Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more.
In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases.
1. 4.1 Introduction - p. 87 2. 4.2 Leishmaniasis, Chagas disease, and African sleeping sickness as protozoan neglected tropical diseases and quinoline-based molecules: background - p. 89 3. 4.3 Current chemotherapy and drugs on clinical trials - p. 93 4. 4.4 Recent phytoresearch on alkaloid extracts from plants and marine organisms for drug development against NTDs - p. 95 5. 4.5 Quinolines: functional and structural diversity - p. 99 6. 4.6 Natural sources of quinoline alkaloids with antiparasitic activity - p. 101 7. 4.7 Synthetic efforts for targeted quinoline compounds - p. 105 8. 4.8 Quinoline compounds as antitrypanosomal agents - p. 127 9. 4.9 Concluding remarks - p. 148 10. Acknowledgment - p. 148 11. List of abbreviations - p. 149 12. References - p. 150 13. Further reading - p. 150 14. 5. Promising trypanocidal heterocyclic compounds of natural origin and their synthetic analogs - p. 165 15. 6. Oxidative stress in schistosomiasis, echinococcosis, and trypanosomiasis: a therapeutic approach - p. 219 16. 7. Plant-derived compounds against protozoan neglected diseases: toward sustainable drug development - p. 241 17. 8. Leishmaniasis control: limitations of current drugs and prospects of natural products - p. 293 18. 9. Natural antileprotic agents: a boon for the management of leprosy - p. 351 19. 10. Aloe vera: a promising hope against Buruli ulcer - p. 373 20. 11. Plant and marine products: a promising hope in the search of therapeutics against dengue - p. 385 21. 12. Total synthetic approaches for lucidone: a promising natural lead candidate against dengue infection - p. 407 22. Index - p. 413
Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more.
In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases.
1. 4.1 Introduction - p. 87 2. 4.2 Leishmaniasis, Chagas disease, and African sleeping sickness as protozoan neglected tropical diseases and quinoline-based molecules: background - p. 89 3. 4.3 Current chemotherapy and drugs on clinical trials - p. 93 4. 4.4 Recent phytoresearch on alkaloid extracts from plants and marine organisms for drug development against NTDs - p. 95 5. 4.5 Quinolines: functional and structural diversity - p. 99 6. 4.6 Natural sources of quinoline alkaloids with antiparasitic activity - p. 101 7. 4.7 Synthetic efforts for targeted quinoline compounds - p. 105 8. 4.8 Quinoline compounds as antitrypanosomal agents - p. 127 9. 4.9 Concluding remarks - p. 148 10. Acknowledgment - p. 148 11. List of abbreviations - p. 149 12. References - p. 150 13. Further reading - p. 150 14. 5. Promising trypanocidal heterocyclic compounds of natural origin and their synthetic analogs - p. 165 15. 6. Oxidative stress in schistosomiasis, echinococcosis, and trypanosomiasis: a therapeutic approach - p. 219 16. 7. Plant-derived compounds against protozoan neglected diseases: toward sustainable drug development - p. 241 17. 8. Leishmaniasis control: limitations of current drugs and prospects of natural products - p. 293 18. 9. Natural antileprotic agents: a boon for the management of leprosy - p. 351 19. 10. Aloe vera: a promising hope against Buruli ulcer - p. 373 20. 11. Plant and marine products: a promising hope in the search of therapeutics against dengue - p. 385 21. 12. Total synthetic approaches for lucidone: a promising natural lead candidate against dengue infection - p. 407 22. Index - p. 413
