This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of breast pathology, it incorporates the most recent clinical, pathological, radiological, staging, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Breast is a one-stop reference for accurate, complete surgical pathology evaluation—ideal as a day-to-day reference or as a reliable training resource.
Includes a wide range of new information on breast pathology, including material specific to core needle biopsies, to help you identify, diagnose, and manage disease
Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays
Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer
Features new chapters covering gene expression profiling; immunotherapy; the differential diagnosis for common histologic patterns; solid papillary carcinoma; acinic cell carcinoma; and intraoperative consultations, including a video showing how to process specimens with radioactive seeds
Offers expert guidance on evaluation of postneoadjuvant resection specimens, sentinel lymph nodes, and extent of disease and multifocality
Contains thousands of extensively annotated images, including gross pathology photographs, histopathology photomicrographs with a wide range of immunohistochemical stains, fluorescent in situ hybridization, and full-color illustrations
Features a templated, highly formatted design; concise, bulleted text; diagnostic pearls; key facts in each chapter; and an extensive index for easy reference
1. Chapter 56: Introduction: Prognostic and Predictive Factors - p. 401 2. Chapter 57: AJCC Breast Cancer Staging - p. 409 3. Chapter 58: Locally Advanced Breast Cancer - p. 417 4. Main Text - p. 417 5. Image Gallery - p. 419 6. ANATOMIC FACTORS - p. 421 7. Chapter 59: Locally Recurrent Carcinoma - p. 421 8. Chapter 60: Neoadjuvant Therapy - p. 427 9. Chapter 61: Histologic Grade - p. 437 10. Chapter 62: Lymph Node Metastases - p. 443 11. Chapter 63: Lymphovascular Invasion - p. 455 12. Chapter 64: Size and Multiple Foci - p. 463 13. MOLECULAR FACTORS - p. 467 14. Chapter 65: Hormone Receptors (ER/PR) - p. 467 15. Chapter 66: HER2 Evaluation - p. 477 16. Chapter 67: DNA Analysis - p. 491 17. Chapter 68: Circulating Tumor Cells and Circulating Tumor DNA - p. 495 18. Chapter 69: Immunotherapy: Markers - p. 499 19. Chapter 70: Expression Profiling, mRNA - p. 503 20. Chapter 71: Expression Profiling, Oncotype DX Assay - p. 509 21. Chapter 72: Expression Profiling, MammaPrint Assay - p. 513 22. Chapter 73: Expression Profiling, Prosigna (NanoString)/PAM50 - p. 515 23. Chapter 74: Expression Profiling, Protein - p. 517 24. Chapter 75: Expression Profiling, EndoPredict - p. 525 25. SECTION 8: STROMAL LESIONS - p. 527 26. Chapter 76: Fibroadenoma - p. 527 27. Chapter 77: Phyllodes Tumor - p. 537 28. Chapter 78: Pseudoangiomatous Stromal Hyperplasia - p. 547 29. Chapter 79: Myofibroblastoma - p. 551 30. Chapter 80: Lipoma and Angiolipoma - p. 559 31. Chapter 81: Diabetic Mastopathy/Lymphocytic Mastopathy - p. 563 32. Chapter 82: Granular Cell Tumor - p. 567 33. Chapter 83: Nodular Fasciitis - p. 573 34. Chapter 84: Fibromatosis - p. 579 35. Chapter 85: Hemangiomas - p. 587 36. Chapter 86: Papillary Endothelial Hyperplasia - p. 593 37. Chapter 87: Atypical Vascular Lesions of Skin - p. 595 38. Chapter 88: Angiosarcoma - p. 599 39. Chapter 89: Sarcomas - p. 609 40. SECTION 9: INFLAMMATORY LESIONS - p. 615 41. Chapter 90: Lactational Abscess - p. 615 42. Chapter 91: Nonlactational Abscess - p. 619 43. Chapter 92: Fat Necrosis - p. 627 44. Chapter 93: Duct Ectasia - p. 631 45. Chapter 94: Squamous Metaplasia of Lactiferous Ducts - p. 633 46. Chapter 95: Implant Pathology - p. 639 47. Chapter 96: Sarcoidosis - p. 647 48. Chapter 97: Amyloid of the Breast - p. 649 49. Chapter 98: Lupus Mastitis - p. 651 50. Chapter 99: IgG4-Related Sclerosing Mastitis - p. 653 51. SECTION 10: OTHER TYPES OF MALIGNANCIES - p. 657 52. Chapter 100: Metastases to Breast - p. 657 53. Chapter 101: Lymphoma - p. 665 54. SECTION 11: HEREDITARY BREAST DISEASE - p. 675 55. Chapter 102: Hereditary Breast Cancer - p. 675 56. Chapter 103: Germline Mutations Conferring Increased Risk of Breast Cancer: Tables - p. 685 57. Chapter 104: Breast/Ovarian Cancer Syndrome: BRCA1 - p. 687 58. Chapter 105: Breast/Ovarian Cancer Syndrome: BRCA2 - p. 693 59. Chapter 106: Li-Fraumeni Syndrome - p. 697 60. SECTION 12: UNUSUAL PRESENTATIONS OF BREAST LESIONS - p. 703 61. Chapter 107: Breast Carcinoma, Male - p. 703 62. Chapter 108: Iatrogenic Changes - p. 709 63. Index - p. 719
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of breast pathology, it incorporates the most recent clinical, pathological, radiological, staging, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Breast is a one-stop reference for accurate, complete surgical pathology evaluation—ideal as a day-to-day reference or as a reliable training resource.
Includes a wide range of new information on breast pathology, including material specific to core needle biopsies, to help you identify, diagnose, and manage disease
Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays
Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer
Features new chapters covering gene expression profiling; immunotherapy; the differential diagnosis for common histologic patterns; solid papillary carcinoma; acinic cell carcinoma; and intraoperative consultations, including a video showing how to process specimens with radioactive seeds
Offers expert guidance on evaluation of postneoadjuvant resection specimens, sentinel lymph nodes, and extent of disease and multifocality
Contains thousands of extensively annotated images, including gross pathology photographs, histopathology photomicrographs with a wide range of immunohistochemical stains, fluorescent in situ hybridization, and full-color illustrations
Features a templated, highly formatted design; concise, bulleted text; diagnostic pearls; key facts in each chapter; and an extensive index for easy reference
1. Chapter 56: Introduction: Prognostic and Predictive Factors - p. 401 2. Chapter 57: AJCC Breast Cancer Staging - p. 409 3. Chapter 58: Locally Advanced Breast Cancer - p. 417 4. Main Text - p. 417 5. Image Gallery - p. 419 6. ANATOMIC FACTORS - p. 421 7. Chapter 59: Locally Recurrent Carcinoma - p. 421 8. Chapter 60: Neoadjuvant Therapy - p. 427 9. Chapter 61: Histologic Grade - p. 437 10. Chapter 62: Lymph Node Metastases - p. 443 11. Chapter 63: Lymphovascular Invasion - p. 455 12. Chapter 64: Size and Multiple Foci - p. 463 13. MOLECULAR FACTORS - p. 467 14. Chapter 65: Hormone Receptors (ER/PR) - p. 467 15. Chapter 66: HER2 Evaluation - p. 477 16. Chapter 67: DNA Analysis - p. 491 17. Chapter 68: Circulating Tumor Cells and Circulating Tumor DNA - p. 495 18. Chapter 69: Immunotherapy: Markers - p. 499 19. Chapter 70: Expression Profiling, mRNA - p. 503 20. Chapter 71: Expression Profiling, Oncotype DX Assay - p. 509 21. Chapter 72: Expression Profiling, MammaPrint Assay - p. 513 22. Chapter 73: Expression Profiling, Prosigna (NanoString)/PAM50 - p. 515 23. Chapter 74: Expression Profiling, Protein - p. 517 24. Chapter 75: Expression Profiling, EndoPredict - p. 525 25. SECTION 8: STROMAL LESIONS - p. 527 26. Chapter 76: Fibroadenoma - p. 527 27. Chapter 77: Phyllodes Tumor - p. 537 28. Chapter 78: Pseudoangiomatous Stromal Hyperplasia - p. 547 29. Chapter 79: Myofibroblastoma - p. 551 30. Chapter 80: Lipoma and Angiolipoma - p. 559 31. Chapter 81: Diabetic Mastopathy/Lymphocytic Mastopathy - p. 563 32. Chapter 82: Granular Cell Tumor - p. 567 33. Chapter 83: Nodular Fasciitis - p. 573 34. Chapter 84: Fibromatosis - p. 579 35. Chapter 85: Hemangiomas - p. 587 36. Chapter 86: Papillary Endothelial Hyperplasia - p. 593 37. Chapter 87: Atypical Vascular Lesions of Skin - p. 595 38. Chapter 88: Angiosarcoma - p. 599 39. Chapter 89: Sarcomas - p. 609 40. SECTION 9: INFLAMMATORY LESIONS - p. 615 41. Chapter 90: Lactational Abscess - p. 615 42. Chapter 91: Nonlactational Abscess - p. 619 43. Chapter 92: Fat Necrosis - p. 627 44. Chapter 93: Duct Ectasia - p. 631 45. Chapter 94: Squamous Metaplasia of Lactiferous Ducts - p. 633 46. Chapter 95: Implant Pathology - p. 639 47. Chapter 96: Sarcoidosis - p. 647 48. Chapter 97: Amyloid of the Breast - p. 649 49. Chapter 98: Lupus Mastitis - p. 651 50. Chapter 99: IgG4-Related Sclerosing Mastitis - p. 653 51. SECTION 10: OTHER TYPES OF MALIGNANCIES - p. 657 52. Chapter 100: Metastases to Breast - p. 657 53. Chapter 101: Lymphoma - p. 665 54. SECTION 11: HEREDITARY BREAST DISEASE - p. 675 55. Chapter 102: Hereditary Breast Cancer - p. 675 56. Chapter 103: Germline Mutations Conferring Increased Risk of Breast Cancer: Tables - p. 685 57. Chapter 104: Breast/Ovarian Cancer Syndrome: BRCA1 - p. 687 58. Chapter 105: Breast/Ovarian Cancer Syndrome: BRCA2 - p. 693 59. Chapter 106: Li-Fraumeni Syndrome - p. 697 60. SECTION 12: UNUSUAL PRESENTATIONS OF BREAST LESIONS - p. 703 61. Chapter 107: Breast Carcinoma, Male - p. 703 62. Chapter 108: Iatrogenic Changes - p. 709 63. Index - p. 719
