This expert volume in the Diagnostic Pathology series is not only an up-to-date, comprehensive diagnostic support tool for surgical pathologists, but also a valuable resource for all health care workers who provide care to patients with breast disease, including radiologists as well as surgical, medical, and radiation oncologists. An excellent point-of-care reference for practitioners at all levels of experience and training, the fourth edition of Diagnostic Pathology: Breast, Fourth Edition provides details on normal breast histology, information to assist in processing breast specimens, and multichapter sections on diagnostic patterns, benign lesions, carcinomas, predictive and prognostic factors, stromal lesions, inflammatory lesions, lymphomas, and hereditary breast disease. Richly illustrated and easy to use, this volume is ideal as a one-stop resource for day-to-day reference or as a reliable training resource.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. DEDICATIONS - p. iii 6. PREFACE - p. v 7. ACKNOWLEDGMENTS - p. vii 8. SECTIONS - p. ix 9. PATHOLOGY ABBREVIATION INDEX - p. xi 10. List of Tables - p. xiii 11. SECTION 1: NORMAL BREAST - p. xiii 12. Chapter 1: Histology of Normal Breast - p. xiii 13. Chapter 2: Breast Life Cycle Changes - p. 13 14. SECTION 2: BREAST AND LYMPH NODE SPECIMENS, PROCESSING - p. 19 15. Chapter 3: Breast Specimens Overview - p. 19 16. Chapter 4: Core Needle Biopsies - p. 27 17. Chapter 5: Excisions and Oncoplastic Surgery - p. 41 18. Chapter 6: Margins and Reexcisions - p. 47 19. Chapter 7: Mastectomies - p. 53 20. Chapter 8: Reduction Mammoplasties - p. 59 21. Chapter 9: Lymph Nodes - p. 63 22. Chapter 10: Intraoperative Consultation - p. 67 23. SECTION 3: OVERVIEW - p. 77 24. Chapter 11: Papillary Lesions - p. 77 25. Chapter 12: Spindle Cell Lesions - p. 89 26. Chapter 13: Small Tubular Proliferations - p. 97 27. Chapter 14: Epithelial/Myoepithelial Lesions - p. 107 28. Chapter 15: Vascular and Pseudovascular Lesions - p. 115 29. Chapter 16: Nipple Lesions - p. 119 30. Chapter 17: Iatrogenic Changes - p. 127 31. Chapter 18: Immunohistochemical Studies - p. 137 32. SECTION 4: BENIGN CHANGES - p. 149 33. Chapter 19: Nonproliferative Changes - p. 149 34. Chapter 20: Columnar Cell Change, Columnar Cell Hyperplasia, and Flat Epithelial Atypia - p. 155 35. Chapter 21: Usual Ductal Hyperplasia - p. 161 36. Chapter 22: Sclerosing Adenosis - p. 165 37. Chapter 23: Radial Sclerosing Lesion/Radial Scar - p. 173 38. Chapter 24: Papilloma, Large Duct and Small Duct - p. 179 39. Chapter 25: Nipple Adenoma - p. 187 40. Chapter 26: Mucocele-Like Lesions - p. 193 41. Chapter 27: Collagenous Spherulosis - p. 197 42. Chapter 28: Juvenile Papillomatosis - p. 201 43. Chapter 29: Gynecomastia in Men and Gynecomastia-Like Changes in Women - p. 203 44. Chapter 30: Mammary Hamartoma (Fibroadenolipoma) - p. 207 45. Chapter 31: Syringomatous Tumor of the Nipple - p. 211 46. Chapter 32: Adenomyoepithelioma - p. 217 47. Chapter 33: Cystic Hypersecretory Lesions - p. 225 48. Chapter 34: Microglandular Adenosis - p. 227 49. Chapter 35: Atypical Ductal Hyperplasia - p. 235 50. Chapter 36: Atypical Lobular Hyperplasia - p. 243 51. SECTION 5: CARCINOMAS - p. 249 52. RISK FACTORS FOR DEVELOPING CARCINOMA - p. 249 53. Chapter 37: Overview of Risk Factors for Developing Breast Carcinoma - p. 249 54. Chapter 38: Benign Breast Disease as a Risk Factor for Developing Breast Carcinoma - p. 257 55. CARCINOMA IN SITU - p. 263 56. Chapter 39: Lobular Carcinoma In Situ - p. 263 57. Chapter 40: Ductal Carcinoma In Situ - p. 273 58. Chapter 41: Ductal Carcinoma In Situ, Paget Disease - p. 287 59. SPECIAL PAPILLARY CARCINOMAS - p. 297 60. Chapter 42: Encapsulated Papillary Carcinoma - p. 297 61. Chapter 43: Solid Papillary Carcinoma - p. 303 62. INVASIVE CARCINOMA - p. 309 63. Chapter 44: Invasive Carcinoma: Histologic and Molecular Classifications - p. 309 64. Chapter 45: Male Breast Carcinoma - p. 315 65. HISTOLOGIC TYPES - p. 319 66. Chapter 46: Invasive Breast Carcinoma of No Special Type - p. 319 67. Chapter 47: Microinvasive Carcinoma - p. 327 68. Chapter 48: Invasive Lobular Carcinoma - p. 333 69. Chapter 49: Invasive Tubular Carcinoma and Invasive Cribriform Carcinoma - p. 345 70. Chapter 50: Invasive Mucinous (Colloid) Carcinoma - p. 353 71. Chapter 51: Invasive Papillary Carcinoma - p. 363 72. Chapter 52: Invasive Micropapillary Carcinoma - p. 365 73. Chapter 53: Invasive Apocrine Carcinoma - p. 373 74. Chapter 54: Invasive Neuroendocrine Carcinoma - p. 379 75. Chapter 55: Invasive Carcinoma With Osteoclast-Like Giant Cells - p. 387 76. Chapter 56: Metaplastic Breast Carcinoma - p. 389 77. Chapter 57: Adenoid Cystic Carcinoma - p. 401 78. Chapter 58: Secretory Carcinoma - p. 413 79. MOLECULAR TYPES - p. 419 80. Chapter 59: Luminal Breast Carcinoma (ER Positive/HER2 Negative) - p. 419 81. Chapter 60: HER2-Positive Breast Carcinoma - p. 423 82. Chapter 61: Triple Negative Breast Carcinoma and Basal-Like Breast Carcinoma - p. 433 83. SECTION 6: PROGNOSTIC AND PREDICTIVE FACTORS - p. 443 84. Chapter 62: Overview of Prognostic and Predictive Factors - p. 443 85. Chapter 63: AJCC Breast Cancer Staging - p. 451 86. ANATOMIC FACTORS - p. 459 87. Chapter 64: Histologic Grade - p. 459 88. Chapter 65: Size and Multiple Foci - p. 465 89. Chapter 66: Lymphovascular Invasion - p. 469 90. Chapter 67: Inflammatory Carcinoma - p. 477 91. Chapter 68: Locally Advanced Carcinoma - p. 483 92. Chapter 69: Lymph Node Metastases - p. 487 93. Chapter 70: Response to Neoadjuvant Therapy - p. 497 94. Chapter 71: Locally Recurrent Carcinoma - p. 507 95. Chapter 72: Carcinoma With Extensive Intraductal Component - p. 513 96. MOLECULAR FACTORS - p. 517 97. Chapter 73: Hormone Receptors (ER/PR/AR) - p. 517 98. Chapter 74: HER2 - p. 527 99. Chapter 75: HER2-Low Breast Carcinoma - p. 541 100. Chapter 76: Proliferation - p. 545 101. Chapter 77: DNA Analysis and Gene Copy Number Alterations - p. 549 102. Chapter 78: Circulating Tumor Cells, Circulating Tumor DNA, and Next-Generation Sequencing - p. 553 103. Chapter 79: Immunotherapy - p. 559 104. Chapter 80: Expression Profiling, mRNA: Overview - p. 565 105. Chapter 81: Expression Profiling: Oncotype DX Assay - p. 571 106. Chapter 82: Expression Profiling: MammaPrint Assay - p. 575 107. Chapter 83: Expression Profiling: Prosigna - p. 577 108. Chapter 84: Expression Profiling: EndoPredict - p. 579 109. Chapter 85: Expression Profiling: Protein - p. 581 110. SECTION 7: STROMAL LESIONS - p. 585 111. Chapter 86: Pseudoangiomatous Stromal Hyperplasia - p. 585 112. Chapter 87: Nodular Fasciitis - p. 591 113. Chapter 88: Fibromatosis - p. 597 114. Chapter 89: Myofibroblastoma - p. 605 115. Chapter 90: Lipoma and Angiolipoma - p. 613 116. Chapter 91: Fibroadenoma - p. 617 117. Chapter 92: Phyllodes Tumor - p. 625 118. Chapter 93: Granular Cell Tumor - p. 635 119. Chapter 94: Papillary Endothelial Hyperplasia - p. 641 120. Chapter 95: Hemangiomas - p. 643 121. Chapter 96: Atypical Vascular Lesions: Post Radiation - p. 649 122. Chapter 97: Angiosarcoma - p. 653 123. Chapter 98: Sarcomas - p. 663 124. SECTION 8: INFLAMMATORY LESIONS - p. 669 125. Chapter 99: Lactational Abscess - p. 669 126. Chapter 100: Nonlactational Abscess - p. 673 127. Chapter 101: Squamous Metaplasia of Lactiferous Ducts - p. 681 128. Chapter 102: Fat Necrosis - p. 687 129. Chapter 103: Duct Ectasia - p. 691 130. Chapter 104: Sarcoidosis - p. 693 131. Chapter 105: Amyloid of the Breast - p. 695 132. Chapter 106: Lupus Mastitis - p. 697 133. Chapter 107: IgG4-Related Sclerosing Mastitis - p. 699 134. Chapter 108: Lymphocytic Lobulitis/Mastopathy - p. 703 135. Chapter 109: Implant Pathology - p. 707 136. SECTION 9: OTHER TYPES OF MALIGNANCIES - p. 715 137. Chapter 110: Hematolymphoid Tumors - p. 715 138. Chapter 111: Metastases to Breast - p. 727 139. SECTION 10: HEREDITARY BREAST DISEASE - p. 733 140. Chapter 112: Overview of Hereditary Breast Cancer - p. 733 141. Chapter 113: Table of Germline Mutations - p. 743 142. Chapter 114: BRCA1: Hereditary Breast and Ovarian Cancer Syndrome 1 - p. 745 143. Chapter 115: BRCA2: Hereditary Breast and Ovarian Cancer Syndrome 2 - p. 751 144. Chapter 116: TP53: Li-Fraumeni Syndrome - p. 755 145. INDEX - p. 761
This expert volume in the Diagnostic Pathology series is not only an up-to-date, comprehensive diagnostic support tool for surgical pathologists, but also a valuable resource for all health care workers who provide care to patients with breast disease, including radiologists as well as surgical, medical, and radiation oncologists. An excellent point-of-care reference for practitioners at all levels of experience and training, the fourth edition of Diagnostic Pathology: Breast, Fourth Edition provides details on normal breast histology, information to assist in processing breast specimens, and multichapter sections on diagnostic patterns, benign lesions, carcinomas, predictive and prognostic factors, stromal lesions, inflammatory lesions, lymphomas, and hereditary breast disease. Richly illustrated and easy to use, this volume is ideal as a one-stop resource for day-to-day reference or as a reliable training resource.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. DEDICATIONS - p. iii 6. PREFACE - p. v 7. ACKNOWLEDGMENTS - p. vii 8. SECTIONS - p. ix 9. PATHOLOGY ABBREVIATION INDEX - p. xi 10. List of Tables - p. xiii 11. SECTION 1: NORMAL BREAST - p. xiii 12. Chapter 1: Histology of Normal Breast - p. xiii 13. Chapter 2: Breast Life Cycle Changes - p. 13 14. SECTION 2: BREAST AND LYMPH NODE SPECIMENS, PROCESSING - p. 19 15. Chapter 3: Breast Specimens Overview - p. 19 16. Chapter 4: Core Needle Biopsies - p. 27 17. Chapter 5: Excisions and Oncoplastic Surgery - p. 41 18. Chapter 6: Margins and Reexcisions - p. 47 19. Chapter 7: Mastectomies - p. 53 20. Chapter 8: Reduction Mammoplasties - p. 59 21. Chapter 9: Lymph Nodes - p. 63 22. Chapter 10: Intraoperative Consultation - p. 67 23. SECTION 3: OVERVIEW - p. 77 24. Chapter 11: Papillary Lesions - p. 77 25. Chapter 12: Spindle Cell Lesions - p. 89 26. Chapter 13: Small Tubular Proliferations - p. 97 27. Chapter 14: Epithelial/Myoepithelial Lesions - p. 107 28. Chapter 15: Vascular and Pseudovascular Lesions - p. 115 29. Chapter 16: Nipple Lesions - p. 119 30. Chapter 17: Iatrogenic Changes - p. 127 31. Chapter 18: Immunohistochemical Studies - p. 137 32. SECTION 4: BENIGN CHANGES - p. 149 33. Chapter 19: Nonproliferative Changes - p. 149 34. Chapter 20: Columnar Cell Change, Columnar Cell Hyperplasia, and Flat Epithelial Atypia - p. 155 35. Chapter 21: Usual Ductal Hyperplasia - p. 161 36. Chapter 22: Sclerosing Adenosis - p. 165 37. Chapter 23: Radial Sclerosing Lesion/Radial Scar - p. 173 38. Chapter 24: Papilloma, Large Duct and Small Duct - p. 179 39. Chapter 25: Nipple Adenoma - p. 187 40. Chapter 26: Mucocele-Like Lesions - p. 193 41. Chapter 27: Collagenous Spherulosis - p. 197 42. Chapter 28: Juvenile Papillomatosis - p. 201 43. Chapter 29: Gynecomastia in Men and Gynecomastia-Like Changes in Women - p. 203 44. Chapter 30: Mammary Hamartoma (Fibroadenolipoma) - p. 207 45. Chapter 31: Syringomatous Tumor of the Nipple - p. 211 46. Chapter 32: Adenomyoepithelioma - p. 217 47. Chapter 33: Cystic Hypersecretory Lesions - p. 225 48. Chapter 34: Microglandular Adenosis - p. 227 49. Chapter 35: Atypical Ductal Hyperplasia - p. 235 50. Chapter 36: Atypical Lobular Hyperplasia - p. 243 51. SECTION 5: CARCINOMAS - p. 249 52. RISK FACTORS FOR DEVELOPING CARCINOMA - p. 249 53. Chapter 37: Overview of Risk Factors for Developing Breast Carcinoma - p. 249 54. Chapter 38: Benign Breast Disease as a Risk Factor for Developing Breast Carcinoma - p. 257 55. CARCINOMA IN SITU - p. 263 56. Chapter 39: Lobular Carcinoma In Situ - p. 263 57. Chapter 40: Ductal Carcinoma In Situ - p. 273 58. Chapter 41: Ductal Carcinoma In Situ, Paget Disease - p. 287 59. SPECIAL PAPILLARY CARCINOMAS - p. 297 60. Chapter 42: Encapsulated Papillary Carcinoma - p. 297 61. Chapter 43: Solid Papillary Carcinoma - p. 303 62. INVASIVE CARCINOMA - p. 309 63. Chapter 44: Invasive Carcinoma: Histologic and Molecular Classifications - p. 309 64. Chapter 45: Male Breast Carcinoma - p. 315 65. HISTOLOGIC TYPES - p. 319 66. Chapter 46: Invasive Breast Carcinoma of No Special Type - p. 319 67. Chapter 47: Microinvasive Carcinoma - p. 327 68. Chapter 48: Invasive Lobular Carcinoma - p. 333 69. Chapter 49: Invasive Tubular Carcinoma and Invasive Cribriform Carcinoma - p. 345 70. Chapter 50: Invasive Mucinous (Colloid) Carcinoma - p. 353 71. Chapter 51: Invasive Papillary Carcinoma - p. 363 72. Chapter 52: Invasive Micropapillary Carcinoma - p. 365 73. Chapter 53: Invasive Apocrine Carcinoma - p. 373 74. Chapter 54: Invasive Neuroendocrine Carcinoma - p. 379 75. Chapter 55: Invasive Carcinoma With Osteoclast-Like Giant Cells - p. 387 76. Chapter 56: Metaplastic Breast Carcinoma - p. 389 77. Chapter 57: Adenoid Cystic Carcinoma - p. 401 78. Chapter 58: Secretory Carcinoma - p. 413 79. MOLECULAR TYPES - p. 419 80. Chapter 59: Luminal Breast Carcinoma (ER Positive/HER2 Negative) - p. 419 81. Chapter 60: HER2-Positive Breast Carcinoma - p. 423 82. Chapter 61: Triple Negative Breast Carcinoma and Basal-Like Breast Carcinoma - p. 433 83. SECTION 6: PROGNOSTIC AND PREDICTIVE FACTORS - p. 443 84. Chapter 62: Overview of Prognostic and Predictive Factors - p. 443 85. Chapter 63: AJCC Breast Cancer Staging - p. 451 86. ANATOMIC FACTORS - p. 459 87. Chapter 64: Histologic Grade - p. 459 88. Chapter 65: Size and Multiple Foci - p. 465 89. Chapter 66: Lymphovascular Invasion - p. 469 90. Chapter 67: Inflammatory Carcinoma - p. 477 91. Chapter 68: Locally Advanced Carcinoma - p. 483 92. Chapter 69: Lymph Node Metastases - p. 487 93. Chapter 70: Response to Neoadjuvant Therapy - p. 497 94. Chapter 71: Locally Recurrent Carcinoma - p. 507 95. Chapter 72: Carcinoma With Extensive Intraductal Component - p. 513 96. MOLECULAR FACTORS - p. 517 97. Chapter 73: Hormone Receptors (ER/PR/AR) - p. 517 98. Chapter 74: HER2 - p. 527 99. Chapter 75: HER2-Low Breast Carcinoma - p. 541 100. Chapter 76: Proliferation - p. 545 101. Chapter 77: DNA Analysis and Gene Copy Number Alterations - p. 549 102. Chapter 78: Circulating Tumor Cells, Circulating Tumor DNA, and Next-Generation Sequencing - p. 553 103. Chapter 79: Immunotherapy - p. 559 104. Chapter 80: Expression Profiling, mRNA: Overview - p. 565 105. Chapter 81: Expression Profiling: Oncotype DX Assay - p. 571 106. Chapter 82: Expression Profiling: MammaPrint Assay - p. 575 107. Chapter 83: Expression Profiling: Prosigna - p. 577 108. Chapter 84: Expression Profiling: EndoPredict - p. 579 109. Chapter 85: Expression Profiling: Protein - p. 581 110. SECTION 7: STROMAL LESIONS - p. 585 111. Chapter 86: Pseudoangiomatous Stromal Hyperplasia - p. 585 112. Chapter 87: Nodular Fasciitis - p. 591 113. Chapter 88: Fibromatosis - p. 597 114. Chapter 89: Myofibroblastoma - p. 605 115. Chapter 90: Lipoma and Angiolipoma - p. 613 116. Chapter 91: Fibroadenoma - p. 617 117. Chapter 92: Phyllodes Tumor - p. 625 118. Chapter 93: Granular Cell Tumor - p. 635 119. Chapter 94: Papillary Endothelial Hyperplasia - p. 641 120. Chapter 95: Hemangiomas - p. 643 121. Chapter 96: Atypical Vascular Lesions: Post Radiation - p. 649 122. Chapter 97: Angiosarcoma - p. 653 123. Chapter 98: Sarcomas - p. 663 124. SECTION 8: INFLAMMATORY LESIONS - p. 669 125. Chapter 99: Lactational Abscess - p. 669 126. Chapter 100: Nonlactational Abscess - p. 673 127. Chapter 101: Squamous Metaplasia of Lactiferous Ducts - p. 681 128. Chapter 102: Fat Necrosis - p. 687 129. Chapter 103: Duct Ectasia - p. 691 130. Chapter 104: Sarcoidosis - p. 693 131. Chapter 105: Amyloid of the Breast - p. 695 132. Chapter 106: Lupus Mastitis - p. 697 133. Chapter 107: IgG4-Related Sclerosing Mastitis - p. 699 134. Chapter 108: Lymphocytic Lobulitis/Mastopathy - p. 703 135. Chapter 109: Implant Pathology - p. 707 136. SECTION 9: OTHER TYPES OF MALIGNANCIES - p. 715 137. Chapter 110: Hematolymphoid Tumors - p. 715 138. Chapter 111: Metastases to Breast - p. 727 139. SECTION 10: HEREDITARY BREAST DISEASE - p. 733 140. Chapter 112: Overview of Hereditary Breast Cancer - p. 733 141. Chapter 113: Table of Germline Mutations - p. 743 142. Chapter 114: BRCA1: Hereditary Breast and Ovarian Cancer Syndrome 1 - p. 745 143. Chapter 115: BRCA2: Hereditary Breast and Ovarian Cancer Syndrome 2 - p. 751 144. Chapter 116: TP53: Li-Fraumeni Syndrome - p. 755 145. INDEX - p. 761
