Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource.
Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. About the Editors - p. v 6. About the Contributors - p. v 7. Dedication - p. xiii 8. Acknowledgments - p. xv 9. Preface - p. xvii 10. Presentation - p. xix 11. I: Structure and Functions - p. xx 12. Section I: Structure and Development - p. xx 13. Chapter 1: The Vascular Endothelium - p. xx 14. Chapter 2: Development of the Coronary System: Perspectives for Cell Therapy From Precursor Differentiation - p. 10 15. Chapter 3: Signal Transduction Pathways in Endothelial Cells: Implications for Angiogenesis - p. 22 16. Chapter 4: Endothelial Barrier: Factors That Regulate Its Permeability - p. 36 17. Chapter 5: Vascular Growth Factors, Progenitor Cells, and Angiogenesis - p. 48 18. Chapter 6: Characteristics of the Endothelium in Both Sexes - p. 62 19. Section II: Endocrine Functions and Metabolic Interactions - p. 81 20. Chapter 7: Hemodynamic Forces in the Endothelium: From Mechanotransduction to Implications on Development of Atherosclerosis - p. 81 21. Chapter 8: Endothelium-Dependent Vasodilation: Nitric Oxide and Other Mediators - p. 95 22. Chapter 9: Vasoconstrictor Substances Produced by the Endothelium - p. 113 23. Chapter 10: Redox Cellular Signaling Pathways in Endothelial Dysfunction and Vascular Disease - p. 125 24. Chapter 11: Blood Coagulation and Endothelium - p. 145 25. Chapter 12: Endothelium and Genetics - p. 152 26. Chapter 13: Epigenetic Regulation of Endothelial Function: With Focus on MicroRNAs - p. 169 27. Chapter 14: Adhesion Molecules and Endothelium - p. 187 28. Chapter 15: Endothelium and the Renin-Angiotensin System - p. 201 29. II: Endothelial Dysfunction and Clinical Syndromes - p. 211 30. Section III: Methods of Investigation - p. 211 31. Chapter 16: Methods to Investigate Endothelial Function in Humans - p. 211 32. Chapter 17: Endothelial Biomarkers - p. 228 33. Section IV: Aging and Cognitive Functions - p. 233 34. Chapter 18: Endothelial Alterations in Aging - p. 233 35. Chapter 19: Vascular Function and Cognitive Decline - p. 251 36. Chapter 20: Emotional Stress and Influences on Endothelium - p. 264 37. Section V: Lipoproteins - p. 282 38. Chapter 21: Lipids and Lipoprotein Mediators of Endothelial Function and Dysfunction - p. 282 39. Chapter 22: HDL and Endothelium - p. 296 40. Chapter 23: Artificial Lipoproteins in Endothelial Dysfunction and Atherosclerosis - p. 317 41. Section VI: Diet and Endothelium - p. 338 42. Chapter 24: Influence of Diet on Endothelial Dysfunction - p. 338 43. Chapter 25: Effects of Mediterranean Diet on Endothelial Function - p. 362 44. Chapter 26: Action of Red Wine and Polyphenols Upon Endothelial Function and Clinical Events - p. 389 45. Section VII: Kidney and Hypertension - p. 418 46. Chapter 27: Kidney and Endothelium - p. 418 47. Chapter 28: Endothelium and Arterial Hypertension - p. 428 48. Chapter 29: Endothelial Alterations in Pulmonary Hypertension - p. 437 49. Section VIII: Coronary Disease and Atherosclerosis - p. 451 50. Chapter 30: Endothelial Alterations in Chronic Coronary Disease - p. 451 51. Chapter 31: Molecular Mechanisms of the Arterial Wall in Acute Coronary Syndromes - p. 472 52. Chapter 32: Endothelium: A Coordinator of Acute and Chronic Inflammation - p. 483 53. Chapter 33: Endothelium in Atherosclerosis: Plaque Formation and Its Complications - p. 491 54. Chapter 34: Endothelial Function and Cardiovascular Risk Factors - p. 512 55. Chapter 35: Sleep Disorders and Endothelial Dysfunction - p. 526 56. Chapter 36: Smoking and the Endothelium - p. 536 57. Chapter 37: Endothelial Dysfunction and Coronary Microvascular Dysfunction in Women With Angina and Nonobstructive Coronaries - p. 554 58. Section IX: Heart Failure - p. 562 59. Chapter 38: Endothelial Alterations in Heart Failure—Mechanisms and Molecular Basis - p. 562 60. Chapter 39: Heart Failure: Influence of Drug Interventions on Vessels - p. 573 61. Section X: Percutaneous Coronary Interventions and Cardiac Surgery - p. 588 62. Chapter 40: Postpercutaneous Interventions: Endothelial Repair - p. 588 63. Chapter 41: Stents and the Endothelium - p. 596 64. Chapter 42: Vascular Disease of the Transplanted Heart: Physiopathology and Therapeutic Options - p. 608 65. Section XI: Diabetes and Erectile Dysfunction - p. 625 66. Chapter 43: Erectile Dysfunction and the Endothelium - p. 625 67. Chapter 44: Obesity, Diabetes, and Endothelium: Molecular Interactions - p. 637 68. Section XII: Non-Cardiovascular Diseases and Endothelium - p. 652 69. Chapter 45: Endothelial Mechanisms in Preeclampsia - p. 652 70. Chapter 46: Endothelium and Nitric Oxide: Interactions in Cancer Evolution - p. 664 71. Chapter 47: Endothelial Function in Skin Microcirculation - p. 671 72. Section XIII: Treatment of Endothelial Dysfunction - p. 679 73. Chapter 48: Clinical Endothelial Dysfunction: Prognosis and Therapeutic Target - p. 679 74. Chapter 49: Physical Exercise and the Endothelium - p. 697 75. Chapter 50: Endothelium and Immunological Alterations in Atherosclerosis - p. 709 76. Index - p. 717
Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource.
Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. About the Editors - p. v 6. About the Contributors - p. v 7. Dedication - p. xiii 8. Acknowledgments - p. xv 9. Preface - p. xvii 10. Presentation - p. xix 11. I: Structure and Functions - p. xx 12. Section I: Structure and Development - p. xx 13. Chapter 1: The Vascular Endothelium - p. xx 14. Chapter 2: Development of the Coronary System: Perspectives for Cell Therapy From Precursor Differentiation - p. 10 15. Chapter 3: Signal Transduction Pathways in Endothelial Cells: Implications for Angiogenesis - p. 22 16. Chapter 4: Endothelial Barrier: Factors That Regulate Its Permeability - p. 36 17. Chapter 5: Vascular Growth Factors, Progenitor Cells, and Angiogenesis - p. 48 18. Chapter 6: Characteristics of the Endothelium in Both Sexes - p. 62 19. Section II: Endocrine Functions and Metabolic Interactions - p. 81 20. Chapter 7: Hemodynamic Forces in the Endothelium: From Mechanotransduction to Implications on Development of Atherosclerosis - p. 81 21. Chapter 8: Endothelium-Dependent Vasodilation: Nitric Oxide and Other Mediators - p. 95 22. Chapter 9: Vasoconstrictor Substances Produced by the Endothelium - p. 113 23. Chapter 10: Redox Cellular Signaling Pathways in Endothelial Dysfunction and Vascular Disease - p. 125 24. Chapter 11: Blood Coagulation and Endothelium - p. 145 25. Chapter 12: Endothelium and Genetics - p. 152 26. Chapter 13: Epigenetic Regulation of Endothelial Function: With Focus on MicroRNAs - p. 169 27. Chapter 14: Adhesion Molecules and Endothelium - p. 187 28. Chapter 15: Endothelium and the Renin-Angiotensin System - p. 201 29. II: Endothelial Dysfunction and Clinical Syndromes - p. 211 30. Section III: Methods of Investigation - p. 211 31. Chapter 16: Methods to Investigate Endothelial Function in Humans - p. 211 32. Chapter 17: Endothelial Biomarkers - p. 228 33. Section IV: Aging and Cognitive Functions - p. 233 34. Chapter 18: Endothelial Alterations in Aging - p. 233 35. Chapter 19: Vascular Function and Cognitive Decline - p. 251 36. Chapter 20: Emotional Stress and Influences on Endothelium - p. 264 37. Section V: Lipoproteins - p. 282 38. Chapter 21: Lipids and Lipoprotein Mediators of Endothelial Function and Dysfunction - p. 282 39. Chapter 22: HDL and Endothelium - p. 296 40. Chapter 23: Artificial Lipoproteins in Endothelial Dysfunction and Atherosclerosis - p. 317 41. Section VI: Diet and Endothelium - p. 338 42. Chapter 24: Influence of Diet on Endothelial Dysfunction - p. 338 43. Chapter 25: Effects of Mediterranean Diet on Endothelial Function - p. 362 44. Chapter 26: Action of Red Wine and Polyphenols Upon Endothelial Function and Clinical Events - p. 389 45. Section VII: Kidney and Hypertension - p. 418 46. Chapter 27: Kidney and Endothelium - p. 418 47. Chapter 28: Endothelium and Arterial Hypertension - p. 428 48. Chapter 29: Endothelial Alterations in Pulmonary Hypertension - p. 437 49. Section VIII: Coronary Disease and Atherosclerosis - p. 451 50. Chapter 30: Endothelial Alterations in Chronic Coronary Disease - p. 451 51. Chapter 31: Molecular Mechanisms of the Arterial Wall in Acute Coronary Syndromes - p. 472 52. Chapter 32: Endothelium: A Coordinator of Acute and Chronic Inflammation - p. 483 53. Chapter 33: Endothelium in Atherosclerosis: Plaque Formation and Its Complications - p. 491 54. Chapter 34: Endothelial Function and Cardiovascular Risk Factors - p. 512 55. Chapter 35: Sleep Disorders and Endothelial Dysfunction - p. 526 56. Chapter 36: Smoking and the Endothelium - p. 536 57. Chapter 37: Endothelial Dysfunction and Coronary Microvascular Dysfunction in Women With Angina and Nonobstructive Coronaries - p. 554 58. Section IX: Heart Failure - p. 562 59. Chapter 38: Endothelial Alterations in Heart Failure—Mechanisms and Molecular Basis - p. 562 60. Chapter 39: Heart Failure: Influence of Drug Interventions on Vessels - p. 573 61. Section X: Percutaneous Coronary Interventions and Cardiac Surgery - p. 588 62. Chapter 40: Postpercutaneous Interventions: Endothelial Repair - p. 588 63. Chapter 41: Stents and the Endothelium - p. 596 64. Chapter 42: Vascular Disease of the Transplanted Heart: Physiopathology and Therapeutic Options - p. 608 65. Section XI: Diabetes and Erectile Dysfunction - p. 625 66. Chapter 43: Erectile Dysfunction and the Endothelium - p. 625 67. Chapter 44: Obesity, Diabetes, and Endothelium: Molecular Interactions - p. 637 68. Section XII: Non-Cardiovascular Diseases and Endothelium - p. 652 69. Chapter 45: Endothelial Mechanisms in Preeclampsia - p. 652 70. Chapter 46: Endothelium and Nitric Oxide: Interactions in Cancer Evolution - p. 664 71. Chapter 47: Endothelial Function in Skin Microcirculation - p. 671 72. Section XIII: Treatment of Endothelial Dysfunction - p. 679 73. Chapter 48: Clinical Endothelial Dysfunction: Prognosis and Therapeutic Target - p. 679 74. Chapter 49: Physical Exercise and the Endothelium - p. 697 75. Chapter 50: Endothelium and Immunological Alterations in Atherosclerosis - p. 709 76. Index - p. 717
