Early diagnosis of HNSCC can cause improved treatment, treatment response rates and reduction in mortality rates. Recently, miRNA-based diagnostics and therapeutics have gained considerable attention among the scientific community. MiRNAs are known to have great potential as biomarkers for early diagnosis, prediction, and prognosis of HNSCC, and play a role in development of targeted gene therapy.Diagnostic, Prognostic and Therapeutic Role of MicroRNAs in Head and Neck Cancer provides detailed information on various miRNA-based approaches for diagnosis, prognosis, and treatment of HNSCC. It encompasses various miRNA-based point of care diagnostics and drug delivery systems for HNSCC along with the information on the clinical trials of miRNAs for improved clinical outcomes in HNSCC patients. The book provides a comprehensive overview of currently available miRNAs associated with HNSCC and their extensive application for early diagnosis, prognosis, and treatment. This book will help scientists and clinicians to win the battle against HNSCC.
1. Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer - p. ii 2. Cover - p. ii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. v 6. List of contributors - p. xi 7. Chapter 1 Epidemiology, pathology, and genomic topography of head and neck cancers - p. 1 8. Chapter 2 Association of human papillomavirus with head and neck cancers - p. 23 9. Chapter 3 MicroRNA regulation of different subtypes of head and neck malignancies - p. 35 10. Chapter 4 Oncogenic and tumor suppressor microRNAs in head and neck cancer - p. 61 11. Chapter 5 Epigenetic regulation of head and neck cancer by microRNAs - p. 79 12. Chapter 6 Association of genetic variations in microRNAs with susceptibility to head and neck cancer - p. 95 13. Chapter 7 Role of microRNAs in metastasis, recurrence, and chemoradiation resistance of head and neck cancer - p. 111 14. Chapter 8 Regulation of head and neck tumor microenvironment by microRNAs - p. 127 15. Chapter 9 Genome-wide discovery and prediction of microRNA-based biomarkers in head and neck squamous cell carcinoma - p. 157 16. Chapter 10 Computational modeling for identification of microRNAs as diagnostic and prognostic biomarkers for head and neck cancer - p. 183 17. Chapter 11 Development of microRNA as prognostic markers in head and neck cancer - p. 193 18. Chapter 12 Development of microRNA as diagnostic markers in head and neck cancer - p. 207 19. Chapter 13 Exosomal microRNA for diagnosis and prognosis of head and neck cancer - p. 221 20. Chapter 14 MicroRNA expression profiling for disease progression assessment - p. 237 21. Chapter 15 MicroRNA-based point-of-care devices for diagnosis and prognosis of head and neck cancer - p. 247 22. Chapter 16 Therapeutic role of microRNAs in management of head and neck cancer - p. 265 23. Chapter 17 Role of microRNA in nutritional deficiencies and cachexia associated with head and neck cancer: current status and future research directions - p. 285 24. Chapter 18 MicroRNA-based nanomedicine for the treatment of head and neck cancer - p. 307 25. Chapter 19 MicroRNA-based clinical trials for head and neck cancer - p. 325 26. Index - p. 337
Early diagnosis of HNSCC can cause improved treatment, treatment response rates and reduction in mortality rates. Recently, miRNA-based diagnostics and therapeutics have gained considerable attention among the scientific community. MiRNAs are known to have great potential as biomarkers for early diagnosis, prediction, and prognosis of HNSCC, and play a role in development of targeted gene therapy.Diagnostic, Prognostic and Therapeutic Role of MicroRNAs in Head and Neck Cancer provides detailed information on various miRNA-based approaches for diagnosis, prognosis, and treatment of HNSCC. It encompasses various miRNA-based point of care diagnostics and drug delivery systems for HNSCC along with the information on the clinical trials of miRNAs for improved clinical outcomes in HNSCC patients. The book provides a comprehensive overview of currently available miRNAs associated with HNSCC and their extensive application for early diagnosis, prognosis, and treatment. This book will help scientists and clinicians to win the battle against HNSCC.
1. Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer - p. ii 2. Cover - p. ii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. v 6. List of contributors - p. xi 7. Chapter 1 Epidemiology, pathology, and genomic topography of head and neck cancers - p. 1 8. Chapter 2 Association of human papillomavirus with head and neck cancers - p. 23 9. Chapter 3 MicroRNA regulation of different subtypes of head and neck malignancies - p. 35 10. Chapter 4 Oncogenic and tumor suppressor microRNAs in head and neck cancer - p. 61 11. Chapter 5 Epigenetic regulation of head and neck cancer by microRNAs - p. 79 12. Chapter 6 Association of genetic variations in microRNAs with susceptibility to head and neck cancer - p. 95 13. Chapter 7 Role of microRNAs in metastasis, recurrence, and chemoradiation resistance of head and neck cancer - p. 111 14. Chapter 8 Regulation of head and neck tumor microenvironment by microRNAs - p. 127 15. Chapter 9 Genome-wide discovery and prediction of microRNA-based biomarkers in head and neck squamous cell carcinoma - p. 157 16. Chapter 10 Computational modeling for identification of microRNAs as diagnostic and prognostic biomarkers for head and neck cancer - p. 183 17. Chapter 11 Development of microRNA as prognostic markers in head and neck cancer - p. 193 18. Chapter 12 Development of microRNA as diagnostic markers in head and neck cancer - p. 207 19. Chapter 13 Exosomal microRNA for diagnosis and prognosis of head and neck cancer - p. 221 20. Chapter 14 MicroRNA expression profiling for disease progression assessment - p. 237 21. Chapter 15 MicroRNA-based point-of-care devices for diagnosis and prognosis of head and neck cancer - p. 247 22. Chapter 16 Therapeutic role of microRNAs in management of head and neck cancer - p. 265 23. Chapter 17 Role of microRNA in nutritional deficiencies and cachexia associated with head and neck cancer: current status and future research directions - p. 285 24. Chapter 18 MicroRNA-based nanomedicine for the treatment of head and neck cancer - p. 307 25. Chapter 19 MicroRNA-based clinical trials for head and neck cancer - p. 325 26. Index - p. 337
