Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders. In addition, the book covers earlier discoveries, including those from the last and 19th centuries. It is split into five sections that cover the vascular tree as an integrative structure, the endothelium in inflammation, endothelial signaling, activation and toxicity with chemotherapy, radiation induced endothelial dysfunction and vascular disease, and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content truly applicable.
This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and members of the biomedical field who are conducting studies related to the endothelium and vascular disease.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xiii 8. Preface - p. xv 9. Section 1: The vascular tree as an integrative structure - p. xvi 10. Chapter 1. The vascular system: components, signaling, and regulation - p. 3 11. Section 2: Endothelial signaling in inflammatory diseases - p. 12 12. Chapter 2. Reactive oxygen species-induced reactive oxygen species release in vascular signaling and disease - p. 17 13. Chapter 3. Nitric oxide as a vascular modulator to resistance training - p. 29 14. Chapter 4. Reactive oxygen species, redox signaling, and regulation of vascular endothelial signaling - p. 37 15. Chapter 5. Cross talk between the endothelium and bone: vascular endothelial cells in bone development - p. 47 16. Chapter 6. Endothelial signaling in coronary artery disease - p. 59 17. Chapter 7. An activated endothelium after organ transplantation: the pathogenesis of rejection - p. 69 18. Chapter 8. Angiogenesis: Aspects in wound healing - p. 77 19. Chapter 9. Normalization of the tumor vasculature - p. 91 20. Chapter 10. Vascular endothelial growth factor and tumor immune microenvironment - p. 105 21. Section 3: Radiation-induced endothelial dysfunction - p. 109 22. Chapter 11. Human radiation exposures (occupational, medical, environmental, and radiation incidents) and vascular dysfunction - p. 115 23. Chapter 12. Flow-adapted vascular systems: mimicking the vascular network to predict clinical response to radiation - p. 129 24. Chapter 13. Effects of space radiation on the endovasculature: implications for future human deep space exploration - p. 147 25. Chapter 14. Role of endothelial cells in normal tissue radiation injury - p. 157 26. Section 4: Infection, vascular signaling and injury - p. 161 27. Chapter 15. Hemeoxygenase and its metabolites in regulation of vascular endothelial health - p. 169 28. Chapter 16. Experimental models for identifying target events in vascular injury - p. 179 29. Chapter 17. The endothelium as a target for bacterial infection: challenges at the bedside - p. 195 30. Chapter 18. Coronavirus disease (COVID-19) and the endothelium - p. 205 31. Chapter 19. Endothelial dysfunction and cardiovascular diseases through oxidative stress pathways - p. 213 32. Section 5: Approaches in understanding endothelial function - p. 216 33. Chapter 20. Mathematical modeling of endothelial network - p. 223 34. Chapter 21. Comparative assessment of electrocardiographic parameters of some birds—an essential diagnostic tool in veterinary practice - p. 233 35. Section 6: Therapeutic interventions to limit vascular disease - p. 240 36. Chapter 22. Percutaneous coronary interventions: scaffolds versus stents - p. 245 37. Chapter 23. Statins in venous thrombosis: biochemical approaches to limiting vascular disease - p. 249 38. Index - p. 255
Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders. In addition, the book covers earlier discoveries, including those from the last and 19th centuries. It is split into five sections that cover the vascular tree as an integrative structure, the endothelium in inflammation, endothelial signaling, activation and toxicity with chemotherapy, radiation induced endothelial dysfunction and vascular disease, and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content truly applicable.
This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and members of the biomedical field who are conducting studies related to the endothelium and vascular disease.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xiii 8. Preface - p. xv 9. Section 1: The vascular tree as an integrative structure - p. xvi 10. Chapter 1. The vascular system: components, signaling, and regulation - p. 3 11. Section 2: Endothelial signaling in inflammatory diseases - p. 12 12. Chapter 2. Reactive oxygen species-induced reactive oxygen species release in vascular signaling and disease - p. 17 13. Chapter 3. Nitric oxide as a vascular modulator to resistance training - p. 29 14. Chapter 4. Reactive oxygen species, redox signaling, and regulation of vascular endothelial signaling - p. 37 15. Chapter 5. Cross talk between the endothelium and bone: vascular endothelial cells in bone development - p. 47 16. Chapter 6. Endothelial signaling in coronary artery disease - p. 59 17. Chapter 7. An activated endothelium after organ transplantation: the pathogenesis of rejection - p. 69 18. Chapter 8. Angiogenesis: Aspects in wound healing - p. 77 19. Chapter 9. Normalization of the tumor vasculature - p. 91 20. Chapter 10. Vascular endothelial growth factor and tumor immune microenvironment - p. 105 21. Section 3: Radiation-induced endothelial dysfunction - p. 109 22. Chapter 11. Human radiation exposures (occupational, medical, environmental, and radiation incidents) and vascular dysfunction - p. 115 23. Chapter 12. Flow-adapted vascular systems: mimicking the vascular network to predict clinical response to radiation - p. 129 24. Chapter 13. Effects of space radiation on the endovasculature: implications for future human deep space exploration - p. 147 25. Chapter 14. Role of endothelial cells in normal tissue radiation injury - p. 157 26. Section 4: Infection, vascular signaling and injury - p. 161 27. Chapter 15. Hemeoxygenase and its metabolites in regulation of vascular endothelial health - p. 169 28. Chapter 16. Experimental models for identifying target events in vascular injury - p. 179 29. Chapter 17. The endothelium as a target for bacterial infection: challenges at the bedside - p. 195 30. Chapter 18. Coronavirus disease (COVID-19) and the endothelium - p. 205 31. Chapter 19. Endothelial dysfunction and cardiovascular diseases through oxidative stress pathways - p. 213 32. Section 5: Approaches in understanding endothelial function - p. 216 33. Chapter 20. Mathematical modeling of endothelial network - p. 223 34. Chapter 21. Comparative assessment of electrocardiographic parameters of some birds—an essential diagnostic tool in veterinary practice - p. 233 35. Section 6: Therapeutic interventions to limit vascular disease - p. 240 36. Chapter 22. Percutaneous coronary interventions: scaffolds versus stents - p. 245 37. Chapter 23. Statins in venous thrombosis: biochemical approaches to limiting vascular disease - p. 249 38. Index - p. 255
