DNA Repair, Volume 115, the latest release in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair, their involvement in maintaining chromatin repair, the balance between chromosome breaks repair pathways, tumorigenesis, immune signaling and infection-induced inflammation. Specific chapters cover the Structure and function of the multi-subunit TFIIH with insights into nucleotide excision repair, Chromatin repair: how DNA packaging controls double-strand break repair, Controlling the balance between chromosome breaks repair pathways, The targeting of DNA repair pathways in the era of precision oncology, and much more.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xiii 7. Chapter One: DNA repair by photolyases - p. xiii 8. Chapter Two: TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair - p. 19 9. Chapter Three: Chromatin control in double strand break repair - p. 67 10. Chapter Four: Controlling the balance between chromosome break repair pathways - p. 94 11. Chapter Five: Targeting DNA repair in precision medicine - p. 134 12. Chapter Six: Replication stress: Driver and therapeutic target in genomically instable cancers - p. 155 13. Chapter Seven: Claspin: From replication stress and DNA damage responses to cancer therapy - p. 201 14. Chapter Eight: cAMP-mediated regulation of melanocyte genomic instability: A melanoma-preventive strategy - p. 246 15. Chapter Nine: Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling - p. 295 16. Chapter Ten: Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach - p. 324 17. Chapter Eleven: A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase - p. 350
DNA Repair, Volume 115, the latest release in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair, their involvement in maintaining chromatin repair, the balance between chromosome breaks repair pathways, tumorigenesis, immune signaling and infection-induced inflammation. Specific chapters cover the Structure and function of the multi-subunit TFIIH with insights into nucleotide excision repair, Chromatin repair: how DNA packaging controls double-strand break repair, Controlling the balance between chromosome breaks repair pathways, The targeting of DNA repair pathways in the era of precision oncology, and much more.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xiii 7. Chapter One: DNA repair by photolyases - p. xiii 8. Chapter Two: TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair - p. 19 9. Chapter Three: Chromatin control in double strand break repair - p. 67 10. Chapter Four: Controlling the balance between chromosome break repair pathways - p. 94 11. Chapter Five: Targeting DNA repair in precision medicine - p. 134 12. Chapter Six: Replication stress: Driver and therapeutic target in genomically instable cancers - p. 155 13. Chapter Seven: Claspin: From replication stress and DNA damage responses to cancer therapy - p. 201 14. Chapter Eight: cAMP-mediated regulation of melanocyte genomic instability: A melanoma-preventive strategy - p. 246 15. Chapter Nine: Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling - p. 295 16. Chapter Ten: Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach - p. 324 17. Chapter Eleven: A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase - p. 350
