Erythrokeratodermas, and Related Disorders - p. 894 89. Abstract - p. 894 90. Chapter Contents - p. 894 91. INTRODUCTION - p. 894 92. COMMON ICHTHYOSES - p. 900 93. KERATINOPATHIC ICHTHYOSES - p. 903 94. AUTOSOMAL RECESSIVE CONGENITAL ICHTHYOSES - p. 907 95. SYNDROMIC ICHTHYOSES - p. 913 96. ERYTHROKERATODERMAS - p. 918 97. X-LINKED DOMINANT ICHTHYOSIFORM DISORDERS - p. 922 98. OTHER ICHTHYOSES, PEELING SKIN SYNDROMES, AND RELATED DISORDERS - p. 925 99. REFERENCES - p. 930.e5 100. 58. Palmoplantar Keratodermas - p. 931 101. 59. Darier Disease and Hailey–Hailey Disease - p. 951 102. 60. Primary Immunodeficiencies - p. 962 103. Abstract - p. 962 104. Chapter Contents - p. 962 105. INTRODUCTION - p. 962 106. ATAXIA–TELANGIECTASIA - p. 962 107. CHRONIC MUCOCUTANEOUS CANDIDIASIS - p. 965 108. CARTILAGE–HAIR HYPOPLASIA SYNDROME - p. 969 109. CHÉDIAK–HIGASHI SYNDROME - p. 969 110. COMPLEMENT DISORDERS - p. 971 111. CHRONIC GRANULOMATOUS DISEASE - p. 973 112. HYPERIMMUNOGLOBULIN E SYNDROMES - p. 978 113. IMMUNOGLOBULIN DEFICIENCIES - p. 981 114. IPEX SYNDROME - p. 981 115. LEUKOCYTE ADHESION DEFICIENCY - p. 981 116. SEVERE COMBINED IMMUNODEFICIENCY AND OMENN SYNDROME - p. 986 117. WISKOTT–ALDRICH SYNDROME - p. 988 118. REFERENCES - p. 991.e3 119. 61. Neurofibromatosis and Tuberous Sclerosis Complex - p. 992 120. 62. Mosaicism and Linear Lesions - p. 1012 121. 63. Other Genodermatoses - p. 1035 122. Abstract - p. 1035 123. Chapter Contents - p. 1035 124. DISORDERS FEATURING TUMORIGENESIS - p. 1035 125. MULTIPLE ENDOCRINE NEOPLASIA - p. 1035 126. PTEN HAMARTOMA TUMOR SYNDROME, INCLUDING COWDEN SYNDROME - p. 1035 127. GARDNER SYNDROME (VARIANT OF FAMILIAL ADENOMATOUS POLYPOSIS) - p. 1040 128. MUIR–TORRE SYNDROME (VARIANT OF LYNCH SYNDROME) - p. 1041 129. ENZYME DEFICIENCY DISEASES - p. 1043 130. ALKAPTONURIA - p. 1043 131. BIOTINIDASE AND HOLOCARBOXYLASE SYNTHETASE DEFICIENCIES - p. 1044 132. FABRY DISEASE - p. 1044 133. FUCOSIDOSIS - p. 1045 134. GAUCHER DISEASE - p. 1046 135. HARTNUP DISEASE - p. 1047 136. MITOCHONDRIAL DISORDERS - p. 1048 137. ACID SPHINGOMYELINASE DEFICIENCY (NIEMANN–PICK DISEASE) - p. 1048 138. PHENYLKETONURIA - p. 1048 139. Acknowledgment - p. 1049 140. PREMATURE AGING SYNDROMES AND POIKILODERMAS - p. 1049 141. HUTCHINSON–GILFORD PROGERIA SYNDROME - p. 1049 142. WERNER SYNDROME - p. 1054 143. ECTODERMAL DYSPLASIAS - p. 1055 144. HYPOHIDROTIC ECTODERMAL DYSPLASIA - p. 1057 145. HYPOHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNE DEFICIENCY - p. 1059 146. HIDROTIC ECTODERMAL DYSPLASIA - p. 1060 147. WITKOP TOOTH AND NAIL SYNDROME - p. 1061 148. ANKYLOBLEPHARON–ECTODERMAL DEFECTS–CLEFT LIP/PALATE SYNDROME - p. 1061 149. ECTODERMAL DYSPLASIA–ECTRODACTYLY–CLEFTING SYNDROME - p. 1062 150. Acknowledgments and disclosures - p. 1063 151. REFERENCES - p. 1066.e2 152. 64. Developmental Anomalies - p. 1067 153. Section 10: Pigmentary Disorders - p. 1085.e3 154. 65. Melanocyte Biology - p. 1086 155. 66. Vitiligo and Other Disorders of Hypopigmentation - p. 1098 156. 67. Disorders of Hyperpigmentation - p. 1125 157. Section 11: Hair, Nails, and Mucous Membranes - p. 1154.e4 158. 68. Biology of Hair and Nails - p. 1155 159. 69. Alopecias - p. 1173 160. 70. Hypertrichosis and Hirsutism - p. 1198 161. 71. Nail Disorders - p. 1214 162. 72. Oral Diseases - p. 1232 163. 73. Anogenital (Non-venereal) Diseases - p. 1255 164. Section 12: Infections, Infestations, and Bites - p. 1272.e3 165. 74. Bacterial Diseases - p. 1273 166. Abstract - p. 1273 167. Chapter Contents - p. 1273 168. THE CUTANEOUS MICROBIOTA - p. 1273 169. GRAM-POSITIVE BACTERIA - p. 1273 170. GRAM-NEGATIVE BACTERIA - p. 1293 171. SPIROCHETES - p. 1303 172. BACTERIA PREVIOUSLY CLASSIFIED AS FUNGI - p. 1306 173. REFERENCES - p. 1309.e8 174. 75. Mycobacterial Infections - p. 1310 175. 76. Rickettsial Diseases - p. 1333 176. 77. Fungal Diseases - p. 1343 177. 78. Cutaneous Manifestations of HIV Infection - p. 1376 178. 79. Human Papillomaviruses - p. 1394 179. 80. Human Herpesviruses - p. 1412 180. 81. Other Viral Diseases - p. 1437 181. 82. Sexually Transmitted Infections - p. 1461 182. 83. Protozoa and Worms - p. 1485 183. 84. Infestations - p. 1519 184. 85. Bites and Stings - p. 1533 185. Section 13: Disorders Due to Physical Agents - p. 1552.e3 186. 86. Ultraviolet Radiation - p. 1553 187. 87. Photodermatologic Disorders - p. 1564 188. 88. Environmental and Sports-Related Skin Diseases - p. 1585 189. 89. Signs of Substance Use Disorder - p. 1611 190. 90. Skin Signs of Abuse - p. 1622 191. Section 14: Disorders of Langerhans Cells and Macrophages - p. 1628.e1 192. 91. Histiocytoses - p. 1629 193. 92. Xanthomas - p. 1649 194. 93. Non-infectious Granulomas - p. 1660 195. 94. Foreign Body Reactions - p. 1681 196. Section 15: Atrophies and Disorders of Dermal Connective Tissues - p. 1692.e2 197. 95. Biology of the Extracellular Matrix - p. 1693 198. 96. Perforating Diseases - p. 1707 199. 97. Heritable Disorders of Connective Tissue - p. 1714 200. 98. Dermal Hypertrophies - p. 1730 201. 99. Atrophies of Connective Tissue - p. 1741 202. Section 16: Disorders of Subcutaneous Fat - p. 1750.e2 203. 100. Panniculitis - p. 1751 204. 101. Lipodystrophies - p. 1775 205. Section 17: Vascular Disorders - p. 1789.e2 206. 102. Vascular Biology - p. 1790 207. 103. Infantile Hemangiomas - p. 1801 208. 104. Vascular Malformations - p. 1819 209. 105. Ulcers Ariela Hafner and Eli Sprecher - p. 1844 210. 106. Other Vascular Disorders - p. 1864 211. Section 18: Neoplasms of the Skin - p. 1874.e3 212. 107. Principles of Cutaneous Tumor Biology - p. 1875 213. 108. Actinic Keratosis, Basal Cell Carcinoma, and Squamous Cell Carcinoma - p. 1888 214. 109. Benign Epidermal Tumors and Proliferations - p. 1911 215. 110. Cysts - p. 1935 216. 111. Adnexal Neoplasms - p. 1948 217. 112. Benign Melanocytic Neoplasms and Melanotic Lesions - p. 1973 218. 113. Melanoma - p. 2009 219. Abstract - p. 2009 220. Chapter Contents - p. 2009 221. INTRODUCTION - p. 2009 222. MOLECULAR PATHOGENESIS - p. 2009 223. HOST IMMUNE RESPONSE TO MELANOMA - p. 2010 224. EPIDEMIOLOGY - p. 2010 225. RISK FACTORS FOR CUTANEOUS MELANOMA - p. 2012 226. TYPES OF PRIMARY MELANOMAS - p. 2016 227. OTHER MELANOMA VARIANTS - p. 2019 228. MELANOMA AND PREGNANCY - p. 2022 229. MELANOMA IN THE PEDIATRIC AND ADOLESCENT POPULATION - p. 2022 230. DIAGNOSIS - p. 2022 231. PATHOLOGY - p. 2025 232. STAGING - p. 2030 233. PROGNOSIS - p. 2031 234. EVALUATION OF A PATIENT WITH SUSPECTED MELANOMA - p. 2031 235. MANAGEMENT - p. 2034 236. MELANOMA SURVEILLANCE - p. 2040 237. REFERENCES - p. 2044.e9 238. 114. Vascular Neoplasms and Neoplastic-Like Proliferations - p. 2045 239. Abstract - p. 2045 240. Chapter Contents - p. 2045 241. INTRODUCTION - p. 2045 242. BENIGN VASCULAR NEOPLASMS AND REACTIVE HYPERPLASIAS - p. 2045 243. BORDERLINE AND LOW-GRADE MALIGNANT VASCULAR NEOPLASMS - p. 2060 244. MALIGNANT VASCULAR NEOPLASMS - p. 2067 245. PERIVASCULAR NEOPLASMS AND NEOPLASTIC-LIKE PROLIFERATIONS - p. 2070 246. REFERENCES - p. 2076.e5 247. 115. Neural and Neuroendocrine Neoplasms (Other than Neurofibromatosis) - p. 2077 248. 116. Fibroblastic, Myofibroblastic, and “Fibrohistiocytic” Proliferations and Neoplasms of the Skin - p. 2096 249. 117. Smooth Muscle, Adipose, and Cartilage Neoplasms - p. 2116 250. 118. Mastocytosis - p. 2131 251. 119. B Cell Lymphomas of the Skin - p. 2142 252. 120. Cutaneous T Cell Lymphoma - p. 2156 253. 121. Other Lymphoproliferative and Myeloproliferative Diseases - p. 2177 254. 122. Cutaneous Metastases - p. 2189 255. Section 19: Medical Therapy - p. 2196.e2 256. 123. Public Health and Dermatology - p. 2197 257. 124-1. Skin Barrier - p. 2206 258. 125. Glucocorticoids - p. 2217 259. 126. Retinoids - p. 2231 260. 127. Antimicrobial Drugs - p. 2246 261. 128. Systemic Immunomodulators - p. 2272 262. 129. Other Topical Medications - p. 2295 263. 130. Other Systemic Drugs - p. 2311 264. 131. Drug Interactions - p. 2330 265. 132. Sunscreens and Photoprotection - p. 2344 266. 133. Complementary and Alternative Medicine - p. 2354 267. Section 20: Physical Treatment Modalities - p. 2361.e1 268. 134. Ultraviolet Therapy - p. 2362 269. 135. Photodynamic Therapy - p. 2379 270. 136. Lasers and Other Energy-Based Technologies – Principles and Skin Interactions - p. 2390 271. 137. Lasers and Other Energy-Based Therapies - p. 2400 272. 138. Cryosurgery - p. 2422 273. 139. Radiotherapy - p. 2430 274. 140. Electrosurgery - p. 2442 275. Section 21: Surgery - p. 2450 276. 141. Biology of Wound Healing - p. 2451 277. 142. Surgical Anatomy of the Head and Neck - p. 2464 278. 143. Anesthesia - p. 2479 279. 144. Wound Closure Materials and Instruments - p. 2489 280. 145. Dressings - p. 2501 281. 146. Biopsy Techniques and Basic Excisions - p. 2517 282. 147. Flaps - p. 2534 283. 148. Grafts - p. 2556 284. 149. Nail Surgery - p. 2570 285. 150. Mohs Micrographic Surgery - p. 2582 286. 151. Surgical Complications and Optimizing Outcomes - p. 2596 287. Section 22: Cosmetic Surgery - p. 2610.e2 288. 152. Evaluation of Beauty and the Aging Face - p. 2611 289. 153. Cosmetics and Cosmeceuticals - p. 2619 290. 154. Chemical and Mechanical Skin Resurfacing - p. 2633 291. 155. Phlebology and Treatment of Leg Veins - p. 2650 292. 156. Body Contouring: Liposuction and Non-invasive Modalities - p. 2666.e1 293. 157. Hair Restoration - p. 2678 294. 158. Injectable Soft Tissue Augmentation - p. 2691 295. 159. Botulinum Toxin - p. 2705 296. Index - p. I-1
