This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of blood and bone marrow, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Blood and Bone Marrow is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, oncologist, hematologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Provides practicing pathologists with key details about new entities, newly recognized causes of morphologic change in blood and bone marrow abnormalities, and new strategies for appropriate workup of neoplastic processes—all with a focus on key tests and key differential diagnostic considerations
Helps pathologists recognize unique blood and bone marrow findings that can be an indicator for specific exposures, such as new medications, new targeted therapies, or toxins
Integrates updated technologies, newly recognized disorders, complications/features in blood and bone marrow, new targeted therapies, and the increased use of homeopathic remedies
Contains new chapters covering SARS-CoV-2 infection features in blood and bone marrow, myelodysplastic syndrome (MDS) mimics, blood and bone marrow findings linked to targeted therapies, blood and bone marrow findings linked to other medications, and more
Updates all existing chapters and contains expanded information on T-cell neoplasms in blood and bone marrow and intravascular large B-cell lymphoma in blood and bone marrow
Includes details from the World Health Organization (WHO) fifth edition Classification of Haematolymphoid Tumours and the very latest 2023 International Consensus Classification (ICC) publications, reflecting new and renamed diagnostic entities, tumor classification changes and updates, and terminology changes and updates
Discusses molecular testing strategies based on specific neoplasms and specific differential diagnostic consideration
Clearly delineates numerous genetic disorders often found in blood and bone marrow
Features more than 2,500 superb images, including histology and gross pathology photographs, full-color illustrations and graphics, clinical photographs and radiologic images, and many new tables and charts/algorithms
Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
1. SECTION 1: INTRODUCTION - p. xiii 2. Chapter 1: Hematopoiesis and Bone Marrow Histology - p. xiii 3. Chapter 2: Bone Marrow Examination and Techniques - p. 13 4. Chapter 3: Synoptic/Integrated Bone Marrow Reporting and Algorithmic Testing - p. 25 5. Chapter 4: Overview of Constitutional and Acquired Bone Marrow Disorders - p. 29 6. SECTION 2: ANEMIA - p. 35 7. Chapter 5: Overview of Anemia - p. 35 8. ACQUIRED ANEMIAS - p. 43 9. Chapter 6: Anemias of Inflammation, Chronic Kidney Disease, and Cancer - p. 43 10. Chapter 7: Iron Deficiency Anemia - p. 47 11. Chapter 8: Autoimmune Hemolytic Anemias - p. 51 12. Chapter 9: Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn - p. 57 13. Chapter 10: Microangiopathic Hemolytic Anemia - p. 61 14. Chapter 11: Megaloblastic Anemia - p. 67 15. Chapter 12: Acquired Nonneoplastic Sideroblastic Anemia - p. 75 16. Chapter 13: Alcoholism-Associated Anemia - p. 79 17. Chapter 14: Anemia in Older Adults - p. 83 18. Chapter 15: Copper Deficiency-Associated Anemia - p. 87 19. Chapter 16: Acquired Red Cell Aplasia - p. 91 20. Chapter 17: Transient Erythroblastopenia of Childhood - p. 95 21. Chapter 18: Parvovirus-Induced Red Cell Aplasia - p. 97 22. Chapter 19: Paroxysmal Nocturnal Hemoglobinuria - p. 101 23. Chapter 20: Acquired Aplastic Anemia - p. 107 24. CONSTITUTIONAL ANEMIAS - p. 111 25. Chapter 21: Thalassemia - p. 111 26. Chapter 22: Sickle Cell Anemia - p. 117 27. Chapter 23: Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency - p. 121 28. Chapter 24: Pyruvate Kinase Deficiency - p. 123 29. Chapter 25: Hereditary Spherocytosis - p. 125 30. Chapter 26: Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis - p. 131 31. Chapter 27: Diamond-Blackfan Anemia - p. 135 32. Chapter 28: Fanconi Anemia - p. 139 33. Chapter 29: Congenital Dyserythropoietic Anemia - p. 143 34. Chapter 30: Congenital Sideroblastic Anemia - p. 149 35. Chapter 31: Congenital Megaloblastic Anemia - p. 153 36. SECTION 3: ERYTHROCYTOSIS - p. 159 37. CONSTITUTIONAL - p. 159 38. Chapter 32: Congenital Erythrocytosis - p. 159 39. ACQUIRED - p. 165 40. Chapter 33: Acquired Erythrocytosis - p. 165 41. SECTION 4: BENIGN LEUKOCYTE DISORDERS IN BLOOD AND BONE MARROW - p. 169 42. Chapter 34: Overview of Benign Leukocyte Disorders in Blood and Bone Marrow - p. 169 43. Chapter 35: Pancytopenia - p. 175 44. Chapter 36: Neutropenia - p. 183 45. Chapter 37: Neutrophilia - p. 189 46. Chapter 38: Monocytosis - p. 195 47. Chapter 39: Eosinophilia - p. 201 48. Chapter 40: Basophilia - p. 209 49. Chapter 41: Lymphocytosis - p. 211 50. Chapter 42: Lymphopenia, Constitutional and Acquired - p. 215 51. Chapter 43: Plasmacytosis of Bone Marrow - p. 219 52. Chapter 44: Hematogones in Bone Marrow - p. 227 53. Chapter 45: Lymphoid Aggregates in Bone Marrow - p. 237 54. Chapter 46: Granulomas in Bone Marrow - p. 245 55. SECTION 5: CONSTITUTIONAL GRANULOCYTIC DISORDERS - p. 251 56. CONSTITUTIONAL NEUTROPENIAS - p. 251 57. Chapter 47: Severe Congenital Neutropenia and Cyclic Neutropenia - p. 251 58. Chapter 48: Shwachman-Diamond Syndrome - p. 257 59. Chapter 49: Chediak-Higashi Syndrome - p. 261 60. Chapter 50: Myelokathexis in WHIM Syndrome - p. 265 61. CONSTITUTIONAL NEUTROPHIL ANOMALIES - p. 269 62. Chapter 51: Pelger-Huët Anomaly - p. 269 63. Chapter 52: MYH9-Related Disorders - p. 273 64. Chapter 53: Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation - p. 277 65. SECTION 6: MEGAKARYOCYTIC DISORDERS - p. 283 66. Chapter 54: Overview of Megakaryocytic Disorders - p. 283 67. ACQUIRED PLATELET DISORDERS WITH THROMBOCYTOPENIA - p. 295 68. Chapter 55: Immune-Mediated Thrombocytopenia - p. 295 69. Chapter 56: Hemolytic Uremic Syndrome - p. 301 70. Chapter 57: Heparin-Induced Thrombocytopenia (HIT) - p. 307 71. Chapter 58: Thrombotic Thrombocytopenic Purpura - p. 311 72. Chapter 59: Pregnancy-Associated Thrombocytopenia - p. 315 73. CONSTITUTIONAL PLATELET DISORDERS WITH THROMBOCYTOPENIA - p. 319 74. Chapter 60: Thrombocytopenia Absent Radius Syndrome - p. 319 75. Chapter 61: Congenital Amegakaryocytic Thrombocytopenia - p. 323 76. Chapter 62: Gray Platelet Syndrome - p. 327 77. Chapter 63: Wiskott-Aldrich Syndrome-Related Disorders - p. 331 78. Chapter 64: Congenital Thrombotic Thrombocytopenic Purpura - p. 335 79. THROMBOCYTOSIS - p. 339 80. Chapter 65: Thrombocytosis - p. 339 81. SECTION 7: INFECTIONS - p. 343 82. Chapter 66: Overview of Infections - p. 343 83. Chapter 67: Hantavirus Pulmonary Syndrome - p. 349 84. Chapter 68: Human Immunodeficiency Virus - p. 353 85. Chapter 69: Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus) - p. 363 86. Chapter 70: Parvovirus B19 Infection - p. 373 87. Chapter 71: Bacterial Infections, Blood and Bone Marrow Features - p. 377 88. Chapter 72: Fungal Infections, Blood and Bone Marrow Features - p. 387 89. Chapter 73: Helminthic Infections - p. 393 90. Chapter 74: Malaria - p. 397 91. Chapter 75: Other Protozoan Infections - p. 405 92. Chapter 76: COVID-19 Infection (SARS-CoV-2) - p. 411 93. SECTION 8: MISCELLANEOUS NONNEOPLASTIC DISORDERS AND CONDITIONS - p. 415 94. Chapter 77: Overview and Classification of Hemophagocytic Disorders in Bone Marrow - p. 415 95. Chapter 78: Hematologic Manifestations of Collagen Vascular Disorders - p. 425 96. Chapter 79: Hematologic Manifestations of Chronic Kidney Disease - p. 431 97. Chapter 80: Lysosomal Storage Diseases With Predominantly Histiocytic Storage - p. 433 98. Chapter 81: Homeopathic Remedies and Medications Affecting Blood and Bone Marrow Morphology - p. 439 99. Chapter 82: Other Pregnancy-Associated Hematologic Disorders - p. 443 100. Chapter 83: VEXAS Syndrome - p. 447 101. Chapter 84: Gelatinous Transformation and Other Bone Marrow Stromal Disorders - p. 451 102. Chapter 85: Bone Marrow Necrosis - p. 455 103. Chapter 86: Crystals in Bone Marrow - p. 459 104. Chapter 87: Bone Abnormalities in Bone Marrow Specimens - p. 465 105. SECTION 9: MYELOID NEOPLASMS - p. 473 106. Chapter 88: Overview and Classification of Myeloid Neoplasms - p. 473 107. Chapter 89: Specialized Testing in Myeloid Neoplasms - p. 480 108. MYELOPROLIFERATIVE NEOPLASMS - p. 483 109. Chapter 90: Overview of Myeloproliferative Neoplasms - p. 483 110. Chapter 91: Chronic Myeloid Leukemia - p. 487 111. Chapter 92: Chronic Neutrophilic Leukemia - p. 497 112. Chapter 93: Polycythemia Vera - p. 505 113. Chapter 94: Primary Myelofibrosis - p. 511 114. Chapter 95: Essential Thrombocythemia - p. 521 115. Chapter 96: Chronic Eosinophilic Leukemia, Not Otherwise Specified - p. 529 116. Chapter 97: Myeloproliferative Neoplasm, Unclassifiable - p. 536 117. MASTOCYTOSIS - p. 543 118. Chapter 98: Systemic Mastocytosis - p. 543 119. Chapter 99: Mast Cell Leukemia - p. 552 120. MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND TYROSINE KINASE GENE FUSIONS - p. 561 121. Chapter 100: Myeloid/Lymphoid Neoplasms With Eosinophilia and PDGFRA - p. 561 122. Chapter 101: Myeloid/Lymphoid Neoplasms With Eosinophilia and PDGFRB - p. 563 123. Chapter 102: Myeloid/Lymphoid Neoplasms With Eosinophilia and FGFR1 - p. 565 124. Chapter 103: Myeloid/Lymphoid Neoplasms With Eosinophilia and FLT3 and Other Uncommon Fusion Genes - p. 567 125. MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS - p. 569 126. Chapter 104: Overview of Myelodysplastic/Myeloproliferative Neoplasms - p. 569 127. Chapter 105: Chronic Myelomonocytic Leukemia and Precursor Lesions - p. 573 128. Chapter 106: Atypical Chronic Myeloid Leukemia - p. 577 129. Chapter 107: Myelodysplastic/Myeloproliferative Neoplasm With and Without SF3B1 Mutation and Thrombocytosis - p. 581 130. Chapter 108: Myelodysplastic/Myeloproliferative Neoplasms, Not Otherwise Specified, and Provisional Entity - p. 585 131. MYELODYSPLASTIC SYNDROMES - p. 587 132. Chapter 109: Overview and Classification of Myelodysplastic Syndromes - p. 587 133. Chapter 110: Myelodysplastic Syndrome Precursor Lesions - p. 596 134. Chapter 111: Myelodysplastic Syndromes With Mutated SF3B1 - p. 599 135. Chapter 112: Myelodysplastic Syndrome With del(5q) - p. 603 136. Chapter 113: Myelodysplastic Syndrome With Multihit TP53 Mutation - p. 611 137. Chapter 114: Myelodysplastic Syndromes, Not Otherwise Specified - p. 613 138. Chapter 115: Myelodysplastic Syndromes With Excess Blasts - p. 619 139. Chapter 116: Myelodysplastic Syndrome/Acute Myeloid Leukemia - p. 623 140. Chapter 117: Mimics of Myelodysplasia - p. 627 141. HEMATOLOGIC NEOPLASMS WITH GERMLINE PREDISPOSITION, PEDIATRIC MYELODYSPLASTIC SYNDROME, AND JUVENILE MYELOMONOCYTIC LEUKEMIA - p. 631 142. Chapter 118: Juvenile Myelomonocytic Leukemia and Similar Neoplasms - p. 631 143. Chapter 119: Pediatric Myelodysplastic Syndrome (Refractory Cytopenia of Childhood) - p. 635 144. Chapter 120: Hematologic Neoplasms With Germline Predisposition - p. 641 145. Chapter 121: Myeloid Proliferations Related to Down Syndrome - p. 643 146. ACUTE MYELOID LEUKEMIA - p. 647 147. Chapter 122: Overview of Acute Myeloid Leukemia - p. 647 148. Chapter 123: Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2)/PML::RARA - p. 655 149. Chapter 124: Acute Promyelocytic Leukemia With Other RARA Rearrangements - p. 661 150. Chapter 125: Acute Myeloid Leukemia With t(8;21)(q22;q22.1)/RUNX1::RUNX1T1 - p. 663 151. Chapter 126: Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22)/CBFB::MYH11 - p. 673 152. Chapter 127: Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3)/MLLT3::KMT2A and Other KMT2A Rearrangements - p. 681 153. Chapter 128: Acute Myeloid Leukemia With Mutated TP53 - p. 689 154. Chapter 129: Acute Myeloid Leukemia With Uncommon Cytogenetic Abnormalities - p. 693 155. Chapter 130: Acute Myeloid Leukemia With Myelodysplasia-Related Gene Mutations or Cytogenetic Abnormalities - p. 697 156. Chapter 131: Acute Myeloid Leukemia, Not Otherwise Specified - p. 703 157. Chapter 132: Acute Leukemia of Ambiguous Lineage - p. 707 158. Chapter 133: Measurable Residual Disease Testing Strategies in Acute Myeloid Leukemia - p. 713 159. BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM - p. 717 160. Chapter 134: Blastic Plasmacytoid Dendritic Cell Neoplasm - p. 717 161. SECTION 10: LYMPHOID NEOPLASMS - p. 725 162. Chapter 135: Overview of Lymphoid Neoplasms - p. 725 163. Chapter 136: Specialized Testing in Lymphoid Neoplasms - p. 733 164. B-PRECURSOR NEOPLASMS - p. 737 165. Chapter 137: B-Acute Lymphoblastic Leukemias: Cytogenetic Subtypes and Not Otherwise Specified (ICC) - p. 737 166. Chapter 138: B-Acute Lymphoblastic Leukemia, BCR::ABL1-Like - p. 745 167. Chapter 139: Novel Genetic Subtypes of B-Acute Lymphoblastic Leukemia - p. 749 168. Chapter 140: Measurable Residual Disease Testing Strategies in Acute Lymphoblastic Leukemia - p. 753 169. T-PRECURSOR NEOPLASMS - p. 755 170. Chapter 141: T- and NK-Cell Acute Lymphoblastic Leukemia (ICC) - p. 755 171. Chapter 142: Early T-Cell Precursor Acute Lymphoblastic Leukemia - p. 761 172. MATURE B-CELL NEOPLASMS - p. 763 173. Chapter 143: Overview and Classification of Mature B-Cell Leukemias, Immunosecretory Neoplasms - p. 763 174. Chapter 144: Monoclonal B-Cell Lymphocytosis - p. 771 175. Chapter 145: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma - p. 775 176. Chapter 146: B-Cell Prolymphocytic Leukemia - p. 784 177. Chapter 147: Splenic Marginal Zone Lymphoma - p. 787 178. Chapter 148: Hairy Cell Leukemia - p. 793 179. Chapter 149: Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant - p. 803 180. Chapter 150: Lymphoplasmacytic Lymphoma - p. 805 181. Chapter 151: γ-Heavy Chain Disease - p. 811 182. Chapter 152: Monoclonal Gammopathy - p. 815 183. Chapter 153: Multiple Myeloma - p. 821 184. Chapter 154: Burkitt Lymphoma - p. 833 185. Chapter 155: Mantle Cell Lymphoma in Blood and Bone Marrow - p. 841 186. Chapter 156: Follicular Lymphoma in Blood and Bone Marrow - p. 845 187. Chapter 157: Marginal Zone Lymphoma in Blood and Bone Marrow - p. 849 188. Chapter 158: Intravascular Large B-Cell Lymphoma - p. 853 189. Chapter 159: Other Large B-Cell Lymphomas in Blood and Bone Marrow - p. 857 190. MATURE T-/NK-CELL NEOPLASMS - p. 859 191. Chapter 160: Overview and Classification of Mature T-/NK-Cell Neoplasms in Blood and Bone Marrow - p. 859 192. Chapter 161: T-Cell Prolymphocytic Leukemia - p. 863 193. Chapter 162: T-Cell Large Granular Lymphocytic Leukemia - p. 869 194. Chapter 163: Chronic Lymphoproliferative Disorder of NK Cells - p. 875 195. Chapter 164: Aggressive NK-Cell Leukemia - p. 877 196. Chapter 165: Adult T-Cell Leukemia - p. 881 197. Chapter 166: Sézary Syndrome - p. 883 198. Chapter 167: Anaplastic Large Cell Lymphoma in Blood and Bone Marrow - p. 889 199. Chapter 168: Angioimmunoblastic T-Cell Lymphoma in Blood and Bone Marrow - p. 895 200. Chapter 169: Other Mature T-Cell Lymphomas Involving Blood and Bone Marrow - p. 897 201. HODGKIN LYMPHOMA IN BONE MARROW - p. 901 202. Chapter 170: Classic Hodgkin and Nodular Lymphocyte-Predominant B-Cell Lymphomas in Bone Marrow - p. 901 203. SECTION 11: OTHER NEOPLASMS INVOLVING BONE MARROW - p. 907 204. Chapter 171: Langerhans Cell Histiocytosis in Bone Marrow - p. 907 205. Chapter 172: Posttransplant Lymphoproliferative Disorders in Bone Marrow - p. 913 206. Chapter 173: Metastatic Carcinoma and Sarcoma - p. 919 207. INDEX - p. 925
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of blood and bone marrow, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Blood and Bone Marrow is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, oncologist, hematologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Provides practicing pathologists with key details about new entities, newly recognized causes of morphologic change in blood and bone marrow abnormalities, and new strategies for appropriate workup of neoplastic processes—all with a focus on key tests and key differential diagnostic considerations
Helps pathologists recognize unique blood and bone marrow findings that can be an indicator for specific exposures, such as new medications, new targeted therapies, or toxins
Integrates updated technologies, newly recognized disorders, complications/features in blood and bone marrow, new targeted therapies, and the increased use of homeopathic remedies
Contains new chapters covering SARS-CoV-2 infection features in blood and bone marrow, myelodysplastic syndrome (MDS) mimics, blood and bone marrow findings linked to targeted therapies, blood and bone marrow findings linked to other medications, and more
Updates all existing chapters and contains expanded information on T-cell neoplasms in blood and bone marrow and intravascular large B-cell lymphoma in blood and bone marrow
Includes details from the World Health Organization (WHO) fifth edition Classification of Haematolymphoid Tumours and the very latest 2023 International Consensus Classification (ICC) publications, reflecting new and renamed diagnostic entities, tumor classification changes and updates, and terminology changes and updates
Discusses molecular testing strategies based on specific neoplasms and specific differential diagnostic consideration
Clearly delineates numerous genetic disorders often found in blood and bone marrow
Features more than 2,500 superb images, including histology and gross pathology photographs, full-color illustrations and graphics, clinical photographs and radiologic images, and many new tables and charts/algorithms
Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
1. SECTION 1: INTRODUCTION - p. xiii 2. Chapter 1: Hematopoiesis and Bone Marrow Histology - p. xiii 3. Chapter 2: Bone Marrow Examination and Techniques - p. 13 4. Chapter 3: Synoptic/Integrated Bone Marrow Reporting and Algorithmic Testing - p. 25 5. Chapter 4: Overview of Constitutional and Acquired Bone Marrow Disorders - p. 29 6. SECTION 2: ANEMIA - p. 35 7. Chapter 5: Overview of Anemia - p. 35 8. ACQUIRED ANEMIAS - p. 43 9. Chapter 6: Anemias of Inflammation, Chronic Kidney Disease, and Cancer - p. 43 10. Chapter 7: Iron Deficiency Anemia - p. 47 11. Chapter 8: Autoimmune Hemolytic Anemias - p. 51 12. Chapter 9: Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn - p. 57 13. Chapter 10: Microangiopathic Hemolytic Anemia - p. 61 14. Chapter 11: Megaloblastic Anemia - p. 67 15. Chapter 12: Acquired Nonneoplastic Sideroblastic Anemia - p. 75 16. Chapter 13: Alcoholism-Associated Anemia - p. 79 17. Chapter 14: Anemia in Older Adults - p. 83 18. Chapter 15: Copper Deficiency-Associated Anemia - p. 87 19. Chapter 16: Acquired Red Cell Aplasia - p. 91 20. Chapter 17: Transient Erythroblastopenia of Childhood - p. 95 21. Chapter 18: Parvovirus-Induced Red Cell Aplasia - p. 97 22. Chapter 19: Paroxysmal Nocturnal Hemoglobinuria - p. 101 23. Chapter 20: Acquired Aplastic Anemia - p. 107 24. CONSTITUTIONAL ANEMIAS - p. 111 25. Chapter 21: Thalassemia - p. 111 26. Chapter 22: Sickle Cell Anemia - p. 117 27. Chapter 23: Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency - p. 121 28. Chapter 24: Pyruvate Kinase Deficiency - p. 123 29. Chapter 25: Hereditary Spherocytosis - p. 125 30. Chapter 26: Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis - p. 131 31. Chapter 27: Diamond-Blackfan Anemia - p. 135 32. Chapter 28: Fanconi Anemia - p. 139 33. Chapter 29: Congenital Dyserythropoietic Anemia - p. 143 34. Chapter 30: Congenital Sideroblastic Anemia - p. 149 35. Chapter 31: Congenital Megaloblastic Anemia - p. 153 36. SECTION 3: ERYTHROCYTOSIS - p. 159 37. CONSTITUTIONAL - p. 159 38. Chapter 32: Congenital Erythrocytosis - p. 159 39. ACQUIRED - p. 165 40. Chapter 33: Acquired Erythrocytosis - p. 165 41. SECTION 4: BENIGN LEUKOCYTE DISORDERS IN BLOOD AND BONE MARROW - p. 169 42. Chapter 34: Overview of Benign Leukocyte Disorders in Blood and Bone Marrow - p. 169 43. Chapter 35: Pancytopenia - p. 175 44. Chapter 36: Neutropenia - p. 183 45. Chapter 37: Neutrophilia - p. 189 46. Chapter 38: Monocytosis - p. 195 47. Chapter 39: Eosinophilia - p. 201 48. Chapter 40: Basophilia - p. 209 49. Chapter 41: Lymphocytosis - p. 211 50. Chapter 42: Lymphopenia, Constitutional and Acquired - p. 215 51. Chapter 43: Plasmacytosis of Bone Marrow - p. 219 52. Chapter 44: Hematogones in Bone Marrow - p. 227 53. Chapter 45: Lymphoid Aggregates in Bone Marrow - p. 237 54. Chapter 46: Granulomas in Bone Marrow - p. 245 55. SECTION 5: CONSTITUTIONAL GRANULOCYTIC DISORDERS - p. 251 56. CONSTITUTIONAL NEUTROPENIAS - p. 251 57. Chapter 47: Severe Congenital Neutropenia and Cyclic Neutropenia - p. 251 58. Chapter 48: Shwachman-Diamond Syndrome - p. 257 59. Chapter 49: Chediak-Higashi Syndrome - p. 261 60. Chapter 50: Myelokathexis in WHIM Syndrome - p. 265 61. CONSTITUTIONAL NEUTROPHIL ANOMALIES - p. 269 62. Chapter 51: Pelger-Huët Anomaly - p. 269 63. Chapter 52: MYH9-Related Disorders - p. 273 64. Chapter 53: Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation - p. 277 65. SECTION 6: MEGAKARYOCYTIC DISORDERS - p. 283 66. Chapter 54: Overview of Megakaryocytic Disorders - p. 283 67. ACQUIRED PLATELET DISORDERS WITH THROMBOCYTOPENIA - p. 295 68. Chapter 55: Immune-Mediated Thrombocytopenia - p. 295 69. Chapter 56: Hemolytic Uremic Syndrome - p. 301 70. Chapter 57: Heparin-Induced Thrombocytopenia (HIT) - p. 307 71. Chapter 58: Thrombotic Thrombocytopenic Purpura - p. 311 72. Chapter 59: Pregnancy-Associated Thrombocytopenia - p. 315 73. CONSTITUTIONAL PLATELET DISORDERS WITH THROMBOCYTOPENIA - p. 319 74. Chapter 60: Thrombocytopenia Absent Radius Syndrome - p. 319 75. Chapter 61: Congenital Amegakaryocytic Thrombocytopenia - p. 323 76. Chapter 62: Gray Platelet Syndrome - p. 327 77. Chapter 63: Wiskott-Aldrich Syndrome-Related Disorders - p. 331 78. Chapter 64: Congenital Thrombotic Thrombocytopenic Purpura - p. 335 79. THROMBOCYTOSIS - p. 339 80. Chapter 65: Thrombocytosis - p. 339 81. SECTION 7: INFECTIONS - p. 343 82. Chapter 66: Overview of Infections - p. 343 83. Chapter 67: Hantavirus Pulmonary Syndrome - p. 349 84. Chapter 68: Human Immunodeficiency Virus - p. 353 85. Chapter 69: Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus) - p. 363 86. Chapter 70: Parvovirus B19 Infection - p. 373 87. Chapter 71: Bacterial Infections, Blood and Bone Marrow Features - p. 377 88. Chapter 72: Fungal Infections, Blood and Bone Marrow Features - p. 387 89. Chapter 73: Helminthic Infections - p. 393 90. Chapter 74: Malaria - p. 397 91. Chapter 75: Other Protozoan Infections - p. 405 92. Chapter 76: COVID-19 Infection (SARS-CoV-2) - p. 411 93. SECTION 8: MISCELLANEOUS NONNEOPLASTIC DISORDERS AND CONDITIONS - p. 415 94. Chapter 77: Overview and Classification of Hemophagocytic Disorders in Bone Marrow - p. 415 95. Chapter 78: Hematologic Manifestations of Collagen Vascular Disorders - p. 425 96. Chapter 79: Hematologic Manifestations of Chronic Kidney Disease - p. 431 97. Chapter 80: Lysosomal Storage Diseases With Predominantly Histiocytic Storage - p. 433 98. Chapter 81: Homeopathic Remedies and Medications Affecting Blood and Bone Marrow Morphology - p. 439 99. Chapter 82: Other Pregnancy-Associated Hematologic Disorders - p. 443 100. Chapter 83: VEXAS Syndrome - p. 447 101. Chapter 84: Gelatinous Transformation and Other Bone Marrow Stromal Disorders - p. 451 102. Chapter 85: Bone Marrow Necrosis - p. 455 103. Chapter 86: Crystals in Bone Marrow - p. 459 104. Chapter 87: Bone Abnormalities in Bone Marrow Specimens - p. 465 105. SECTION 9: MYELOID NEOPLASMS - p. 473 106. Chapter 88: Overview and Classification of Myeloid Neoplasms - p. 473 107. Chapter 89: Specialized Testing in Myeloid Neoplasms - p. 480 108. MYELOPROLIFERATIVE NEOPLASMS - p. 483 109. Chapter 90: Overview of Myeloproliferative Neoplasms - p. 483 110. Chapter 91: Chronic Myeloid Leukemia - p. 487 111. Chapter 92: Chronic Neutrophilic Leukemia - p. 497 112. Chapter 93: Polycythemia Vera - p. 505 113. Chapter 94: Primary Myelofibrosis - p. 511 114. Chapter 95: Essential Thrombocythemia - p. 521 115. Chapter 96: Chronic Eosinophilic Leukemia, Not Otherwise Specified - p. 529 116. Chapter 97: Myeloproliferative Neoplasm, Unclassifiable - p. 536 117. MASTOCYTOSIS - p. 543 118. Chapter 98: Systemic Mastocytosis - p. 543 119. Chapter 99: Mast Cell Leukemia - p. 552 120. MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND TYROSINE KINASE GENE FUSIONS - p. 561 121. Chapter 100: Myeloid/Lymphoid Neoplasms With Eosinophilia and PDGFRA - p. 561 122. Chapter 101: Myeloid/Lymphoid Neoplasms With Eosinophilia and PDGFRB - p. 563 123. Chapter 102: Myeloid/Lymphoid Neoplasms With Eosinophilia and FGFR1 - p. 565 124. Chapter 103: Myeloid/Lymphoid Neoplasms With Eosinophilia and FLT3 and Other Uncommon Fusion Genes - p. 567 125. MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS - p. 569 126. Chapter 104: Overview of Myelodysplastic/Myeloproliferative Neoplasms - p. 569 127. Chapter 105: Chronic Myelomonocytic Leukemia and Precursor Lesions - p. 573 128. Chapter 106: Atypical Chronic Myeloid Leukemia - p. 577 129. Chapter 107: Myelodysplastic/Myeloproliferative Neoplasm With and Without SF3B1 Mutation and Thrombocytosis - p. 581 130. Chapter 108: Myelodysplastic/Myeloproliferative Neoplasms, Not Otherwise Specified, and Provisional Entity - p. 585 131. MYELODYSPLASTIC SYNDROMES - p. 587 132. Chapter 109: Overview and Classification of Myelodysplastic Syndromes - p. 587 133. Chapter 110: Myelodysplastic Syndrome Precursor Lesions - p. 596 134. Chapter 111: Myelodysplastic Syndromes With Mutated SF3B1 - p. 599 135. Chapter 112: Myelodysplastic Syndrome With del(5q) - p. 603 136. Chapter 113: Myelodysplastic Syndrome With Multihit TP53 Mutation - p. 611 137. Chapter 114: Myelodysplastic Syndromes, Not Otherwise Specified - p. 613 138. Chapter 115: Myelodysplastic Syndromes With Excess Blasts - p. 619 139. Chapter 116: Myelodysplastic Syndrome/Acute Myeloid Leukemia - p. 623 140. Chapter 117: Mimics of Myelodysplasia - p. 627 141. HEMATOLOGIC NEOPLASMS WITH GERMLINE PREDISPOSITION, PEDIATRIC MYELODYSPLASTIC SYNDROME, AND JUVENILE MYELOMONOCYTIC LEUKEMIA - p. 631 142. Chapter 118: Juvenile Myelomonocytic Leukemia and Similar Neoplasms - p. 631 143. Chapter 119: Pediatric Myelodysplastic Syndrome (Refractory Cytopenia of Childhood) - p. 635 144. Chapter 120: Hematologic Neoplasms With Germline Predisposition - p. 641 145. Chapter 121: Myeloid Proliferations Related to Down Syndrome - p. 643 146. ACUTE MYELOID LEUKEMIA - p. 647 147. Chapter 122: Overview of Acute Myeloid Leukemia - p. 647 148. Chapter 123: Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2)/PML::RARA - p. 655 149. Chapter 124: Acute Promyelocytic Leukemia With Other RARA Rearrangements - p. 661 150. Chapter 125: Acute Myeloid Leukemia With t(8;21)(q22;q22.1)/RUNX1::RUNX1T1 - p. 663 151. Chapter 126: Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22)/CBFB::MYH11 - p. 673 152. Chapter 127: Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3)/MLLT3::KMT2A and Other KMT2A Rearrangements - p. 681 153. Chapter 128: Acute Myeloid Leukemia With Mutated TP53 - p. 689 154. Chapter 129: Acute Myeloid Leukemia With Uncommon Cytogenetic Abnormalities - p. 693 155. Chapter 130: Acute Myeloid Leukemia With Myelodysplasia-Related Gene Mutations or Cytogenetic Abnormalities - p. 697 156. Chapter 131: Acute Myeloid Leukemia, Not Otherwise Specified - p. 703 157. Chapter 132: Acute Leukemia of Ambiguous Lineage - p. 707 158. Chapter 133: Measurable Residual Disease Testing Strategies in Acute Myeloid Leukemia - p. 713 159. BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM - p. 717 160. Chapter 134: Blastic Plasmacytoid Dendritic Cell Neoplasm - p. 717 161. SECTION 10: LYMPHOID NEOPLASMS - p. 725 162. Chapter 135: Overview of Lymphoid Neoplasms - p. 725 163. Chapter 136: Specialized Testing in Lymphoid Neoplasms - p. 733 164. B-PRECURSOR NEOPLASMS - p. 737 165. Chapter 137: B-Acute Lymphoblastic Leukemias: Cytogenetic Subtypes and Not Otherwise Specified (ICC) - p. 737 166. Chapter 138: B-Acute Lymphoblastic Leukemia, BCR::ABL1-Like - p. 745 167. Chapter 139: Novel Genetic Subtypes of B-Acute Lymphoblastic Leukemia - p. 749 168. Chapter 140: Measurable Residual Disease Testing Strategies in Acute Lymphoblastic Leukemia - p. 753 169. T-PRECURSOR NEOPLASMS - p. 755 170. Chapter 141: T- and NK-Cell Acute Lymphoblastic Leukemia (ICC) - p. 755 171. Chapter 142: Early T-Cell Precursor Acute Lymphoblastic Leukemia - p. 761 172. MATURE B-CELL NEOPLASMS - p. 763 173. Chapter 143: Overview and Classification of Mature B-Cell Leukemias, Immunosecretory Neoplasms - p. 763 174. Chapter 144: Monoclonal B-Cell Lymphocytosis - p. 771 175. Chapter 145: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma - p. 775 176. Chapter 146: B-Cell Prolymphocytic Leukemia - p. 784 177. Chapter 147: Splenic Marginal Zone Lymphoma - p. 787 178. Chapter 148: Hairy Cell Leukemia - p. 793 179. Chapter 149: Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant - p. 803 180. Chapter 150: Lymphoplasmacytic Lymphoma - p. 805 181. Chapter 151: γ-Heavy Chain Disease - p. 811 182. Chapter 152: Monoclonal Gammopathy - p. 815 183. Chapter 153: Multiple Myeloma - p. 821 184. Chapter 154: Burkitt Lymphoma - p. 833 185. Chapter 155: Mantle Cell Lymphoma in Blood and Bone Marrow - p. 841 186. Chapter 156: Follicular Lymphoma in Blood and Bone Marrow - p. 845 187. Chapter 157: Marginal Zone Lymphoma in Blood and Bone Marrow - p. 849 188. Chapter 158: Intravascular Large B-Cell Lymphoma - p. 853 189. Chapter 159: Other Large B-Cell Lymphomas in Blood and Bone Marrow - p. 857 190. MATURE T-/NK-CELL NEOPLASMS - p. 859 191. Chapter 160: Overview and Classification of Mature T-/NK-Cell Neoplasms in Blood and Bone Marrow - p. 859 192. Chapter 161: T-Cell Prolymphocytic Leukemia - p. 863 193. Chapter 162: T-Cell Large Granular Lymphocytic Leukemia - p. 869 194. Chapter 163: Chronic Lymphoproliferative Disorder of NK Cells - p. 875 195. Chapter 164: Aggressive NK-Cell Leukemia - p. 877 196. Chapter 165: Adult T-Cell Leukemia - p. 881 197. Chapter 166: Sézary Syndrome - p. 883 198. Chapter 167: Anaplastic Large Cell Lymphoma in Blood and Bone Marrow - p. 889 199. Chapter 168: Angioimmunoblastic T-Cell Lymphoma in Blood and Bone Marrow - p. 895 200. Chapter 169: Other Mature T-Cell Lymphomas Involving Blood and Bone Marrow - p. 897 201. HODGKIN LYMPHOMA IN BONE MARROW - p. 901 202. Chapter 170: Classic Hodgkin and Nodular Lymphocyte-Predominant B-Cell Lymphomas in Bone Marrow - p. 901 203. SECTION 11: OTHER NEOPLASMS INVOLVING BONE MARROW - p. 907 204. Chapter 171: Langerhans Cell Histiocytosis in Bone Marrow - p. 907 205. Chapter 172: Posttransplant Lymphoproliferative Disorders in Bone Marrow - p. 913 206. Chapter 173: Metastatic Carcinoma and Sarcoma - p. 919 207. INDEX - p. 925
