Environmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects of endocrine-disrupting chemicals (EDCs) and their mechanism of action (MoA) on metabolism, reproduction and the multiple physiological roles of the endocannabinoid system which has recently been indicated as new target. The content systematically covers EDC sources and effects, EDCs as sources of disease and health impairment in laboratory models, EDCs as the cause of disease and health impairment in humans and wild species, and the removal of hazardous pollutants from wastewaters to highlight intervention, mitigation and adaptation for reduced threat.
This content will be a foundational resource for academic and research staff in endocrinology and hormone toxicology as well as for professors, researchers and students in these areas.
1. Environmental Contaminants and Endocrine Health - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Contributors - p. xi 8. Foreword - p. xiii 9. Preface - p. xv 10. Acknowledgments - p. xvii 11. Chapter 1.1 Endocrine system - p. 3 12. Chapter 1.2 Endocrine-disrupting chemicals (EDCs) in environmental matrices and human bodily fluids - p. 25 13. Chapter 1.3 In vitro-, ecological-, murine, and human models for examining the effects of EDCs - p. 45 14. Chapter 1.4 Endocrine-disrupting chemicals and their mode of action: The case of nuclear receptors and the evolution of the Metazoa - p. 55 15. Chapter 1.5 EDCs impacts on human populations. Addressing multiple chemicals in human exposure and epidemiological studies - p. 63 16. Chapter 2.1 EDCs: Focus on metabolic alteration of mammalian and nonmammalian models - p. 73 17. Chapter 2.2 EDCs: Focus on reproductive alterations in mammalian and nonmammalian models - p. 89 18. Chapter 2.3 The EDCs as epigenetic disruptors: Implications for development and health - p. 109 19. Chapter 2.4 Endocrine disrupting chemicals induce the epigenetic transgenerational inheritance of disease - p. 125 20. Chapter 2.5 Endocrine disruption persistence through development and across generations can be mediated by environmental perturbations of the heterochromatin/euchromatin compartmentalization - p. 135 21. Chapter 2.6 Alterations of the endocannabinoid system by endocrine-disrupting chemicals: Effects on metabolism and reproduction - p. 143 22. Chapter 3.1.1 Metabolism disrupting chemicals in the development of human diseases - p. 163 23. Chapter 3.1.2 Focus on reproductive health and alterations in women - p. 179 24. Chapter 3.1.3 EDCs: Focus on reproductive alterations in males - p. 201 25. Chapter 3.1.4 A good start lasts a lifetime: Endocrine-disrupting chemicals and their impact on embryonic and fetal development - p. 213 26. Chapter 3.1.5 Epidemiological studies on the effects of prenatal exposure to endocrine-disrupting compounds on fertility - p. 227 27. Chapter 3.2.1 Metabolism vs. metabolomics: Mechanisms of endocrine disruption - p. 235 28. Chapter 3.2.2 Effects of EDCs on female reproductive system in reptiles - p. 247 29. Chapter 3.2.3 Effects of aquatic contaminants in female fish reproduction - p. 257 30. Chapter 3.2.4 EDCs: Focus on male fish reproductive alterations - p. 269 31. Chapter 3.2.5 Environmental endocrine-disrupting chemicals and their effects in marine mammals - p. 283 32. Chapter 4.1 Conventional wastewater treatment methods and their ability to remove EDCs - p. 309 33. Chapter 4.2 Nanofiltration and ultrafiltration of endocrine-disrupting compounds - p. 329 34. Chapter 4.3 Advanced oxidation processes for wastewater treatment - p. 341 35. Chapter 4.4 Endocrine-disrupting compounds (EDCs) in conventional wastewater treatment: State of art and future challenges - p. 359 36. Index - p. 369
Environmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects of endocrine-disrupting chemicals (EDCs) and their mechanism of action (MoA) on metabolism, reproduction and the multiple physiological roles of the endocannabinoid system which has recently been indicated as new target. The content systematically covers EDC sources and effects, EDCs as sources of disease and health impairment in laboratory models, EDCs as the cause of disease and health impairment in humans and wild species, and the removal of hazardous pollutants from wastewaters to highlight intervention, mitigation and adaptation for reduced threat.
This content will be a foundational resource for academic and research staff in endocrinology and hormone toxicology as well as for professors, researchers and students in these areas.
1. Environmental Contaminants and Endocrine Health - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Contributors - p. xi 8. Foreword - p. xiii 9. Preface - p. xv 10. Acknowledgments - p. xvii 11. Chapter 1.1 Endocrine system - p. 3 12. Chapter 1.2 Endocrine-disrupting chemicals (EDCs) in environmental matrices and human bodily fluids - p. 25 13. Chapter 1.3 In vitro-, ecological-, murine, and human models for examining the effects of EDCs - p. 45 14. Chapter 1.4 Endocrine-disrupting chemicals and their mode of action: The case of nuclear receptors and the evolution of the Metazoa - p. 55 15. Chapter 1.5 EDCs impacts on human populations. Addressing multiple chemicals in human exposure and epidemiological studies - p. 63 16. Chapter 2.1 EDCs: Focus on metabolic alteration of mammalian and nonmammalian models - p. 73 17. Chapter 2.2 EDCs: Focus on reproductive alterations in mammalian and nonmammalian models - p. 89 18. Chapter 2.3 The EDCs as epigenetic disruptors: Implications for development and health - p. 109 19. Chapter 2.4 Endocrine disrupting chemicals induce the epigenetic transgenerational inheritance of disease - p. 125 20. Chapter 2.5 Endocrine disruption persistence through development and across generations can be mediated by environmental perturbations of the heterochromatin/euchromatin compartmentalization - p. 135 21. Chapter 2.6 Alterations of the endocannabinoid system by endocrine-disrupting chemicals: Effects on metabolism and reproduction - p. 143 22. Chapter 3.1.1 Metabolism disrupting chemicals in the development of human diseases - p. 163 23. Chapter 3.1.2 Focus on reproductive health and alterations in women - p. 179 24. Chapter 3.1.3 EDCs: Focus on reproductive alterations in males - p. 201 25. Chapter 3.1.4 A good start lasts a lifetime: Endocrine-disrupting chemicals and their impact on embryonic and fetal development - p. 213 26. Chapter 3.1.5 Epidemiological studies on the effects of prenatal exposure to endocrine-disrupting compounds on fertility - p. 227 27. Chapter 3.2.1 Metabolism vs. metabolomics: Mechanisms of endocrine disruption - p. 235 28. Chapter 3.2.2 Effects of EDCs on female reproductive system in reptiles - p. 247 29. Chapter 3.2.3 Effects of aquatic contaminants in female fish reproduction - p. 257 30. Chapter 3.2.4 EDCs: Focus on male fish reproductive alterations - p. 269 31. Chapter 3.2.5 Environmental endocrine-disrupting chemicals and their effects in marine mammals - p. 283 32. Chapter 4.1 Conventional wastewater treatment methods and their ability to remove EDCs - p. 309 33. Chapter 4.2 Nanofiltration and ultrafiltration of endocrine-disrupting compounds - p. 329 34. Chapter 4.3 Advanced oxidation processes for wastewater treatment - p. 341 35. Chapter 4.4 Endocrine-disrupting compounds (EDCs) in conventional wastewater treatment: State of art and future challenges - p. 359 36. Index - p. 369
