This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of neoplastic dermatopathology, it incorporates the most recent clinical, pathological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, Diagnostic Pathology: Neoplastic Dermatopathology is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
Covers the broad array of cutaneous neoplasms and their differential diagnoses in a concise, practical, and richly illustrated format
Analyzes hundreds of diagnoses, each of which include critical diagnostic information such as definitions, epidemiology, clinical presentation, macro- and microscopic features, differential diagnoses, and pathologic interpretation pearls
Features thorough updates throughout, including new information from molecular pathology studies that describe multiple mutations in different cutaneous tumors, and updated staging details for melanoma, cutaneous lymphoma, and other tumors
Addresses recent advances in molecular pathology—new diagnostic, immunohistochemical, molecular, and genetic techniques used for diagnosis, as well as updated reportable staging details for several new diagnoses and identification of newly recognized tumors
Details the expanded scope of knowledge available from the 2018 update to the World Health Organization and European Organization for Research and Treatment of Cancer (WHO-EORTC)
Includes more than 2,900 carefully annotated photographs, images, and illustrations plus nearly 1,000 additional digital-only images to help practicing and in-training pathologists reach a confident diagnosis
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedications - p. iii 6. Contributing Authors - p. v 7. Preface - p. v 8. Acknowledgments - p. ix 9. Sections - p. xi 10. List of Tables - p. xiii 11. Part I: Nonmelanocytic Tumors of Skin - p. xiii 12. SECTION 1: EPITHELIAL CYSTS - p. xiii 13. Chapter 1: Epidermoid/Epidermal Inclusion Cyst - p. xiii 14. Chapter 2: Pilar (Trichilemmal) Cyst - p. 5 15. Chapter 3: Proliferating Pilar (Trichilemmal) Cyst/Tumor - p. 7 16. Chapter 4: HPV-Related Epidermal Cyst - p. 11 17. Chapter 5: Vellus Hair Cyst - p. 13 18. Chapter 6: Steatocystoma (Multiplex) - p. 15 19. Chapter 7: Cutaneous Keratocyst - p. 17 20. Chapter 8: Milia Cysts - p. 19 21. Chapter 9: Hidrocystoma (Apocrine and Eccrine) - p. 21 22. Chapter 10: Digital Mucous Cyst - p. 23 23. Chapter 11: Bronchogenic Cyst - p. 25 24. Chapter 12: Branchial Cleft Cyst - p. 27 25. Chapter 13: Median Raphe Cyst - p. 33 26. Chapter 14: Cutaneous Ciliated Cyst - p. 35 27. SECTION 2: EPIDERMAL TUMORS - p. 37 28. BENIGN EPIDERMAL TUMORS AND PROLIFERATIVE LESIONS - p. 37 29. Chapter 15: Epidermal Nevus - p. 37 30. Chapter 16: Seborrheic Keratosis (and Variants) - p. 43 31. Chapter 17: Pseudoepitheliomatous Hyperplasia - p. 49 32. Chapter 18: Warty Dyskeratoma - p. 51 33. Chapter 19: Acantholytic and Acantholytic Dyskeratotic Acanthoma - p. 55 34. Chapter 20: Verruca Vulgaris (and Variants) - p. 57 35. Chapter 21: Condyloma Acuminatum (Genital Wart) - p. 61 36. Chapter 22: Prurigo Nodularis - p. 65 37. Chapter 23: Large Cell Acanthoma - p. 67 38. Chapter 24: Clear Cell Acanthoma - p. 69 39. Chapter 25: Clear Cell Papulosis - p. 71 40. Chapter 26: Toker Cell Hyperplasia - p. 73 41. Chapter 27: Porokeratosis - p. 75 42. PREMALIGNANT AND MALIGNANT EPIDERMAL TUMORS - p. 79 43. Chapter 28: Actinic Keratosis - p. 79 44. Chapter 29: Actinic Cheilitis - p. 83 45. Chapter 30: Squamous Cell Carcinoma In Situ (Bowen Disease) - p. 85 46. Chapter 31: Bowenoid Papulosis - p. 89 47. Chapter 32: Penile and Vulvar Intraepithelial Neoplasia - p. 91 48. Chapter 33: Epidermodysplasia Verruciformis - p. 95 49. Chapter 34: Verrucous Carcinoma (and Variants) - p. 97 50. Chapter 35: Squamous Cell Carcinoma (and Variants) - p. 103 51. Chapter 36: Keratoacanthoma - p. 109 52. Chapter 37: Lymphoepithelioma-Like Carcinoma of Skin - p. 113 53. Chapter 38: Basal Cell Carcinoma - p. 115 54. Chapter 39: Extramammary Paget Disease - p. 121 55. Chapter 40: Squamomelanocytic Tumor - p. 125 56. Chapter 41: Staging for Specimens of Squamous Cell Carcinoma of Skin - p. 127 57. SECTION 3: TUMORS AND TUMOR-LIKE CONDITIONS OF THE HAIR FOLLICLE - p. 129 58. Chapter 42: Nevus Sebaceus and Follicular Hamartomas - p. 129 59. Chapter 43: Trichofolliculoma - p. 135 60. Chapter 44: Trichoadenoma - p. 137 61. Chapter 45: Trichoepithelioma - p. 139 62. Chapter 46: Trichoblastoma and Trichoblastic Carcinoma - p. 143 63. Chapter 47: Panfolliculoma - p. 147 64. Chapter 48: Tumor of the Follicular Infundibulum - p. 149 65. Chapter 49: Dilated Pore of Winer - p. 151 66. Chapter 50: Pilar Sheath Acanthoma - p. 153 67. Chapter 51: Inverted Follicular Keratosis - p. 155 68. Chapter 52: Trichilemmoma - p. 157 69. Chapter 53: Trichilemmal Carcinoma - p. 161 70. Chapter 54: Pilomatrixoma and Pilomatrical Carcinoma - p. 163 71. Chapter 55: Fibrofolliculoma and Trichodiscoma - p. 167 72. SECTION 4: TUMORS AND TUMOR-LIKE CONDITIONS WITH SEBACEOUS DIFFERENTIATION - p. 169 73. Chapter 56: Sebaceous Hyperplasia - p. 169 74. Chapter 57: Superficial Epithelioma With Sebaceous Differentiation - p. 173 75. Chapter 58: Sebaceoma (Sebaceous Epithelioma) - p. 175 76. Chapter 59: Sebaceous Adenoma - p. 179 77. Chapter 60: Sebaceous Carcinoma - p. 181 78. SECTION 5: NEOPLASMS AND PROLIFERATIONS OF ECCRINE AND APOCRINE SWEAT GLANDS - p. 187 79. Chapter 61: Apocrine (Papillary) Tubular Adenoma - p. 187 80. Chapter 62: Syringocystadenoma Papilliferum - p. 191 81. Chapter 63: Hidradenoma Papilliferum - p. 195 82. Chapter 64: Hidradenoma - p. 197 83. Chapter 65: Hidradenocarcinoma - p. 201 84. Chapter 66: Poroma and Dermal Duct Tumor - p. 205 85. Chapter 67: Porocarcinoma - p. 209 86. Chapter 68: Cylindroma and Cylindrocarcinoma - p. 211 87. Chapter 69: Spiradenoma and Spiradenocarcinoma - p. 217 88. Chapter 70: Adenoid Cystic Carcinoma - p. 221 89. Chapter 71: Primary Cutaneous Endocrine Mucin-Producing Carcinoma - p. 223 90. Chapter 72: Primary Cutaneous Mucinous Carcinoma - p. 225 91. Chapter 73: Apocrine Carcinoma (Apocrine Adenocarcinoma) - p. 229 92. Chapter 74: Digital Papillary Adenocarcinoma - p. 231 93. Chapter 75: Eccrine Hamartomas - p. 235 94. Chapter 76: Papillary Eccrine Adenoma - p. 237 95. Chapter 77: Syringoma - p. 239 96. Chapter 78: Syringofibroadenoma - p. 241 97. Chapter 79: Eccrine Carcinoma - p. 243 98. Chapter 80: Squamoid Eccrine Ductal Carcinoma - p. 245 99. Chapter 81: Microcystic Adnexal Carcinoma - p. 247 100. Chapter 82: Cutaneous Mixed Tumor (Chondroid Syringoma) - p. 251 101. Chapter 83: Malignant Mixed Tumor - p. 255 102. SECTION 6: METASTATIC TUMORS - p. 257 103. Chapter 84: Metastatic Skin Tumors - p. 257 104. Chapter 85: Metastatic Tumors to the Skin - p. 263 105. SECTION 7: FIBROUS AND “FIBROHISTIOCYTIC” TISSUE TUMORS - p. 269 106. BENIGN FIBROUS AND “FIBROHISTIOCYTIC” TISSUE TUMORS - p. 269 107. Chapter 86: Fibroepithelial Polyps (Acrochordons) - p. 269 108. Chapter 87: Keloid and Cellular Scar - p. 273 109. Chapter 88: Desmoplastic Fibroblastoma - p. 275 110. Chapter 89: Pleomorphic Fibroma - p. 277 111. Chapter 90: Sclerotic Fibroma - p. 279 112. Chapter 91: Fibromatosis - p. 281 113. Chapter 92: Juvenile Hyaline Fibromatosis - p. 287 114. Chapter 93: Angiofibroma and Related Lesions - p. 289 115. Chapter 94: Acral Fibrokeratoma - p. 291 116. Chapter 95: Dermatofibroma and Fibrous Histiocytoma - p. 293 117. Chapter 96: Epithelioid Cell Histiocytoma - p. 299 118. Chapter 97: Dermatomyofibroma - p. 301 119. Chapter 98: Fibrous Hamartoma of Infancy - p. 303 120. Chapter 99: Digital Fibromatosis (Infantile Digital Fibromatosis) - p. 309 121. Chapter 100: Angiomyofibroblastoma - p. 313 122. Chapter 101: Multinucleate Cell Angiohistiocytoma - p. 317 123. Chapter 102: Localized-Type Tenosynovial Giant Cell Tumor - p. 319 124. Chapter 103: Myofibroma and Myofibromatosis - p. 325 125. Chapter 104: Cutaneous Myxoma and Angiomyxoma - p. 329 126. Chapter 105: Superficial Acral Fibromyxoma - p. 331 127. Chapter 106: Pseudosarcomatous Fibroblastic Proliferations - p. 333 128. ATYPICAL AND MALIGNANT FIBROUS AND “FIBROHISTIOCYTIC” TISSUE TUMORS - p. 341 129. Chapter 107: Angiomatoid Fibrous Histiocytoma - p. 341 130. Chapter 108: Plexiform Fibrohistiocytic Tumor - p. 349 131. Chapter 109: Dermatofibrosarcoma Protuberans - p. 353 132. Chapter 110: Atypical Fibroxanthoma - p. 359 133. Chapter 111: Pleomorphic (Dermal) Sarcoma - p. 365 134. Chapter 112: Adult-Type Fibrosarcoma - p. 367 135. Chapter 113: Myxofibrosarcoma - p. 369 136. Chapter 114: Superficial Low-Grade Fibromyxoid Sarcoma - p. 373 137. Chapter 115: Myxoinflammatory Fibroblastic Sarcoma - p. 375 138. SECTION 8: VASCULAR AND PERIVASCULAR TUMORS AND PSEUDOTUMORS - p. 383 139. Chapter 116: Vascular Malformations - p. 383 140. Chapter 117: Arteriovenous Hemangioma (Malformation) - p. 389 141. Chapter 118: Capillary, Venous, and Cavernous Hemangiomas - p. 391 142. Chapter 119: Infantile (Juvenile) Hemangioma - p. 397 143. Chapter 120: Sinusoidal Hemangioma - p. 403 144. Chapter 121: Tufted Angioma - p. 405 145. Chapter 122: Glomeruloid Hemangioma - p. 407 146. Chapter 123: Angiolymphoid Hyperplasia With Eosinophilia - p. 409 147. Chapter 124: Hobnail (Targetoid Hemosiderotic) Hemangioma - p. 411 148. Chapter 125: Spindle Cell Hemangioma - p. 413 149. Chapter 126: Microvenular Hemangioma - p. 415 150. Chapter 127: Verrucous Hemangioma - p. 417 151. Chapter 128: Angiokeratoma - p. 419 152. Chapter 129: Venous Lake - p. 421 153. Chapter 130: Papillary Endothelial Hyperplasia (Masson Tumor) - p. 423 154. Chapter 131: Glomus Tumors - p. 425 155. Chapter 132: Lymphangioma and Superficial Lymphangioma - p. 431 156. Chapter 133: Progressive Lymphangioma - p. 435 157. Chapter 134: Bacillary Angiomatosis - p. 437 158. Chapter 135: Kaposi Sarcoma - p. 439 159. Chapter 136: Kaposiform Hemangioendothelioma - p. 447 160. Chapter 137: Epithelioid Hemangioendothelioma - p. 449 161. Chapter 138: Retiform Hemangioendothelioma - p. 453 162. Chapter 139: Papillary Intralymphatic Angioendothelioma (Dabska Tumor) - p. 455 163. Chapter 140: Atypical Vascular Lesion - p. 457 164. Chapter 141: Angiosarcoma - p. 459 165. SECTION 9: TUMORS AND TUMOR-LIKE CONDITIONS WITH NEURAL, NERVE SHEATH, AND NEUROENDOCRINE DIFFERENTIATION - p. 465 166. Chapter 142: Neuromas - p. 465 167. Chapter 143: Neurofibroma - p. 471 168. Chapter 144: Schwannoma - p. 479 169. Chapter 145: Dermal Nerve Sheath Myxoma - p. 493 170. Chapter 146: Granular Cell Tumor - p. 497 171. Chapter 147: Lipomatosis of Nerve - p. 503 172. Chapter 148: Perineurioma - p. 505 173. Chapter 149: Nasal Glial Heterotopia - p. 509 174. Chapter 150: Ectopic Meningioma - p. 511 175. Chapter 151: Superficial Malignant Peripheral Nerve Sheath Tumor - p. 513 176. Chapter 152: Superficial Ewing Sarcoma - p. 517 177. Chapter 153: Primary Neuroendocrine (Merkel Cell) Carcinoma - p. 521 178. SECTION 10: TUMORS OF MUSCLE, FAT, CARTILAGE, AND BONE - p. 525 179. Chapter 154: Congenital Smooth Muscle Hamartoma - p. 525 180. Chapter 155: Leiomyoma (Pilar) - p. 529 181. Chapter 156: Angioleiomyoma - p. 533 182. Chapter 157: Leiomyosarcoma - p. 535 183. Chapter 158: Rhabdomyoma - p. 539 184. Chapter 159: Cutaneous Rhabdomyosarcoma - p. 543 185. Chapter 160: Lipoma - p. 547 186. Chapter 161: Angiolipoma - p. 553 187. Chapter 162: Spindle Cell/Pleomorphic Lipoma - p. 557 188. Chapter 163: Chondroid Lipoma - p. 563 189. Chapter 164: Nevus Lipomatosus - p. 567 190. Chapter 165: Hibernoma - p. 569 191. Chapter 166: Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma - p. 571 192. Chapter 167: Soft Tissue Chondroma - p. 577 193. Chapter 168: Osteoma Cutis - p. 583 194. SECTION 11: HISTIOCYTIC PROLIFERATIONS - p. 585 195. Chapter 169: Juvenile and Adult-Type Xanthogranuloma - p. 585 196. Chapter 170: Reticulohistiocytoma - p. 591 197. Chapter 171: Multicentric Reticulohistiocytosis - p. 595 198. Chapter 172: Langerhans Cell Histiocytosis - p. 597 199. Chapter 173: Non-Langerhans Cell Histiocytoses - p. 601 200. Chapter 174: Rosai-Dorfman Disease - p. 609 201. Chapter 175: Histiocytic Sarcoma - p. 615 202. Chapter 176: Polyvinylpyrrolidone Storage Disease - p. 619 203. Chapter 177: Xanthomas - p. 621 204. Chapter 178: Verruciform Xanthoma - p. 625 205. SECTION 12: LYMPHOMAS AND HEMATOPOIETIC PROLIFERATIONS - p. 627 206. B-CELL NEOPLASMS - p. 627 207. Chapter 179: Cutaneous Plasmacytoma - p. 627 208. Chapter 180: Primary Cutaneous Marginal Zone Lymphoma - p. 633 209. Chapter 181: Primary Cutaneous Follicle Center Lymphoma - p. 639 210. Chapter 182: Diffuse Large B-Cell Lymphoma, Leg Type - p. 645 211. Chapter 183: Lymphomatoid Granulomatosis - p. 653 212. Chapter 184: Systemic B-Cell Lymphomas Involving Skin - p. 657 213. Chapter 185: Intravascular Large B-Cell Lymphoma - p. 665 214. T-CELL AND NK-CELL NEOPLASMS - p. 669 215. Chapter 186: Mycosis Fungoides (and Subtypes) - p. 669 216. Chapter 187: Adult T-Cell Leukemia/Lymphoma - p. 681 217. Chapter 188: Subcutaneous Panniculitis-Like T-Cell Lymphoma - p. 685 218. Chapter 189: Extranodal NK-/T-Cell Lymphoma, Nasal Type - p. 691 219. Chapter 190: Lymphomatoid Papulosis - p. 697 220. Chapter 191: Primary Cutaneous Anaplastic Large Cell Lymphoma - p. 703 221. Chapter 192: Aggressive Epidermotropic CD8(+) Cytotoxic T-Cell Lymphoma - p. 708 222. Chapter 193: Primary Cutaneous CD4(+) Small/Medium T-Cell Lymphoproliferative Disorder - p. 713 223. Chapter 194: Cutaneous Gamma-Delta T-Cell Lymphoma - p. 719 224. Chapter 195: Angioimmunoblastic T-Cell Lymphoma - p. 725 225. Chapter 196: Systemic T-Cell and NK-Cell Lymphomas Involving Skin - p. 731 226. LEUKEMIC AND NONLYMPHOID INFILTRATES - p. 737 227. Chapter 197: Leukemia Cutis - p. 737 228. Chapter 198: Blastic Plasmacytoid Dendritic Cell Neoplasm - p. 743 229. Chapter 199: Extramedullary Hematopoiesis - p. 751 230. Chapter 200: Cutaneous and Systemic Mastocytosis - p. 753 231. SECTION 13: TUMORS OF UNCERTAIN LINEAGE - p. 761 232. Chapter 201: Myoepithelioma of Soft Tissue - p. 761 233. Chapter 202: Epithelioid Sarcoma - p. 771 234. Chapter 203: Cellular Neurothekeoma - p. 777 235. Chapter 204: Distinctive Dermal Clear Cell Mesenchymal Tumor - p. 781 236. Chapter 205: PEComas - p. 783 237. Part II: Melanocytic Tumors of Skin - p. 789 238. SECTION 1: BENIGN MELANOCYTIC TUMORS (NEVI) - p. 789 239. Chapter 206: Congenital Melanocytic Nevi - p. 789 240. Chapter 207: Common Acquired Melanocytic Nevi - p. 793 241. Chapter 208: Conventional Blue Nevi - p. 797 242. Chapter 209: Cellular Blue Nevi - p. 801 243. Chapter 210: Combined Nevi - p. 805 244. Chapter 211: Halo Nevi - p. 807 245. Chapter 212: Nevi of Special Sites - p. 809 246. Chapter 213: Inverted Type A Nevi - p. 813 247. Chapter 214: Deep Penetrating Nevi - p. 817 248. Chapter 215: Conjunctival Melanocytic Nevi - p. 823 249. Chapter 216: Dermal Melanocytoses (Nevus of Ota and Ito, Mongolian Spot) - p. 827 250. Chapter 217: Paraganglioma-Like Dermal Melanocytic Tumor - p. 829 251. Chapter 218: Dysplastic Melanocytic Nevi - p. 831 252. Chapter 219: Spitz (Spindle and Epithelioid Cell) Nevi - p. 837 253. Chapter 220: Pigmented Spindle Cell Nevus (Reed Nevus) - p. 843 254. Chapter 221: BAP1-Inactivated Melanocytoma - p. 847 255. SECTION 2: MALIGNANT TUMORS (MELANOMAS AND RELATED LESIONS) - p. 851 256. MELANOMA IN SITU - p. 851 257. Chapter 222: Melanoma In Situ, Lentigo Maligna Type - p. 851 258. Chapter 223: Melanoma In Situ, Superficial Spreading Type - p. 859 259. Chapter 224: Melanoma In Situ, Not Otherwise Specified - p. 863 260. INVASIVE MELANOMA - p. 867 261. Chapter 225: Childhood Melanoma - p. 867 262. Chapter 226: Atypical/Borderline and Malignant Spitz Tumors - p. 875 263. Chapter 227: Melanoma, Lentigo Maligna Type - p. 879 264. Chapter 228: Melanoma, Superficial Spreading Type - p. 883 265. Chapter 229: Melanoma, Nodular Type - p. 887 266. Chapter 230: Desmoplastic Melanoma - p. 891 267. Chapter 231: Nevoid Melanoma - p. 897 268. Chapter 232: Acral Lentiginous Melanoma - p. 901 269. Chapter 233: Oral Melanoma - p. 907 270. Chapter 234: Mucosal Melanoma (Genital) - p. 911 271. Chapter 235: Sinonasal Melanoma - p. 915 272. Chapter 236: Conjunctival Melanoma - p. 921 273. Chapter 237: Malignant Cellular Blue Nevus (Melanoma Arising in or Mimicking a Cellular Blue Nevus) - p. 925 274. Chapter 238: Pigmented Epithelioid Melanocytoma ("Animal-Type Melanoma") - p. 929 275. Chapter 239: Primary Dermal Melanoma - p. 935 276. Chapter 240: Other Unusual and Rare Variants of Melanoma - p. 937 277. Chapter 241: Staging for Specimens of Malignant Melanoma of Skin - p. 941 278. INDEX - p. 945
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of neoplastic dermatopathology, it incorporates the most recent clinical, pathological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, Diagnostic Pathology: Neoplastic Dermatopathology is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
Covers the broad array of cutaneous neoplasms and their differential diagnoses in a concise, practical, and richly illustrated format
Analyzes hundreds of diagnoses, each of which include critical diagnostic information such as definitions, epidemiology, clinical presentation, macro- and microscopic features, differential diagnoses, and pathologic interpretation pearls
Features thorough updates throughout, including new information from molecular pathology studies that describe multiple mutations in different cutaneous tumors, and updated staging details for melanoma, cutaneous lymphoma, and other tumors
Addresses recent advances in molecular pathology—new diagnostic, immunohistochemical, molecular, and genetic techniques used for diagnosis, as well as updated reportable staging details for several new diagnoses and identification of newly recognized tumors
Details the expanded scope of knowledge available from the 2018 update to the World Health Organization and European Organization for Research and Treatment of Cancer (WHO-EORTC)
Includes more than 2,900 carefully annotated photographs, images, and illustrations plus nearly 1,000 additional digital-only images to help practicing and in-training pathologists reach a confident diagnosis
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedications - p. iii 6. Contributing Authors - p. v 7. Preface - p. v 8. Acknowledgments - p. ix 9. Sections - p. xi 10. List of Tables - p. xiii 11. Part I: Nonmelanocytic Tumors of Skin - p. xiii 12. SECTION 1: EPITHELIAL CYSTS - p. xiii 13. Chapter 1: Epidermoid/Epidermal Inclusion Cyst - p. xiii 14. Chapter 2: Pilar (Trichilemmal) Cyst - p. 5 15. Chapter 3: Proliferating Pilar (Trichilemmal) Cyst/Tumor - p. 7 16. Chapter 4: HPV-Related Epidermal Cyst - p. 11 17. Chapter 5: Vellus Hair Cyst - p. 13 18. Chapter 6: Steatocystoma (Multiplex) - p. 15 19. Chapter 7: Cutaneous Keratocyst - p. 17 20. Chapter 8: Milia Cysts - p. 19 21. Chapter 9: Hidrocystoma (Apocrine and Eccrine) - p. 21 22. Chapter 10: Digital Mucous Cyst - p. 23 23. Chapter 11: Bronchogenic Cyst - p. 25 24. Chapter 12: Branchial Cleft Cyst - p. 27 25. Chapter 13: Median Raphe Cyst - p. 33 26. Chapter 14: Cutaneous Ciliated Cyst - p. 35 27. SECTION 2: EPIDERMAL TUMORS - p. 37 28. BENIGN EPIDERMAL TUMORS AND PROLIFERATIVE LESIONS - p. 37 29. Chapter 15: Epidermal Nevus - p. 37 30. Chapter 16: Seborrheic Keratosis (and Variants) - p. 43 31. Chapter 17: Pseudoepitheliomatous Hyperplasia - p. 49 32. Chapter 18: Warty Dyskeratoma - p. 51 33. Chapter 19: Acantholytic and Acantholytic Dyskeratotic Acanthoma - p. 55 34. Chapter 20: Verruca Vulgaris (and Variants) - p. 57 35. Chapter 21: Condyloma Acuminatum (Genital Wart) - p. 61 36. Chapter 22: Prurigo Nodularis - p. 65 37. Chapter 23: Large Cell Acanthoma - p. 67 38. Chapter 24: Clear Cell Acanthoma - p. 69 39. Chapter 25: Clear Cell Papulosis - p. 71 40. Chapter 26: Toker Cell Hyperplasia - p. 73 41. Chapter 27: Porokeratosis - p. 75 42. PREMALIGNANT AND MALIGNANT EPIDERMAL TUMORS - p. 79 43. Chapter 28: Actinic Keratosis - p. 79 44. Chapter 29: Actinic Cheilitis - p. 83 45. Chapter 30: Squamous Cell Carcinoma In Situ (Bowen Disease) - p. 85 46. Chapter 31: Bowenoid Papulosis - p. 89 47. Chapter 32: Penile and Vulvar Intraepithelial Neoplasia - p. 91 48. Chapter 33: Epidermodysplasia Verruciformis - p. 95 49. Chapter 34: Verrucous Carcinoma (and Variants) - p. 97 50. Chapter 35: Squamous Cell Carcinoma (and Variants) - p. 103 51. Chapter 36: Keratoacanthoma - p. 109 52. Chapter 37: Lymphoepithelioma-Like Carcinoma of Skin - p. 113 53. Chapter 38: Basal Cell Carcinoma - p. 115 54. Chapter 39: Extramammary Paget Disease - p. 121 55. Chapter 40: Squamomelanocytic Tumor - p. 125 56. Chapter 41: Staging for Specimens of Squamous Cell Carcinoma of Skin - p. 127 57. SECTION 3: TUMORS AND TUMOR-LIKE CONDITIONS OF THE HAIR FOLLICLE - p. 129 58. Chapter 42: Nevus Sebaceus and Follicular Hamartomas - p. 129 59. Chapter 43: Trichofolliculoma - p. 135 60. Chapter 44: Trichoadenoma - p. 137 61. Chapter 45: Trichoepithelioma - p. 139 62. Chapter 46: Trichoblastoma and Trichoblastic Carcinoma - p. 143 63. Chapter 47: Panfolliculoma - p. 147 64. Chapter 48: Tumor of the Follicular Infundibulum - p. 149 65. Chapter 49: Dilated Pore of Winer - p. 151 66. Chapter 50: Pilar Sheath Acanthoma - p. 153 67. Chapter 51: Inverted Follicular Keratosis - p. 155 68. Chapter 52: Trichilemmoma - p. 157 69. Chapter 53: Trichilemmal Carcinoma - p. 161 70. Chapter 54: Pilomatrixoma and Pilomatrical Carcinoma - p. 163 71. Chapter 55: Fibrofolliculoma and Trichodiscoma - p. 167 72. SECTION 4: TUMORS AND TUMOR-LIKE CONDITIONS WITH SEBACEOUS DIFFERENTIATION - p. 169 73. Chapter 56: Sebaceous Hyperplasia - p. 169 74. Chapter 57: Superficial Epithelioma With Sebaceous Differentiation - p. 173 75. Chapter 58: Sebaceoma (Sebaceous Epithelioma) - p. 175 76. Chapter 59: Sebaceous Adenoma - p. 179 77. Chapter 60: Sebaceous Carcinoma - p. 181 78. SECTION 5: NEOPLASMS AND PROLIFERATIONS OF ECCRINE AND APOCRINE SWEAT GLANDS - p. 187 79. Chapter 61: Apocrine (Papillary) Tubular Adenoma - p. 187 80. Chapter 62: Syringocystadenoma Papilliferum - p. 191 81. Chapter 63: Hidradenoma Papilliferum - p. 195 82. Chapter 64: Hidradenoma - p. 197 83. Chapter 65: Hidradenocarcinoma - p. 201 84. Chapter 66: Poroma and Dermal Duct Tumor - p. 205 85. Chapter 67: Porocarcinoma - p. 209 86. Chapter 68: Cylindroma and Cylindrocarcinoma - p. 211 87. Chapter 69: Spiradenoma and Spiradenocarcinoma - p. 217 88. Chapter 70: Adenoid Cystic Carcinoma - p. 221 89. Chapter 71: Primary Cutaneous Endocrine Mucin-Producing Carcinoma - p. 223 90. Chapter 72: Primary Cutaneous Mucinous Carcinoma - p. 225 91. Chapter 73: Apocrine Carcinoma (Apocrine Adenocarcinoma) - p. 229 92. Chapter 74: Digital Papillary Adenocarcinoma - p. 231 93. Chapter 75: Eccrine Hamartomas - p. 235 94. Chapter 76: Papillary Eccrine Adenoma - p. 237 95. Chapter 77: Syringoma - p. 239 96. Chapter 78: Syringofibroadenoma - p. 241 97. Chapter 79: Eccrine Carcinoma - p. 243 98. Chapter 80: Squamoid Eccrine Ductal Carcinoma - p. 245 99. Chapter 81: Microcystic Adnexal Carcinoma - p. 247 100. Chapter 82: Cutaneous Mixed Tumor (Chondroid Syringoma) - p. 251 101. Chapter 83: Malignant Mixed Tumor - p. 255 102. SECTION 6: METASTATIC TUMORS - p. 257 103. Chapter 84: Metastatic Skin Tumors - p. 257 104. Chapter 85: Metastatic Tumors to the Skin - p. 263 105. SECTION 7: FIBROUS AND “FIBROHISTIOCYTIC” TISSUE TUMORS - p. 269 106. BENIGN FIBROUS AND “FIBROHISTIOCYTIC” TISSUE TUMORS - p. 269 107. Chapter 86: Fibroepithelial Polyps (Acrochordons) - p. 269 108. Chapter 87: Keloid and Cellular Scar - p. 273 109. Chapter 88: Desmoplastic Fibroblastoma - p. 275 110. Chapter 89: Pleomorphic Fibroma - p. 277 111. Chapter 90: Sclerotic Fibroma - p. 279 112. Chapter 91: Fibromatosis - p. 281 113. Chapter 92: Juvenile Hyaline Fibromatosis - p. 287 114. Chapter 93: Angiofibroma and Related Lesions - p. 289 115. Chapter 94: Acral Fibrokeratoma - p. 291 116. Chapter 95: Dermatofibroma and Fibrous Histiocytoma - p. 293 117. Chapter 96: Epithelioid Cell Histiocytoma - p. 299 118. Chapter 97: Dermatomyofibroma - p. 301 119. Chapter 98: Fibrous Hamartoma of Infancy - p. 303 120. Chapter 99: Digital Fibromatosis (Infantile Digital Fibromatosis) - p. 309 121. Chapter 100: Angiomyofibroblastoma - p. 313 122. Chapter 101: Multinucleate Cell Angiohistiocytoma - p. 317 123. Chapter 102: Localized-Type Tenosynovial Giant Cell Tumor - p. 319 124. Chapter 103: Myofibroma and Myofibromatosis - p. 325 125. Chapter 104: Cutaneous Myxoma and Angiomyxoma - p. 329 126. Chapter 105: Superficial Acral Fibromyxoma - p. 331 127. Chapter 106: Pseudosarcomatous Fibroblastic Proliferations - p. 333 128. ATYPICAL AND MALIGNANT FIBROUS AND “FIBROHISTIOCYTIC” TISSUE TUMORS - p. 341 129. Chapter 107: Angiomatoid Fibrous Histiocytoma - p. 341 130. Chapter 108: Plexiform Fibrohistiocytic Tumor - p. 349 131. Chapter 109: Dermatofibrosarcoma Protuberans - p. 353 132. Chapter 110: Atypical Fibroxanthoma - p. 359 133. Chapter 111: Pleomorphic (Dermal) Sarcoma - p. 365 134. Chapter 112: Adult-Type Fibrosarcoma - p. 367 135. Chapter 113: Myxofibrosarcoma - p. 369 136. Chapter 114: Superficial Low-Grade Fibromyxoid Sarcoma - p. 373 137. Chapter 115: Myxoinflammatory Fibroblastic Sarcoma - p. 375 138. SECTION 8: VASCULAR AND PERIVASCULAR TUMORS AND PSEUDOTUMORS - p. 383 139. Chapter 116: Vascular Malformations - p. 383 140. Chapter 117: Arteriovenous Hemangioma (Malformation) - p. 389 141. Chapter 118: Capillary, Venous, and Cavernous Hemangiomas - p. 391 142. Chapter 119: Infantile (Juvenile) Hemangioma - p. 397 143. Chapter 120: Sinusoidal Hemangioma - p. 403 144. Chapter 121: Tufted Angioma - p. 405 145. Chapter 122: Glomeruloid Hemangioma - p. 407 146. Chapter 123: Angiolymphoid Hyperplasia With Eosinophilia - p. 409 147. Chapter 124: Hobnail (Targetoid Hemosiderotic) Hemangioma - p. 411 148. Chapter 125: Spindle Cell Hemangioma - p. 413 149. Chapter 126: Microvenular Hemangioma - p. 415 150. Chapter 127: Verrucous Hemangioma - p. 417 151. Chapter 128: Angiokeratoma - p. 419 152. Chapter 129: Venous Lake - p. 421 153. Chapter 130: Papillary Endothelial Hyperplasia (Masson Tumor) - p. 423 154. Chapter 131: Glomus Tumors - p. 425 155. Chapter 132: Lymphangioma and Superficial Lymphangioma - p. 431 156. Chapter 133: Progressive Lymphangioma - p. 435 157. Chapter 134: Bacillary Angiomatosis - p. 437 158. Chapter 135: Kaposi Sarcoma - p. 439 159. Chapter 136: Kaposiform Hemangioendothelioma - p. 447 160. Chapter 137: Epithelioid Hemangioendothelioma - p. 449 161. Chapter 138: Retiform Hemangioendothelioma - p. 453 162. Chapter 139: Papillary Intralymphatic Angioendothelioma (Dabska Tumor) - p. 455 163. Chapter 140: Atypical Vascular Lesion - p. 457 164. Chapter 141: Angiosarcoma - p. 459 165. SECTION 9: TUMORS AND TUMOR-LIKE CONDITIONS WITH NEURAL, NERVE SHEATH, AND NEUROENDOCRINE DIFFERENTIATION - p. 465 166. Chapter 142: Neuromas - p. 465 167. Chapter 143: Neurofibroma - p. 471 168. Chapter 144: Schwannoma - p. 479 169. Chapter 145: Dermal Nerve Sheath Myxoma - p. 493 170. Chapter 146: Granular Cell Tumor - p. 497 171. Chapter 147: Lipomatosis of Nerve - p. 503 172. Chapter 148: Perineurioma - p. 505 173. Chapter 149: Nasal Glial Heterotopia - p. 509 174. Chapter 150: Ectopic Meningioma - p. 511 175. Chapter 151: Superficial Malignant Peripheral Nerve Sheath Tumor - p. 513 176. Chapter 152: Superficial Ewing Sarcoma - p. 517 177. Chapter 153: Primary Neuroendocrine (Merkel Cell) Carcinoma - p. 521 178. SECTION 10: TUMORS OF MUSCLE, FAT, CARTILAGE, AND BONE - p. 525 179. Chapter 154: Congenital Smooth Muscle Hamartoma - p. 525 180. Chapter 155: Leiomyoma (Pilar) - p. 529 181. Chapter 156: Angioleiomyoma - p. 533 182. Chapter 157: Leiomyosarcoma - p. 535 183. Chapter 158: Rhabdomyoma - p. 539 184. Chapter 159: Cutaneous Rhabdomyosarcoma - p. 543 185. Chapter 160: Lipoma - p. 547 186. Chapter 161: Angiolipoma - p. 553 187. Chapter 162: Spindle Cell/Pleomorphic Lipoma - p. 557 188. Chapter 163: Chondroid Lipoma - p. 563 189. Chapter 164: Nevus Lipomatosus - p. 567 190. Chapter 165: Hibernoma - p. 569 191. Chapter 166: Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma - p. 571 192. Chapter 167: Soft Tissue Chondroma - p. 577 193. Chapter 168: Osteoma Cutis - p. 583 194. SECTION 11: HISTIOCYTIC PROLIFERATIONS - p. 585 195. Chapter 169: Juvenile and Adult-Type Xanthogranuloma - p. 585 196. Chapter 170: Reticulohistiocytoma - p. 591 197. Chapter 171: Multicentric Reticulohistiocytosis - p. 595 198. Chapter 172: Langerhans Cell Histiocytosis - p. 597 199. Chapter 173: Non-Langerhans Cell Histiocytoses - p. 601 200. Chapter 174: Rosai-Dorfman Disease - p. 609 201. Chapter 175: Histiocytic Sarcoma - p. 615 202. Chapter 176: Polyvinylpyrrolidone Storage Disease - p. 619 203. Chapter 177: Xanthomas - p. 621 204. Chapter 178: Verruciform Xanthoma - p. 625 205. SECTION 12: LYMPHOMAS AND HEMATOPOIETIC PROLIFERATIONS - p. 627 206. B-CELL NEOPLASMS - p. 627 207. Chapter 179: Cutaneous Plasmacytoma - p. 627 208. Chapter 180: Primary Cutaneous Marginal Zone Lymphoma - p. 633 209. Chapter 181: Primary Cutaneous Follicle Center Lymphoma - p. 639 210. Chapter 182: Diffuse Large B-Cell Lymphoma, Leg Type - p. 645 211. Chapter 183: Lymphomatoid Granulomatosis - p. 653 212. Chapter 184: Systemic B-Cell Lymphomas Involving Skin - p. 657 213. Chapter 185: Intravascular Large B-Cell Lymphoma - p. 665 214. T-CELL AND NK-CELL NEOPLASMS - p. 669 215. Chapter 186: Mycosis Fungoides (and Subtypes) - p. 669 216. Chapter 187: Adult T-Cell Leukemia/Lymphoma - p. 681 217. Chapter 188: Subcutaneous Panniculitis-Like T-Cell Lymphoma - p. 685 218. Chapter 189: Extranodal NK-/T-Cell Lymphoma, Nasal Type - p. 691 219. Chapter 190: Lymphomatoid Papulosis - p. 697 220. Chapter 191: Primary Cutaneous Anaplastic Large Cell Lymphoma - p. 703 221. Chapter 192: Aggressive Epidermotropic CD8(+) Cytotoxic T-Cell Lymphoma - p. 708 222. Chapter 193: Primary Cutaneous CD4(+) Small/Medium T-Cell Lymphoproliferative Disorder - p. 713 223. Chapter 194: Cutaneous Gamma-Delta T-Cell Lymphoma - p. 719 224. Chapter 195: Angioimmunoblastic T-Cell Lymphoma - p. 725 225. Chapter 196: Systemic T-Cell and NK-Cell Lymphomas Involving Skin - p. 731 226. LEUKEMIC AND NONLYMPHOID INFILTRATES - p. 737 227. Chapter 197: Leukemia Cutis - p. 737 228. Chapter 198: Blastic Plasmacytoid Dendritic Cell Neoplasm - p. 743 229. Chapter 199: Extramedullary Hematopoiesis - p. 751 230. Chapter 200: Cutaneous and Systemic Mastocytosis - p. 753 231. SECTION 13: TUMORS OF UNCERTAIN LINEAGE - p. 761 232. Chapter 201: Myoepithelioma of Soft Tissue - p. 761 233. Chapter 202: Epithelioid Sarcoma - p. 771 234. Chapter 203: Cellular Neurothekeoma - p. 777 235. Chapter 204: Distinctive Dermal Clear Cell Mesenchymal Tumor - p. 781 236. Chapter 205: PEComas - p. 783 237. Part II: Melanocytic Tumors of Skin - p. 789 238. SECTION 1: BENIGN MELANOCYTIC TUMORS (NEVI) - p. 789 239. Chapter 206: Congenital Melanocytic Nevi - p. 789 240. Chapter 207: Common Acquired Melanocytic Nevi - p. 793 241. Chapter 208: Conventional Blue Nevi - p. 797 242. Chapter 209: Cellular Blue Nevi - p. 801 243. Chapter 210: Combined Nevi - p. 805 244. Chapter 211: Halo Nevi - p. 807 245. Chapter 212: Nevi of Special Sites - p. 809 246. Chapter 213: Inverted Type A Nevi - p. 813 247. Chapter 214: Deep Penetrating Nevi - p. 817 248. Chapter 215: Conjunctival Melanocytic Nevi - p. 823 249. Chapter 216: Dermal Melanocytoses (Nevus of Ota and Ito, Mongolian Spot) - p. 827 250. Chapter 217: Paraganglioma-Like Dermal Melanocytic Tumor - p. 829 251. Chapter 218: Dysplastic Melanocytic Nevi - p. 831 252. Chapter 219: Spitz (Spindle and Epithelioid Cell) Nevi - p. 837 253. Chapter 220: Pigmented Spindle Cell Nevus (Reed Nevus) - p. 843 254. Chapter 221: BAP1-Inactivated Melanocytoma - p. 847 255. SECTION 2: MALIGNANT TUMORS (MELANOMAS AND RELATED LESIONS) - p. 851 256. MELANOMA IN SITU - p. 851 257. Chapter 222: Melanoma In Situ, Lentigo Maligna Type - p. 851 258. Chapter 223: Melanoma In Situ, Superficial Spreading Type - p. 859 259. Chapter 224: Melanoma In Situ, Not Otherwise Specified - p. 863 260. INVASIVE MELANOMA - p. 867 261. Chapter 225: Childhood Melanoma - p. 867 262. Chapter 226: Atypical/Borderline and Malignant Spitz Tumors - p. 875 263. Chapter 227: Melanoma, Lentigo Maligna Type - p. 879 264. Chapter 228: Melanoma, Superficial Spreading Type - p. 883 265. Chapter 229: Melanoma, Nodular Type - p. 887 266. Chapter 230: Desmoplastic Melanoma - p. 891 267. Chapter 231: Nevoid Melanoma - p. 897 268. Chapter 232: Acral Lentiginous Melanoma - p. 901 269. Chapter 233: Oral Melanoma - p. 907 270. Chapter 234: Mucosal Melanoma (Genital) - p. 911 271. Chapter 235: Sinonasal Melanoma - p. 915 272. Chapter 236: Conjunctival Melanoma - p. 921 273. Chapter 237: Malignant Cellular Blue Nevus (Melanoma Arising in or Mimicking a Cellular Blue Nevus) - p. 925 274. Chapter 238: Pigmented Epithelioid Melanocytoma ("Animal-Type Melanoma") - p. 929 275. Chapter 239: Primary Dermal Melanoma - p. 935 276. Chapter 240: Other Unusual and Rare Variants of Melanoma - p. 937 277. Chapter 241: Staging for Specimens of Malignant Melanoma of Skin - p. 941 278. INDEX - p. 945
