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Diagnostic Pathology: Breast - EBook

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This expert volume in the Diagnostic Pathology series is not only an up-to-date, comprehensive diagnostic support tool for surgical pathologists, but also a valuable resource for all health care workers who provide care to patients with breast disease, including radiologists as well as surgical, medical, and radiation oncologists. An excellent point-of-care reference for practitioners at all levels of experience and training, the fourth edition of Diagnostic Pathology: Breast provides details on normal breast histology, information to assist in processing breast specimens, and multichapter sections on diagnostic patterns, benign lesions, carcinomas, predictive and prognostic factors, stromal lesions, inflammatory lesions, lymphomas, and hereditary breast disease. Richly illustrated and easy to use, this volume is a visually stunning, one-stop resource for day-to-day reference or as a reliable training resource.

  • Incorporates the most up-to-date scientific and technical knowledge, providing a comprehensive overview of all key issues relevant to today’s practice
  • Emphasizes the correlation of pathologic lesions with findings on breast imaging and provides guidance on the interpretation of core needle biopsies
  • Contains new overview chapters that lay the groundwork for initial evaluation and assistance with differential diagnosis, as well as new chapters on HER2-low breast carcinoma, immunohistochemical studies for diagnosis, proliferation, and more
  • Provides important updates throughout, covering the evaluation of ESR1, PIK3CA, AKT, and BRCA1 mutations to guide therapy; tumor-infiltrating lymphocytes and PD-L1 for treatment planning; HER2-low assessment to determine eligibility for antibody-drug conjugates; and much more
  • Features new animations and new videos to assist in understanding three-dimensional anatomy, radiologic-pathologic correlation, the processing of breast specimens, and the gross identification of breast lesions
  • Contains nearly 3,700 extensively annotated images, including gross pathology photographs, histopathology photomicrographs, a wide range of immunohistochemical stains, fluorescent in situ hybridization, breast-imaging studies, and full-color illustrations
  • Employs consistently templated chapters, bulleted content, key facts, annotated images, and an extensive index for quick, expert reference at the point of care
• Expanded Diagnostic Patterns section: new overview chapters with differential diagnoses to help guide pathologists • Updated Carcinomas section with new grouping of histologic types of invasive carcinomas with new chapters on molecular carcinomas such as Luminal, HER2 and basal/Triple Negative • Emphasis on new graphics that show breast cancers incidence by age and ethnic group, recurrence over time, metastatic patterns, and survival over time • Addition of videos for 4th ed (eBook): 10-12 videos that show excisions, margins and re-excisions, mastectomies, reduction mammoplasties, and intraoperative consultation techniques

1. Cover Image - p. Cover 2. Title Page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedications - p. iii 6. Preface - p. v 7. Acknowledgments - p. vii 8. Videos - p. ix 9. Sections - p. ix 10. Pathology Abbreviation Index - p. xi 11. List of Tables - p. xiii 12. Section 1: Normal Breast - p. xiii 13. Chapter 1: Histology of Normal Breast - p. xiii 14. Chapter 2: Breast Life Cycle Changes - p. 13 15. Section 2: Breast and Lymph Node Specimens, Processing - p. 19 16. Chapter 3: Breast Specimens Overview - p. 19 17. Chapter 4: Core Needle Biopsies - p. 27 18. Chapter 5: Excisions and Oncoplastic Surgery - p. 41 19. Chapter 6: Margins and Reexcisions - p. 47 20. Chapter 7: Mastectomies - p. 53 21. Chapter 8: Reduction Mammoplasties - p. 59 22. Chapter 9: Lymph Nodes - p. 63 23. Chapter 10: Intraoperative Consultation - p. 67 24. Section 3: Overview - p. 77 25. Chapter 11: Papillary Lesions - p. 77 26. Chapter 12: Spindle Cell Lesions - p. 89 27. Chapter 13: Small Tubular Proliferations - p. 97 28. Chapter 14: Epithelial/Myoepithelial Lesions - p. 107 29. Chapter 15: Vascular and Pseudovascular Lesions - p. 115 30. Chapter 16: Nipple Lesions - p. 119 31. Chapter 17: Iatrogenic Changes - p. 127 32. Chapter 18: Immunohistochemical Studies - p. 137 33. Section 4: Benign Changes - p. 149 34. Chapter 19: Nonproliferative Changes - p. 149 35. Chapter 20: Columnar Cell Change, Columnar Cell Hyperplasia, and Flat Epithelial Atypia - p. 155 36. Chapter 21: Usual Ductal Hyperplasia - p. 161 37. Chapter 22: Sclerosing Adenosis - p. 165 38. Chapter 23: Radial Sclerosing Lesion/Radial Scar - p. 173 39. Chapter 24: Papilloma, Large Duct and Small Duct - p. 179 40. Chapter 25: Nipple Adenoma - p. 187 41. Chapter 26: Mucocele-Like Lesions - p. 193 42. Chapter 27: Collagenous Spherulosis - p. 197 43. Chapter 28: Juvenile Papillomatosis - p. 201 44. Chapter 29: Gynecomastia in Men and Gynecomastia-Like Changes in Women - p. 203 45. Chapter 30: Mammary Hamartoma (Fibroadenolipoma) - p. 207 46. Chapter 31: Syringomatous Tumor of the Nipple - p. 211 47. Chapter 32: Adenomyoepithelioma - p. 217 48. Chapter 33: Cystic Hypersecretory Lesions - p. 225 49. Chapter 34: Microglandular Adenosis - p. 227 50. Chapter 35: Atypical Ductal Hyperplasia - p. 235 51. Chapter 36: Atypical Lobular Hyperplasia - p. 243 52. Section 5: Carcinomas - p. 249 53. Risk Factors for Developing Carcinoma - p. 249 54. Chapter 37: Overview of Risk Factors for Developing Breast Carcinoma - p. 249 55. Chapter 38: Benign Breast Disease as a Risk Factor for Developing Breast Carcinoma - p. 257 56. Carcinoma In Situ - p. 263 57. Chapter 39: Lobular Carcinoma In Situ - p. 263 58. Chapter 40: Ductal Carcinoma In Situ - p. 273 59. Chapter 41: Ductal Carcinoma In Situ, Paget Disease - p. 287 60. Special Papillary Carcinomas - p. 297 61. Chapter 42: Encapsulated Papillary Carcinoma - p. 297 62. Chapter 43: Solid Papillary Carcinoma - p. 303 63. Invasive Carcinoma - p. 309 64. Chapter 44: Invasive Carcinoma: Histologic and Molecular Classifications - p. 309 65. Chapter 45: Male Breast Carcinoma - p. 315 66. Histologic Types - p. 319 67. Chapter 46: Invasive Breast Carcinoma of no Special Type - p. 319 68. Chapter 47: Microinvasive Carcinoma - p. 327 69. Chapter 48: Invasive Lobular Carcinoma - p. 333 70. Chapter 49: Invasive Tubular Carcinoma and Invasive Cribriform Carcinoma - p. 345 71. Chapter 50: Invasive Mucinous (Colloid) Carcinoma - p. 353 72. Chapter 51: Invasive Papillary Carcinoma - p. 363 73. Chapter 52: Invasive Micropapillary Carcinoma - p. 365 74. Chapter 53: Invasive Apocrine Carcinoma - p. 373 75. Chapter 54: Invasive Neuroendocrine Carcinoma - p. 379 76. Chapter 55: Invasive Carcinoma with Osteoclast-Like Giant Cells - p. 387 77. Chapter 56: Metaplastic Breast Carcinoma - p. 389 78. Chapter 57: Adenoid Cystic Carcinoma - p. 401 79. Chapter 58: Secretory Carcinoma - p. 413 80. Molecular Types - p. 419 81. Chapter 59: Luminal Breast Carcinoma (ER Positive/HER2 Negative) - p. 419 82. Chapter 60: HER2-Positive Breast Carcinoma - p. 423 83. Chapter 61: Triple Negative Breast Carcinoma and Basal-Like Breast Carcinoma - p. 433 84. Section 6: Prognostic and Predictive Factors - p. 443 85. Chapter 62: Overview of Prognostic and Predictive Factors - p. 443 86. Chapter 63: AJCC Breast Cancer Staging - p. 451 87. Anatomic Factors - p. 459 88. Chapter 64: Histologic Grade - p. 459 89. Chapter 65: Size and Multiple Foci - p. 465 90. Chapter 66: Lymphovascular Invasion - p. 469 91. Chapter 67: Inflammatory Carcinoma - p. 477 92. Chapter 68: Locally Advanced Carcinoma - p. 483 93. Chapter 69: Lymph Node Metastases - p. 487 94. Chapter 70: Response to Neoadjuvant Therapy - p. 497 95. Chapter 71: Locally Recurrent Carcinoma - p. 507 96. Chapter 72: Carcinoma with Extensive Intraductal Component - p. 513 97. Molecular Factors - p. 517 98. Chapter 73: Hormone Receptors (ER/PR/AR) - p. 517 99. Chapter 74: HER2 - p. 527 100. Chapter 75: HER2-Low Breast Carcinoma - p. 541 101. Chapter 76: Proliferation - p. 545 102. Chapter 77: DNA Analysis and Gene Copy Number Alterations - p. 549 103. Chapter 78: Circulating Tumor Cells, Circulating Tumor DNA, and Next-Generation Sequencing - p. 553 104. Chapter 79: Immunotherapy - p. 559 105. Chapter 80: Expression Profiling, mRNA: Overview - p. 565 106. Chapter 81: Expression Profiling: Oncotype DX Assay - p. 571 107. Chapter 82: Expression Profiling: MammaPrint Assay - p. 575 108. Chapter 83: Expression Profiling: Prosigna - p. 577 109. Chapter 84: Expression Profiling: EndoPredict - p. 579 110. Chapter 85: Expression Profiling: Protein - p. 581 111. Section 7: Stromal Lesions - p. 585 112. Chapter 86: Pseudoangiomatous Stromal Hyperplasia - p. 585 113. Chapter 87: Nodular Fasciitis - p. 591 114. Chapter 88: Fibromatosis - p. 597 115. Chapter 89: Myofibroblastoma - p. 605 116. Chapter 90: Lipoma and Angiolipoma - p. 613 117. Chapter 91: Fibroadenoma - p. 617 118. Chapter 92: Phyllodes Tumor - p. 625 119. Chapter 93: Granular Cell Tumor - p. 635 120. Chapter 94: Papillary Endothelial Hyperplasia - p. 641 121. Chapter 95: Hemangiomas - p. 643 122. Chapter 96: Atypical Vascular Lesions: Post Radiation - p. 649 123. Chapter 97: Angiosarcoma - p. 653 124. Chapter 98: Sarcomas - p. 663 125. Section 8: Inflammatory Lesions - p. 669 126. Chapter 99: Lactational Abscess - p. 669 127. Chapter 100: Nonlactational Abscess - p. 673 128. Chapter 101: Squamous Metaplasia of Lactiferous Ducts - p. 681 129. Chapter 102: Fat Necrosis - p. 687 130. Chapter 103: Duct Ectasia - p. 691 131. Chapter 104: Sarcoidosis - p. 693 132. Chapter 105: Amyloid of the Breast - p. 695 133. Chapter 106: Lupus Mastitis - p. 697 134. Chapter 107: IgG4-Related Sclerosing Mastitis - p. 699 135. Chapter 108: Lymphocytic Lobulitis/Mastopathy - p. 703 136. Chapter 109: Implant Pathology - p. 707 137. Section 9: Other Types of Malignancies - p. 715 138. Chapter 110: Hematolymphoid Tumors - p. 715 139. Chapter 111: Metastases to Breast - p. 727 140. Section 10: Hereditary Breast Disease - p. 733 141. Chapter 112: Overview of Hereditary Breast Cancer - p. 733 142. Chapter 113: Table of Germline Mutations - p. 743 143. Chapter 114: BRCA1: Hereditary Breast and Ovarian Cancer Syndrome 1 - p. 745 144. Chapter 115: BRCA2: Hereditary Breast and Ovarian Cancer Syndrome 2 - p. 751 145. Chapter 116: TP53: Li-Fraumeni Syndrome - p. 755 146. Index - p. 761

Descripcion
Descripción

This expert volume in the Diagnostic Pathology series is not only an up-to-date, comprehensive diagnostic support tool for surgical pathologists, but also a valuable resource for all health care workers who provide care to patients with breast disease, including radiologists as well as surgical, medical, and radiation oncologists. An excellent point-of-care reference for practitioners at all levels of experience and training, the fourth edition of Diagnostic Pathology: Breast provides details on normal breast histology, information to assist in processing breast specimens, and multichapter sections on diagnostic patterns, benign lesions, carcinomas, predictive and prognostic factors, stromal lesions, inflammatory lesions, lymphomas, and hereditary breast disease. Richly illustrated and easy to use, this volume is a visually stunning, one-stop resource for day-to-day reference or as a reliable training resource.

  • Incorporates the most up-to-date scientific and technical knowledge, providing a comprehensive overview of all key issues relevant to today’s practice
  • Emphasizes the correlation of pathologic lesions with findings on breast imaging and provides guidance on the interpretation of core needle biopsies
  • Contains new overview chapters that lay the groundwork for initial evaluation and assistance with differential diagnosis, as well as new chapters on HER2-low breast carcinoma, immunohistochemical studies for diagnosis, proliferation, and more
  • Provides important updates throughout, covering the evaluation of ESR1, PIK3CA, AKT, and BRCA1 mutations to guide therapy; tumor-infiltrating lymphocytes and PD-L1 for treatment planning; HER2-low assessment to determine eligibility for antibody-drug conjugates; and much more
  • Features new animations and new videos to assist in understanding three-dimensional anatomy, radiologic-pathologic correlation, the processing of breast specimens, and the gross identification of breast lesions
  • Contains nearly 3,700 extensively annotated images, including gross pathology photographs, histopathology photomicrographs, a wide range of immunohistochemical stains, fluorescent in situ hybridization, breast-imaging studies, and full-color illustrations
  • Employs consistently templated chapters, bulleted content, key facts, annotated images, and an extensive index for quick, expert reference at the point of care
• Expanded Diagnostic Patterns section: new overview chapters with differential diagnoses to help guide pathologists • Updated Carcinomas section with new grouping of histologic types of invasive carcinomas with new chapters on molecular carcinomas such as Luminal, HER2 and basal/Triple Negative • Emphasis on new graphics that show breast cancers incidence by age and ethnic group, recurrence over time, metastatic patterns, and survival over time • Addition of videos for 4th ed (eBook): 10-12 videos that show excisions, margins and re-excisions, mastectomies, reduction mammoplasties, and intraoperative consultation techniques

1. Cover Image - p. Cover 2. Title Page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedications - p. iii 6. Preface - p. v 7. Acknowledgments - p. vii 8. Videos - p. ix 9. Sections - p. ix 10. Pathology Abbreviation Index - p. xi 11. List of Tables - p. xiii 12. Section 1: Normal Breast - p. xiii 13. Chapter 1: Histology of Normal Breast - p. xiii 14. Chapter 2: Breast Life Cycle Changes - p. 13 15. Section 2: Breast and Lymph Node Specimens, Processing - p. 19 16. Chapter 3: Breast Specimens Overview - p. 19 17. Chapter 4: Core Needle Biopsies - p. 27 18. Chapter 5: Excisions and Oncoplastic Surgery - p. 41 19. Chapter 6: Margins and Reexcisions - p. 47 20. Chapter 7: Mastectomies - p. 53 21. Chapter 8: Reduction Mammoplasties - p. 59 22. Chapter 9: Lymph Nodes - p. 63 23. Chapter 10: Intraoperative Consultation - p. 67 24. Section 3: Overview - p. 77 25. Chapter 11: Papillary Lesions - p. 77 26. Chapter 12: Spindle Cell Lesions - p. 89 27. Chapter 13: Small Tubular Proliferations - p. 97 28. Chapter 14: Epithelial/Myoepithelial Lesions - p. 107 29. Chapter 15: Vascular and Pseudovascular Lesions - p. 115 30. Chapter 16: Nipple Lesions - p. 119 31. Chapter 17: Iatrogenic Changes - p. 127 32. Chapter 18: Immunohistochemical Studies - p. 137 33. Section 4: Benign Changes - p. 149 34. Chapter 19: Nonproliferative Changes - p. 149 35. Chapter 20: Columnar Cell Change, Columnar Cell Hyperplasia, and Flat Epithelial Atypia - p. 155 36. Chapter 21: Usual Ductal Hyperplasia - p. 161 37. Chapter 22: Sclerosing Adenosis - p. 165 38. Chapter 23: Radial Sclerosing Lesion/Radial Scar - p. 173 39. Chapter 24: Papilloma, Large Duct and Small Duct - p. 179 40. Chapter 25: Nipple Adenoma - p. 187 41. Chapter 26: Mucocele-Like Lesions - p. 193 42. Chapter 27: Collagenous Spherulosis - p. 197 43. Chapter 28: Juvenile Papillomatosis - p. 201 44. Chapter 29: Gynecomastia in Men and Gynecomastia-Like Changes in Women - p. 203 45. Chapter 30: Mammary Hamartoma (Fibroadenolipoma) - p. 207 46. Chapter 31: Syringomatous Tumor of the Nipple - p. 211 47. Chapter 32: Adenomyoepithelioma - p. 217 48. Chapter 33: Cystic Hypersecretory Lesions - p. 225 49. Chapter 34: Microglandular Adenosis - p. 227 50. Chapter 35: Atypical Ductal Hyperplasia - p. 235 51. Chapter 36: Atypical Lobular Hyperplasia - p. 243 52. Section 5: Carcinomas - p. 249 53. Risk Factors for Developing Carcinoma - p. 249 54. Chapter 37: Overview of Risk Factors for Developing Breast Carcinoma - p. 249 55. Chapter 38: Benign Breast Disease as a Risk Factor for Developing Breast Carcinoma - p. 257 56. Carcinoma In Situ - p. 263 57. Chapter 39: Lobular Carcinoma In Situ - p. 263 58. Chapter 40: Ductal Carcinoma In Situ - p. 273 59. Chapter 41: Ductal Carcinoma In Situ, Paget Disease - p. 287 60. Special Papillary Carcinomas - p. 297 61. Chapter 42: Encapsulated Papillary Carcinoma - p. 297 62. Chapter 43: Solid Papillary Carcinoma - p. 303 63. Invasive Carcinoma - p. 309 64. Chapter 44: Invasive Carcinoma: Histologic and Molecular Classifications - p. 309 65. Chapter 45: Male Breast Carcinoma - p. 315 66. Histologic Types - p. 319 67. Chapter 46: Invasive Breast Carcinoma of no Special Type - p. 319 68. Chapter 47: Microinvasive Carcinoma - p. 327 69. Chapter 48: Invasive Lobular Carcinoma - p. 333 70. Chapter 49: Invasive Tubular Carcinoma and Invasive Cribriform Carcinoma - p. 345 71. Chapter 50: Invasive Mucinous (Colloid) Carcinoma - p. 353 72. Chapter 51: Invasive Papillary Carcinoma - p. 363 73. Chapter 52: Invasive Micropapillary Carcinoma - p. 365 74. Chapter 53: Invasive Apocrine Carcinoma - p. 373 75. Chapter 54: Invasive Neuroendocrine Carcinoma - p. 379 76. Chapter 55: Invasive Carcinoma with Osteoclast-Like Giant Cells - p. 387 77. Chapter 56: Metaplastic Breast Carcinoma - p. 389 78. Chapter 57: Adenoid Cystic Carcinoma - p. 401 79. Chapter 58: Secretory Carcinoma - p. 413 80. Molecular Types - p. 419 81. Chapter 59: Luminal Breast Carcinoma (ER Positive/HER2 Negative) - p. 419 82. Chapter 60: HER2-Positive Breast Carcinoma - p. 423 83. Chapter 61: Triple Negative Breast Carcinoma and Basal-Like Breast Carcinoma - p. 433 84. Section 6: Prognostic and Predictive Factors - p. 443 85. Chapter 62: Overview of Prognostic and Predictive Factors - p. 443 86. Chapter 63: AJCC Breast Cancer Staging - p. 451 87. Anatomic Factors - p. 459 88. Chapter 64: Histologic Grade - p. 459 89. Chapter 65: Size and Multiple Foci - p. 465 90. Chapter 66: Lymphovascular Invasion - p. 469 91. Chapter 67: Inflammatory Carcinoma - p. 477 92. Chapter 68: Locally Advanced Carcinoma - p. 483 93. Chapter 69: Lymph Node Metastases - p. 487 94. Chapter 70: Response to Neoadjuvant Therapy - p. 497 95. Chapter 71: Locally Recurrent Carcinoma - p. 507 96. Chapter 72: Carcinoma with Extensive Intraductal Component - p. 513 97. Molecular Factors - p. 517 98. Chapter 73: Hormone Receptors (ER/PR/AR) - p. 517 99. Chapter 74: HER2 - p. 527 100. Chapter 75: HER2-Low Breast Carcinoma - p. 541 101. Chapter 76: Proliferation - p. 545 102. Chapter 77: DNA Analysis and Gene Copy Number Alterations - p. 549 103. Chapter 78: Circulating Tumor Cells, Circulating Tumor DNA, and Next-Generation Sequencing - p. 553 104. Chapter 79: Immunotherapy - p. 559 105. Chapter 80: Expression Profiling, mRNA: Overview - p. 565 106. Chapter 81: Expression Profiling: Oncotype DX Assay - p. 571 107. Chapter 82: Expression Profiling: MammaPrint Assay - p. 575 108. Chapter 83: Expression Profiling: Prosigna - p. 577 109. Chapter 84: Expression Profiling: EndoPredict - p. 579 110. Chapter 85: Expression Profiling: Protein - p. 581 111. Section 7: Stromal Lesions - p. 585 112. Chapter 86: Pseudoangiomatous Stromal Hyperplasia - p. 585 113. Chapter 87: Nodular Fasciitis - p. 591 114. Chapter 88: Fibromatosis - p. 597 115. Chapter 89: Myofibroblastoma - p. 605 116. Chapter 90: Lipoma and Angiolipoma - p. 613 117. Chapter 91: Fibroadenoma - p. 617 118. Chapter 92: Phyllodes Tumor - p. 625 119. Chapter 93: Granular Cell Tumor - p. 635 120. Chapter 94: Papillary Endothelial Hyperplasia - p. 641 121. Chapter 95: Hemangiomas - p. 643 122. Chapter 96: Atypical Vascular Lesions: Post Radiation - p. 649 123. Chapter 97: Angiosarcoma - p. 653 124. Chapter 98: Sarcomas - p. 663 125. Section 8: Inflammatory Lesions - p. 669 126. Chapter 99: Lactational Abscess - p. 669 127. Chapter 100: Nonlactational Abscess - p. 673 128. Chapter 101: Squamous Metaplasia of Lactiferous Ducts - p. 681 129. Chapter 102: Fat Necrosis - p. 687 130. Chapter 103: Duct Ectasia - p. 691 131. Chapter 104: Sarcoidosis - p. 693 132. Chapter 105: Amyloid of the Breast - p. 695 133. Chapter 106: Lupus Mastitis - p. 697 134. Chapter 107: IgG4-Related Sclerosing Mastitis - p. 699 135. Chapter 108: Lymphocytic Lobulitis/Mastopathy - p. 703 136. Chapter 109: Implant Pathology - p. 707 137. Section 9: Other Types of Malignancies - p. 715 138. Chapter 110: Hematolymphoid Tumors - p. 715 139. Chapter 111: Metastases to Breast - p. 727 140. Section 10: Hereditary Breast Disease - p. 733 141. Chapter 112: Overview of Hereditary Breast Cancer - p. 733 142. Chapter 113: Table of Germline Mutations - p. 743 143. Chapter 114: BRCA1: Hereditary Breast and Ovarian Cancer Syndrome 1 - p. 745 144. Chapter 115: BRCA2: Hereditary Breast and Ovarian Cancer Syndrome 2 - p. 751 145. Chapter 116: TP53: Li-Fraumeni Syndrome - p. 755 146. Index - p. 761

Indice
Autores
Muestra
Ficha Técnica