Divided into four main sections, Dietary Sugar, Salt and Fat in Human Health explores the biochemical, pharmacological and medicinal aspects related to the overindulgence of dietary salt, sugar, and fat, along with possible remedies.
Beginning with a general overview, the text outlines aspects associated with advancing age and human physiology, such as different aspects of insulin resistance, the advancing age phenomenon, central fat accumulation and metabolic perturbations and the role of the modern Western diet and the influence of dietary sugar, salt, and fat, with particular focus on their relation to multiple biochemical pathophysiological pathways. The second section of the book focuses on the roles of dietary sugars and their correlation with the chronic disease epidemic, with an emphasis on carbohydrate metabolism and its biochemistry, GI absorption, the glycemic index and the influence of fructose. The historical background of dietary sugars is discussed alongside Atkin’s hypothesis, and an overview of the correlation between dietary fibre and the glycemic index, including a chapter on sugar addiction. Section three contains an exhaustive review of the influence of dietary salt and its diverse mechanistic aspects, including salt-sensitive hypertension, contribution of two steroid receptor pathways, vascular NO, intrarenal RAAS system and angiotensin. The fourth section highlights the biochemistry of dietary saturated, polyunsaturated and trans fat and its influence on human health and various diseases, and further explores NAFLD and gender specific problems. Chapters in this section also investigate the benefits of the Mediterranean diet as well as myths related to cholesterol.
Collected and carefully organized for researchers in nutrition, physiology, epidemiology, or sensory science, this book will also benefit general practitioners, surgeons, nurses, health professionals and practitioners, and students studying the role of diet in cardiometabolic disorders and disease.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. List of contributors - p. 23 7. Preface - p. xxix 8. General background - p. xxxi 9. Chapter 1. Epidemiological perspectives of dietary sugars, salts and fats - p. 3 10. Chapter 2. Advancing age, influence of dietary sugars, salts, and fats on chronic diseases and metabolic disorders - p. 14 11. Chapter 3. Dietary fat, salt, and sugar: a clinical perspective of the social catastrophe - p. 67 12. Chapter 4. Influences of food ingredients on enterohepatic circulation of bile acids - p. 93 13. Chapter 5. Anemia: influence of dietary fat, sugar, and salt on hemoglobin and blood health - p. 103 14. Food behavior, food addiction and metabolic syndrome - p. 122 15. Chapter 6. Sensory drivers of food behavior - p. 131 16. Chapter 7. Focusing the fight against processed food addiction - p. 157 17. Chapter 8. Dietary influences on pediatric obesity and metabolic syndrome - p. 171 18. Chapter 9. An overview of addiction to sugar - p. 195 19. Dietary sugar and health - p. 209 20. Chapter 10. Influence of dietary sugars on blood pressure regulation: historical, epidemiological, laboratory, and clinical considerations - p. 219 21. Chapter 11. Glycation-induced protein aggregation and cellular toxicity: an insight into the disease realm of high dietary sugar intake - p. 251 22. Chapter 12. Probing various pro and con health aspects of the glucose–insulin system in non-diabetics: focusing on insulin resistance and dietary implications - p. 277 23. Chapter 13. Evaluating proposed surrogates to estimate insulin resistance in non-diabetics: emphasizing the ratio triglycerides/HDL-cholesterol versus fasting blood glucose - p. 291 24. Chapter 14. Associations of high blood sugar with oxidative stress and inflammation in patients with type 2 diabetes - p. 305 25. Chapter 15. Assessing the triglyceride/HDL-cholesterol ratio as a surrogate for insulin resistance and its link to the metabolic syndrome in Hispanics and African-Americans - p. 325 26. Chapter 16. The benefit of Indian jaggery over sugar on human health - p. 347 27. Chapter 17. Linking fasting blood glucose quartiles of nondiabetic volunteers ages 21–84 years to metabolic syndrome components: focusing on the aging paradox - p. 361 28. Overindulgence of dietary salt - p. 371 29. Chapter 18. Salt-induced inappropriate augmentation of renin–angiotensin–aldosterone system in chronic kidney disease - p. 377 30. Chapter 19. Table salt (sodium chloride): vital aspects of metabolism and blood pressure regulation in health and disease - p. 395 31. Chapter 20. Nutraceuticals and functional foods in the prevention of hypertension induced by excessive intake of dietary salt - p. 423 32. Dietary fat and cholesterol - p. 441 33. Chapter 21. Physiological role of cholesterol in human body - p. 453 34. Chapter 22. Interplay between dietary sugars and fats and insulin resistance - p. 483 35. Chapter 23. Erythrocyte membranes in metabolic and neurological diseases—supplementation with fatty acids and membranes remodeling - p. 505 36. Dietary fiber, ketogenic diets, and benefits - p. 523 37. Chapter 24. Dietary fiber: a functional food ingredient with physiological benefits - p. 531 38. Chapter 25. The ketogenic diet in health and disease - p. 557 39. Chapter 26. Dietary fat, salt, and sugar—a teenager’s view - p. 621 40. Appendix. Commentary: From the Editor’s desk Reflecting on changes in nutritional risk factors over time - p. 623 41. Index - p. 629
Divided into four main sections, Dietary Sugar, Salt and Fat in Human Health explores the biochemical, pharmacological and medicinal aspects related to the overindulgence of dietary salt, sugar, and fat, along with possible remedies.
Beginning with a general overview, the text outlines aspects associated with advancing age and human physiology, such as different aspects of insulin resistance, the advancing age phenomenon, central fat accumulation and metabolic perturbations and the role of the modern Western diet and the influence of dietary sugar, salt, and fat, with particular focus on their relation to multiple biochemical pathophysiological pathways. The second section of the book focuses on the roles of dietary sugars and their correlation with the chronic disease epidemic, with an emphasis on carbohydrate metabolism and its biochemistry, GI absorption, the glycemic index and the influence of fructose. The historical background of dietary sugars is discussed alongside Atkin’s hypothesis, and an overview of the correlation between dietary fibre and the glycemic index, including a chapter on sugar addiction. Section three contains an exhaustive review of the influence of dietary salt and its diverse mechanistic aspects, including salt-sensitive hypertension, contribution of two steroid receptor pathways, vascular NO, intrarenal RAAS system and angiotensin. The fourth section highlights the biochemistry of dietary saturated, polyunsaturated and trans fat and its influence on human health and various diseases, and further explores NAFLD and gender specific problems. Chapters in this section also investigate the benefits of the Mediterranean diet as well as myths related to cholesterol.
Collected and carefully organized for researchers in nutrition, physiology, epidemiology, or sensory science, this book will also benefit general practitioners, surgeons, nurses, health professionals and practitioners, and students studying the role of diet in cardiometabolic disorders and disease.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. List of contributors - p. 23 7. Preface - p. xxix 8. General background - p. xxxi 9. Chapter 1. Epidemiological perspectives of dietary sugars, salts and fats - p. 3 10. Chapter 2. Advancing age, influence of dietary sugars, salts, and fats on chronic diseases and metabolic disorders - p. 14 11. Chapter 3. Dietary fat, salt, and sugar: a clinical perspective of the social catastrophe - p. 67 12. Chapter 4. Influences of food ingredients on enterohepatic circulation of bile acids - p. 93 13. Chapter 5. Anemia: influence of dietary fat, sugar, and salt on hemoglobin and blood health - p. 103 14. Food behavior, food addiction and metabolic syndrome - p. 122 15. Chapter 6. Sensory drivers of food behavior - p. 131 16. Chapter 7. Focusing the fight against processed food addiction - p. 157 17. Chapter 8. Dietary influences on pediatric obesity and metabolic syndrome - p. 171 18. Chapter 9. An overview of addiction to sugar - p. 195 19. Dietary sugar and health - p. 209 20. Chapter 10. Influence of dietary sugars on blood pressure regulation: historical, epidemiological, laboratory, and clinical considerations - p. 219 21. Chapter 11. Glycation-induced protein aggregation and cellular toxicity: an insight into the disease realm of high dietary sugar intake - p. 251 22. Chapter 12. Probing various pro and con health aspects of the glucose–insulin system in non-diabetics: focusing on insulin resistance and dietary implications - p. 277 23. Chapter 13. Evaluating proposed surrogates to estimate insulin resistance in non-diabetics: emphasizing the ratio triglycerides/HDL-cholesterol versus fasting blood glucose - p. 291 24. Chapter 14. Associations of high blood sugar with oxidative stress and inflammation in patients with type 2 diabetes - p. 305 25. Chapter 15. Assessing the triglyceride/HDL-cholesterol ratio as a surrogate for insulin resistance and its link to the metabolic syndrome in Hispanics and African-Americans - p. 325 26. Chapter 16. The benefit of Indian jaggery over sugar on human health - p. 347 27. Chapter 17. Linking fasting blood glucose quartiles of nondiabetic volunteers ages 21–84 years to metabolic syndrome components: focusing on the aging paradox - p. 361 28. Overindulgence of dietary salt - p. 371 29. Chapter 18. Salt-induced inappropriate augmentation of renin–angiotensin–aldosterone system in chronic kidney disease - p. 377 30. Chapter 19. Table salt (sodium chloride): vital aspects of metabolism and blood pressure regulation in health and disease - p. 395 31. Chapter 20. Nutraceuticals and functional foods in the prevention of hypertension induced by excessive intake of dietary salt - p. 423 32. Dietary fat and cholesterol - p. 441 33. Chapter 21. Physiological role of cholesterol in human body - p. 453 34. Chapter 22. Interplay between dietary sugars and fats and insulin resistance - p. 483 35. Chapter 23. Erythrocyte membranes in metabolic and neurological diseases—supplementation with fatty acids and membranes remodeling - p. 505 36. Dietary fiber, ketogenic diets, and benefits - p. 523 37. Chapter 24. Dietary fiber: a functional food ingredient with physiological benefits - p. 531 38. Chapter 25. The ketogenic diet in health and disease - p. 557 39. Chapter 26. Dietary fat, salt, and sugar—a teenager’s view - p. 621 40. Appendix. Commentary: From the Editor’s desk Reflecting on changes in nutritional risk factors over time - p. 623 41. Index - p. 629
