DNA in Health, Identity and Ancestry examines the human genome and advances in molecular techniques in relation to their value in health, genetic ancestry, and forensic DNA. This book systematically presents these three areas, providing new insights into recent developments in these fields, including gene editing, ancestral fraction determination, and DNA profiling. It covers the latest advances in molecular biology to understand the pertinent issues in these areas. DNA in Health, Identity and Ancestry provides an introduction to human genomes, and then delves into health, forensics and ancestry across 36 chapters. Each section is concluded with practical case studies to demonstrate the application of the principles discussed in each respective section. This book is a valuable resource for researchers, practitioners, and postgraduate students in biochemistry, molecular biology and genetics. It not only provides them with fundamental knowledge on genetics, diseases, population genetics and forensic DNA, but also presents advances, technical operational standards, analytical tools and recent developments in these respective areas.
• Offers a comprehensive understanding of genomes in relation to health, forensics, and ancestry
• Provides detailed technical and operating standards, including for gene editing, genetic testing, ancestral fraction determination, DNA profiling, and ancient DNA analysis
• Genome and advances in molecular techniques in relation to their value in medical genetics, ancestral fraction determinations, and forensic DNA
1. Chapter 1. Introduction to human genomes: nuclear and mitochondrial DNA - p. 1 2. Chapter 2. Genetic testing: a biomedical, social, and ethical framework - p. 9 3. Chapter 3. CRISPR/Cas9: the future of human gene editing - p. 53 4. Chapter 4. Pharmacogenomics - p. 83 5. Chapter 5. Infectious disease diagnosis via DNA analysis - p. 109 6. Chapter 6. Donor and recipient matching for transfusion and transplantation surgery - p. 123 7. Chapter 7. Cell-free DNA: history, applications, and promises - p. 137 8. Chapter 8. Metagenomics studies of environmental samples - p. 179 9. Chapter 9. DNA extraction methods for pathogen analysis - p. 203 10. Chapter 10. Characterization and application of environmental DNA in multispecies biofilms - p. 217 11. Chapter 11. Variants in TLR gene and immune thrombocytopenia susceptibility - p. 231 12. Chapter 12. X chromosome: genetics, function, and health - p. 243 13. Chapter 13. Food intolerance and celiac disease in past human populations through DNA analysis - p. 259 14. Chapter 14. Puzzling ABO discrepancy case resolved through molecular technique - p. 269 15. Chapter 15. Short tandem repeat and mitochondrial DNA profiling for casework and paternity cases - p. 277 16. Chapter 16. DNA databanking, hit matches, and ethical issues - p. 289 17. Chapter 17. Mitochondrial DNA sequence diversity in Kedayan population - p. 299 18. Chapter 18. The application of dual mitochondrial markers for detecting porcine DNA in gelatine-containing processed food products - p. 311 19. Chapter 19. Identification of Elmina plane crash victims: a case study - p. 323 20. Chapter 20. Archaeogenetics of human history - p. 333 21. Chapter 21. Ancient DNA extraction techniques - p. 357 22. Chapter 22. The usefulness of Y chromosome in the study of past populations - p. 369 23. Chapter 23. A brief history of migration and settlement in the Malay Archipelago - p. 387 24. Chapter 24. Blood groups, HPA, HNA, cytokines, and HLA-G: genetics and ancestry - p. 399 25. Ethnic-specific patterns of GSTM1 and GSTT1 in Malays, Chinese, and Indians with specific comparison to Europeans - p. 433 26. Chapter 26. The Archaeological Heritage of the Niah National Park’s Caves Complex: history, current status, and future prospects - p. 449 27. Chapter 27. The medical significance of human population genetics in Southeast Asia and Oceania - p. 457 28. Chapter 28. Ancestry and health: a mitochondrial DNA perspective - p. 471 29. Index - p. 487
DNA in Health, Identity and Ancestry examines the human genome and advances in molecular techniques in relation to their value in health, genetic ancestry, and forensic DNA. This book systematically presents these three areas, providing new insights into recent developments in these fields, including gene editing, ancestral fraction determination, and DNA profiling. It covers the latest advances in molecular biology to understand the pertinent issues in these areas. DNA in Health, Identity and Ancestry provides an introduction to human genomes, and then delves into health, forensics and ancestry across 36 chapters. Each section is concluded with practical case studies to demonstrate the application of the principles discussed in each respective section. This book is a valuable resource for researchers, practitioners, and postgraduate students in biochemistry, molecular biology and genetics. It not only provides them with fundamental knowledge on genetics, diseases, population genetics and forensic DNA, but also presents advances, technical operational standards, analytical tools and recent developments in these respective areas.
• Offers a comprehensive understanding of genomes in relation to health, forensics, and ancestry
• Provides detailed technical and operating standards, including for gene editing, genetic testing, ancestral fraction determination, DNA profiling, and ancient DNA analysis
• Genome and advances in molecular techniques in relation to their value in medical genetics, ancestral fraction determinations, and forensic DNA
1. Chapter 1. Introduction to human genomes: nuclear and mitochondrial DNA - p. 1 2. Chapter 2. Genetic testing: a biomedical, social, and ethical framework - p. 9 3. Chapter 3. CRISPR/Cas9: the future of human gene editing - p. 53 4. Chapter 4. Pharmacogenomics - p. 83 5. Chapter 5. Infectious disease diagnosis via DNA analysis - p. 109 6. Chapter 6. Donor and recipient matching for transfusion and transplantation surgery - p. 123 7. Chapter 7. Cell-free DNA: history, applications, and promises - p. 137 8. Chapter 8. Metagenomics studies of environmental samples - p. 179 9. Chapter 9. DNA extraction methods for pathogen analysis - p. 203 10. Chapter 10. Characterization and application of environmental DNA in multispecies biofilms - p. 217 11. Chapter 11. Variants in TLR gene and immune thrombocytopenia susceptibility - p. 231 12. Chapter 12. X chromosome: genetics, function, and health - p. 243 13. Chapter 13. Food intolerance and celiac disease in past human populations through DNA analysis - p. 259 14. Chapter 14. Puzzling ABO discrepancy case resolved through molecular technique - p. 269 15. Chapter 15. Short tandem repeat and mitochondrial DNA profiling for casework and paternity cases - p. 277 16. Chapter 16. DNA databanking, hit matches, and ethical issues - p. 289 17. Chapter 17. Mitochondrial DNA sequence diversity in Kedayan population - p. 299 18. Chapter 18. The application of dual mitochondrial markers for detecting porcine DNA in gelatine-containing processed food products - p. 311 19. Chapter 19. Identification of Elmina plane crash victims: a case study - p. 323 20. Chapter 20. Archaeogenetics of human history - p. 333 21. Chapter 21. Ancient DNA extraction techniques - p. 357 22. Chapter 22. The usefulness of Y chromosome in the study of past populations - p. 369 23. Chapter 23. A brief history of migration and settlement in the Malay Archipelago - p. 387 24. Chapter 24. Blood groups, HPA, HNA, cytokines, and HLA-G: genetics and ancestry - p. 399 25. Ethnic-specific patterns of GSTM1 and GSTT1 in Malays, Chinese, and Indians with specific comparison to Europeans - p. 433 26. Chapter 26. The Archaeological Heritage of the Niah National Park’s Caves Complex: history, current status, and future prospects - p. 449 27. Chapter 27. The medical significance of human population genetics in Southeast Asia and Oceania - p. 457 28. Chapter 28. Ancestry and health: a mitochondrial DNA perspective - p. 471 29. Index - p. 487
