Endotoxin in Critical Illness intricately explores the theme of endotoxin and sepsis through the lenses of basic, clinical, and translational science. This work consolidates and synthesizes novel clinical insights and groundbreaking scientific discoveries into one comprehensive resource on endotoxic septic shock and sheds light on cutting-edge approaches in treatment. Beginning with a historical journey, the book traces the evolution of understanding from ancient concepts to modern molecular insights. It covers the physiological aspects of endotoxin sensitivity, tolerance, and human response variation. The crucial role of the gut microbiome in critical illness serves as a translational link between foundational science and clinical implications, and the complex language of bacterial communication is introduced, merging basic science with potential translational applications. In the clinical arena, chapters cover the critical role of endotoxin in septic shock, trauma, and its relevance in COVID-19, providing a translational bridge between laboratory findings and real-world clinical scenarios. The historical context of anti-endotoxin drug development is revisited, emphasizing the translational challenges faced in bridging basic science discoveries to clinical applications. The discussion on quantifying endotoxin concentration as well as the exploration of therapeutic rationale and clinical experiences with endotoxin removal therapy serve as a culmination of basic understanding translated into practical applications. The book concludes by contemplating the complexity of sepsis and acknowledging the challenges in achieving personalized medicine and underscoring the dynamic nature of the translational journey. In essence, this comprehensive exploration provides clinicians, researchers, and scientists with a holistic understanding of endotoxin and sepsis and potential advancements in patient care.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. vii 7. Preface - p. xi 8. Chapter 1. Sepsis and endotoxin: A brief history - p. 1 9. Chapter 2. Antiendotoxin therapies - p. 11 10. Chapter 3. Endotoxemia in COVID-19 - p. 25 11. Chapter 4. Endotoxin signaling: the TLR4 pathway and alternates - p. 43 12. Chapter 5. Endotoxin pathophysiology - p. 63 13. Chapter 6. Origins of human sensitivity to endotoxin and implications for sepsis therapeutic development - p. 87 14. Chapter 7. Endotoxin and the gut microbiome - p. 109 15. Chapter 8. Quantifying endotoxin in the blood of humans; a personal journey toward development of the endotoxin activity assay - p. 121 16. Chapter 9. Endotoxic septic shock - p. 133 17. Chapter 10. Endotoxin in trauma - p. 147 18. Chapter 11. Therapeutic rationale for endotoxin removal with polymyxin B immobilized fiber column hemoperfusion (PMX-HP) for endotoxemic septic shock - p. 159 19. Chapter 12. Clinical experience with PMX cartridge in sepsis and septic shock management - p. 171 20. Chapter 13. Precision medicine for sepsis: A dream or a reality? - p. 183 21. Index - p. 207
Endotoxin in Critical Illness intricately explores the theme of endotoxin and sepsis through the lenses of basic, clinical, and translational science. This work consolidates and synthesizes novel clinical insights and groundbreaking scientific discoveries into one comprehensive resource on endotoxic septic shock and sheds light on cutting-edge approaches in treatment. Beginning with a historical journey, the book traces the evolution of understanding from ancient concepts to modern molecular insights. It covers the physiological aspects of endotoxin sensitivity, tolerance, and human response variation. The crucial role of the gut microbiome in critical illness serves as a translational link between foundational science and clinical implications, and the complex language of bacterial communication is introduced, merging basic science with potential translational applications. In the clinical arena, chapters cover the critical role of endotoxin in septic shock, trauma, and its relevance in COVID-19, providing a translational bridge between laboratory findings and real-world clinical scenarios. The historical context of anti-endotoxin drug development is revisited, emphasizing the translational challenges faced in bridging basic science discoveries to clinical applications. The discussion on quantifying endotoxin concentration as well as the exploration of therapeutic rationale and clinical experiences with endotoxin removal therapy serve as a culmination of basic understanding translated into practical applications. The book concludes by contemplating the complexity of sepsis and acknowledging the challenges in achieving personalized medicine and underscoring the dynamic nature of the translational journey. In essence, this comprehensive exploration provides clinicians, researchers, and scientists with a holistic understanding of endotoxin and sepsis and potential advancements in patient care.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. vii 7. Preface - p. xi 8. Chapter 1. Sepsis and endotoxin: A brief history - p. 1 9. Chapter 2. Antiendotoxin therapies - p. 11 10. Chapter 3. Endotoxemia in COVID-19 - p. 25 11. Chapter 4. Endotoxin signaling: the TLR4 pathway and alternates - p. 43 12. Chapter 5. Endotoxin pathophysiology - p. 63 13. Chapter 6. Origins of human sensitivity to endotoxin and implications for sepsis therapeutic development - p. 87 14. Chapter 7. Endotoxin and the gut microbiome - p. 109 15. Chapter 8. Quantifying endotoxin in the blood of humans; a personal journey toward development of the endotoxin activity assay - p. 121 16. Chapter 9. Endotoxic septic shock - p. 133 17. Chapter 10. Endotoxin in trauma - p. 147 18. Chapter 11. Therapeutic rationale for endotoxin removal with polymyxin B immobilized fiber column hemoperfusion (PMX-HP) for endotoxemic septic shock - p. 159 19. Chapter 12. Clinical experience with PMX cartridge in sepsis and septic shock management - p. 171 20. Chapter 13. Precision medicine for sepsis: A dream or a reality? - p. 183 21. Index - p. 207
