Pesticides and Neurotoxicant Exposures: Impacts of Neurodevelopment and Long-Term Brain Health explores neuroscience research, revealing how chronic pesticide exposure contributes to neurodegenerative diseases and cognitive decline. This new volume synthesizes findings on the mechanisms of pesticide-induced neurotoxicity and its impact on brain health. Targeted at researchers, clinicians, and policymakers, the book explores gaps in knowledge and the urgent need for improved regulation to protect vulnerable populations. By bridging scientific insights with public health, the book aims to advance understanding and prevention of pesticide-related neurological disorders.
1. Section 1: Introduction to pesticides and neurotoxicity - p. P1 2. Chapter 1. Pesticides and human health: an overview - p. 3 3. Chapter 2. Neurotoxic effects of pesticides: mechanisms and pathways - p. 13 4. Chapter 3. Classification of pesticides and their neurotoxic potential - p. 31 5. Chapter 4. Routes of pesticide exposure and bioaccumulation - p. 45 6. Chapter 5. Epidemiological evidence of pesticide-induced neurotoxicity - p. 69 7. Section 2: Pesticides classes and their neurotoxic effects - p. P89 8. Chapter 6. Organophosphate and acetylcholinesterase inhibition - p. 91 9. Chapter 7. Carbamates: mechanisms of neurotoxicity - p. 103 10. Chapter 8. Organochlorines and their impact on the nervous system - p. 123 11. Chapter 9. Pyrethroids: effects on ion channels and neurotransmission - p. 139 12. Chapter 10. Neonicotinoids and their influence on the central nervous system - p. 153 13. Chapter 11. Herbicides and neurodegeneration: the case of paraquat and glyphosate - p. 177 14. Chapter 12. Fungicides and neurotoxicity: a neglected risk? - p. 199 15. Chapter 13. Rodenticides and their impact on brain function - p. 213 16. Chapter 14. Biopesticides: safer alternatives or hidden neurotoxins? - p. 229 17. Section 3: Cellular and molecular mechanisms of pesticide-induced neurotoxicity - p. P243 18. Chapter 15. Oxidative stress, reactive oxygen species, and mitochondrial dysfunction in pesticide toxicity - p. 245 19. Chapter 16. Neuroinflammation and glial cell activation in pesticide exposure - p. 261 20. Chapter 17. Neurotransmitter dysregulation induced by pesticides - p. 283 21. Chapter 18. Epigenetic modifications in pesticide-induced neurotoxicity - p. 301 22. Chapter 19. Blood–brain barrier disruption mechanisms by pesticides - p. 313 23. Chapter 20. Autophagy, apoptosis, and cell death pathways in pesticide toxicity - p. 329 24. Section 4: Pesticides and neurodevelopmental disorders - p. P345 25. Chapter 21. Prenatal and early-life pesticide exposure: impacts on brain development - p. 347 26. Chapter 22. Pesticides and autism spectrum disorders: evidence and mechanisms - p. 367 27. Chapter 23. Attention-deficit hyperactivity disorder and pesticide exposure - p. 389 28. Chapter 24. Pesticides and cognitive impairments in children - p. 405 29. Section 5: Pesticides and neurodegenerative diseases - p. P417 30. Chapter 25. Pesticides and Alzheimer’s disease: risk factors and mechanisms - p. 419 31. Chapter 26. Parkinson’s disease and pesticide exposure: a strong association? - p. 445 32. Chapter 27. Amyotrophic lateral sclerosis and neurotoxicity of pesticides - p. 461 33. Chapter 28. Multiple sclerosis and pesticides: possible links - p. 485 34. Section 6: Biomarkers and detection of pesticide-induced neurotoxicity - p. P503 35. Chapter 29. Biomarkers of pesticide exposure in the nervous system - p. 505 36. Chapter 30. Neuroimaging, computational, and artificial intelligence approaches in pesticide toxicity assessment - p. 527 37. Chapter 31. Advances in toxicogenomics for evaluating pesticide-induced neurotoxicity - p. 539 38. Section 7: Mitigation strategies and future directions - p. P567 39. Chapter 32. Precision agriculture and artificial intelligence–driven pest management to reduce pesticide dependency - p. 569 40. Chapter 33. Detoxification pathways and neuroprotection against pesticides - p. 587 41. Chapter 34. Dietary and nutritional interventions for reducing neurotoxic effects - p. 603 42. Chapter 35. Regulatory policies and risk assessment of neurotoxic pesticides - p. 623 43. Chapter 36. Eco-friendly alternatives: reducing the neurotoxic burden of pesticides - p. 645 44. Chapter 37. Public awareness and education on pesticide neurotoxicity - p. 667 45. Chapter 38. Novel therapeutic strategies for pesticide-induced neurotoxicity - p. 679 46. Chapter 39. Innovations in pesticide formulation for reduced neurotoxicity - p. 699 47. Chapter 40. Artificial intelligence and big data in neurotoxicology research - p. 717 48. Chapter 41. Future perspectives on pesticide use and neurotoxic risks - p. 735 49. Index - p. 761
Pesticides and Neurotoxicant Exposures: Impacts of Neurodevelopment and Long-Term Brain Health explores neuroscience research, revealing how chronic pesticide exposure contributes to neurodegenerative diseases and cognitive decline. This new volume synthesizes findings on the mechanisms of pesticide-induced neurotoxicity and its impact on brain health. Targeted at researchers, clinicians, and policymakers, the book explores gaps in knowledge and the urgent need for improved regulation to protect vulnerable populations. By bridging scientific insights with public health, the book aims to advance understanding and prevention of pesticide-related neurological disorders.
1. Section 1: Introduction to pesticides and neurotoxicity - p. P1 2. Chapter 1. Pesticides and human health: an overview - p. 3 3. Chapter 2. Neurotoxic effects of pesticides: mechanisms and pathways - p. 13 4. Chapter 3. Classification of pesticides and their neurotoxic potential - p. 31 5. Chapter 4. Routes of pesticide exposure and bioaccumulation - p. 45 6. Chapter 5. Epidemiological evidence of pesticide-induced neurotoxicity - p. 69 7. Section 2: Pesticides classes and their neurotoxic effects - p. P89 8. Chapter 6. Organophosphate and acetylcholinesterase inhibition - p. 91 9. Chapter 7. Carbamates: mechanisms of neurotoxicity - p. 103 10. Chapter 8. Organochlorines and their impact on the nervous system - p. 123 11. Chapter 9. Pyrethroids: effects on ion channels and neurotransmission - p. 139 12. Chapter 10. Neonicotinoids and their influence on the central nervous system - p. 153 13. Chapter 11. Herbicides and neurodegeneration: the case of paraquat and glyphosate - p. 177 14. Chapter 12. Fungicides and neurotoxicity: a neglected risk? - p. 199 15. Chapter 13. Rodenticides and their impact on brain function - p. 213 16. Chapter 14. Biopesticides: safer alternatives or hidden neurotoxins? - p. 229 17. Section 3: Cellular and molecular mechanisms of pesticide-induced neurotoxicity - p. P243 18. Chapter 15. Oxidative stress, reactive oxygen species, and mitochondrial dysfunction in pesticide toxicity - p. 245 19. Chapter 16. Neuroinflammation and glial cell activation in pesticide exposure - p. 261 20. Chapter 17. Neurotransmitter dysregulation induced by pesticides - p. 283 21. Chapter 18. Epigenetic modifications in pesticide-induced neurotoxicity - p. 301 22. Chapter 19. Blood–brain barrier disruption mechanisms by pesticides - p. 313 23. Chapter 20. Autophagy, apoptosis, and cell death pathways in pesticide toxicity - p. 329 24. Section 4: Pesticides and neurodevelopmental disorders - p. P345 25. Chapter 21. Prenatal and early-life pesticide exposure: impacts on brain development - p. 347 26. Chapter 22. Pesticides and autism spectrum disorders: evidence and mechanisms - p. 367 27. Chapter 23. Attention-deficit hyperactivity disorder and pesticide exposure - p. 389 28. Chapter 24. Pesticides and cognitive impairments in children - p. 405 29. Section 5: Pesticides and neurodegenerative diseases - p. P417 30. Chapter 25. Pesticides and Alzheimer’s disease: risk factors and mechanisms - p. 419 31. Chapter 26. Parkinson’s disease and pesticide exposure: a strong association? - p. 445 32. Chapter 27. Amyotrophic lateral sclerosis and neurotoxicity of pesticides - p. 461 33. Chapter 28. Multiple sclerosis and pesticides: possible links - p. 485 34. Section 6: Biomarkers and detection of pesticide-induced neurotoxicity - p. P503 35. Chapter 29. Biomarkers of pesticide exposure in the nervous system - p. 505 36. Chapter 30. Neuroimaging, computational, and artificial intelligence approaches in pesticide toxicity assessment - p. 527 37. Chapter 31. Advances in toxicogenomics for evaluating pesticide-induced neurotoxicity - p. 539 38. Section 7: Mitigation strategies and future directions - p. P567 39. Chapter 32. Precision agriculture and artificial intelligence–driven pest management to reduce pesticide dependency - p. 569 40. Chapter 33. Detoxification pathways and neuroprotection against pesticides - p. 587 41. Chapter 34. Dietary and nutritional interventions for reducing neurotoxic effects - p. 603 42. Chapter 35. Regulatory policies and risk assessment of neurotoxic pesticides - p. 623 43. Chapter 36. Eco-friendly alternatives: reducing the neurotoxic burden of pesticides - p. 645 44. Chapter 37. Public awareness and education on pesticide neurotoxicity - p. 667 45. Chapter 38. Novel therapeutic strategies for pesticide-induced neurotoxicity - p. 679 46. Chapter 39. Innovations in pesticide formulation for reduced neurotoxicity - p. 699 47. Chapter 40. Artificial intelligence and big data in neurotoxicology research - p. 717 48. Chapter 41. Future perspectives on pesticide use and neurotoxic risks - p. 735 49. Index - p. 761
