Dihydropyrimidinones as Potent Anticancer Agents gives readers a unique update on scientific knowledge, accomplishments and recent advances in the medicinal chemistry of dihydropyrimidinones in cancer treatment. Dihydropyrimidinones are known to be active scaffold and have been reported to show some exceptional results with regards to malignancies. With ever increasing knowledge and information about synthesis, pharmacology and other aspects of dihydropyrimidinones, there is need to document such information in one place. Since the field of medicinal chemistry is dynamic, with new emerging trends, it provides readily available updated information on chemistry and pharmacology aspects of dihydropyrimidinones in cancer. This book covers everything about dihydropyrimidinones from synthesis, derivatives, mode of action and potential therapeutic targets. It will also provide insights about the clinical trials and way forward in cancer research of dihydropyrimidinones. Covers dihydropyrimidinones synthesis, derivatives and mode of action Includes recent advances in dihydropyrimidinones for cancer treatment Highlights potential therapeutic targetsa
1. Chapter 1. Introduction of dihydropyrimidinones: a medicinal chemistry perspective - p. 1 2. Chapter 2. Synthetic strategies of dihydropyrimidinones - p. 17 3. Chapter 3. Biological activities of dihydropyrimidinones - p. 39 4. Chapter 4. Dihydropyrimidinone scaffold and potential therapeutic targets - p. 67 5. Chapter 5. Dihydropyrimidinones scaffold and potential anticancer targets - p. 103 6. Chapter 6. Recent advances of dihydropyrimidinone derivatives in cancer research - p. 153 7. Chapter 7. Applications of dihydropyrimidinone derivatives on blood cancer and colon cancer - p. 173 8. Chapter 8. Novel dihydropyrimidine as potential cytotoxic agents in hepatic and blood cancers - p. 199 9. Chapter 9. REMOVED: Advances in the discovery of DHPMs as Eg5 inhibitors for the management of breast cancer - p. 223 10. Chapter 10. Dihydropyrimidinones inhibit proliferation and tumor growth - p. 243 11. Index - p. 273
Dihydropyrimidinones as Potent Anticancer Agents gives readers a unique update on scientific knowledge, accomplishments and recent advances in the medicinal chemistry of dihydropyrimidinones in cancer treatment. Dihydropyrimidinones are known to be active scaffold and have been reported to show some exceptional results with regards to malignancies. With ever increasing knowledge and information about synthesis, pharmacology and other aspects of dihydropyrimidinones, there is need to document such information in one place. Since the field of medicinal chemistry is dynamic, with new emerging trends, it provides readily available updated information on chemistry and pharmacology aspects of dihydropyrimidinones in cancer. This book covers everything about dihydropyrimidinones from synthesis, derivatives, mode of action and potential therapeutic targets. It will also provide insights about the clinical trials and way forward in cancer research of dihydropyrimidinones. Covers dihydropyrimidinones synthesis, derivatives and mode of action Includes recent advances in dihydropyrimidinones for cancer treatment Highlights potential therapeutic targetsa
1. Chapter 1. Introduction of dihydropyrimidinones: a medicinal chemistry perspective - p. 1 2. Chapter 2. Synthetic strategies of dihydropyrimidinones - p. 17 3. Chapter 3. Biological activities of dihydropyrimidinones - p. 39 4. Chapter 4. Dihydropyrimidinone scaffold and potential therapeutic targets - p. 67 5. Chapter 5. Dihydropyrimidinones scaffold and potential anticancer targets - p. 103 6. Chapter 6. Recent advances of dihydropyrimidinone derivatives in cancer research - p. 153 7. Chapter 7. Applications of dihydropyrimidinone derivatives on blood cancer and colon cancer - p. 173 8. Chapter 8. Novel dihydropyrimidine as potential cytotoxic agents in hepatic and blood cancers - p. 199 9. Chapter 9. REMOVED: Advances in the discovery of DHPMs as Eg5 inhibitors for the management of breast cancer - p. 223 10. Chapter 10. Dihydropyrimidinones inhibit proliferation and tumor growth - p. 243 11. Index - p. 273
