Offering complete, practical guidance on the evaluation of the surgical pathology specimen, the Manual of Surgical Pathology concentrates decades of experience from the faculty and staff of one of the busiest and most respected pathology departments in the world. From a specimen’s arrival in the department to preparation of the final report, you’ll find step-by-step instructions on specimen processing, tissue handling, gross dissection technique, histological examination, application of special stains, development of a differential diagnosis, and more. The fully revised 4th Edition is an invaluable reference for practicing pathologists, residents, and pathology assistants as a practical, everyday resource for learning and applying optimal specimen evaluation as well as an excellent guide for board review.
1. INTRODUCTION AND OVERVIEW - p. iii 2. List of Tables - p. iii 3. Chapter 1: Introduction to Renal Cell Tumors - p. iii 4. Chapter 2: Classification of Kidney Tumors and Tumor-Like Lesions - p. 9 5. FAMILIAL CANCER SYNDROMES - p. 11 6. Chapter 3: von Hippel-Lindau Syndrome - p. 11 7. Chapter 4: Birt-Hogg-Dubé Syndrome - p. 15 8. Chapter 5: Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome - p. 19 9. Chapter 6: Tuberous Sclerosis Complex - p. 23 10. Chapter 7: Succinate Dehydrogenase Complex Deficiency Syndrome - p. 27 11. Chapter 8: Hereditary Papillary Renal Cancer and Miscellaneous Other Familial Cancer Syndromes - p. 31 12. NONNEOPLASTIC LESIONS - p. 37 13. Chapter 9: Renal Tuberculosis, Xanthogranulomatous Pyelonephritis, Renal Malakoplakia - p. 37 14. RENAL CELL TUMORS, BENIGN - p. 43 15. Chapter 10: Papillary Adenoma - p. 43 16. Chapter 11: Renal Oncocytoma - p. 47 17. RENAL CELL CARCINOMA - p. 53 18. Chapter 12: Clear Cell Renal Cell Carcinoma - p. 53 19. Chapter 13: Multilocular Cystic Renal Neoplasm of Low Malignant Potential - p. 63 20. Chapter 14: Clear Cell Renal Cancers With Fibromyomatous Stroma, Including *ELOC* (Formerly *TCEB1*)-Mutated Renal Cell Carcinoma - p. 67 21. Chapter 15: Clear Cell Papillary Renal Cell Tumor - p. 73 22. Chapter 16: Papillary Renal Cell Carcinoma - p. 81 23. Chapter 17: Chromophobe Renal Cell Carcinoma - p. 91 24. Chapter 18: Collecting Duct Carcinoma - p. 99 25. Chapter 19: SMARCB1-Deficient Renal Medullary Carcinoma and SMARCB1-Deficient Medullary-Like Renal Cell Carcinoma - p. 105 26. Chapter 20: *TFE3*- and *TFEB*-Rearranged Renal Cell Carcinomas - p. 110 27. Chapter 21: Mucinous Tubular and Spindle Cell Carcinoma - p. 119 28. Chapter 22: Tubulocystic Renal Cell Carcinoma - p. 125 29. Chapter 23: Thyroid-Like Follicular Carcinoma of Kidney - p. 129 30. Chapter 24: Acquired Cystic Disease-Associated Renal Cell Carcinoma - p. 133 31. Chapter 25: Fumarate Hydratase-Deficient Renal Cell Carcinoma - p. 139 32. Chapter 26: *ALK* Rearrangement-Associated Renal Cell Carcinoma - p. 143 33. Chapter 27: Eosinophilic Solid and Cystic Renal Cell Carcinoma - p. 147 34. Chapter 28: Other Eosinophilic/Oncocytic Tumors, Including ESC, EVT, and LOT - p. 149 35. Chapter 29: Subsequent 2nd Tumors - p. 153 36. Chapter 30: Renal Cell Carcinoma, Not Otherwise Specified - p. 157 37. METANEPHRIC TUMORS - p. 161 38. Chapter 31: Metanephric Adenoma - p. 161 39. Chapter 32: Metanephric Tumors Other Than Metanephric Adenoma - p. 167 40. NEPHROBLASTIC TUMORS - p. 171 41. Chapter 33: Nephrogenic Rests - p. 171 42. Chapter 34: Nephroblastoma (Wilms Tumor) - p. 175 43. Chapter 35: Cystic Partially Differentiated Nephroblastoma - p. 185 44. MESENCHYMAL TUMORS - p. 187 45. Chapter 36: Angiomyolipoma - p. 187 46. Chapter 37: Epithelioid Angiomyolipoma/Epithelioid PEComa - p. 193 47. Chapter 38: Congenital Mesoblastic Nephroma - p. 199 48. Chapter 39: Clear Cell Sarcoma of Kidney - p. 203 49. Chapter 40: Rhabdoid Tumor of Kidney - p. 207 50. MIXED MESENCHYMAL AND EPITHELIAL TUMORS - p. 211 51. Chapter 41: Mixed Epithelial and Stromal Tumor (MEST) Family Tumors - p. 211 52. Chapter 42: Pediatric Cystic Nephroma - p. 219 53. Chapter 43: Synovial Sarcoma - p. 223 54. NEUROENDOCRINE TUMORS - p. 227 55. Chapter 44: Renal Neuroendocrine Tumor/Carcinoid Tumor and Neuroendocrine Carcinoma - p. 227 56. Chapter 45: Renal Ewing Sarcoma - p. 230 57. HEMATOPOIETIC TUMORS - p. 235 58. Chapter 46: Hematopoietic Tumors - p. 235 59. METASTATIC AND OTHER TUMORS - p. 241 60. Chapter 47: Juxtaglomerular Cell Tumor (Reninoma) - p. 241 61. Chapter 48: Renomedullary Interstitial Cell Tumor - p. 245 62. Chapter 49: Other Rare Tumors - p. 249 63. Chapter 50: Metastatic Tumors - p. 257 64. IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS INVOLVING KIDNEY - p. 261 65. Chapter 51: Immunohistochemistry, Kidney - p. 261 66. SECTION 2: URINARY TRACT - p. 267 67. INTRODUCTION AND OVERVIEW - p. 267 68. Chapter 52: Classification of Bladder Tumors and Tumor-Like Lesions - p. 267 69. MICROSCOPIC ANATOMY - p. 271 70. Chapter 53: Microscopic Anatomy of Urinary Bladder - p. 271 71. Chapter 54: Microscopic Anatomy of Urethra - p. 275 72. Chapter 55: Microscopic Anatomy of Ureter - p. 279 73. Chapter 56: Microscopic Anatomy of Renal Pelvis - p. 281 74. NONNEOPLASTIC LESIONS OF URINARY TRACT - p. 285 75. Chapter 57: Overview of Cystitis - p. 285 76. Chapter 58: Polypoid Cystitis - p. 291 77. Chapter 59: Malakoplakia - p. 299 78. Chapter 60: Schistosomiasis - p. 305 79. Chapter 61: von Brunn Nests - p. 307 80. Chapter 62: Nephrogenic Adenoma (Metaplasia) - p. 313 81. Chapter 63: Fibroepithelial Polyp - p. 321 82. Chapter 64: Prostatic-Type Polyp (Ectopic Prostate) - p. 325 83. Chapter 65: Amyloidosis - p. 329 84. Chapter 66: Müllerian Lesions - p. 331 85. Chapter 67: Pseudocarcinomatous Hyperplasia - p. 335 86. Chapter 68: Hamartoma - p. 343 87. UROTHELIAL NEOPLASMS, GENERAL - p. 345 88. Chapter 69: Overview of Urinary Bladder Neoplasms - p. 345 89. FLAT UROTHELIAL LESIONS - p. 349 90. Chapter 70: Urothelial Carcinoma In Situ - p. 349 91. Chapter 71: Flat Urothelial Lesions Other Than Carcinoma In Situ - p. 357 92. UROTHELIAL NEOPLASMS, NONINVASIVE - p. 361 93. Chapter 72: Atypical Urothelial Proliferations, Flat and Tented Type (Formerly Flat and Papillary Hyperplasia) - p. 361 94. Chapter 73: Urothelial Papilloma - p. 363 95. Chapter 74: Papillary Urothelial Neoplasm of Low Malignant Potential - p. 369 96. Chapter 75: Low-Grade Papillary Urothelial Carcinoma - p. 373 97. Chapter 76: High-Grade Papillary Urothelial Carcinoma - p. 377 98. Chapter 77: Inverted Urothelial Neoplasia - p. 383 99. UROTHELIAL NEOPLASMS, INVASIVE - p. 393 100. Chapter 78: Invasive Urothelial Carcinoma - p. 393 101. Chapter 79: Urothelial Carcinoma, Subtypes and Divergent Differentiation - p. 403 102. GLANDULAR LESIONS - p. 425 103. Chapter 80: Cystitis Cystica et Glandularis - p. 425 104. Chapter 81: Villous Adenoma - p. 428 105. Chapter 82: Invasive Adenocarcinoma - p. 431 106. Chapter 83: Clear Cell Adenocarcinoma - p. 437 107. SQUAMOUS LESIONS - p. 443 108. Chapter 84: Squamous Proliferations Other Than Carcinoma - p. 443 109. Chapter 85: Invasive Squamous Cell Carcinoma - p. 447 110. MESENCHYMAL LESIONS - p. 453 111. Chapter 86: Myofibroblastic Proliferations - p. 453 112. Chapter 87: Smooth Muscle Tumors - p. 461 113. Chapter 88: Rhabdomyosarcoma - p. 469 114. Chapter 89: Other Mesenchymal Tumors - p. 475 115. OTHER TUMORS OF URINARY BLADDER - p. 483 116. Chapter 90: Paraganglioma - p. 483 117. Chapter 91: Metastatic/Secondary Involvement of Bladder - p. 491 118. DIVERTICULA OF URINARY TRACT - p. 499 119. Chapter 92: Diverticula - p. 499 120. Chapter 93: Diverticular-Associated Neoplasia - p. 503 121. URETHRA - p. 507 122. Chapter 94: Inflammatory Lesions of Urethra - p. 507 123. Chapter 95: Carcinoma of Urethra - p. 511 124. Chapter 96: Other Tumors and Tumor-Like Lesions of Urethra - p. 515 125. URETER - p. 519 126. Chapter 97: Urothelial Carcinoma of Ureter - p. 519 127. Chapter 98: Other Tumors and Tumor-Like Lesions of Ureter - p. 523 128. RENAL PELVIS - p. 529 129. Chapter 99: Urothelial Carcinoma of Renal Pelvis - p. 529 130. Chapter 100: Other Tumors and Tumor-Like Lesions of Renal Pelvis - p. 539 131. URACHUS - p. 545 132. Chapter 101: Urachal Remnants - p. 545 133. Chapter 102: Tumors of Urachus - p. 547 134. IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS INVOLVING URINARY BLADDER - p. 553 135. Chapter 103: Immunohistochemistry, Urinary Tract - p. 553 136. SECTION 3: PROSTATE GLAND AND SEMINAL VESICLE - p. 559 137. INTRODUCTION AND OVERVIEW - p. 559 138. Chapter 104: Classification of Prostate Tumors and Tumor-Like Lesions - p. 559 139. Chapter 105: General Concepts, Prostate - p. 563 140. Chapter 106: Microanatomy and Zonal Variations - p. 569 141. Chapter 107: Imaging Considerations for Pathologists - p. 579 142. NONNEOPLASTIC LESIONS - p. 583 143. Chapter 108: Prostatitis - p. 583 144. Chapter 109: Prostate Hyperplasia - p. 587 145. Chapter 110: Adenosis - p. 595 146. Chapter 111: Atrophy and Its Patterns - p. 599 147. Chapter 112: Hyperplasia of Mesonephric Remnants - p. 605 148. Chapter 113: Verumontanum Mucosal Gland Hyperplasia - p. 609 149. Chapter 114: Nephrogenic Adenoma (Metaplasia) of Prostatic Urethra - p. 611 150. PUTATIVE PREMALIGNANT LESIONS AND LESIONS FALLING SHORT OF MALIGNANT DIAGNOSIS - p. 619 151. Chapter 115: Prostatic Intraepithelial Neoplasia - p. 619 152. PROSTATE NEOPLASMS - p. 629 153. Chapter 116: General Concepts, Prostate Carcinoma - p. 629 154. Chapter 117: Acinar Adenocarcinoma - p. 637 155. Chapter 118: Acinar Adenocarcinoma Subtypes and Patterns - p. 655 156. Chapter 119: Atypical Small Acinar Proliferations - p. 667 157. Chapter 120: Intraductal Proliferations and Ductal Carcinoma - p. 673 158. Chapter 121: Ductal Adenocarcinoma - p. 681 159. Chapter 122: Urothelial Carcinoma Involving Prostate Gland - p. 689 160. Chapter 123: Prostate Carcinoma With Neuroendocrine Differentiation - p. 695 161. Chapter 124: Adenoid Cystic (Basal Cell) Carcinoma of Prostate - p. 703 162. Chapter 125: Sarcomatoid Carcinoma of Prostate - p. 709 163. Chapter 126: Carcinomas With Squamous Differentiation - p. 715 164. Chapter 127: Cystic Epithelial Tumors of Prostate - p. 721 165. Chapter 128: Stromal Tumors - p. 723 166. Chapter 129: Mesenchymal Tumors of Prostate - p. 731 167. Chapter 130: Melanocytic Lesions of Prostate - p. 739 168. Chapter 131: Hematopoietic Neoplasms of Prostate - p. 743 169. Chapter 132: Secondary Tumors of Prostate - p. 747 170. TUMORS OF SEMINAL VESICLE - p. 751 171. Chapter 133: Mixed Epithelial and Stromal Tumor - p. 751 172. Chapter 134: Seminal Vesicle Adenocarcinoma - p. 755 173. IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS AND TUMOR-LIKE LESIONS INVOLVING PROSTATE GLAND - p. 757 174. Chapter 135: Immunohistochemistry, Prostate - p. 757 175. SECTION 4: TESTIS AND PARATESTICULAR STRUCTURES - p. 763 176. INTRODUCTION AND OVERVIEW - p. 763 177. Chapter 136: Classification of Testis and Paratestis Tumors and Tumor-Like Lesions - p. 763 178. NONNEOPLASTIC LESIONS - p. 767 179. Chapter 137: Cryptorchidism - p. 767 180. Chapter 138: Sertoli Cell-Only Syndrome - p. 771 181. Chapter 139: Nontuberculous Infections - p. 775 182. Chapter 140: Nonspecific Granulomatous Orchitis - p. 777 183. Chapter 141: Tuberculous Epididymo-Orchitis - p. 779 184. GERM CELL TUMORS - p. 781 185. Chapter 142: General Concepts, Germ Cell Tumors - p. 781 186. GERM CELL TUMORS RELATED TO GERM CELL NEOPLASIA IN SITU - p. 789 187. Chapter 143: Germ Cell Neoplasia In Situ - p. 789 188. Chapter 144: Seminoma - p. 795 189. Chapter 145: Intratubular Seminoma - p. 803 190. Chapter 146: Intratubular Embryonal Carcinoma - p. 805 191. Chapter 147: Embryonal Carcinoma - p. 807 192. Chapter 148: Yolk Sac Tumor - p. 813 193. Chapter 149: Choriocarcinoma and Other Trophoblastic Tumors - p. 821 194. Chapter 150: Postpubertal-Type Teratoma - p. 827 195. Chapter 151: Mixed Germ Cell Tumors - p. 831 196. Chapter 152: Somatic-Type Malignancy in Germ Cell Tumor - p. 835 197. Chapter 153: Burnt-Out (Regressed) Germ Cell Tumor - p. 837 198. GERM CELL TUMORS UNRELATED TO GERM CELL NEOPLASIA IN SITU - p. 839 199. Chapter 154: Spermatocytic Tumor - p. 839 200. Chapter 155: Pediatric Germ Cell Tumor, General Concepts - p. 843 201. Chapter 156: Prepubertal-Type Teratoma - p. 845 202. Chapter 157: Yolk Sac Tumor, Prepubertal Type - p. 849 203. Chapter 158: Mixed Teratoma and Yolk Sac Tumor, Prepubertal Type - p. 853 204. Chapter 159: Well-Differentiated Neuroendocrine Tumor (Monodermal Teratoma) - p. 855 205. SEX CORD-/GONADAL STROMAL TUMORS - p. 859 206. Chapter 160: General Concepts, Sex Cord-/Gonadal Stromal Tumors - p. 859 207. Chapter 161: Leydig Cell Tumors - p. 867 208. Chapter 162: Sertoli Cell Tumors - p. 871 209. Chapter 163: Large Cell Calcifying Sertoli Cell Tumor - p. 877 210. Chapter 164: Intratubular Large Cell Hyalinizing Sertoli Cell Tumor - p. 881 211. Chapter 165: Granulosa Cell Tumor - p. 883 212. Chapter 166: Juvenile Granulosa Cell Tumor - p. 887 213. Chapter 167: Fibroma-Thecoma - p. 891 214. Chapter 168: Myoid Gonadal Stromal Tumor - p. 893 215. Chapter 169: Signet-Ring Stromal Tumors - p. 895 216. Chapter 170: Testicular Tumor of Adrenogenital Syndrome - p. 897 217. Chapter 171: Sex Cord-Stromal Tumor, Mixed/Unclassified - p. 901 218. Chapter 172: Gonadoblastoma - p. 905 219. HEMATOPOIETIC TUMORS - p. 909 220. Chapter 173: Lymphoma/Leukemia/Plasmacytoma - p. 909 221. TUMORS OF PARATESTICULAR STRUCTURES - p. 915 222. Chapter 174: Adenomatoid Tumor - p. 915 223. Chapter 175: Well-Differentiated Papillary Mesothelial Tumor - p. 919 224. Chapter 176: Malignant Mesothelioma - p. 921 225. Chapter 177: Adenocarcinoma of Rete Testis/Epididymis - p. 925 226. Chapter 178: Epididymal Tumors - p. 927 227. Chapter 179: Ovarian Epithelial-Type Tumors - p. 929 228. Chapter 180: Liposarcoma - p. 933 229. Chapter 181: Melanotic Neuroectodermal Tumor - p. 939 230. Chapter 182: Rhabdomyosarcoma - p. 943 231. Chapter 183: Other Sarcomas - p. 949 232. METASTATIC TUMORS, TESTIS AND PARATESTICULAR STRUCTURES - p. 953 233. Chapter 184: Metastatic Tumors, Testis and Paratesticular Structures - p. 953 234. IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS INVOLVING TESTIS AND PARATESTICULAR STRUCTURES - p. 957 235. Chapter 185: Immunohistochemistry, Testis - p. 957 236. SECTION 5: PENIS AND SCROTUM - p. 965 237. FREQUENT LESIONS OF UNCERTAIN RELATIONSHIP TO PENILE NEOPLASIA - p. 965 238. Chapter 186: Condyloma - p. 965 239. Chapter 187: Lichen Sclerosus et Atrophicus - p. 971 240. Chapter 188: Squamous Hyperplasia - p. 973 241. Chapter 189: Lipogranuloma - p. 977 242. Chapter 190: Scrotal Calcinosis - p. 979 243. PENILE INTRAEPITHELIAL NEOPLASIA - p. 981 244. Chapter 191: Penile Intraepithelial Neoplasia - p. 981 245. PRIMARY EPITHELIAL TUMORS - p. 987 246. Chapter 192: General Concepts, Squamous Cell Carcinoma (Including Staging and Molecular Pathology) - p. 987 247. Chapter 193: Overview of HPV- and Non-HPV-Related Tumors - p. 1001 248. SQUAMOUS CELL CARCINOMA AND ITS SUBTYPES - p. 1005 249. Chapter 194: Squamous Cell Carcinoma, Usual Type - p. 1005 250. Chapter 195: Basaloid Squamous Cell Carcinoma - p. 1009 251. Chapter 196: Basaloid Squamous Cell Carcinoma, Papillary Subtype - p. 1013 252. Chapter 197: Warty (Condylomatous) Squamous Cell Carcinoma - p. 1015 253. Chapter 198: Warty-Basaloid Squamous Cell Carcinoma - p. 1019 254. Chapter 199: Verrucous Squamous Cell Carcinoma - p. 1021 255. Chapter 200: Papillary Squamous Cell Carcinoma, Not Otherwise Specified - p. 1025 256. Chapter 201: Pseudoglandular Squamous Cell Carcinoma - p. 1029 257. Chapter 202: Pseudohyperplastic Squamous Cell Carcinoma - p. 1031 258. Chapter 203: Cuniculatum Squamous Cell Carcinoma - p. 1033 259. Chapter 204: Sarcomatoid Squamous Cell Carcinoma - p. 1037 260. Chapter 205: Mixed Squamous Cell Carcinoma - p. 1041 261. Chapter 206: Undifferentiated to Poorly Differentiated Squamous Cell Carcinomas With Prominent Inflammatory Infiltrate - p. 1045 262. Chapter 207: Clear Cell Carcinoma - p. 1047 263. OTHER NEOPLASTIC CONDITIONS - p. 1049 264. Chapter 208: Extramammary Paget Disease - p. 1049 265. Chapter 209: Kaposi Sarcoma - p. 1053 266. Chapter 210: Myointimoma - p. 1055 267. METASTATIC TUMORS - p. 1057 268. Chapter 211: Metastatic Tumors, Penis - p. 1057 269. IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS INVOLVING PENIS - p. 1059 270. Chapter 212: Immunohistochemistry, Penis - p. 1059 271. INDEX - p. 1061
Offering complete, practical guidance on the evaluation of the surgical pathology specimen, the Manual of Surgical Pathology concentrates decades of experience from the faculty and staff of one of the busiest and most respected pathology departments in the world. From a specimen’s arrival in the department to preparation of the final report, you’ll find step-by-step instructions on specimen processing, tissue handling, gross dissection technique, histological examination, application of special stains, development of a differential diagnosis, and more. The fully revised 4th Edition is an invaluable reference for practicing pathologists, residents, and pathology assistants as a practical, everyday resource for learning and applying optimal specimen evaluation as well as an excellent guide for board review.
1. INTRODUCTION AND OVERVIEW - p. iii 2. List of Tables - p. iii 3. Chapter 1: Introduction to Renal Cell Tumors - p. iii 4. Chapter 2: Classification of Kidney Tumors and Tumor-Like Lesions - p. 9 5. FAMILIAL CANCER SYNDROMES - p. 11 6. Chapter 3: von Hippel-Lindau Syndrome - p. 11 7. Chapter 4: Birt-Hogg-Dubé Syndrome - p. 15 8. Chapter 5: Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome - p. 19 9. Chapter 6: Tuberous Sclerosis Complex - p. 23 10. Chapter 7: Succinate Dehydrogenase Complex Deficiency Syndrome - p. 27 11. Chapter 8: Hereditary Papillary Renal Cancer and Miscellaneous Other Familial Cancer Syndromes - p. 31 12. NONNEOPLASTIC LESIONS - p. 37 13. Chapter 9: Renal Tuberculosis, Xanthogranulomatous Pyelonephritis, Renal Malakoplakia - p. 37 14. RENAL CELL TUMORS, BENIGN - p. 43 15. Chapter 10: Papillary Adenoma - p. 43 16. Chapter 11: Renal Oncocytoma - p. 47 17. RENAL CELL CARCINOMA - p. 53 18. Chapter 12: Clear Cell Renal Cell Carcinoma - p. 53 19. Chapter 13: Multilocular Cystic Renal Neoplasm of Low Malignant Potential - p. 63 20. Chapter 14: Clear Cell Renal Cancers With Fibromyomatous Stroma, Including *ELOC* (Formerly *TCEB1*)-Mutated Renal Cell Carcinoma - p. 67 21. Chapter 15: Clear Cell Papillary Renal Cell Tumor - p. 73 22. Chapter 16: Papillary Renal Cell Carcinoma - p. 81 23. Chapter 17: Chromophobe Renal Cell Carcinoma - p. 91 24. Chapter 18: Collecting Duct Carcinoma - p. 99 25. Chapter 19: SMARCB1-Deficient Renal Medullary Carcinoma and SMARCB1-Deficient Medullary-Like Renal Cell Carcinoma - p. 105 26. Chapter 20: *TFE3*- and *TFEB*-Rearranged Renal Cell Carcinomas - p. 110 27. Chapter 21: Mucinous Tubular and Spindle Cell Carcinoma - p. 119 28. Chapter 22: Tubulocystic Renal Cell Carcinoma - p. 125 29. Chapter 23: Thyroid-Like Follicular Carcinoma of Kidney - p. 129 30. Chapter 24: Acquired Cystic Disease-Associated Renal Cell Carcinoma - p. 133 31. Chapter 25: Fumarate Hydratase-Deficient Renal Cell Carcinoma - p. 139 32. Chapter 26: *ALK* Rearrangement-Associated Renal Cell Carcinoma - p. 143 33. Chapter 27: Eosinophilic Solid and Cystic Renal Cell Carcinoma - p. 147 34. Chapter 28: Other Eosinophilic/Oncocytic Tumors, Including ESC, EVT, and LOT - p. 149 35. Chapter 29: Subsequent 2nd Tumors - p. 153 36. Chapter 30: Renal Cell Carcinoma, Not Otherwise Specified - p. 157 37. METANEPHRIC TUMORS - p. 161 38. Chapter 31: Metanephric Adenoma - p. 161 39. Chapter 32: Metanephric Tumors Other Than Metanephric Adenoma - p. 167 40. NEPHROBLASTIC TUMORS - p. 171 41. Chapter 33: Nephrogenic Rests - p. 171 42. Chapter 34: Nephroblastoma (Wilms Tumor) - p. 175 43. Chapter 35: Cystic Partially Differentiated Nephroblastoma - p. 185 44. MESENCHYMAL TUMORS - p. 187 45. Chapter 36: Angiomyolipoma - p. 187 46. Chapter 37: Epithelioid Angiomyolipoma/Epithelioid PEComa - p. 193 47. Chapter 38: Congenital Mesoblastic Nephroma - p. 199 48. Chapter 39: Clear Cell Sarcoma of Kidney - p. 203 49. Chapter 40: Rhabdoid Tumor of Kidney - p. 207 50. MIXED MESENCHYMAL AND EPITHELIAL TUMORS - p. 211 51. Chapter 41: Mixed Epithelial and Stromal Tumor (MEST) Family Tumors - p. 211 52. Chapter 42: Pediatric Cystic Nephroma - p. 219 53. Chapter 43: Synovial Sarcoma - p. 223 54. NEUROENDOCRINE TUMORS - p. 227 55. Chapter 44: Renal Neuroendocrine Tumor/Carcinoid Tumor and Neuroendocrine Carcinoma - p. 227 56. Chapter 45: Renal Ewing Sarcoma - p. 230 57. HEMATOPOIETIC TUMORS - p. 235 58. Chapter 46: Hematopoietic Tumors - p. 235 59. METASTATIC AND OTHER TUMORS - p. 241 60. Chapter 47: Juxtaglomerular Cell Tumor (Reninoma) - p. 241 61. Chapter 48: Renomedullary Interstitial Cell Tumor - p. 245 62. Chapter 49: Other Rare Tumors - p. 249 63. Chapter 50: Metastatic Tumors - p. 257 64. IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS INVOLVING KIDNEY - p. 261 65. Chapter 51: Immunohistochemistry, Kidney - p. 261 66. SECTION 2: URINARY TRACT - p. 267 67. INTRODUCTION AND OVERVIEW - p. 267 68. Chapter 52: Classification of Bladder Tumors and Tumor-Like Lesions - p. 267 69. MICROSCOPIC ANATOMY - p. 271 70. Chapter 53: Microscopic Anatomy of Urinary Bladder - p. 271 71. Chapter 54: Microscopic Anatomy of Urethra - p. 275 72. Chapter 55: Microscopic Anatomy of Ureter - p. 279 73. Chapter 56: Microscopic Anatomy of Renal Pelvis - p. 281 74. NONNEOPLASTIC LESIONS OF URINARY TRACT - p. 285 75. Chapter 57: Overview of Cystitis - p. 285 76. Chapter 58: Polypoid Cystitis - p. 291 77. Chapter 59: Malakoplakia - p. 299 78. Chapter 60: Schistosomiasis - p. 305 79. Chapter 61: von Brunn Nests - p. 307 80. Chapter 62: Nephrogenic Adenoma (Metaplasia) - p. 313 81. Chapter 63: Fibroepithelial Polyp - p. 321 82. Chapter 64: Prostatic-Type Polyp (Ectopic Prostate) - p. 325 83. Chapter 65: Amyloidosis - p. 329 84. Chapter 66: Müllerian Lesions - p. 331 85. Chapter 67: Pseudocarcinomatous Hyperplasia - p. 335 86. Chapter 68: Hamartoma - p. 343 87. UROTHELIAL NEOPLASMS, GENERAL - p. 345 88. Chapter 69: Overview of Urinary Bladder Neoplasms - p. 345 89. FLAT UROTHELIAL LESIONS - p. 349 90. Chapter 70: Urothelial Carcinoma In Situ - p. 349 91. Chapter 71: Flat Urothelial Lesions Other Than Carcinoma In Situ - p. 357 92. UROTHELIAL NEOPLASMS, NONINVASIVE - p. 361 93. Chapter 72: Atypical Urothelial Proliferations, Flat and Tented Type (Formerly Flat and Papillary Hyperplasia) - p. 361 94. Chapter 73: Urothelial Papilloma - p. 363 95. Chapter 74: Papillary Urothelial Neoplasm of Low Malignant Potential - p. 369 96. Chapter 75: Low-Grade Papillary Urothelial Carcinoma - p. 373 97. Chapter 76: High-Grade Papillary Urothelial Carcinoma - p. 377 98. Chapter 77: Inverted Urothelial Neoplasia - p. 383 99. UROTHELIAL NEOPLASMS, INVASIVE - p. 393 100. Chapter 78: Invasive Urothelial Carcinoma - p. 393 101. Chapter 79: Urothelial Carcinoma, Subtypes and Divergent Differentiation - p. 403 102. GLANDULAR LESIONS - p. 425 103. Chapter 80: Cystitis Cystica et Glandularis - p. 425 104. Chapter 81: Villous Adenoma - p. 428 105. Chapter 82: Invasive Adenocarcinoma - p. 431 106. Chapter 83: Clear Cell Adenocarcinoma - p. 437 107. SQUAMOUS LESIONS - p. 443 108. Chapter 84: Squamous Proliferations Other Than Carcinoma - p. 443 109. Chapter 85: Invasive Squamous Cell Carcinoma - p. 447 110. MESENCHYMAL LESIONS - p. 453 111. Chapter 86: Myofibroblastic Proliferations - p. 453 112. Chapter 87: Smooth Muscle Tumors - p. 461 113. Chapter 88: Rhabdomyosarcoma - p. 469 114. Chapter 89: Other Mesenchymal Tumors - p. 475 115. OTHER TUMORS OF URINARY BLADDER - p. 483 116. Chapter 90: Paraganglioma - p. 483 117. Chapter 91: Metastatic/Secondary Involvement of Bladder - p. 491 118. DIVERTICULA OF URINARY TRACT - p. 499 119. Chapter 92: Diverticula - p. 499 120. Chapter 93: Diverticular-Associated Neoplasia - p. 503 121. URETHRA - p. 507 122. Chapter 94: Inflammatory Lesions of Urethra - p. 507 123. Chapter 95: Carcinoma of Urethra - p. 511 124. Chapter 96: Other Tumors and Tumor-Like Lesions of Urethra - p. 515 125. URETER - p. 519 126. Chapter 97: Urothelial Carcinoma of Ureter - p. 519 127. Chapter 98: Other Tumors and Tumor-Like Lesions of Ureter - p. 523 128. RENAL PELVIS - p. 529 129. Chapter 99: Urothelial Carcinoma of Renal Pelvis - p. 529 130. Chapter 100: Other Tumors and Tumor-Like Lesions of Renal Pelvis - p. 539 131. URACHUS - p. 545 132. Chapter 101: Urachal Remnants - p. 545 133. Chapter 102: Tumors of Urachus - p. 547 134. IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS INVOLVING URINARY BLADDER - p. 553 135. Chapter 103: Immunohistochemistry, Urinary Tract - p. 553 136. SECTION 3: PROSTATE GLAND AND SEMINAL VESICLE - p. 559 137. INTRODUCTION AND OVERVIEW - p. 559 138. Chapter 104: Classification of Prostate Tumors and Tumor-Like Lesions - p. 559 139. Chapter 105: General Concepts, Prostate - p. 563 140. Chapter 106: Microanatomy and Zonal Variations - p. 569 141. Chapter 107: Imaging Considerations for Pathologists - p. 579 142. NONNEOPLASTIC LESIONS - p. 583 143. Chapter 108: Prostatitis - p. 583 144. Chapter 109: Prostate Hyperplasia - p. 587 145. Chapter 110: Adenosis - p. 595 146. Chapter 111: Atrophy and Its Patterns - p. 599 147. Chapter 112: Hyperplasia of Mesonephric Remnants - p. 605 148. Chapter 113: Verumontanum Mucosal Gland Hyperplasia - p. 609 149. Chapter 114: Nephrogenic Adenoma (Metaplasia) of Prostatic Urethra - p. 611 150. PUTATIVE PREMALIGNANT LESIONS AND LESIONS FALLING SHORT OF MALIGNANT DIAGNOSIS - p. 619 151. Chapter 115: Prostatic Intraepithelial Neoplasia - p. 619 152. PROSTATE NEOPLASMS - p. 629 153. Chapter 116: General Concepts, Prostate Carcinoma - p. 629 154. Chapter 117: Acinar Adenocarcinoma - p. 637 155. Chapter 118: Acinar Adenocarcinoma Subtypes and Patterns - p. 655 156. Chapter 119: Atypical Small Acinar Proliferations - p. 667 157. Chapter 120: Intraductal Proliferations and Ductal Carcinoma - p. 673 158. Chapter 121: Ductal Adenocarcinoma - p. 681 159. Chapter 122: Urothelial Carcinoma Involving Prostate Gland - p. 689 160. Chapter 123: Prostate Carcinoma With Neuroendocrine Differentiation - p. 695 161. Chapter 124: Adenoid Cystic (Basal Cell) Carcinoma of Prostate - p. 703 162. Chapter 125: Sarcomatoid Carcinoma of Prostate - p. 709 163. Chapter 126: Carcinomas With Squamous Differentiation - p. 715 164. Chapter 127: Cystic Epithelial Tumors of Prostate - p. 721 165. Chapter 128: Stromal Tumors - p. 723 166. Chapter 129: Mesenchymal Tumors of Prostate - p. 731 167. Chapter 130: Melanocytic Lesions of Prostate - p. 739 168. Chapter 131: Hematopoietic Neoplasms of Prostate - p. 743 169. Chapter 132: Secondary Tumors of Prostate - p. 747 170. TUMORS OF SEMINAL VESICLE - p. 751 171. Chapter 133: Mixed Epithelial and Stromal Tumor - p. 751 172. Chapter 134: Seminal Vesicle Adenocarcinoma - p. 755 173. IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS AND TUMOR-LIKE LESIONS INVOLVING PROSTATE GLAND - p. 757 174. Chapter 135: Immunohistochemistry, Prostate - p. 757 175. SECTION 4: TESTIS AND PARATESTICULAR STRUCTURES - p. 763 176. INTRODUCTION AND OVERVIEW - p. 763 177. Chapter 136: Classification of Testis and Paratestis Tumors and Tumor-Like Lesions - p. 763 178. NONNEOPLASTIC LESIONS - p. 767 179. Chapter 137: Cryptorchidism - p. 767 180. Chapter 138: Sertoli Cell-Only Syndrome - p. 771 181. Chapter 139: Nontuberculous Infections - p. 775 182. Chapter 140: Nonspecific Granulomatous Orchitis - p. 777 183. Chapter 141: Tuberculous Epididymo-Orchitis - p. 779 184. GERM CELL TUMORS - p. 781 185. Chapter 142: General Concepts, Germ Cell Tumors - p. 781 186. GERM CELL TUMORS RELATED TO GERM CELL NEOPLASIA IN SITU - p. 789 187. Chapter 143: Germ Cell Neoplasia In Situ - p. 789 188. Chapter 144: Seminoma - p. 795 189. Chapter 145: Intratubular Seminoma - p. 803 190. Chapter 146: Intratubular Embryonal Carcinoma - p. 805 191. Chapter 147: Embryonal Carcinoma - p. 807 192. Chapter 148: Yolk Sac Tumor - p. 813 193. Chapter 149: Choriocarcinoma and Other Trophoblastic Tumors - p. 821 194. Chapter 150: Postpubertal-Type Teratoma - p. 827 195. Chapter 151: Mixed Germ Cell Tumors - p. 831 196. Chapter 152: Somatic-Type Malignancy in Germ Cell Tumor - p. 835 197. Chapter 153: Burnt-Out (Regressed) Germ Cell Tumor - p. 837 198. GERM CELL TUMORS UNRELATED TO GERM CELL NEOPLASIA IN SITU - p. 839 199. Chapter 154: Spermatocytic Tumor - p. 839 200. Chapter 155: Pediatric Germ Cell Tumor, General Concepts - p. 843 201. Chapter 156: Prepubertal-Type Teratoma - p. 845 202. Chapter 157: Yolk Sac Tumor, Prepubertal Type - p. 849 203. Chapter 158: Mixed Teratoma and Yolk Sac Tumor, Prepubertal Type - p. 853 204. Chapter 159: Well-Differentiated Neuroendocrine Tumor (Monodermal Teratoma) - p. 855 205. SEX CORD-/GONADAL STROMAL TUMORS - p. 859 206. Chapter 160: General Concepts, Sex Cord-/Gonadal Stromal Tumors - p. 859 207. Chapter 161: Leydig Cell Tumors - p. 867 208. Chapter 162: Sertoli Cell Tumors - p. 871 209. Chapter 163: Large Cell Calcifying Sertoli Cell Tumor - p. 877 210. Chapter 164: Intratubular Large Cell Hyalinizing Sertoli Cell Tumor - p. 881 211. Chapter 165: Granulosa Cell Tumor - p. 883 212. Chapter 166: Juvenile Granulosa Cell Tumor - p. 887 213. Chapter 167: Fibroma-Thecoma - p. 891 214. Chapter 168: Myoid Gonadal Stromal Tumor - p. 893 215. Chapter 169: Signet-Ring Stromal Tumors - p. 895 216. Chapter 170: Testicular Tumor of Adrenogenital Syndrome - p. 897 217. Chapter 171: Sex Cord-Stromal Tumor, Mixed/Unclassified - p. 901 218. Chapter 172: Gonadoblastoma - p. 905 219. HEMATOPOIETIC TUMORS - p. 909 220. Chapter 173: Lymphoma/Leukemia/Plasmacytoma - p. 909 221. TUMORS OF PARATESTICULAR STRUCTURES - p. 915 222. Chapter 174: Adenomatoid Tumor - p. 915 223. Chapter 175: Well-Differentiated Papillary Mesothelial Tumor - p. 919 224. Chapter 176: Malignant Mesothelioma - p. 921 225. Chapter 177: Adenocarcinoma of Rete Testis/Epididymis - p. 925 226. Chapter 178: Epididymal Tumors - p. 927 227. Chapter 179: Ovarian Epithelial-Type Tumors - p. 929 228. Chapter 180: Liposarcoma - p. 933 229. Chapter 181: Melanotic Neuroectodermal Tumor - p. 939 230. Chapter 182: Rhabdomyosarcoma - p. 943 231. Chapter 183: Other Sarcomas - p. 949 232. METASTATIC TUMORS, TESTIS AND PARATESTICULAR STRUCTURES - p. 953 233. Chapter 184: Metastatic Tumors, Testis and Paratesticular Structures - p. 953 234. IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS INVOLVING TESTIS AND PARATESTICULAR STRUCTURES - p. 957 235. Chapter 185: Immunohistochemistry, Testis - p. 957 236. SECTION 5: PENIS AND SCROTUM - p. 965 237. FREQUENT LESIONS OF UNCERTAIN RELATIONSHIP TO PENILE NEOPLASIA - p. 965 238. Chapter 186: Condyloma - p. 965 239. Chapter 187: Lichen Sclerosus et Atrophicus - p. 971 240. Chapter 188: Squamous Hyperplasia - p. 973 241. Chapter 189: Lipogranuloma - p. 977 242. Chapter 190: Scrotal Calcinosis - p. 979 243. PENILE INTRAEPITHELIAL NEOPLASIA - p. 981 244. Chapter 191: Penile Intraepithelial Neoplasia - p. 981 245. PRIMARY EPITHELIAL TUMORS - p. 987 246. Chapter 192: General Concepts, Squamous Cell Carcinoma (Including Staging and Molecular Pathology) - p. 987 247. Chapter 193: Overview of HPV- and Non-HPV-Related Tumors - p. 1001 248. SQUAMOUS CELL CARCINOMA AND ITS SUBTYPES - p. 1005 249. Chapter 194: Squamous Cell Carcinoma, Usual Type - p. 1005 250. Chapter 195: Basaloid Squamous Cell Carcinoma - p. 1009 251. Chapter 196: Basaloid Squamous Cell Carcinoma, Papillary Subtype - p. 1013 252. Chapter 197: Warty (Condylomatous) Squamous Cell Carcinoma - p. 1015 253. Chapter 198: Warty-Basaloid Squamous Cell Carcinoma - p. 1019 254. Chapter 199: Verrucous Squamous Cell Carcinoma - p. 1021 255. Chapter 200: Papillary Squamous Cell Carcinoma, Not Otherwise Specified - p. 1025 256. Chapter 201: Pseudoglandular Squamous Cell Carcinoma - p. 1029 257. Chapter 202: Pseudohyperplastic Squamous Cell Carcinoma - p. 1031 258. Chapter 203: Cuniculatum Squamous Cell Carcinoma - p. 1033 259. Chapter 204: Sarcomatoid Squamous Cell Carcinoma - p. 1037 260. Chapter 205: Mixed Squamous Cell Carcinoma - p. 1041 261. Chapter 206: Undifferentiated to Poorly Differentiated Squamous Cell Carcinomas With Prominent Inflammatory Infiltrate - p. 1045 262. Chapter 207: Clear Cell Carcinoma - p. 1047 263. OTHER NEOPLASTIC CONDITIONS - p. 1049 264. Chapter 208: Extramammary Paget Disease - p. 1049 265. Chapter 209: Kaposi Sarcoma - p. 1053 266. Chapter 210: Myointimoma - p. 1055 267. METASTATIC TUMORS - p. 1057 268. Chapter 211: Metastatic Tumors, Penis - p. 1057 269. IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS INVOLVING PENIS - p. 1059 270. Chapter 212: Immunohistochemistry, Penis - p. 1059 271. INDEX - p. 1061
