Dr. Rustgi has assembled the leading experts in the management of Heptatitis B to present the current treatment and clinical course for diagnosis and management of the disease. Articles are devoted to: Drug metabolism in the liver; Mechanism of Liver Damage including the RUCAM scale; Drug-induced acute liver failure; Epidemiology and genetic risk factors; Adverse drug reactions: type A (intrinsic or pharmacological) or type B (idiosyncratic); Pathology of injury including phenotypes; The clinical course of drug-induced liver disease; Environmental factors of drug hepatotoxicity; Newer agents in drug hepatotoxicity; Drug hepatotoxicity: herbal products; Drug hepatotoxicity: models including “human on a chip and zebrafish; Acute and chronic liver failure from drugs: impact on the kidney; and Management of acute hepatotoxicity including medical agents and liver support systems. Readers will come away with the cutting edge science behind the latest innovations in the treatment of Hepatitis B.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Preface - p. xiii 8. Drug Metabolism in the Liver - p. 1 9. Drug-Induced Liver Disease: Clinical Course - p. 21 10. Mechanisms of Drug-Induced Hepatotoxicity - p. 35 11. Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity - p. 55 12. Adverse Drug Reactions: Type A (Intrinsic) or Type B (Idiosyncratic) - p. 73 13. Phenotypes and Pathology of Drug-Induced Liver Disease - p. 89 14. Drug Hepatotoxicity: Environmental Factors - p. 103 15. Drug Hepatotoxicity: Newer Agents - p. 115 16. Herbal and Dietary Supplement–Induced Liver Injury - p. 135 17. Drug-Induced Acute Liver Failure - p. 151 18. Management of Acute Hepatotoxicity Including Medical Agents and Liver Support Systems - p. 163 19. Drug Metabolism, Drug Interactions, and Drug-Induced Liver Injury in Living Donor Liver Transplant Patients - p. 181 20. Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy - p. 197
Dr. Rustgi has assembled the leading experts in the management of Heptatitis B to present the current treatment and clinical course for diagnosis and management of the disease. Articles are devoted to: Drug metabolism in the liver; Mechanism of Liver Damage including the RUCAM scale; Drug-induced acute liver failure; Epidemiology and genetic risk factors; Adverse drug reactions: type A (intrinsic or pharmacological) or type B (idiosyncratic); Pathology of injury including phenotypes; The clinical course of drug-induced liver disease; Environmental factors of drug hepatotoxicity; Newer agents in drug hepatotoxicity; Drug hepatotoxicity: herbal products; Drug hepatotoxicity: models including “human on a chip and zebrafish; Acute and chronic liver failure from drugs: impact on the kidney; and Management of acute hepatotoxicity including medical agents and liver support systems. Readers will come away with the cutting edge science behind the latest innovations in the treatment of Hepatitis B.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Preface - p. xiii 8. Drug Metabolism in the Liver - p. 1 9. Drug-Induced Liver Disease: Clinical Course - p. 21 10. Mechanisms of Drug-Induced Hepatotoxicity - p. 35 11. Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity - p. 55 12. Adverse Drug Reactions: Type A (Intrinsic) or Type B (Idiosyncratic) - p. 73 13. Phenotypes and Pathology of Drug-Induced Liver Disease - p. 89 14. Drug Hepatotoxicity: Environmental Factors - p. 103 15. Drug Hepatotoxicity: Newer Agents - p. 115 16. Herbal and Dietary Supplement–Induced Liver Injury - p. 135 17. Drug-Induced Acute Liver Failure - p. 151 18. Management of Acute Hepatotoxicity Including Medical Agents and Liver Support Systems - p. 163 19. Drug Metabolism, Drug Interactions, and Drug-Induced Liver Injury in Living Donor Liver Transplant Patients - p. 181 20. Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy - p. 197
