The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles.
Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse.
This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations.
1. Introduction - p. xv 2. Section I: Static Nervous System Diseases - p. xviii 3. Chapter 1. Cerebrovascular Infarct: Stroke - p. 3 4. Chapter 2. Central Nervous System Trauma - p. 29 5. Chapter 3. Seizure Disorders and Epilepsy - p. 70 6. Section II: Progressive Neurodegenerative Diseases - p. 77 7. Chapter 4. Aging, Dementia, and Alzheimer Disease - p. 81 8. Chapter 5. Parkinson Disease - p. 109 9. Chapter 6. Diseases of Motor Neurons and Neuromuscular Junctions - p. 135 10. Chapter 7. Huntington Disease - p. 161 11. Section III: Secondary Progressive Neurodegenerative Diseases - p. 180 12. Chapter 8. Multiple Sclerosis - p. 183 13. Chapter 9. Brain Tumors - p. 207 14. Chapter 10. Infectious Diseases of the Nervous System - p. 235 15. Section IV: Developmental Neurological Conditions - p. 255 16. Chapter 11. Neurodevelopmental Disorders - p. 259 17. Section V: Neuropsychiatric Illnesses - p. 280 18. Chapter 12. Mood Disorders and Depression - p. 283 19. Chapter 13. Schizophrenia - p. 303 20. Chapter 14. Pain - p. 325 21. Chapter 15. Drug Addiction - p. 357 22. Section VI: Common Concepts in Neurological and Neuropsychiatric Illnesses - p. 381 23. Chapter 16. Shared Mechanisms of Disease - p. 385 24. Section VII: Bench-To-Bedside Translation - p. 414 25. Chapter 17. Drug Discovery and Personalized Medicine - p. 417 26. Section VIII: Neuroscience Jargon - p. 428 27. Chapter 18. “Neuro”-Dictionary - p. 431 28. Index - p. 469
The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles.
Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse.
This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations.
1. Introduction - p. xv 2. Section I: Static Nervous System Diseases - p. xviii 3. Chapter 1. Cerebrovascular Infarct: Stroke - p. 3 4. Chapter 2. Central Nervous System Trauma - p. 29 5. Chapter 3. Seizure Disorders and Epilepsy - p. 70 6. Section II: Progressive Neurodegenerative Diseases - p. 77 7. Chapter 4. Aging, Dementia, and Alzheimer Disease - p. 81 8. Chapter 5. Parkinson Disease - p. 109 9. Chapter 6. Diseases of Motor Neurons and Neuromuscular Junctions - p. 135 10. Chapter 7. Huntington Disease - p. 161 11. Section III: Secondary Progressive Neurodegenerative Diseases - p. 180 12. Chapter 8. Multiple Sclerosis - p. 183 13. Chapter 9. Brain Tumors - p. 207 14. Chapter 10. Infectious Diseases of the Nervous System - p. 235 15. Section IV: Developmental Neurological Conditions - p. 255 16. Chapter 11. Neurodevelopmental Disorders - p. 259 17. Section V: Neuropsychiatric Illnesses - p. 280 18. Chapter 12. Mood Disorders and Depression - p. 283 19. Chapter 13. Schizophrenia - p. 303 20. Chapter 14. Pain - p. 325 21. Chapter 15. Drug Addiction - p. 357 22. Section VI: Common Concepts in Neurological and Neuropsychiatric Illnesses - p. 381 23. Chapter 16. Shared Mechanisms of Disease - p. 385 24. Section VII: Bench-To-Bedside Translation - p. 414 25. Chapter 17. Drug Discovery and Personalized Medicine - p. 417 26. Section VIII: Neuroscience Jargon - p. 428 27. Chapter 18. “Neuro”-Dictionary - p. 431 28. Index - p. 469
