The Neurobiology, Physiology and Psychology of Pain focuses on bettering readers’ understanding of acute and chronic pain. Featuring chapters on neurotransmitters, pharmacology, and brain imaging, this volume discusses, in detail, the mechanisms of pain and experimental studies undertaken to better understand the pathways involved. The translational work in this area has applicability for neurologists, anesthesiologists, pharmacologists, and anyone working in the intersection of these areas. This volume is integral for anyone interested in the molecular underpinnings of pain at every level.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_xv 6. Preface - p. page_xxi 7. Part I: Molecular and cellular aspects - p. page_xxii 8. Chapter 1: KCNQ/Kv7 channels as therapeutic target to treat neuropathic pain - p. page_3 9. Chapter 2: A new mutation in NTRK1 gene is associated with congenital insensitivity to pain without anhidrosis - p. page_13 10. Chapter 3: Prdm12, a key transcriptional regulator of the nociceptive lineage - p. page_23 11. Chapter 4: Genetics of chronic widespread musculoskeletal pain - p. page_33 12. Chapter 5: Fentanyl: Polymorphisms, and adverse events - p. page_45 13. Chapter 6: Propofol anesthesia and molecular changes in the brain - p. page_57 14. Chapter 7: Protein kinase G is a molecular switch for pain - p. page_67 15. Chapter 8: Adrenergic agonists and antagonists enhance opioid receptor activity - p. page_79 16. Chapter 9: Inflammatory and neuropathic pain impact on the opioid function in the mesocorticolimbic system - p. page_91 17. Chapter 10: Clinacanthus nutans L., analgesia, and the l-arginine/nitric oxide-mediated/cyclic-guanosine monophosphate-independent pathway - p. page_103 18. Chapter 11: The orally bioavailable imidazodiazepine, KRM-II-81, is a novel potentiator of α2/3-containing GABAA receptors with analgesic efficacy - p. page_117 19. Chapter 12: Extrasynaptic α5GABAA receptors and their role in nociception and pathological pain - p. page_129 20. Chapter 13: ATP-sensitive potassium channels in pain and analgesia - p. page_139 21. Chapter 14: Astrocyte-neuron lactate shuttle and pain - p. page_151 22. Chapter 15: Nociception and sweet solutions: Applications to inflammatory pain - p. page_161 23. Chapter 16: Interlinking interleukin-33 (IL-33), neuroinflammation and neuropathic pain - p. page_171 24. Chapter 17: Neurons of the parabrachial nucleus, nociceptive input, and pain pathways - p. page_183 25. Chapter 18: Anterior cingulate cortex, pain perception, and pathological neuronal plasticity during chronic pain - p. page_193 26. Chapter 19: Sleep deprivation, headache, and Fos immunohistochemistry - p. page_203 27. Chapter 20: Antinociceptive glucagon-like peptides - p. page_217 28. Chapter 21: Pain transmission and peripheral group III metabotropic glutamate receptors (mGluRs) - p. page_227 29. Chapter 22: TRPM8 receptor and menthol in pain management - p. page_239 30. Part II: Physiology, imaging and physical recordings - p. page_251 31. Chapter 23: Anesthetic and proconvulsant effects of ketamine on EEG - p. page_255 32. Chapter 24: Electroencephalography and anesthetic doses of ketamine - p. page_265 33. Chapter 25: Linking heart function and analgesia - p. page_275 34. Chapter 26: Computed tomography-guided procedures for epidural injections - p. page_287 35. Chapter 27: Chronic pain: Linking deep brain stimulation and sensory functional MRI - p. page_299 36. Chapter 28: Neurocognition and placebo analgesia: Linking in functional magnetic resonance imaging - p. page_307 37. Chapter 29: Linking the cortex, functional spectroscopy, and pain: Features and applications - p. page_319 38. Chapter 30: Muscle origins of myofascial pain syndrome - p. page_337 39. Part III: Psychology and behavior - p. page_345 40. Chapter 31: Behavioral markers of pain: Understanding the cognitive, motor, and societal interactions in the pain experience - p. page_349 41. Chapter 32: Adverse life events, sensitization of spinal nociception, and chronic pain risk - p. page_359 42. Chapter 33: Cognitive-affective modulation of pain: The placebo and nocebo phenomena and their impact on pain treatment - p. page_375 43. Chapter 34: Nociception-related behavioral phenotypes in adult zebrafish - p. page_387 44. Chapter 35: Pain, implantable pain devices, and psychosocial aspects of pain - p. page_395 45. Chapter 36: Influence of psychological factors on myofascial pain - p. page_405 46. Part IV: Resources - p. page_415 47. Chapter 37: Recommended resources, sites, and research groups for the neuroscience of anesthetics and analgesics - p. page_419 48. Index - p. page_427
The Neurobiology, Physiology and Psychology of Pain focuses on bettering readers’ understanding of acute and chronic pain. Featuring chapters on neurotransmitters, pharmacology, and brain imaging, this volume discusses, in detail, the mechanisms of pain and experimental studies undertaken to better understand the pathways involved. The translational work in this area has applicability for neurologists, anesthesiologists, pharmacologists, and anyone working in the intersection of these areas. This volume is integral for anyone interested in the molecular underpinnings of pain at every level.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_xv 6. Preface - p. page_xxi 7. Part I: Molecular and cellular aspects - p. page_xxii 8. Chapter 1: KCNQ/Kv7 channels as therapeutic target to treat neuropathic pain - p. page_3 9. Chapter 2: A new mutation in NTRK1 gene is associated with congenital insensitivity to pain without anhidrosis - p. page_13 10. Chapter 3: Prdm12, a key transcriptional regulator of the nociceptive lineage - p. page_23 11. Chapter 4: Genetics of chronic widespread musculoskeletal pain - p. page_33 12. Chapter 5: Fentanyl: Polymorphisms, and adverse events - p. page_45 13. Chapter 6: Propofol anesthesia and molecular changes in the brain - p. page_57 14. Chapter 7: Protein kinase G is a molecular switch for pain - p. page_67 15. Chapter 8: Adrenergic agonists and antagonists enhance opioid receptor activity - p. page_79 16. Chapter 9: Inflammatory and neuropathic pain impact on the opioid function in the mesocorticolimbic system - p. page_91 17. Chapter 10: Clinacanthus nutans L., analgesia, and the l-arginine/nitric oxide-mediated/cyclic-guanosine monophosphate-independent pathway - p. page_103 18. Chapter 11: The orally bioavailable imidazodiazepine, KRM-II-81, is a novel potentiator of α2/3-containing GABAA receptors with analgesic efficacy - p. page_117 19. Chapter 12: Extrasynaptic α5GABAA receptors and their role in nociception and pathological pain - p. page_129 20. Chapter 13: ATP-sensitive potassium channels in pain and analgesia - p. page_139 21. Chapter 14: Astrocyte-neuron lactate shuttle and pain - p. page_151 22. Chapter 15: Nociception and sweet solutions: Applications to inflammatory pain - p. page_161 23. Chapter 16: Interlinking interleukin-33 (IL-33), neuroinflammation and neuropathic pain - p. page_171 24. Chapter 17: Neurons of the parabrachial nucleus, nociceptive input, and pain pathways - p. page_183 25. Chapter 18: Anterior cingulate cortex, pain perception, and pathological neuronal plasticity during chronic pain - p. page_193 26. Chapter 19: Sleep deprivation, headache, and Fos immunohistochemistry - p. page_203 27. Chapter 20: Antinociceptive glucagon-like peptides - p. page_217 28. Chapter 21: Pain transmission and peripheral group III metabotropic glutamate receptors (mGluRs) - p. page_227 29. Chapter 22: TRPM8 receptor and menthol in pain management - p. page_239 30. Part II: Physiology, imaging and physical recordings - p. page_251 31. Chapter 23: Anesthetic and proconvulsant effects of ketamine on EEG - p. page_255 32. Chapter 24: Electroencephalography and anesthetic doses of ketamine - p. page_265 33. Chapter 25: Linking heart function and analgesia - p. page_275 34. Chapter 26: Computed tomography-guided procedures for epidural injections - p. page_287 35. Chapter 27: Chronic pain: Linking deep brain stimulation and sensory functional MRI - p. page_299 36. Chapter 28: Neurocognition and placebo analgesia: Linking in functional magnetic resonance imaging - p. page_307 37. Chapter 29: Linking the cortex, functional spectroscopy, and pain: Features and applications - p. page_319 38. Chapter 30: Muscle origins of myofascial pain syndrome - p. page_337 39. Part III: Psychology and behavior - p. page_345 40. Chapter 31: Behavioral markers of pain: Understanding the cognitive, motor, and societal interactions in the pain experience - p. page_349 41. Chapter 32: Adverse life events, sensitization of spinal nociception, and chronic pain risk - p. page_359 42. Chapter 33: Cognitive-affective modulation of pain: The placebo and nocebo phenomena and their impact on pain treatment - p. page_375 43. Chapter 34: Nociception-related behavioral phenotypes in adult zebrafish - p. page_387 44. Chapter 35: Pain, implantable pain devices, and psychosocial aspects of pain - p. page_395 45. Chapter 36: Influence of psychological factors on myofascial pain - p. page_405 46. Part IV: Resources - p. page_415 47. Chapter 37: Recommended resources, sites, and research groups for the neuroscience of anesthetics and analgesics - p. page_419 48. Index - p. page_427
