This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the 2nd edition of Diagnostic Pathology: Spleen is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
Provides essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses
Presents up-to-date information on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms
Features an Antibody Index and Molecular Factors Index to assist with identification and diagnosis
Includes 14 new chapters covering topics such as autoimmune disease involving the spleen, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging, leukemic non-nodal mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many others
Includes approximately 2,000 high-quality clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis
Includes updated criteria, terminology, and classifications from the 2017 World Health Organization Classification of Lymphoid Neoplasms
Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care
1. Chapter 1: Introduction to Spleen - p. xiii 2. Chapter 2: Imaging of Splenic Disorders - p. 11 3. Chapter 3: Handling, Processing, and Gross Pathology of Spleen - p. 17 4. Chapter 4: Fine-Needle Aspiration and Core Biopsy of Spleen - p. 25 5. Chapter 5: Immunohistochemistry of Spleen - p. 31 6. Chapter 6: Flow Cytometry - p. 39 7. Chapter 7: Molecular Techniques - p. 45 8. SECTION 2: NONNEOPLASTIC SPLENIC DISORDERS - p. 51 9. LYMPHOID HYPERPLASIA - p. 51 10. Chapter 8: Florid Follicular Hyperplasia - p. 51 11. Chapter 9: Autoimmune Disease - p. 55 12. Chapter 10: HIV in Spleen - p. 61 13. Chapter 11: Castleman Disease - p. 67 14. Chapter 12: Marginal Zone Hyperplasia - p. 69 15. GRANULOMATOUS LESIONS/DISORDERS - p. 71 16. Chapter 13: Lipogranulomas - p. 71 17. Chapter 14: Sarcoidosis - p. 77 18. Chapter 15: Chronic Granulomatous Disease - p. 81 19. INFECTIONS - p. 85 20. Chapter 16: Mycobacteriosis - p. 85 21. Chapter 17: Selected Bacterial Infections - p. 89 22. Chapter 18: Candidiasis - p. 93 23. Chapter 19: Histoplasmosis - p. 95 24. Chapter 20: Cryptococcosis - p. 97 25. Chapter 21: Coccidioidomycosis - p. 99 26. Chapter 22: Pneumocystosis - p. 103 27. Chapter 23: Infectious Mononucleosis - p. 107 28. Chapter 24: Cytomegalovirus Infection - p. 111 29. Chapter 25: Herpes Simplex Virus Infection - p. 113 30. Chapter 26: Echinococcosis - p. 115 31. Chapter 27: Malaria - p. 119 32. NONINFECTIOUS CYSTS - p. 121 33. Chapter 28: Epithelial Cyst - p. 121 34. Chapter 29: False Cyst - p. 123 35. NONNEOPLASTIC VASCULAR PROCESSES - p. 125 36. Chapter 30: Chronic Passive Congestion - p. 125 37. Chapter 31: Infarct - p. 127 38. Chapter 32: Peliosis - p. 135 39. Chapter 33: Sclerosing Angiomatoid Nodular Transformation - p. 137 40. RED CELL DISORDERS - p. 143 41. Chapter 34: Sickle Cell Disease - p. 143 42. Chapter 35: Thalassemia - p. 145 43. Chapter 36: Hereditary Spherocytosis - p. 149 44. Chapter 37: Thrombotic Thrombocytopenic Purpura - p. 151 45. MISCELLANEOUS LESIONS/DISORDERS - p. 157 46. Chapter 38: Heterotaxy Syndromes - p. 157 47. Chapter 39: Congenital Splenic Abnormalities - p. 159 48. Chapter 40: Extramedullary Hematopoiesis - p. 163 49. Chapter 41: Gamna-Gandy Bodies - p. 165 50. Chapter 42: Hemophagocytic Lymphohistiocytosis - p. 167 51. Chapter 43: Immune Thrombocytopenic Purpura - p. 173 52. Chapter 44: Niemann-Pick Disease - p. 177 53. Chapter 45: Gaucher Disease - p. 183 54. Chapter 46: Sea-Blue (Ceroid) Histiocytosis - p. 187 55. Chapter 47: Gangliosidosis Lysosomal Disorder - p. 191 56. Chapter 48: Therapy Effect on Spleen - p. 193 57. Chapter 49: Traumatic and Nontraumatic Splenic Injuries - p. 201 58. SECTION 3: NEOPLASTIC SPLENIC DISORDERS - p. 205 59. BENIGN MESENCHYMAL LESIONS - p. 205 60. Chapter 50: Introduction to Vascular Lesions - p. 205 61. Chapter 51: Hemangioma - p. 209 62. Chapter 52: Lymphangioma - p. 217 63. Chapter 53: Littoral Cell Angioma - p. 221 64. Chapter 54: Inflammatory Pseudotumor - p. 227 65. Chapter 55: Postchemotherapy Histiocyte-Rich Pseudotumor of Spleen - p. 235 66. Chapter 56: Splenic Hamartoma - p. 241 67. Chapter 57: Myelolipoma - p. 245 68. MALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS - p. 247 69. Chapter 58: Angiosarcoma - p. 247 70. Chapter 59: Hemangioendothelioma - p. 255 71. Chapter 60: Kaposi Sarcoma - p. 257 72. Chapter 61: Leiomyosarcoma - p. 259 73. Chapter 62: Gastrointestinal Stromal Tumor - p. 265 74. Chapter 63: Follicular Dendritic Cell Sarcoma - p. 271 75. Chapter 64: Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma - p. 279 76. Chapter 65: Langerhans Cell Histiocytosis - p. 285 77. Chapter 66: Histiocytic Sarcoma - p. 291 78. LYMPHOMA - p. 299 79. Chapter 67: Introduction to Lymphoma - p. 299 80. Chapter 68: Splenic Marginal Zone Lymphoma - p. 309 81. Chapter 69: Hairy Cell Leukemia - p. 317 82. Chapter 70: Hairy Cell Leukemia Variant - p. 325 83. Chapter 71: Lymphoplasmacytic Lymphoma - p. 333 84. Chapter 72: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma - p. 341 85. Chapter 73: Follicular Lymphoma - p. 349 86. Chapter 74: Mantle Cell Lymphoma - p. 357 87. Chapter 75: Leukemic Nonnodal Mantle Cell Lymphoma - p. 365 88. Chapter 76: Splenic Diffuse Red Pulp B-Cell Lymphoma - p. 369 89. Chapter 77: B-Cell Prolymphocytic Leukemia - p. 375 90. Chapter 78: Diffuse Large B-Cell Lymphoma - p. 377 91. Chapter 79: Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst - p. 383 92. Chapter 80: T-Cell/Histiocyte-Rich Large B-Cell Lymphoma - p. 389 93. Chapter 81: Burkitt Lymphoma - p. 397 94. Chapter 82: Classic Hodgkin Lymphoma - p. 405 95. Chapter 83: Nodular Lymphocyte-Predominant Hodgkin Lymphoma - p. 415 96. Chapter 84: Peripheral T-Cell Lymphoma, Unspecified - p. 425 97. Chapter 85: Hepatosplenic T-Cell Lymphoma - p. 431 98. Chapter 86: T-Cell Prolymphocytic Leukemia - p. 439 99. Chapter 87: T-Cell Large Granular Lymphocytic Leukemia - p. 447 100. Chapter 88: Aggressive NK-Cell Leukemia - p. 455 101. Chapter 89: Transformation of Splenic Disorders - p. 461 102. LEUKEMIA - p. 465 103. Chapter 90: Acute Myeloid Leukemia - p. 465 104. Chapter 91: Lymphoblastic Leukemia/Lymphoma - p. 473 105. CHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES - p. 479 106. Chapter 92: Myeloproliferative Neoplasm Overview - p. 479 107. Chapter 93: Chronic Myeloid Leukemia, BCR::ABL1 Positive - p. 481 108. Chapter 94: Essential Thrombocythemia - p. 487 109. Chapter 95: Polycythemia Vera - p. 491 110. Chapter 96: Primary Myelofibrosis - p. 495 111. Chapter 97: Mastocytosis - p. 505 112. Chapter 98: Chronic Myelomonocytic Leukemia - p. 513 113. PLASMA CELL-ASSOCIATED DISORDERS - p. 519 114. Chapter 99: Amyloidosis - p. 519 115. Chapter 100: Heavy Chain Disease - p. 525 116. Chapter 101: Plasma Cell Myeloma/Plasmacytoma - p. 529 117. METASTASIS - p. 533 118. Chapter 102: Metastatic Tumors - p. 533 119. INDEX - p. 537
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the 2nd edition of Diagnostic Pathology: Spleen is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
Provides essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses
Presents up-to-date information on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms
Features an Antibody Index and Molecular Factors Index to assist with identification and diagnosis
Includes 14 new chapters covering topics such as autoimmune disease involving the spleen, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging, leukemic non-nodal mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many others
Includes approximately 2,000 high-quality clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis
Includes updated criteria, terminology, and classifications from the 2017 World Health Organization Classification of Lymphoid Neoplasms
Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care
1. Chapter 1: Introduction to Spleen - p. xiii 2. Chapter 2: Imaging of Splenic Disorders - p. 11 3. Chapter 3: Handling, Processing, and Gross Pathology of Spleen - p. 17 4. Chapter 4: Fine-Needle Aspiration and Core Biopsy of Spleen - p. 25 5. Chapter 5: Immunohistochemistry of Spleen - p. 31 6. Chapter 6: Flow Cytometry - p. 39 7. Chapter 7: Molecular Techniques - p. 45 8. SECTION 2: NONNEOPLASTIC SPLENIC DISORDERS - p. 51 9. LYMPHOID HYPERPLASIA - p. 51 10. Chapter 8: Florid Follicular Hyperplasia - p. 51 11. Chapter 9: Autoimmune Disease - p. 55 12. Chapter 10: HIV in Spleen - p. 61 13. Chapter 11: Castleman Disease - p. 67 14. Chapter 12: Marginal Zone Hyperplasia - p. 69 15. GRANULOMATOUS LESIONS/DISORDERS - p. 71 16. Chapter 13: Lipogranulomas - p. 71 17. Chapter 14: Sarcoidosis - p. 77 18. Chapter 15: Chronic Granulomatous Disease - p. 81 19. INFECTIONS - p. 85 20. Chapter 16: Mycobacteriosis - p. 85 21. Chapter 17: Selected Bacterial Infections - p. 89 22. Chapter 18: Candidiasis - p. 93 23. Chapter 19: Histoplasmosis - p. 95 24. Chapter 20: Cryptococcosis - p. 97 25. Chapter 21: Coccidioidomycosis - p. 99 26. Chapter 22: Pneumocystosis - p. 103 27. Chapter 23: Infectious Mononucleosis - p. 107 28. Chapter 24: Cytomegalovirus Infection - p. 111 29. Chapter 25: Herpes Simplex Virus Infection - p. 113 30. Chapter 26: Echinococcosis - p. 115 31. Chapter 27: Malaria - p. 119 32. NONINFECTIOUS CYSTS - p. 121 33. Chapter 28: Epithelial Cyst - p. 121 34. Chapter 29: False Cyst - p. 123 35. NONNEOPLASTIC VASCULAR PROCESSES - p. 125 36. Chapter 30: Chronic Passive Congestion - p. 125 37. Chapter 31: Infarct - p. 127 38. Chapter 32: Peliosis - p. 135 39. Chapter 33: Sclerosing Angiomatoid Nodular Transformation - p. 137 40. RED CELL DISORDERS - p. 143 41. Chapter 34: Sickle Cell Disease - p. 143 42. Chapter 35: Thalassemia - p. 145 43. Chapter 36: Hereditary Spherocytosis - p. 149 44. Chapter 37: Thrombotic Thrombocytopenic Purpura - p. 151 45. MISCELLANEOUS LESIONS/DISORDERS - p. 157 46. Chapter 38: Heterotaxy Syndromes - p. 157 47. Chapter 39: Congenital Splenic Abnormalities - p. 159 48. Chapter 40: Extramedullary Hematopoiesis - p. 163 49. Chapter 41: Gamna-Gandy Bodies - p. 165 50. Chapter 42: Hemophagocytic Lymphohistiocytosis - p. 167 51. Chapter 43: Immune Thrombocytopenic Purpura - p. 173 52. Chapter 44: Niemann-Pick Disease - p. 177 53. Chapter 45: Gaucher Disease - p. 183 54. Chapter 46: Sea-Blue (Ceroid) Histiocytosis - p. 187 55. Chapter 47: Gangliosidosis Lysosomal Disorder - p. 191 56. Chapter 48: Therapy Effect on Spleen - p. 193 57. Chapter 49: Traumatic and Nontraumatic Splenic Injuries - p. 201 58. SECTION 3: NEOPLASTIC SPLENIC DISORDERS - p. 205 59. BENIGN MESENCHYMAL LESIONS - p. 205 60. Chapter 50: Introduction to Vascular Lesions - p. 205 61. Chapter 51: Hemangioma - p. 209 62. Chapter 52: Lymphangioma - p. 217 63. Chapter 53: Littoral Cell Angioma - p. 221 64. Chapter 54: Inflammatory Pseudotumor - p. 227 65. Chapter 55: Postchemotherapy Histiocyte-Rich Pseudotumor of Spleen - p. 235 66. Chapter 56: Splenic Hamartoma - p. 241 67. Chapter 57: Myelolipoma - p. 245 68. MALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS - p. 247 69. Chapter 58: Angiosarcoma - p. 247 70. Chapter 59: Hemangioendothelioma - p. 255 71. Chapter 60: Kaposi Sarcoma - p. 257 72. Chapter 61: Leiomyosarcoma - p. 259 73. Chapter 62: Gastrointestinal Stromal Tumor - p. 265 74. Chapter 63: Follicular Dendritic Cell Sarcoma - p. 271 75. Chapter 64: Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma - p. 279 76. Chapter 65: Langerhans Cell Histiocytosis - p. 285 77. Chapter 66: Histiocytic Sarcoma - p. 291 78. LYMPHOMA - p. 299 79. Chapter 67: Introduction to Lymphoma - p. 299 80. Chapter 68: Splenic Marginal Zone Lymphoma - p. 309 81. Chapter 69: Hairy Cell Leukemia - p. 317 82. Chapter 70: Hairy Cell Leukemia Variant - p. 325 83. Chapter 71: Lymphoplasmacytic Lymphoma - p. 333 84. Chapter 72: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma - p. 341 85. Chapter 73: Follicular Lymphoma - p. 349 86. Chapter 74: Mantle Cell Lymphoma - p. 357 87. Chapter 75: Leukemic Nonnodal Mantle Cell Lymphoma - p. 365 88. Chapter 76: Splenic Diffuse Red Pulp B-Cell Lymphoma - p. 369 89. Chapter 77: B-Cell Prolymphocytic Leukemia - p. 375 90. Chapter 78: Diffuse Large B-Cell Lymphoma - p. 377 91. Chapter 79: Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst - p. 383 92. Chapter 80: T-Cell/Histiocyte-Rich Large B-Cell Lymphoma - p. 389 93. Chapter 81: Burkitt Lymphoma - p. 397 94. Chapter 82: Classic Hodgkin Lymphoma - p. 405 95. Chapter 83: Nodular Lymphocyte-Predominant Hodgkin Lymphoma - p. 415 96. Chapter 84: Peripheral T-Cell Lymphoma, Unspecified - p. 425 97. Chapter 85: Hepatosplenic T-Cell Lymphoma - p. 431 98. Chapter 86: T-Cell Prolymphocytic Leukemia - p. 439 99. Chapter 87: T-Cell Large Granular Lymphocytic Leukemia - p. 447 100. Chapter 88: Aggressive NK-Cell Leukemia - p. 455 101. Chapter 89: Transformation of Splenic Disorders - p. 461 102. LEUKEMIA - p. 465 103. Chapter 90: Acute Myeloid Leukemia - p. 465 104. Chapter 91: Lymphoblastic Leukemia/Lymphoma - p. 473 105. CHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES - p. 479 106. Chapter 92: Myeloproliferative Neoplasm Overview - p. 479 107. Chapter 93: Chronic Myeloid Leukemia, BCR::ABL1 Positive - p. 481 108. Chapter 94: Essential Thrombocythemia - p. 487 109. Chapter 95: Polycythemia Vera - p. 491 110. Chapter 96: Primary Myelofibrosis - p. 495 111. Chapter 97: Mastocytosis - p. 505 112. Chapter 98: Chronic Myelomonocytic Leukemia - p. 513 113. PLASMA CELL-ASSOCIATED DISORDERS - p. 519 114. Chapter 99: Amyloidosis - p. 519 115. Chapter 100: Heavy Chain Disease - p. 525 116. Chapter 101: Plasma Cell Myeloma/Plasmacytoma - p. 529 117. METASTASIS - p. 533 118. Chapter 102: Metastatic Tumors - p. 533 119. INDEX - p. 537
